Biomolecules, Vol. 9, Pages 306: Antrodia cinnamomea Enhances Chemo-Sensitivity of 5-FU and Suppresses Colon Tumorigenesis and Cancer Stemness via Up-Regulation of Tumor Suppressor miR-142-3p Biomolecules doi: 10.3390/biom9080306 Authors: Huang Yadav Srivastava Wu Huynh Wei Huang Huang 5-Fluorouracil (5-FU) regimen remains the backbone of the first-line agent to treat colon cancer, but often these patients develop resistance. Cancer stem cells (CSC’s)...
Thu Jul 25, 2019 03:00
Biomolecules, Vol. 9, Pages 305: Role of MCC/Eisosome in Fungal Lipid Homeostasis Biomolecules doi: 10.3390/biom9080305 Authors: Zahumensky Malinsky One of the best characterized fungal membrane microdomains is the MCC/eisosome. The MCC (membrane compartment of Can1) is an evolutionarily conserved ergosterol-rich plasma membrane domain. It is stabilized on its cytosolic face by the eisosome, a hemitubular protein complex composed of Bin/Amphiphysin/Rvs (BAR) domain-containing Pil1...
Thu Jul 25, 2019 03:00
Biomolecules, Vol. 9, Pages 307: Embryonic Exposure to Bisphenol A Impairs Primordial Germ Cell Migration without Jeopardizing Male Breeding Capacity Biomolecules doi: 10.3390/biom9080307 Authors: Lombó Getino-Álvarez Depincé Labbé Herráez A large amount of chemicals are released to the environment each year. Among them, bisphenol A (BPA) is of utmost concern since it interferes with the reproductive system of wild organisms due to its capacity to bind to hormone receptors....
Thu Jul 25, 2019 03:00
Biomolecules, Vol. 9, Pages 303: Role of Transmembrane Proteins for Phase Separation and Domain Registration in Asymmetric Lipid Bilayers Biomolecules doi: 10.3390/biom9080303 Authors: Guilherme Volpe Bossa Sean Gunderson Rachel Downing Sylvio May It is well known that the formation and spatial correlation of lipid domains in the two apposed leaflets of a bilayer are influenced by weak lipid–lipid interactions across the bilayer’s midplane. Transmembrane...
Thu Jul 25, 2019 03:00
Biomolecules, Vol. 9, Pages 304: New Monoclonal Antibodies for a Selective Detection of Membrane-Associated and Soluble Forms of Carbonic Anhydrase IX in Human Cell Lines and Biological Samples Biomolecules doi: 10.3390/biom9080304 Authors: Dovile Stravinskiene Aiste Imbrasaite Vilma Petrikaite Daumantas Matulis Jurgita Matuliene Aurelija Zvirbliene Monoclonal antibodies (MAbs) selectively targeting tumor-associated antigens such as carbonic anhydrase IX (CA IX) can significantly...
Thu Jul 25, 2019 03:00
Biomolecules, Vol. 9, Pages 302: Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells Biomolecules doi: 10.3390/biom9080302 Authors: Xin Zhang Yao Qin Zhaohai Pan Minjing Li Xiaona Liu Xiaoyu Chen Guiwu Qu Ling Zhou Maolei Xu Qiusheng Zheng Defang Li The main chemical component of cannabis, cannabidiol (CBD), has been shown to have antitumor properties. The present study examined the in vitro effects of CBD on human...
Thu Jul 25, 2019 03:00
Biomolecules, Vol. 9, Pages 301: Antioxidants and Atherosclerosis: Mechanistic Aspects Biomolecules doi: 10.3390/biom9080301 Authors: Khojasteh Malekmohammad Robert D. E. Sewell Mahmoud Rafieian-Kopaei Atherosclerosis is a chronic inflammatory disease which is a major cause of coronary heart disease and stroke in humans. It is characterized by intimal plaques and cholesterol accumulation in arterial walls. The side effects of currently prescribed synthetic drugs and their high...
Thu Jul 25, 2019 03:00
Biomolecules, Vol. 9, Pages 298: The Anticancer Agent Elesclomol Has Direct Effects on Mitochondrial Bioenergetic Function in Isolated Mammalian Mitochondria Biomolecules doi: 10.3390/biom9080298 Authors: Modica-Napolitano Bharath Hanlon Hurley Elesclomol ((N-malonyl-bis(N'-methyl-N'-thiobenzoylhydrazide)); formerly STA-4783) is a mitochondria-targeted chemotherapeutic agent that has demonstrated efficacy in selective cancer cell killing in pre-clinical and clinical testing....
Wed Jul 24, 2019 03:00
Biomolecules, Vol. 9, Pages 299: Small Genomes and Big Data: Adaptation of Plastid Genomics to the High-Throughput Era Biomolecules doi: 10.3390/biom9080299 Authors: Klinger Richardson Plastid genome sequences are becoming more readily available with the increase in high-throughput sequencing, and whole-organelle genetic data is available for algae and plants from across the diversity of photosynthetic eukaryotes. This has provided incredible opportunities for studying species which...
Wed Jul 24, 2019 03:00
Biomolecules, Vol. 9, Pages 300: The Role of Distinctive Sphingolipids in the Inflammatory and Apoptotic Effects of Electronegative LDL on Monocytes Biomolecules doi: 10.3390/biom9080300 Authors: Núria Puig Montserrat Estruch Lei Jin Jose Luis Sanchez-Quesada Sonia Benitez Electronegative low-density lipoprotein (LDL(−)) is a minor LDL subfraction that is present in blood with inflammatory and apoptotic effects. We aimed to evaluate the role of sphingolipids ceramide...
Wed Jul 24, 2019 03:00
Biomolecules, Vol. 9, Pages 297: The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata Biomolecules doi: 10.3390/biom9080297 Authors: Jonás I. Silva-Marrero Juliana Villasante Ania Rashidpour Mariana Palma Anna Fàbregas María Pilar Almajano Ivan Viegas John G. Jones Montserrat Miñarro Josep R. Ticó Isabel V. Baanante Isidoro Metón...
Wed Jul 24, 2019 03:00
Biomolecules, Vol. 9, Pages 296: The Michael J. Fox Foundation for Parkinson’s Research Strategy to Advance Therapeutic Development of PINK1 and Parkin Biomolecules doi: 10.3390/biom9080296 Authors: Shalini Padmanabhan Nicole K. Polinski Liliana B. Menalled Marco A.S. Baptista Brian K. Fiske The role of mitochondria in Parkinson’s disease (PD) has been investigated since the 1980s and is gaining attention with recent advances in PD genetics research. Mutations in...
Wed Jul 24, 2019 03:00
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