IJMS, Vol. 20, Pages 3649: Ionizing Radiation Increases the Activity of Exosomal Secretory Pathway in MCF-7 Human Breast Cancer Cells: A Possible Way to Communicate Resistance against Radiotherapy International Journal of Molecular Sciences doi: 10.3390/ijms20153649 Authors: Nasrollah Jabbari Muhammad Nawaz Jafar Rezaie Radiation therapy, which applies high-energy rays, to eradicate tumor cells, is considered an essential therapy for the patients with breast cancer. Most tumor...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3648: Inferring the Disease-Associated miRNAs Based on Network Representation Learning and Convolutional Neural Networks International Journal of Molecular Sciences doi: 10.3390/ijms20153648 Authors: Xuan Sun Wang Zhang Pan Identification of disease-associated miRNAs (disease miRNAs) are critical for understanding etiology and pathogenesis. Most previous methods focus on integrating similarities and associating information contained in heterogeneous...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3646: Therapeutic Use of Intranasal Glucagon: Resolution of Hypoglycemia International Journal of Molecular Sciences doi: 10.3390/ijms20153646 Authors: Antonio E. Pontiroli Elena Tagliabue Episodes of hypoglycemia are frequent in patients with diabetes treated with insulin or sulphonylureas. Hypoglycemia can lead to severe acute complications, and, as such, both prevention and treatment of hypoglycemia are important for the well-being of patients with diabetes....
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3647: Behavioral Disturbances in Dementia and Beyond: Time for a New Conceptual Frame? International Journal of Molecular Sciences doi: 10.3390/ijms20153647 Authors: Ambrogio Martella Odetti Monacelli Alzheimer’s disease and vascular dementia are estimated to be the most common causes of dementia, although mixed dementia could represent the most prevalent form of dementia in older adults aged more than 80 years. Behavioral disturbances are...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3645: Efficacy of Polyunsaturated Fatty Acids on Inflammatory Markers in Patients Undergoing Dialysis: A Systematic Review with Network Meta-Analysis of Randomized Clinical Trials International Journal of Molecular Sciences doi: 10.3390/ijms20153645 Authors: Po-Kuan Wu Shu-Ching Yeh Shan-Jen Li Yi-No Kang The effects of polyunsaturated fatty acids (PUFAs) on inflammatory markers among patients receiving dialysis have been discussed for a long time, but previous...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3643: Roles of MicroRNAs in Establishing and Modulating Stem Cell Potential International Journal of Molecular Sciences doi: 10.3390/ijms20153643 Authors: Zhenwu Zhang Lili Zhuang Chao-Po Lin Early embryonic development in mammals, from fertilization to implantation, can be viewed as a process in which stem cells alternate between self-renewal and differentiation. During this process, the fates of stem cells in embryos are gradually specified, from the totipotent...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3644: Combination with l-Menthol Enhances Transdermal Penetration of Indomethacin Solid Nanoparticles International Journal of Molecular Sciences doi: 10.3390/ijms20153644 Authors: Noriaki Nagai Fumihiko Ogata Mizuki Yamaguchi Yuya Fukuoka Hiroko Otake Yosuke Nakazawa Naohito Kawasaki This study designed the transdermal formulations containing indomethacin (IMC)—1% IMC was crushed with 0.5% methylcellulose and 5% 2-hydroxypropyl-β-cyclodextrin...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3642: Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications International Journal of Molecular Sciences doi: 10.3390/ijms20153642 Authors: Baozhen Zhang Ruijing Liang Mingbin Zheng Lintao Cai Xiujun Fan Minimizing exposure of the fetus to medication and reducing adverse off-target effects in the mother are the primary challenges in developing novel drugs to treat pregnancy complications. Nanomedicine has...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3641: Acute Functional Adaptations in Isolated Presynaptic Terminals Unveil Synaptosomal Learning and Memory International Journal of Molecular Sciences doi: 10.3390/ijms20153641 Authors: Anna Pittaluga Synaptosomes are used to decipher the mechanisms involved in chemical transmission, since they permit highlighting the mechanisms of transmitter release and confirming whether the activation of presynaptic receptors/enzymes can modulate this event. In the last two...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3640: Novel Markers of the Metabolic Impact of Exogenous Retinoic Acid with A Focus on Acylcarnitines and Amino Acids International Journal of Molecular Sciences doi: 10.3390/ijms20153640 Authors: Joan Ribot Andrea Arreguín Ondrej Kuda Jan Kopecky Andreu Palou Maria Luisa Bonet Treatment with all-trans retinoic acid (ATRA), the carboxylic form of vitamin A, lowers body weight in rodents by promoting oxidative metabolism in multiple tissues including...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3639: The Role of Prep1 in the Regulation of Mesenchymal Stromal Cells International Journal of Molecular Sciences doi: 10.3390/ijms20153639 Authors: Giorgia Maroni Daniele Panetta Raffaele Luongo Indira Krishnan Federica La Rosa Daniela Campani Piero Salvadori Patricia Iozzo Francesco Blasi Dmitry Penkov Elena Levantini Maria Cristina Magli Molecular mechanisms governing cell fate decision events in bone marrow mesenchymal stromal...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3636: Exploring the Potential of Overexpressed OsCIPK2 Rice as a Nitrogen Utilization Efficient Crop and Analysis of Its Associated Rhizo-Compartmental Microbial Communities International Journal of Molecular Sciences doi: 10.3390/ijms20153636 Authors: Muhammad Umar Khan Penghui Li Hira Amjad Ali Qaiser Khan Yasir Arafat Muhammad Waqas Zhong Li Ali Noman Waqar Islam Linkun Wu Zhixing Zhang Wenxiong Lin Nitrogen (N) is one of the indispensable...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3638: Metabonomics in Gastroenterology and Hepatology International Journal of Molecular Sciences doi: 10.3390/ijms20153638 Authors: Jacob Tveiten Bjerrum Ole Haagen Nielsen Attempts have been made to reveal the true nature of a range of puzzling diseases within gastroenterology and hepatology using different kinds of omics, namely genomics, transcriptomics, proteomics, and metabonomics [...]
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3637: Characterization of UDP-Glucuronosyltransferases and the Potential Contribution to Nicotine Tolerance in Myzus persicae International Journal of Molecular Sciences doi: 10.3390/ijms20153637 Authors: Yiou Pan Pengjun Xu Xiaochun Zeng Xuemei Liu Qingli Shang Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II detoxification enzymes involved in glycosylation of lipophilic endobiotics and xenobiotics, including phytoalexins. Nicotine,...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3633: Herb-Induced Liver Injury: Phylogenetic Relationship, Structure-Toxicity Relationship, and Herb-Ingredient Network Analysis International Journal of Molecular Sciences doi: 10.3390/ijms20153633 Authors: Shuaibing He Chenyang Zhang Ping Zhou Xuelian Zhang Tianyuan Ye Ruiying Wang Guibo Sun Xiaobo Sun Currently, hundreds of herbal products with potential hepatotoxicity were available in the literature. A comprehensive summary and analysis...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3635: Radiosensitivity Differences between EGFR Mutant and Wild-Type Lung Cancer Cells are Larger at Lower Doses International Journal of Molecular Sciences doi: 10.3390/ijms20153635 Authors: Mai Anakura Ankita Nachankar Daijiro Kobayashi Napapat Amornwichet Yuka Hirota Atsushi Shibata Takahiro Oike Takashi Nakano In the era of precision medicine, radiotherapy strategies should be determined based on genetic profiles that predict tumor radiosensitivity....
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3634: A Role for Neutral Sphingomyelinase in Wound Healing Induced by Keratinocyte Proliferation upon 1α, 25-Dihydroxyvitamin D3 Treatment International Journal of Molecular Sciences doi: 10.3390/ijms20153634 Authors: Federica Filomena Patria Maria Rachele Ceccarini Michela Codini Carmela Conte Luana Perioli Tommaso Beccari Elisabetta Albi The skin has many functions, such as providing a barrier against injury and pathogens, protecting from ultraviolet...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3632: 2,4-Dinitrotoluene (DNT) Perturbs Yolk Absorption, Liver Development and Lipid Metabolism/Oxygen Transport Gene Expression in Zebrafish Embryos and Larvae International Journal of Molecular Sciences doi: 10.3390/ijms20153632 Authors: Jianglin Xiong Hang Sha Hualin Zhou Lijuan Peng Lingying Wu Yinsheng Qiu Rui Wang Xianqin Hu 2,4-dinitrotoluene (2,4-DNT) is a common environmental pollutant, and was classified as a group 2B human carcinogenic...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3631: An Omics Approach to Diagnosing or Investigating Fungal Keratitis International Journal of Molecular Sciences doi: 10.3390/ijms20153631 Authors: Ming-Tse Kuo Jiunn-Liang Chen Shiuh-Liang Hsu Alexander Chen Huey-Ling You Fungal keratitis (FK) is one of the most severe corneal infectious diseases. FK often leads to poor visual prognosis and thus requires accurate diagnosis. Conventional approaches, including clinical diagnoses, smears, and cultures,...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3630: Function of Green Tea Catechins in the Brain: Epigallocatechin Gallate and its Metabolites International Journal of Molecular Sciences doi: 10.3390/ijms20153630 Authors: Monira Pervin Keiko Unno Akiko Takagaki Mamoru Isemura Yoriyuki Nakamura Over the last three decades, green tea has been studied for its beneficial effects, including anti-cancer, anti-obesity, anti-diabetes, anti-inflammatory, and neuroprotective effects. At present, a number of...
Thu Jul 25, 2019 03:00
IJMS, Vol. 20, Pages 3629: Ocular-Component-Specific miRNA Expression in a Murine Model of Lens-Induced Myopia International Journal of Molecular Sciences doi: 10.3390/ijms20153629 Authors: Tanaka Kurihara Hagiwara Ikeda Mori Jiang Torii Tsubota To identify tissues and molecules involved in refractive myopic shift and axial length elongation in a murine lens-induced myopia model, we performed a comprehensive analysis of microRNA (miRNA) expression. Three...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3627: New Aspects Towards a Molecular Understanding of the Allicin Immunostimulatory Mechanism via Colec12, MARCO, and SCARB1 Receptors International Journal of Molecular Sciences doi: 10.3390/ijms20153627 Authors: Vlad Al. Toma Adrian Bogdan Tigu Anca D. Farcaș Bogdan Sevastre Marian Taulescu Ana Maria Raluca Gherman Ioana Roman Eva Fischer-Fodor Marcel Pârvu The allicin pleiotropic effects, which include anti-inflammatory, anti-oxidant,...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3628: The Protective Role of Heme Oxygenase-1 in Atherosclerotic Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20153628 Authors: Yoshimi Kishimoto Kazuo Kondo Yukihiko Momiyama Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin. These products have anti-inflammatory, anti-oxidant, anti-apoptotic,...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3626: Battle between Host Immune Cellular Responses and HCMV Immune Evasion International Journal of Molecular Sciences doi: 10.3390/ijms20153626 Authors: Trishna Manandhar Gia-Gia T. Hò Wiebke C. Pump Rainer Blasczyk Christina Bade-Doeding Human cytomegalovirus (HCMV) is ubiquitously prevalent. HCMV infection is typically asymptomatic and controlled by the immune system in healthy individuals, yet HCMV can be severely pathogenic for the fetus during...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3625: Affinity Immobilization of a Bacterial Prolidase onto Metal-Ion-Chelated Magnetic Nanoparticles for the Hydrolysis of Organophosphorus Compounds International Journal of Molecular Sciences doi: 10.3390/ijms20153625 Authors: Tzu-Fan Wang Huei-Fen Lo Meng-Chun Chi Kuan-Ling Lai Min-Guan Lin Long-Liu Lin In this study, silica-coated magnetic nanoparticles (SiMNPs) with isocyanatopropyltriethoxysilane as a metal-chelating ligand were prepared for...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3624: Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20153624 Authors: Matteo Rossi Sebastiano Georgia Konstantinidou The deregulation of cancer cell metabolic networks is now recognized as one of the hallmarks of cancer. Abnormal lipid synthesis and extracellular lipid uptake are advantageous modifications fueling the needs of uncontrolled cancer cell proliferation. Fatty acids are placed...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3622: Intervertebral Disc Nucleus Repair: Hype or Hope? International Journal of Molecular Sciences doi: 10.3390/ijms20153622 Authors: Gauri Tendulkar Tao Chen Sabrina Ehnert Hans-Peter Kaps Andreas K Nüssler Chronic back pain is a common disability, which is often accredited to intervertebral disc degeneration. Gold standard interventions such as spinal fusion, which are mainly designed to mechanically seal the defect, frequently fail to restore the...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3623: Evaluating the Efficiency of gRNAs in CRISPR/Cas9 Mediated Genome Editing in Poplars International Journal of Molecular Sciences doi: 10.3390/ijms20153623 Authors: Tobias Bruegmann Khira Deecke Matthias Fladung CRISPR/Cas9 has become one of the most promising techniques for genome editing in plants and works very well in poplars with an Agrobacterium-mediated transformation system. We selected twelve genes, including SOC1, FUL, and their paralogous genes,...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3621: Pathogenic Variants in STXBP1 and in Genes for GABAa Receptor Subunities Cause Atypical Rett/Rett-like Phenotypes International Journal of Molecular Sciences doi: 10.3390/ijms20153621 Authors: Francesca Cogliati Valentina Giorgini Maura Masciadri Maria Teresa Bonati Margherita Marchi Irene Cracco Davide Gentilini Angela Peron Miriam Nella Savini Luigina Spaccini Barbara Scelsa Silvia Maitz Edvige Veneselli Giulia Prato Maria...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3620: Synthesis and Application of Silver Nanoparticles (Ag NPs) for the Prevention of Infection in Healthcare Workers International Journal of Molecular Sciences doi: 10.3390/ijms20153620 Authors: Shingo Nakamura Masahiro Sato Yoko Sato Naoko Ando Tomohiro Takayama Masanori Fujita Masayuki Ishihara Silver is easily available and is known to have microbicidal effect; moreover, it does not impose any adverse effects on the human body. The microbicidal...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3619: Coexisting Molecular Determinants of Acquired Oxaliplatin Resistance in Human Colorectal and Ovarian Cancer Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms20153619 Authors: Paul Noordhuis Adrianus C. Laan Kasper van de Born Richard J. Honeywell Godefridus J. Peters Oxaliplatin (OHP) treatment of colorectal cancer (CRC) frequently leads to resistance. OHP resistance was induced in CRC cell lines LoVo-92 and LoVo-Li and a...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3617: Shape-Controlled Syntheses of Magnetite Microparticles and Their Magnetorheology International Journal of Molecular Sciences doi: 10.3390/ijms20153617 Authors: Hiroya Abe Takashi Naka Kazuyoshi Sato Yoshikazu Suzuki Masami Nakano Magnetic microspheres in a concentrated suspension can be self-assembled to form chain structures under a magnetic field, resulting in an enhanced viscosity and elasticity of the suspension (i.e., the magnetorheological...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3616: LncRNA NEAT1 Silenced miR-133b Promotes Migration and Invasion of Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms20153616 Authors: Xinping Li Siwei Deng Xinyao Pang Yixiao Song Shiyu Luo Liang Jin Yi Pan Breast cancer, the most prevalent cancer type among women worldwide, remains incurable once metastatic. Long noncoding RNA (lncRNA) and microRNA (miRNA) play important roles in breast cancer by regulating...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3618: Yeast-Derived β-Glucan in Cancer: Novel Uses of a Traditional Therapeutic
IJMS, Vol. 20, Pages 3618: Yeast-Derived β-Glucan in Cancer: Novel Uses of a Traditional Therapeutic International Journal of Molecular Sciences doi: 10.3390/ijms20153618 Authors: Anne Geller Rejeena Shrestha Jun Yan An increased understanding of the complex mechanisms at play within the tumor microenvironment (TME) has emphasized the need for the development of strategies that target immune cells within the TME. Therapeutics that render the TME immune-reactive have a vast potential...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3612: The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis International Journal of Molecular Sciences doi: 10.3390/ijms20153612 Authors: Laetitia Mouly Julia Gilhodes Anthony Lemarié Elizabeth Cohen-Jonathan Moyal Christine Toulas Gilles Favre Olivier Sordet Sylvie Monferran The Rho GTPase family can be classified into classic and atypical members. Classic members cycle between an inactive Guanosine DiPhosphate -bound state...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3615: SOCS1-Derived Peptide Administered by Eye Drops Prevents Retinal Neuroinflammation and Vascular Leakage in Experimental Diabetes International Journal of Molecular Sciences doi: 10.3390/ijms20153615 Authors: Cristina Hernández Patricia Bogdanov Carmen Gómez-Guerrero Joel Sampedro Cristina Solà-Adell Carmen Espejo Marta García-Ramírez Ignacio Prieto Jesús Egido Rafael Simó Current treatments for diabetic retinopathy (DR) target late...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3613: Overexpression of Notch Signaling Induces Hyperosteogeny in Zebrafish International Journal of Molecular Sciences doi: 10.3390/ijms20153613 Authors: Sung-Tzu Liang Jung-Ren Chen Jhih-Jie Tsai Yu-Heng Lai Chung-Der Hsiao Notch signaling is one of the evolutionarily conserved signaling pathways in multicellular organisms. It plays an important role in embryonic development. During skeletal development of vertebrates, it regulates bone homeostasis...
Wed Jul 24, 2019 03:00
IJMS, Vol. 20, Pages 3614: Clinical Therapeutic Strategy and Neuronal Mechanism Underlying Post-Traumatic Stress Disorder (PTSD) International Journal of Molecular Sciences doi: 10.3390/ijms20153614 Authors: Yasushi Yabuki Kohji Fukunaga Post-traumatic stress disorder (PTSD) is characterized by an exaggerated response to contextual memory and impaired fear extinction, with or without mild cognitive impairment, learning deficits, and nightmares. PTSD is often developed by traumatic...
Wed Jul 24, 2019 03:00
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