Cells, Vol. 8, Pages 776: Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates Cells doi: 10.3390/cells8080776 Authors: Acuña Hamadat Corbalán González-Lizárraga dos-Santos-Pereira Rocca Díaz Del-Bel Papy-García Chehín Michel Raisman-Vozari : Aggregated forms of the synaptic protein α-synuclein (αS) have been...
Thu Jul 25, 2019 03:00
Cells, Vol. 8, Pages 775: Immune-Deficient Pfp/Rag2-/- Mice Featured Higher Adipose Tissue Mass and Liver Lipid Accumulation with Growing Age than Wildtype C57BL/6N Mice Cells doi: 10.3390/cells8080775 Authors: Winkler Hempel Hsu Gericke Kühne Brückner Erler Burkhardt Christ Aging is a risk factor for adipose tissue dysfunction, which is associated with inflammatory innate immune mechanisms. Since the adipose tissue/liver axis contributes to hepatosteatosis,...
Thu Jul 25, 2019 03:00
Cells, Vol. 8, Pages 777: FZD10 Carried by Exosomes Sustains Cancer Cell Proliferation Cells doi: 10.3390/cells8080777 Authors: Scavo Depalo Rizzi Ingrosso Fanizza Chieti Messa Denora Laquintana Striccoli Curri Giannelli Extracellular vesicles (EVs) are involved in intercellular communication during carcinogenesis, and cancer cells are able to secrete EVs, in particular exosomes containing molecules, that can be transferred to recipient cells...
Thu Jul 25, 2019 03:00
Cells, Vol. 8, Pages 774: Tubeimoside-1 Inhibits Glioblastoma Growth, Migration, and Invasion via Inducing Ubiquitylation of MET Cells doi: 10.3390/cells8080774 Authors: Cao Zhao Zhu Ji Wei Xu Cui Tubeimoside-1 (TBMS1) is one of the extracts of rhizoma bolbostemmae, which has remarkable anti-cancer function in the treatment of esophagus and gastric cancer in traditional Chinese medicine. However the mechanisms of its anti-cancer function is remain unclear. In...
Thu Jul 25, 2019 03:00
Cells, Vol. 8, Pages 772: Prognostic Value of miRNAs in Head and Neck Cancers: A Comprehensive Systematic and Meta-Analysis Cells doi: 10.3390/cells8080772 Authors: Kumarasamy Madhav Sabarimurugan Krishnan Baxi Gupta Gothandam Jayaraj Head and Neck Cancer (HNC) is the sixth most common type of cancer across the globe, with more than 300,000 deaths each year, globally. However, there are currently no standardised molecular markers that assist in determining...
Thu Jul 25, 2019 03:00
Cells, Vol. 8, Pages 773: An Exosomal Urinary miRNA Signature for Early Diagnosis of Renal Fibrosis in Lupus Nephritis Cells doi: 10.3390/cells8080773 Authors: Solé Moliné Vidal Ordi-Ros Cortés-Hernández For lupus nephritis (LN) management, it is very important to detect fibrosis at an early stage. Urinary exosomal miRNAs profiling can be used as a potential multi-marker phenotyping tool to identify early fibrosis. We isolated and characterised urinary exosomes and cellular...
Thu Jul 25, 2019 03:00
Cells, Vol. 8, Pages 771: Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity Cells doi: 10.3390/cells8080771 Authors: Evgeny P. Barykin Alexandra I. Garifulina Elena V. Kruykova Ekaterina N. Spirova Anastasia A. Anashkina Alexei A. Adzhubei Irina V. Shelukhina Igor E. Kasheverov Vladimir A. Mitkevich Sergey A. Kozin Michael Hollmann Victor I. Tsetlin Alexander A. Makarov Cholinergic dysfunction...
Thu Jul 25, 2019 03:00
Cells, Vol. 8, Pages 770: Structural Consequences of Copper Binding to the Prion Protein Cells doi: 10.3390/cells8080770 Authors: Giulia Salzano Gabriele Giachin Giuseppe Legname Prion, or PrPSc, is the pathological isoform of the cellular prion protein (PrPC) and it is the etiological agent of transmissible spongiform encephalopathies (TSE) affecting humans and animal species. The most relevant function of PrPC is its ability to bind copper ions through its flexible N-terminal...
Thu Jul 25, 2019 03:00
Cells, Vol. 8, Pages 769: Microarray Approach Combined with ddPCR: An Useful Pipeline for the Detection and Quantification of Circulating Tumour dna Mutations Cells doi: 10.3390/cells8080769 Authors: Galbiati Damin Ferraro Soriani Burgio Ronzoni Gianni Ferrari Chiari : It has now been established that in biological fluids such as blood, it is possible to detect cancer causing genomic alterations by analysing circulating tumour DNA (ctDNA). Information...
Wed Jul 24, 2019 03:00
Cells, Vol. 8, Pages 768: Sec20 is Required for Autophagic and Endocytic Degradation Independent of Golgi-ER Retrograde Transport Cells doi: 10.3390/cells8080768 Authors: Lakatos Lőrincz Szabó Benkő Kenéz Csizmadia Juhász Endocytosis and autophagy are evolutionarily conserved degradative processes in all eukaryotes. Both pathways converge to the lysosome where cargo is degraded. Improper lysosomal degradation is observed in many human pathologies, so its regulatory...
Wed Jul 24, 2019 03:00
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