Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Peripheral Blood Leukocytes and Plasma of Children with Nonalcoholic Fatty Liver Disease:
Gene expression profiles of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) were evaluated in peripheral blood leukocytes of children with nonalcoholic fatty liver disease (NAFLD). Gene expression patterns were correlated with their plasma protein counterparts, systemic parameters of liver injury, and selected markers of inflammation. The MMP-2, MMP-9, MMP-12, MMP-14, TIMP-1, TIMP-2, TGF-β, and IL-6 transcripts levels were tested by the real-time PCR. Plasma concentrations of MMP-9, TIMP-1, MMP-9/TIMP-1 ratio, MMP-2/TIMP-2 ratio, sCD14, leptin, resistin, IL-1 beta, and IL-6 and serum markers of liver injury were estimated by ELISA. The MMP-9, TIMP-2 expression levels, plasma amounts of MMP-9, TIMP-1, and the MMP-9/TIMP-1 ratio were increased in children with NAFLD. Concentrations of AST, ALT, GGT, and leptin were elevated in serum patients with NAFLD, while concentration of other inflammatory or liver injury markers was unchanged. The MMP-2 and MMP-9 levels correlated with serum liver injury parameters (ALT and GGT concentrations, respectively); there were no other correlations between MMP/TIMP gene expression profiles, their plasma counterparts, and serum inflammatory markers. Association of MMP-2 and MMP-9 expression with serum liver injury parameters (ALT, GGT) may suggest leukocyte engagement in the early stages of NAFLD development which possibly precedes subsequent systemic inflammatory responses.
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Πληροφορίες
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(276)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (143)
-
►
2022
(1976)
- ► Δεκεμβρίου (116)
- ► Σεπτεμβρίου (158)
- ► Φεβρουαρίου (165)
- ► Ιανουαρίου (161)
-
►
2021
(3661)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (274)
- ► Φεβρουαρίου (64)
- ► Ιανουαρίου (368)
-
▼
2020
(4554)
- ► Δεκεμβρίου (400)
-
▼
Σεπτεμβρίου
(381)
- Medicine by Alexandros G. SfakianakisMedicine by A...
- Medicine by Alexandros G. Sfakianakis
- Medicine by Alexandros G. Sfakianakis
- Brain Sciences
- Economic evaluation of adjuvant trastuzum
- Small bo
- Progression of Fetal Brain Lesions in Tub
- Prognost
- Rare
- High level MYC amplification in B-cell lymphomas: ...
- Rare benign and malignant testicular lesions: hist...
- Acute abdominal pain in an adolescent girl with an...
- Conservative treatment in early stage endometrial ...
- Risk factors and molecular characterization of pen...
- Extrinsic compression of the heart consequent to i...
- Anesthetic Management of an Adult Patient With Hya...
- Epistaxis as an initial symptom of brown tumor in ...
- Space-Making Particle Therapy with Surgical Spacer...
- classification of amyloid deposits.
- Serrated polyposis syndrome (SPS) is a complex dis...
- Management of sporadic vestibular schwannoma with ...
- Novel therapeutic targets in salivary duct carcino...
- Mitomycin and 5-fluorouracil for second-line treat...
- Ossifying fibroma arising from the zygomatic arch:...
- Tumor pH-Responsive Albumin/Polyaniline Assemblies...
- MYCN amplification drives an aggressive form of sp...
- Surgical Intervention for Refractory Donor-Site Se...
- Suspected Familial or Sporadic Nasopharyngeal Carc...
- regnancy epulis with aggressive bone loss mimickin...
- Xeroderma pigmentosum: sensorineural deafness, men...
- Oncology
- Genes
- Biology
- CA
- Chaperone‐mediated autophagy receptor modulates tu...
- Prognostic impact of CRTC1/3‐MAML2 fusions in sali...
- Peripheral chemoresponsiveness during exercise in ...
- TMS over the posterior cerebellum modulates motor ...
- Iatrogenic Laryngotracheal Stenosis and Type II Di...
- DNA mismatch repair protein deficiency in ampullar...
- Decline in circulating viral and human tumor marke...
- Spectrum and frequencies of non GJB2 gene mutation...
- Premature ageing disorders
- Full‐Crown Versus Endocrown Approach
- Expanding the allergen repertoire of salmon and ca...
- Bartter syndrome is characterized by extreme hypok...
- OSA
- skipped-level lumbar disc herniation.....IntraSPIN...
- changes in the levels of catecholamines and blood ...
- Sleep Disordered Breathing ... supplemental O2 red...
- cardiometabolic contributors to brain health.
- Slow-wave sleep is associated with incident hypert...
- Regular use of ibuprofen reduces rat penile prosta...
- Identifying Three Otopathologies in Humans....: 1)...
- Changes in audiometric threshold and frequency sel...
- Positional Installation of Intranasal Corticostero...
- Bilateral Hearing Loss and Unilateral Cochlear Oss...
- Endoscopic Cricopharyngeal Myotomy With Primary Cl...
- recurrent respiratory papillomatosis (RRP) and ben...
- First case of Ethmoid Metastasis From an Induced O...
- microRNA-216b enhances cisplatin-induced apoptosis...
- Congenital Adrenal Hyperplasia Due to 21-Hydroxyla...
- Dapagliflozin in Patients with Chronic Kidney Dise...
- Association Between Prescribed Ibuprofen and Sever...
- Food Immunotherapy: Choosing Wisely
- Pediatric Intracapsular Tonsillectomy
- Solitary ulcero‐necrotic papule on the eyelid
- Adjuvant treatment with secukinumab induced long t...
- The neuropharmacology of cannabinoid receptor liga...
- Ascending aorta pseudoaneurysm simulating mediasti...
- Autophagy regulates levels of tumor suppressor enz...
- SCTR hypermethylation is a diagnostic biomarker in...
- Nutrients
- Molecules
- Journal of Clinical Medicine
- International Journal of Environmental Research ...
- Diagnostics
- Antibiotics
- Medicine by Alexandros G. Sfakianakis
- Medicine by Alexandros G. Sfakianakis
- Medicine by Alexandros G. Sfakianakis
- Medicine by Alexandros G. Sfakianakis
- Medicine by Alexandros G. Sfakianakis
- Medicine by Alexandros G. Sfakianakis
- Serum IL-6 as a prognostic biomarker and IL-6R as ...
- Pathophysiology and Imaging Findings of Bile Duct ...
- [Complex treatment of a patient with neurofibromat...
- Efficacy and Safety of Sorafenib in Unresectable H...
- Risk factors and oncological outcomes of urethral ...
- Comparative genomic profiling of glandular bladder...
- Novel CTNNB1-USP6 fusion in intravascular fasciiti...
- Uniportal VATS right superior lobectomy: managemen...
- MYC amplification on double minute chromosomes in ...
- Cutaneous pilomatrical carcinosarcoma: a case repo...
- ► Φεβρουαρίου (638)
- ► Ιανουαρίου (691)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου