Abstract Giant hypothalamic hamartomas (GHH) are rare neonatal intracerebral congenital malformations responsible for gelastic epilepsy and/or endocrine disturbances. Sacrococcygeal teratomas (SCT) are fetal neoplasms associated with perinatal morbidity and mortality, especially hemorrhagic complications in giant examples (GSCT). Here, we describe an immature ruptured GSCT complicated by hemorrhagic shock at 32-week gestation boy requiring an emergency delivery, followed immediately...
Fri Sep 25, 2020 03:00
Assessing arm and hand sensorimotor impairments that are functionally relevant is essential to optimize the impact of neurorehabilitation interventions. Technology-aided assessments should provide a sensitive ...
Fri Sep 25, 2020 03:00
High Altitude Medicine &Biology, Ahead of Print.
Wed Sep 23, 2020 10:00
In this paper we describe the effects of peripheral cryoneurotomy on a consecutive series of patients with intractable trigeminal neuralgia (TN) who had been treated by a single surgeon over a ten-year period. The results of 55 patients who underwent a total of 102 cryoneurotomies were documented. The age at first cryofreeze was 64 (30-92) years with 24 males and 31 females. Thirty-five had primary TN and 20 secondary TN. The first cryofreeze resulted in 28.2 (5-144) pain free months. Twenty-nine...
Fri Sep 25, 2020 03:00
Discussion about recruitment and length of training in oral and maxillofacial surgery (OMFS) is a welcome initiative.1,2 It is important, however, to acknowledge that these issues and concerns go beyond any single specialty, and Rimmer has published detailed concerns regarding the crisis in the appointment of consultants and trainee physicians.3 Despite the large number of vacancies, which is around 43% in England and Wales, 56% remain vacant due to the lack of applicants, and in 34% of cases the...
Fri Sep 25, 2020 03:00
Oral mucosal defects after ablative surgery may be reconstructed utilising various techniques. The options can range from secondary healing to traditional complex reconstruction with a microvascular free flap. There is a surge in the adaptation of newer techniques, which are simple, effective, and representative of the tissue being replaced with negligible morbidity to the affected population (who are mainly elderly with associated comorbidities). We present a novel approach to restore an oral cancer...
Fri Sep 25, 2020 03:00
Reconstruction of large orbital defects is challenging.1 We present a complex trauma case requiring repair of a medial-lateral 3.5cm orbital floor defect. Reduction of the zygomatic fracture was carried out after trauma. Repair of the orbital floor was delayed due to the large size of the defect, which involved most of the orbital floor with loss of landmarks (Fig. 1). Therefore, a stock plate was inadequate for repair and a second procedure was planned to lift the orbital rim, reconstruct the orbital...
Fri Sep 25, 2020 03:00
Factor Analysis of the Brazilian Version of the Voice-Related Quality of Life (V-RQOL) Questionnaire
To investigate the psychometric properties of the Voice-Related Quality of Life (V-RQOL) questionnaire in Brazilian Portuguese by assessing its reliability and conducting exploratory factor analysis (EFA) and confirmatory factor analysis (CFA).
Fri Sep 25, 2020 03:00
This study described voice use and lifestyle information about student singers with a focus on describing differences in self-reported information at study intake compared to data from 21 consecutive days of a voice Log.
Fri Sep 25, 2020 03:00
This study was designed to evaluate the effectiveness of either steam, semi-occluded vocal tract (SOVT) exercises, or a combination of both as a speaking voice warm-up strategy to be used at the start of the day.
Fri Sep 25, 2020 03:00
To clarify the relationship between voice and respiratory function, and to understand the role for airflow measures in the evaluation of voice patients.
Fri Sep 25, 2020 03:00
Publication date: Available online 24 September 2020Source: Journal of the American College of SurgeonsAuthor(s): Q Lina Hu, Michael C. Grant, Melissa A. Hornor, Natalie N. Merchant, Jessica Y. Liu, Chelsea P. Fischer, Carol J. Peden, Clifford Y. Ko, Melinda Maggard-Gibbons, Christopher L. Wu, Elizabeth C. Wick
Sat Sep 26, 2020 01:08
Abstract Pyruvate kinase catalyses the final step of the glycolytic pathway in central energy metabolism. The monomeric structure comprises three domains: a catalytic TIM-barrel, a regulatory domain involved in allosteric activation, and a lid domain that encloses the substrates. The lid domain is thought to close over the TIM-barrel domain forming contacts with the substrates to promote catalysis and may be involved in stabilising the activated state when the allosteric activator...
Fri Sep 25, 2020 03:00
Abstract Purpose To evaluate the technical success of conventional TMJ arthrocentesis in cadavers, using the tragal-lateral canthus line as an anatomical reference for the puncture points. Methods Ten formalin-treated and 8 fresh cadavers were submitted to the arthrocentesis. A point located 10 mm anteriorly and 2 mm inferiorly to the beginning of...
Fri Sep 25, 2020 03:00
No abstract available
Tue Sep 22, 2020 03:00
Purpose: Complex bony orbital defects are reconstructively challenging due to loss of intraoperative anatomical landmarks and adjacent support. Presized and precontoured porous polyethylene–titanium implants (Medpor Titan 3D Orbital Floor Implant) are designed to reestablish normal orbital floor and medial wall anatomy and are modeled after anatomically averaged orbits. This is the first study to report clinical outcomes with this implant. Methods: This retrospective case series reviewed...
Tue Sep 22, 2020 03:00
A 45-year-old male presented with active progressive thyroid eye disease refractory to intravenous steroids and right orbital radiation. Visual acuity, left relative afferent pupillary defect, and Humphrey visual field defects were consistent with worsening left dysthyroid optic neuropathy. Orbital MRI demonstrated extraocular muscle enlargement and effacement of the left optic nerve sheath. After 2 infusions of teprotumumab, the patient’s visual acuity, relative afferent pupillary defect, Humphrey...
Tue Sep 22, 2020 03:00
Hidradenoma is a rare benign neoplasm, with few cases reported to involve the eyelid. When affecting the eyelid, hidradenomas may mimic other benign or malignant lesions. Rarely, a benign hidradenoma may transform into a malignant hidradenoma and metastasize. The authors present a case of a benign hidradenoma arising from the eyelid, presenting with rapid growth, ulceration, and bleeding, suggestive of a malignant lesion. Accepted for publication July 8, 2020. The authors have no financial...
Tue Sep 22, 2020 03:00
Isolated orbital periphlebitis in the context of nonspecific orbital inflammation is rare. This case series describes 3 patients with periphlebitis of the superior ophthalmic vein, 2 of which were confirmed with pathology. All 3 cases had a history of Graves hyperthyroidism. Superior ophthalmic vein periphlebitis is a rare form of orbital inflammation presenting with proptosis and motility restriction yet few inflammatory signs. It may be associated with autoimmune hyperthyroidism and represent a...
Tue Sep 22, 2020 03:00
The authors report an unusual case of lung adenocarcinoma metastasis to the lacrimal sac. A 61-year-old woman with stage IV non–small cell lung cancer presented with left facial pain and epiphora. She was found to have an elevated tear meniscus associated with a firm, fixed medial canthal mass. Orbital imaging demonstrated nodular enlargement of the lacrimal drainage apparatus. Biopsy of the lacrimal sac was performed, and it revealed a metastatic lung adenocarcinoma. The patient received targeted...
Tue Sep 22, 2020 03:00
Purpose: To investigate the effect of visual supplementation and its mode of delivery in preoperative counseling of patients undergoing oculoplastic surgery. Methods: A prospective randomized controlled trial of consecutive patients undergoing oculoplastic eyebrow and eyelid surgery was conducted. Patients were randomized to an “oral only” group receiving routine preoperative oral counseling or an “oral and visual” group receiving identical counseling visually supplemented with photographs...
Tue Sep 22, 2020 03:00
Purpose: The aim of the study was to investigate the clinical resolution versus radiologic regression of orbital lymphatic malformations (LMs) following treatment with intralesional bleomycin sulfate sclerotherapy. Methods: A retrospective interventional study of 24 eyes with orbital LMs treated with nonimage-guided bleomycin sclerotherapy. The clinical and radiologic outcomes were classified as excellent, good, fair, and poor. Regression was assessed clinically and by radiologic volumetrics....
Tue Sep 22, 2020 03:00
A 48-year-old man presented with an Aspergillus fumigatus complex infection of an exenterated orbit. The OS had been exenterated 7 months ago, together with total parotidectomy and neck dissection followed by irradiation due to a massive squamous cell carcinoma with orbital invasion and lymphatic metastasis. The patient was under permanent immunosuppression with oral prednisone and tacrolimus due to a kidney transplantation 5 years ago. The infected skin of the exenterated orbit was cleared using...
Tue Sep 22, 2020 03:00
Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
Wed Sep 23, 2020 10:00
Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
Wed Sep 23, 2020 10:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08586
Fri Sep 25, 2020 07:00
Cell sheet morphogenesis is essential for metazoan development and homeostasis of animal form - it contributes to developmental milestones including gastrulation, neural tube closure, heart and palate formation and to tissue maintenance during wound healing. Dorsal closure, a well-characterized stage in Drosophila embryogenesis and a model for cell sheet morphogenesis, is a remarkably robust process during which coordination of conserved gene expression patterns and signaling cascades regulate the...
Sat Sep 26, 2020 00:07
Plant growth, development, and nutritional quality depends upon amino acid homeostasis, especially in seeds. However, our understanding of the underlying genetics influencing amino acid content and composition remains limited, with only a few candidate genes and quantitative trait loci identified to date. Improved knowledge of the genetics and biological processes that determine amino acid levels will enable researchers to use this information for plant breeding and biological discovery. Towards...
Sat Sep 26, 2020 00:07
Limited previous research has assessed the psychosocial burden and productivity impact of caring for a child with peanut allergy and factors associated with burden. The objective of this research was to explor...
Fri Sep 25, 2020 03:00
A few studies have reported the association between asthma and osteoporosis. We aimed to analyze the association of asthma and its subgroups with osteoporosis in the Korean adult population.
Fri Sep 25, 2020 03:00
Rationale: An increasing number of automated and artificially intelligent (AI) systems make medical treatment recommendations, including "personalized" recommendations, which can deviate from standard care. Legal scholars argue that following such nonstandard treatment recommendations will increase liability in medical malpractice, undermining the use of potentially beneficial medical AI. However, such liability depends in part on lay judgments by jurors: When physicians use AI systems, in which...
Sat Sep 26, 2020 01:05
This article is the second part in our machine learning series. Part 1 provided a general overview of machine learning in nuclear medicine. Part 2 focuses on neural networks. We start with an example illustrating how neural networks work and a discussion of potential applications. Recognizing there is a spectrum of applications, we focus on recent publications in the areas of image reconstruction, low-dose PET, disease detection and models used for diagnosis and outcome prediction. Finally, since...
Sat Sep 26, 2020 01:05
Cyclooxygenase-1 (COX-1), a biomarker for neuroinflammation, is implicated in ovarian cancer (OvCa) progression and prognosis. This study considered the repurposing of [11C]PS13, a COX-1 PET neuroimaging radiopharmaceutical, in OvCa xenograft mouse models. Methods: [11C]PS13 was evaluated in ICRscid mice with s.c. or i.p. human OVCAR-3 OvCa xenografts by dynamic PET/MR imaging, ex vivo biodistribution and radiometabolite analysis of plasma and tumor. Results: OVCAR-3 xenografts were well visualized...
Sat Sep 26, 2020 01:05
18F-fluciclovine and 68Ga-prostate specific membrane antigen (PSMA) are novel PET imaging radiotracers used to characterize disease burden in biochemical recurrent prostate cancer. 18F-fluciclovine was FDA-approved in 2016 and is reimbursed through public and private payers, while 68Ga-PSMA-11 is considered investigational and accessed through clinical trials. The purpose of this study was to evaluate the demographic differences between patients receiving 18F-fluciclovine and 68Ga-PSMA-11 at a tertiary...
Sat Sep 26, 2020 01:05
Background: Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus, is highly contagious. Global medical systems have been heavily impacted by the COVID-19 pandemic. Although the majority of patients with intracranial disease require time-sensitive surgery, how to conduct neurosurgery and prevent and control nosocomial infection during a pandemic is challenging. Materials and Methods: We retrospectively reviewed the clinical data of patients undergoing neurosurgical and...
Thu Sep 24, 2020 03:00
Abstract Purpose Exposure to prenatal opioids may adversely impact the developing brain networks. The aim of this pilot study was to evaluate alterations in amygdalar functional connectivity in human infants with prenatal opioid exposure. Methods In this prospective IRB approved study, we performed resting state functional MRI (rs-fMRI) in 10 infants...
Sat Sep 26, 2020 03:00
The expression of PD-L1 could be a novel biomarker which predicts that patients are more likely to respond to immunotherapy. Our study investigated the relationship among clinicopathological characteristics, prognosis, PD-L1 expression levels, and FOXP3+ Treg infiltration. In addition, the relationship among clinicopathological characteristics, prognosis, PD-L1 expression levels, and FOXP3+ Treg infiltration was explored. Furthermore, the relationship between PD-L1 expression and FOXP3+ Treg infiltration...
Fri Sep 25, 2020 16:35
During cardiopulmonary bypass (CPB), pulmonary ischemia/reperfusion (I/R) injury can cause acute lung injury (ALI). Our previous research confirmed that abnormal high-mobility group box 1 (HMGB1) release after CPB was closely related to ALI. However, the mechanism underlying the HMGB1-mediated induction of ALI after CPB is unclear. Our previous study found that HMGB1 binds Toll-like receptor 4 (TLR4), leading to lung injury, but direct evidence of a role for these proteins in the mechanism of CPB-induced...
Fri Sep 25, 2020 20:20
Thyroid, Ahead of Print.
Wed Sep 23, 2020 10:00
Future Oncology, Ahead of Print.
Fri Sep 25, 2020 09:18
Future Oncology, Ahead of Print.
Fri Sep 25, 2020 09:38
Future Oncology, Ahead of Print.
Fri Sep 25, 2020 09:50
Future Oncology, Ahead of Print.
Fri Sep 25, 2020 10:04
Rotational beam delivery enables concurrent acquisition of cone-beam CT (CBCT), thereby facilitating further geometric verification of patient setup during radiation treatment. However, it is challenging to ac...
Fri Sep 25, 2020 03:00
Abstract Purpose of Review This narrative review examines the use of behavioral interventions for acute treatment of headache and pain in the emergency department (ED)/urgent care (UC) and inpatient settings. Recent Findings Behavioral interventions demonstrate reductions of pain and associated disability in headache, migraine, and other...
Sat Sep 26, 2020 03:00
Abstract Organisms in the wild have to allocate limited resources towards competing functions such as reproduction, growth, and self-maintenance. These competing investments create significant changes in physiological activity, and we still know little about the relationship between physiological activity and reproductive investment in natura. We investigated trade-offs between physiological activity and reproductive investment in the parthenogenetic Colorado checkered whiptail,...
Sat Sep 26, 2020 03:00
Sat Sep 26, 2020 03:00
Mitochondrial function requires numerous genetic interactions between mitochondrial- and nuclear- encoded genes. While selection for optimal mitonuclear interactions should result in coevolution between both g...
Fri Sep 25, 2020 03:00
I read with enthusiasm the article by Baldwin on “The historical relationship between art and plastic surgery: Is this relationship still relevant to the modern plastic surgeon?”. This highlighted the role artists have played in the development of plastic surgery, and touched upon contemporary evidence of plastic surgeons continuing to engage with the creative arts.1 Correspondence by Sepehripour and Henderson contributed to this latter point by describing their interesting research auditing the...
Fri Sep 25, 2020 03:00
No abstract available
Tue Sep 15, 2020 03:00
Objective: There is a need to highlight individual prognostic factors determining hearing loss in enlarged (wide) vestibular aqueduct, as currently clinicians cannot counsel parents about the expected clinical course, nor provide individualized hearing rehabilitation plans following identification at newborn screening. We apply a novel methodology to specifically outline and assess the accuracy of prognostic factors reporting for hearing loss in enlarged vestibular aqueduct. Data Sources: ...
Tue Sep 15, 2020 03:00
Objective: To evaluate the outcomes and association factors of long-term hearing preservation (HP) in cochlear implantation with lateral wall (LW) electrode arrays. Study Design: Retrospective case review. Setting: Tertiary academic center. Patients: Thirty-four consecutive ears from 32 patients with a ≤ 80 dB HL preoperative low-frequency pure-tone average of 250 to 500 Hz were included. Intervention: Cochlear implantation with LW electrode arrays and the intention of achieving...
Tue Sep 15, 2020 03:00
Objective: To describe a rare case of pneumolabyrinth (PNL) and pneumocephalus (PNC) due to otogenic meningitis in a patient with superior canal dehiscence (SCD) resulting in profound sensorineural hearing loss (SNHL), semicircular canals impairment but preservation of SCD-related enhanced otolith function. Patient: A 65-year-old woman with otogenic meningitis. Intervention: Temporal bone high-resolution computed tomography (CT) scans, brain-magnetic resonance imaging, audiometry, bedside...
Tue Sep 15, 2020 03:00
Objective: Choice of electrode array (EA) design and differences in outcome are major concerns both to patients with single-sided deafness (SSD) and to surgeons before cochlear implant (CI) surgery. The present work investigates the effects of EA design on 1) insertion depths, and 2) audiological outcomes of SSD CI recipients. Study Design: Retrospective study. Setting: Tertiary academic center. Patients: Forty patients with acquired SSD matched according to duration of deafness ...
Tue Sep 15, 2020 03:00
Objective: To compare the postoperative complications between posterior tympanotomy cochlear implantation (PTCI) and subtotal petrosectomy cochlear implantation (SPCI). Study Design: A retrospective cohort study. Setting: Two tertiary referral centers. Patients: Two hundred ninety-eight patients who underwent PTCI and 33 who underwent SPCI. Interventions: Cochlear implantation using either posterior tympanotomy or subtotal petrosectomy. Main Outcome Measures: Postoperative...
Tue Sep 15, 2020 03:00
Objective: Cochlear implants are the gold standard for patients with severe sensorineural hearing loss. A focused electrical stimulation of individual spiral ganglion neurons has not been achieved yet because the scala tympani is a fluid-filled compartment and does not offer a matrix for neuritic outgrowth. Coating of the electrode contacts with swelling hydrogels could fill that gap between the electrode array and the medial wall of the cochlea. Therefore, the exact position of the electrode...
Tue Sep 15, 2020 03:00
Objective: To determine sound quality for extended bandwidth amplification using a direct drive hearing device. Study Design: Prospective double-blind within-subjects repeated measures study. Setting: University hearing research laboratories. Patients: Fifteen experienced hearing aid users with symmetric mild-sloping-to-severe sensorineural hearing loss. Intervention(s): Sound quality ratings of speech and music passages were obtained using the Multiple Stimulus with Hidden...
Tue Sep 15, 2020 03:00
Introduction: Facioscapulohumeral muscular dystrophy type 1 (FSHD) represents one of the most common forms of muscular hereditary diseases and it is characterized by a great clinical variability with the typical muscular symptoms and other clinical features, including hearing impairment. However, etiopathogenetic mechanisms of auditory dysfunction are still not completely understood and it has been suggested that it could be assigned to a cochlear alteration that is present even in those subjects...
Tue Sep 15, 2020 03:00
Objective/Hypothesis: The aim of this study was to investigate cochlear implantation (CI) outcome in children with nerve deficiency. Study Design: Retrospective chart review. Methods: A total of seven children with prelingual profound deficiency (hypoplasia or aplasia) were included. A control group of 10 CI children with no cochlear nerve anomalies was also included. In addition to implant stimulation levels, children's performance on pure-tone audiometry, speech reception measure,...
Tue Sep 15, 2020 03:00
Objective: To describe a technique for mastoid obliteration following canal wall down (CWD) mastoidectomy for chronic otitis media with cholesteatoma, and review its early results in producing a dry, safe ear, and a small mastoid cavity. Study Design: Retrospective review. Setting: Tertiary referral center. Patients: Forty-three consecutive CWD procedures using bone dust obliteration for chronic otitis media. Intervention: All patients underwent CWD mastoidectomy and, if indicated,...
Tue Sep 15, 2020 03:00
Objective: Evaluate the useful length and the diameter of the cochlear lumen (CL) using routine imaging before cochlear implantation to study inter-individual variability and its impact on the insertion depth of the electrode carrier (EC). Study design: Prospective cross-sectional study. Setting: Tertiary referral center. Patients: Thirty-one preoperative and postimplantation temporal bone CT scans were analyzed by two investigators. Intervention: Images were analyzed via orthogonal...
Tue Sep 15, 2020 03:00
Hypothesis: The ototoxic effects of aminoglycosides are well known. Gentamicin carries a substantial risk of hearing loss. Gentamicin is widely used to combat life-threatening infections, despite its ototoxic effects. Calcium dobesilate is a pharmacologically active agent used to treat many disorders due to its vasoprotective and antioxidant effects. We investigated the therapeutic role of calcium dobesilate against gentamicin-induced cochlear nerve ototoxicity in an animal model. Methods: ...
Tue Sep 15, 2020 03:00
No abstract available
Tue Sep 15, 2020 03:00
No abstract available
Tue Sep 15, 2020 03:00
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThis study was performed to examine the effect of dexmedetomidine for intraoperative sedation and postoperative cognitive function in patients with preoperative anxiety undergoing carotid artery stenting.MethodsEighty patients were randomly divided into two groups: the dexmedetomidine group and the control group. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Anxiety was evaluated...
Fri Sep 25, 2020 08:40
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveWe aimed to summarize the clinical characteristics of floating thrombus in the inferior vena cava (IVC).MethodsFrom January 2014 to June 2019, four patients with floating thrombus in the IVC were admitted to our hospital and underwent intracavitary therapy. Diagnosis, therapy, and clinical characteristics of floating thrombus were summarized.ResultsThree patients presented with pulmonary embolism. Three of the...
Fri Sep 25, 2020 08:42
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveAngiolipoma is a benign tumor that rarely occurs in the gastrointestinal (GI) tract. This case series was performed to increase clinicians’ understanding of the diagnosis and management of GI angiolipoma.MethodsWe evaluated the clinical presentations, diagnoses, and treatments of 3 patients with angiolipoma in the upper GI tract in our hospital and 27 cases reported in the literature.ResultsAmong all 30 cases...
Fri Sep 25, 2020 08:46
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Solitary fibrous tumor of the pleura (SFTP) is a rare disease, and most published case reports are in patients over 40 years old. We report a case of SFTP in a 22-year-old woman. The imaging features were observed using contrast-enhanced computed tomography (CT), and histomorphological features were evaluated using pathology and immunohistochemistry. The CT showed a mass in the pleura inside the ninth rib on the left....
Fri Sep 25, 2020 08:50
Background We previously reported on a phase 2 study of everolimus plus bevacizumab across various nonclear cell renal cell carcinoma (nccRCC) histologies and observed encouraging activity among patients with papillary RCC (pRCC) and unclassified RCC (uRCC) with a major papillary component. We subsequently expanded the study to enroll additional patients with pRCC variants. Methods Everolimus plus bevacizumab was administered at standard doses until disease progression or intolerance to therapy....
Fri Sep 25, 2020 17:24
Abstract Background Transcervical arterial ligation has been studied as a useful procedure to prevent bleeding events after transoral robotic surgery (TORS). Methods A systematic review of English‐language literature on arterial ligation in TORS from 2005 to 2019 was conducted using Cochrane, PubMed, Web of Science (WoS), and ScienceDirect databases. Studies evaluating ligation and rates of postoperative hemorrhage were included. Meta‐analysis of included studies was performed to assess...
Fri Sep 25, 2020 22:31
Abstract Background Intraoperative evaluation of lymph nodal metastasis in head and neck squamous cell carcinoma (HNSCC) assumes importance and avoids over‐treatment in clinically node negative (N0) neck. Frozen section (FZ) is the commonly employed technique, but it requires significant investment in resources, time, and personnel. Intraoperative imprint cytology (IC) is a rapid, reliable, and inexpensive alternative. We conducted a prospective study to assess the diagnostic accuracy of intraoperative...
Fri Sep 25, 2020 15:46
Abstract Malignant gastrointestinal neuroectodermal tumor (GNET) is an extremely rare neoplasm. Immunohistochemically, GNET typically demonstrates neural differentiation but lacks melanocytic differentiation, making it distinct from clear cell sarcoma of the soft tissues (CCS). Herein we report for the first time the cytomorphologic features of lymph node metastasis from presumably liver GNET. A 36‐year‐old female presented with fevers, night sweats, loss of appetite, and a 20‐lbs weight loss. Radiographic...
Fri Sep 25, 2020 15:47
Background Lymphomas presenting in effusions could either be primary or secondary, with very limited data from Taiwan. Methods We retrospectively reviewed effusion lymphomas from our archives in a tertiary center from July 2011 to June 2019. Results We identified 59 specimens from 43 patients, including 7 cases with primary effusion lymphoma (PEL) and 36, secondary effusion involvement. Half of the secondary cases presented concurrently with effusion lymphoma, while the remaining half‐experienced...
Fri Sep 25, 2020 15:54
Abstract Current breast cancer risk models identify mostly less aggressive tumors, although only women developing fatal breast cancer will greatly benefit from early identification. Here, we evaluated the use of mammography features (microcalcification clusters, cBIRADS density, and lack of breast density reduction) as early markers of aggressive subtypes and tumor characteristics. Mammograms were retrieved from a population‐based cohort of women that were diagnosed with breast cancer from 2001‐2008...
Fri Sep 25, 2020 11:26
Abstract Alcohol consumption is correlated positively with risk for breast cancer in observational studies, but observational studies are subject to reverse causation and confounding. The association with epithelial ovarian cancer (EOC) is unclear. We performed both observational Cox‐regression and two‐sample Mendelian randomization (MR) analyses using data from various European cohort studies (observational) and publicly available cancer consortia (MR). These estimates were compared with World...
Fri Sep 25, 2020 11:28
Abstract Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population‐based case‐control study (MCC‐Spain) if the time‐of‐day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in‐person interviews. Information on time‐of‐day of activity (assessed approximately...
Fri Sep 25, 2020 11:28
Publication date: Available online 25 September 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Paolo Montemurro, Mubashir Cheema, Ben Khoda, Tommaso Pellegatta, Per Hedén
Sat Sep 26, 2020 12:11
Abstract Coronavirus disease 2019 (COVID‐19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has been a rising international cause of morbidity and mortality. Angiotensin‐converting enzyme 2 (ACE2) is identified as a key cell entry receptor for SARS‐CoV‐2 and suggested to be a limiting factor for viral entry at the initial infection stage. Recent studies have demonstrated that ACE2 expression is highly enriched in nasal epithelial cells and type II alveolar epithelial...
Fri Sep 25, 2020 18:52
AbstractThis article is protected by copyright. All rights reserved.
Fri Sep 25, 2020 11:39
For breast cancer, partial and total breast reconstruction reduce patient's sensation of mutilation, improving their quality of life. On the other hand, the pandemic of the COVID-19 resulted in the implementation of social distancing measures, with a negative effect on the management of different diseases. We read the article of Di Pace et al entitled “Breast reconstruction and the COVID-19 pandemic: A viewpoint1”. We agree that risk-reducing surgeries, contralateral operation and revisional procedures...
Sat Sep 26, 2020 03:00
We read with interest about the implementation of a one-stop hand trauma clinic at the Royal Free Hospital 1 and the correspondence from Leeds Teaching Hospitals regarding patterns of hand trauma during the COVID-19 lockdown 2. Over recent years North Bristol Trust (NBT) Plastic Surgery department has moved away from the one-stop clinic model as we have evolved our hand trauma service. However, during the COVID-19 pandemic we note that single contact care is the gold standard in order to avoid repeated...
Sat Sep 26, 2020 03:00
We thank Dr Cavalcante and colleagues for their constructive comments in response to our viewpoint on breast reconstruction during the COVID-19 pandemic.1 We welcome discussion of this time-sensitive issue within the context of a different healthcare system which they base on an electronic survey of Brazilian surgeons over a two-month period.
Sat Sep 26, 2020 03:00
We read with interest the article by Dale et al and it provides a valuable addition to the literature.1 The evidence regarding optimal neck dissection for regional control of head and neck cutaneous malignant melanoma is limited, and precise management of the neck has frequently been omitted from the major sentinel lymph node biopsy (SLNB) trials, even when queried for subsequent study design by us.
Sat Sep 26, 2020 03:00
As medical students in the United Kingdom with a keen interest in burns management, it is with great interest that we read the article by Moorby et al.1 “A survey of current burns knowledge in UK undergraduate medical students”. We commend the authors’ efforts to highlight the lack of knowledge of medical students in burns management: a topic which remains important in the role of a junior doctor. However we have some concerns with the methodology of the survey and the conclusions drawn thereof.
Sat Sep 26, 2020 03:00
Sat Sep 26, 2020 03:00
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