Chinese Journal of Clinical Pharmacology and Therapeutics. Year 2019 Issue 06 is now available on CAOD.

In this issue: Network pharmacology-based study on the mechanism of Salvia milti-orrhiza in treatment of Parkinson's disease (基于网络药理学研究丹参治疗帕金森病的作用机制) ZHANG Shuijing, ,DU Zhongyan ...... page:601-607 Psychophysiological observation of propofol addiction in rats (丙泊酚成瘾大鼠的心理生理学特性) XU Wenting, ,YANG Liqin, ,ZHANG Zhongnan, ,LIANG Jun, ,JIANG Nan, ,JIANG Miao, ,GUO Wenjun, ,WANG Mengya ...... page:608-614 Improvement of CGRP on vascular endothelial cells insulin resistance via activation of cAMP/PPARγ/eNOS pathway (CGRP通过激活cAMP/PPARγ/eNOS途径改善血管内皮细胞胰岛素抵抗) QUAN Haiyan, ,LIU Yuhuan, ,YANG Li, ,YANG Fang, ,QIN Xuping ...... page:615-622 Expression of miR-222 and MBD2 in gastric cancer patients and their effects on platinum chemosensitivity (miR-222、MBD2在胃癌患者中的表达及对铂类化疗敏感性的影响) DAI Lei, ,LUO Linghe, ,WU Liyan, ,WANG Gang, ,FEI Baoying ...... page:623-629 Effect of hypoxia-inducible factor 2αon chemoresistance of hepatocel-lular carcinoma (缺氧诱导因子2α对肝细胞癌化疗耐药性的影响) YANG Shucai, ,ZHANG Li, ,LIU Liping, ,DENG Weijie, ,ZHOU Jie, ,LIU Hui, ,ZHANG Baohu, ,JIN Tao ...... page:630-636 α-synuclein activates NLRP3 inflammatory bodies to mediated nerve cell pyroptosis (α-突触核蛋白激活NLRP3炎性小体介导神经细胞焦亡的发生) HAN Chenyang, ,ZHANG Xiaoling, ,YANG Yi, ,GUO Li, ,GUAN Qiaobing ...... page:637-643 Expression and mechanism of p38 MAPK signaling pathway in chronic pulpitis rats with pain (p38MAPK信号通路在慢性牙髓炎疼痛大鼠中的表达及作用机制研究) LI Min, ,WANG Shanshan, ,LIU Zhonghe, ,JIANG Deguo ...... page:644-649 Evaluation of Poly NP test and MPNP test for rapid detection of the polymyxin resistance Klebsiella pneumoniae (PolyNP试验及MPNP试验快速检测肺炎克雷伯菌多粘菌素类耐药表型的应用评估) LIU Yanling, ,ZENG Lingbing, ,HU Niya, ,CHEN Kaisen, ,HU Xuefei, ,HU Longhua ...... page:650-657 Inhibitory effect and mechanism of quercetin on secondary endotox-emia in rats with Neisseria infection (槲皮素对奈瑟球菌感染脑膜炎大鼠继发内毒素血症的抑制作用及机制研究) LI Zhengzheng, ,CHEN Jin, ,PAN Zhenzhen, ,PAN Sipei, ,ZHANG Nan ...... page:658-664 Effect of astragaloside on the apoptosis of human renal carcinoma cell ( ACHN) via SDF-1/CXCR4 signaling pathway (黄芪甲苷通过SDF-1/CXCR4信号通路诱导人肾腺癌细胞的凋亡) ZOU Zhaoyin, ,ZHENG Fu, ,XU Xianshun, ,DING Wenjuan, ,CHEN Yan, ,PU Daojing ...... page:665-669 Classification and application of logic check in clinical trail (临床试验逻辑核查的分类及应用) ZHOU Bei, ,YU Hao ...... page:670-674 Bioequivalence of bosentan tablets in healthy Chinese volunteers (波生坦片在中国健康受试者中的生物等效性研究) XU Yichao, ,LOU Honggang, ,RUAN Zourong, ,CHEN Jinliang, ,JIANG Bo, ,SHAO Rong, ,YANG Dandan ...... page:675-680 Investigation of curative effect and mechanism of Chaihu Jiedu Decoc-tion on condyloma acuminatum (柴胡解毒汤治疗尖锐湿疣的疗效观察和机制探讨) BU Zhangyu, ,WU Liming, ,YU Xiaohong, ,LIU Jue, ,DENG Lin ...... page:681-686 Effect of magnesium sulfate mixed ropivacaine femoral nerve block on lower extremity tourniquet reaction in the patients with knee ligament repair (硫酸镁联合罗哌卡因股神经阻滞对膝关节韧带修复术患者下肢止血带反应的疗效观察) WANG Hongzhu, ,LIN Xianju, ,ZHU Lijun ...... page:687-692 Therapeutic effect and related factors of human fibrinogen on traumat-ic traumatic coagulopathy (人纤维蛋白原对急诊外伤致创伤性凝血病疗效及相关因素分析) ZHU Songzhi ...... page:693-698 Effects of agomelatine on depressive disorder and brain-derived neuro-trophic factor (阿戈美拉汀治疗抑郁障碍的疗效及对脑源性神经营养因子的影响) ZHOU Yancan ...... page:699-703 Prognostic factors and safety study of R0 resection colorectal cancer patients received capecitabine based adjuvant chemotherapy in real world (真实世界中R0切除术后结直肠癌患者接受卡培他滨为基础辅助化疗的预后影响因素及安全性探讨) LI Rongzhen, ,MEI Jiazhuan, ,XIA Yunzhan, ,JI Jie ...... page:704-711 p73 gene and spermatogenesis and maturation (p73基因与精子的发生及成熟) WANG Tongsheng, ,WU Delin, ,LI Li, ,NA Sha ...... page:712-715 Research progress of extracellular matrix on skin wound repair (细胞外基质在皮肤创面修复中的研究进展) CHEN Jia, ,LIU Qingwu, ,HE Xiujuan, ,LI Ping ...... page:716-720