Effect of CBX7 deficiency on the socket healing after tooth extractions,Abstract
CBX7 is shown to down-regulate the expression of osteopontin (OPN) that is associated with osteoblast function. Here, we studied the role of CBX7 in the wound healing of tooth extraction socket in which osteoblast activity is critical via comparison between CBX7-knockout (CBX7−/−) mice and their wild-type (WT) counterparts of 6 weeks old with maxillary first molar extracted. Mice were euthanized at 7, 14, and 21 days after extractions, and alveolar sockets were assessed by semi-quantitative histomorphometry for hard tissue healing, including new bone fill (Masson’s trichrome staining), osteoblast activity (OPN/osterix, Osx), osteoclast activity (tartrate-resistant acid phosphatase, TRAP), and for soft tissue healing, including blood vessels (alpha smooth muscle actin, α-SMA). Also, the bone microarchitecture was evaluated by micro-CT. In radiological analysis, CBX7−/− mice increased bone mass significantly more than WT mice did. Consistently, both the amount of new bone fill and OPN/Osx-immunopositive cells in the extraction sockets were significantly increased in CBX7−/− mice at each time point with respect to their WT siblings, while osteoclast number exhibited a trend of more increase in CBX7−/− mice at all time points as well. In agreement with enhanced bone formation during socket healing, significantly elevated α-SMA-immunopositive area was noted in CBX7−/− mice in contrast to WT mice. Taken together, these data suggest that CBX7 deficiency has a positive effect on tooth extraction socket healing.
|
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Πληροφορίες
Ετικέτες
Τετάρτη 10 Ιουλίου 2019
Αναρτήθηκε από
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
στις
10:50 μ.μ.
Ετικέτες
00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(276)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (143)
-
►
2022
(1976)
- ► Δεκεμβρίου (116)
- ► Σεπτεμβρίου (158)
- ► Φεβρουαρίου (165)
- ► Ιανουαρίου (161)
-
►
2021
(3661)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (274)
- ► Φεβρουαρίου (64)
- ► Ιανουαρίου (368)
-
►
2020
(4554)
- ► Δεκεμβρίου (400)
- ► Σεπτεμβρίου (381)
- ► Φεβρουαρίου (638)
- ► Ιανουαρίου (691)
-
▼
2019
(4999)
- ► Δεκεμβρίου (924)
- ► Σεπτεμβρίου (845)
-
▼
Ιουλίου
(732)
- Otology & Neurotology
- Clinical and Translational Gastroenterology
- Anaesthesia
- Menopause
- Clinical Orthopaedics and Related Research(R)
- Therapeutics
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Pediatric Radiology
- Obesity Surgery
- Pediatric Orthopaedics
- Rheumatology
- Anaesthesiology
- Cardiovascular Medicine
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- MDPI
- MDPI
- Nutrients, Vol. 11, Pages 1748: The Modern...
- Molecules, Vol. 24, Pages 2760: Catalytic ...
- JCM, Vol. 8, Pages 1128: NEWS2 is Superior...
- IJMS, Vol. 20, Pages 3718: Transactivation...
- IJERPH, Vol. 16, Pages 2712: The Mental He...
- Cells, Vol. 8, Pages 789: A Ciliary View o...
- Cancers, Vol. 11, Pages 1073: GSK3-β Stimu...
- Biomolecules, Vol. 9, Pages 316: Ellagitan...
- Patterns of care and treatment outcomes for loca...
- Myotomy of sternocleidomastoid muscle as a secon...
- Predicting individualized mortality probabilitie...
- Tongue reconstruction: Rebuilding mobile three‐d...
- Superficial temporal vessels, both anterograde a...
- Comparison of hypocalcemia rates between LigaSur...
- Early oral cavity cancer: The prognostic factors...
- Hallmarks of cancer: Tumor budding as a sign of ...
- Very late xerostomia, dysphagia, and neck fibros...
- Head and neck cancer during pregnancy Jennifer ...
- Oncogenic KIT mutations induce STAT3-dependent a...
- Intraoperative Depth of Invasion Is Accurate in...
- Capnography Detection Using Nasal Cannula Is Sup...
- The use of Transnasal Humidified Rapid‐insufflati...
- Endoscopic Type I Tympanoplasty is as Effective ...
- Nonmelanoma Facial Skin Cancer: A Review of Dia...
- Diagnostic Value of TROP-2 and CK19 Expression in...
- Unexpected Gallbladder Metastasis of Clear Cell ...
- Epstein-Barr Virus–Associated With Lympho...
- Does Ramadan Fasting Affect Spirometric Data of H...
- Signs of chronic itch in the mouse imiquimod mod...
- MaxilloFacial
- Prolonged Dysphagia After Orthognathic Surgery R...
- Factors Associated with the Mental Health and Sa...
- Rituximab to Treat Fibrosing Mediastinitis–Ass...
- Vancomycin-Associated Erythema Multiforme Khi...
- Topical Administration of Amphotericin B as an...
- Imatinib-Associated Pneumocystis jirovecii Pneumonia
- Quetiapine-Associated Pseudotumor Cerebri
- Mitochondria-Targeted Antioxidant SkQ1 for Gam...
- Anti-Xa Activity in Elderly Xabans-Treated Pat...
- Acamprosate for Treatment-Refractory Catatonia...
- Metamizole for Postoperative Pain in Pediatric ...
- Prevalence of Colorectal Neoplasms and Mortalit...
- Cutaneous Spindle Cell Adenolipoma with Eccrine a...
- Number of levels required to assess Breslow thick...
- Generalized congenital epithelioid blue nevi (pi...
- Histopathology of sabra dermatitis: A case repor...
- Benign atypical intralymphatic CD30+ lymphoid pro...
- A case of S‐100‐negative CD1a‐positive indetermi...
- Journal of Cutaneous PathologyEarly View Onli...
- Analysis of air quality indicators at children’s...
- Virtual reality exposure before elective day car...
- Comparison of neostigmine vs. sugammadex for re...
- Development of Quantitative Structure-Property R...
- Extreme pollution, climate change, and depression
- Cellular distribution of cadmium in two amaranth...
- Health behaviors and psychological distress: cha...
- Childhood bullying victimization, self-labellin...
- Dominant control of climate variations over land...
- Post-extubation Dysphagia (PED) in the Critically...
- Office-Based Cricopharyngeus Balloon Dilation f...
- Tumor Contrast Enhancement and Whole-Body Elimin...
- Ausgestrahlt: Die mediale Debatte um “Tscherno...
- Lived Secularism: Studies in India and Turkey An...
- Believing Is Seeing: The “Lens” Metaphor in Cr...
- Metabolic Syndrome, Early-Onset Coronary Artery D...
- Hospitals Help Spread Drug-Resistant Klebsiella ...
- Maintaining optimal hand hygiene. Wearing personal...
- Abnormal Enhancement of the Internal Auditory Can...
- Onyx Embolization Material Extrusion in the Middl...
- Sorafenib, is a kinase inhibitor drug approv...
- Osteonecrosis of the External Auditory Canal Ass...
- CAR T-Cell Therapy: A Microcosm for the Challeng...
- How Histamines Affect Your Body
- Disparities in Neonatal Intensive Care: Conte...
- Pain Expressions in Dementia: Validity of Observ...
- Children with Tourette Syndrome in the United St...
- The official publication of the American Society f...
- Artificial Intelligence in Teledermatology Abstr...
- Experimental DermatologyAccepted Articles Acce...
- Antimicrobial Activity of Substituted Benzopent...
- A Day by the SeaCaring for others is stressful—w...
- Acute resuscitation with polyethylene glycol-20...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου