Related ArticlesMeasuring olfaction instead of asking: it is more than luxury! Eur Arch Otorhinolaryngol. 2019 Jul 19;: Authors: Landis BN, Hummel T PMID: 31325033 [PubMed - as supplied by publisher]
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Related Articles[Systemic treatments of metastatic or locally recurrent adenoid cystic carcinoma of the head and neck, a systematic review]. Bull Cancer. 2019 Jul 16;: Authors: Cherifi F, Rambeau A, Johnson A, Florescu C, Géry B, Babin E, Thariat J Abstract INTRODUCTION: Adenoid Cystic Carcinoma is a rare tumor of the head and neck sphere. The purpose of this review is a state of the art of systemic treatments (chemotherapies, targeted therapies, immunotherapies)...
Embryonic ketamine produces a downregulation of prefrontal cortex NMDA receptors and anxiety-like behavior in adult offspring. Neuroscience. 2019 Jul 17;: Authors: Ren W, Liu X, Cheng L, Wang G, Liu X, Peng L, Wang Y Abstract Previous studies have focused on the effects of N-methyl-D-aspartate receptor (NMDAR) blockade on neonates, but little is known about the effect of the embryonic NMDAR blockade on offspring, especially the long-lasting effect, on...
Related ArticlesMeasuring olfaction instead of asking: it is more than luxury! Eur Arch Otorhinolaryngol. 2019 Jul 19;: Authors: Landis BN, Hummel T PMID: 31325033 [PubMed - as supplied by publisher]
Related ArticlesASRA 44th Annual Regional Anesthesiology and Acute Pain Medicine Meeting. Reg Anesth Pain Med. 2019 Aug;44(8):821-836 Authors: PMID: 31324748 [PubMed - in process]
Related ArticlesQuantifying Argonaute 2 (Ago2) expression to stratify breast cancer. BMC Cancer. 2019 Jul 19;19(1):712 Authors: Casey MC, Prakash A, Holian E, McGuire A, Kalinina O, Shalaby A, Curran C, Webber M, Callagy G, Bourke E, Kerin MJ, Brown JA Abstract BACKGROUND: Argonaute-2 (Ago2) is an essential component of microRNA biogenesis implicated in tumourigenesis. However Ago2 expression and localisation in breast cancer remains undetermined. The...
Between the Person and the Pill: Factors Affecting Medication Adherence in Epilepsy Patients. J Assoc Physicians India. 2018 Jul;66(7):24-26 Authors: Honnekeri B, Rane S, Vast R, Khadilkar SV Abstract Background: The majority of people afflicted with epilepsy live in developing countries. Poor adherence to prescribed medication is considered the main cause of unsuccessful drug treatment for epilepsy. Our study aims to evaluate the factors influencing...
Related ArticlesARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV. Brain Dev. 2019 Jul 16;: Authors: Kwong AK, Chu VL, Rodenburg RJT, Smeitink J, Fung CW Abstract BACKGROUND: ARX genetic defect is associated with a spectrum of neurodevelopmental disorders that exhibit a high degree of phenotypic heterogeneity. METHODS:...
Related ArticlesGenetics of neonatal-onset epilepsies. Handb Clin Neurol. 2019;162:415-433 Authors: Cornet MC, Cilio MR Abstract Although the majority of seizures in neonates are related to acute brain injury, a substantial minority are the first symptom of a neonatal-onset epilepsy often linked to a pathogenic genetic variant. Historically, studies on neonatal seizures including treatment response and long-term consequences have lumped all etiologies...
Related ArticlesSeizure classification, etiology, and management. Handb Clin Neurol. 2019;162:347-361 Authors: Shellhaas RA Abstract The first weeks of life are a time of heightened risk for seizures due to age-dependent physiologic features of the developing brain that lead to increased neuronal excitation and decreased inhibition. Usually, seizures in neonates are a symptom of an acute brain injury; seizures are only rarely due to neonatal-onset epilepsy...
Related ArticlesCongenital and perinatal infections. Handb Clin Neurol. 2019;162:133-153 Authors: Ostrander B, Bale JF Abstract Congenital and perinatal infections represent major causes of permanent disability among children worldwide. Linked together by the acronym TORCH, denoting Toxoplasma gondii, rubella virus, cytomegalovirus, and herpes virus, congenital infections can result from only a modest number of human pathogens that cross the placenta...
Related ArticlesSimilar Safety Profile of the Enantiomeric N-Aminoalkyl Derivatives of Trans-2-Aminocyclohexan-1-ol Demonstrating Anticonvulsant Activity. Molecules. 2019 Jul 09;24(13): Authors: Słoczyńska K, Koczurkiewicz P, Piska K, Powroźnik B, Wójcik-Pszczoła K, Klaś K, Wyszkowska-Kolatko M, Pękala E Abstract Epilepsy is one of the most common neurological disorder in the world. Many antiepileptic drugs cause multiple adverse effects. Moreover, multidrug...
Related ArticlesInfluence of phosphor plate-based radiographic image specifications on fractal analysis of alveolar bone. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Jun 27;: Authors: Oliveira-Santos N, Michels M, Freitas DQ, Haiter-Neto F, Oliveira ML Abstract OBJECTIVE: The aim of this study was to evaluate the influence of spatial resolution, bit depth, and enhancement filters on the fractal dimension (FD) of photostimulable phosphor (PSP) plate-based...
Management of an Extended Bone-Invasive Basal Cell Carcinoma of the Median Forehead. J Stomatol Oral Maxillofac Surg. 2019 Jul 17;: Authors: Slama NB, Adnot J, Trost O Abstract We report the case of a 35-year-old male patient managed for extended basal cell carcinoma of the median forehead, invading the frontal bone. Bone reconstruction was performed by a splitting of calvaria and skin reconstruction was performed using two frontal flaps dissected into...
Related Articles[Incidental durotomy: intraoperative aid in ten steps]. Oper Orthop Traumatol. 2019 Jul 19;: Authors: Papavero L, Kothe R Abstract OBJECTIVE: Management of the intradural structures safely, closure of the dura according to the tear, and minimizing the epidural dead space. INDICATIONS: Incidental durotomy (ID). CONTRAINDICATIONS: None. SURGICAL TECHNIQUE: 1. Bone removal until whole dural tear is visible (if...
Related ArticlesExpression patterns of male germ cell markers in cryptorchid pig testes. Acta Histochem. 2019 Jul 17;: Authors: Park HJ, Song H, Woo JS, Chung HJ, Park JK, Cho KH, Mo Yeo J, Lee WY Abstract Male germ cell apoptosis has been described in heat-damaged testes by cryptorchidism. In the present study, wild type pig testes were compared with cryptorchid testes via histological and immunohistological analyses. Spermatozoa were not detected in...
Related ArticlesUnderstanding the parameters used to classify the shape of tarsal plates. Surg Radiol Anat. 2019 Jul 19;: Authors: Thompson JP, Fry CL PMID: 31324946 [PubMed - as supplied by publisher]
Related ArticlesImproved survival of older patients with advanced breast cancer due to an increase in systemic treatments: a population-based study. Breast Cancer Res Treat. 2019 Jul 19;: Authors: de Glas N, Bastiaannet E, de Boer A, Siesling S, Liefers GJ, Portielje J Abstract PURPOSE: The number of older patients with breast cancer is rapidly increasing. A previous study showed that between 1990 and 2005, the survival of older patients with breast...
Related ArticlesSubtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells. Nat Commun. 2019 Jul 19;10(1):3201 Authors: Wang XD, Hu R, Ding Q, Savage TK, Huffman KE, Williams N, Cobb MH, Minna JD, Johnson JE, Yu Y Abstract Pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC), is a particularly aggressive malignancy. The lineage-specific transcription factors Achaete-scute homolog 1 (ASCL1), NEUROD1 and...
Related ArticlesA novel 18F-labeled PSMA ligand for PET/CT imaging of prostate cancer patients: First-in-man observational study and clinical experience with 18F-JK-PSMA-7 during the first year of application. J Nucl Med. 2019 Jul 19;: Authors: Dietlein F, Hohberg M, Kobe C, Zlatopolskiy BD, Krapf P, Endepols H, Täger P, Hammes J, Heidenreich A, Neumaier B, Drzezga A, Dietlein M Abstract In preclinical trials, the recently developed tracer 18F-JK-PSMA-7...
Related ArticlesIs it possible to automatically assess pretreatment digital rectal examination documentation using natural language processing? A single-centre retrospective study. BMJ Open. 2019 Jul 18;9(7):e027182 Authors: Bozkurt S, Kan KM, Ferrari MK, Rubin DL, Blayney DW, Hernandez-Boussard T, Brooks JD Abstract OBJECTIVES: To develop and test a method for automatic assessment of a quality metric, provider-documented pretreatment digital rectal...
Related ArticlesIgA levels at diagnosis predict for infections, time to treatment, and survival in chronic lymphocytic leukemia. Blood Adv. 2019 Jul 23;3(14):2188-2198 Authors: Ishdorj G, Streu E, Lambert P, Dhaliwal HS, Mahmud SM, Gibson SB, Banerji V, Marshall AJ, Johnston JB Abstract To better understand the relationship between baseline immunoglobulin measurements and subsequent clinical outcomes in chronic lymphocytic leukemia (CLL), we performed...
Related ArticlesMedical Oncology Workload in Europe: One Continent, Several Worlds. Clin Oncol (R Coll Radiol). 2019 Jul 16;: Authors: Seruga B, Sullivan R, Fundytus A, Hopman WM, Ocana A, Joffe J, Bodoky G, Le Tourneau C, Vanderpuye V, Lopes G, Hammad N, Sengar M, Brundage MD, Booth CM Abstract AIMS: The workload pressure on medical oncologists will increase in the near future. There are no comprehensive data available about the current workload of...
Related ArticlesTumor-derived exosomes promote the in vitro osteotropism of melanoma cells by activating the SDF-1/CXCR4/CXCR7 axis. J Transl Med. 2019 Jul 19;17(1):230 Authors: Mannavola F, Tucci M, Felici C, Passarelli A, D'Oronzo S, Silvestris F Abstract BACKGROUND: Bone metastases occur rarely in patients suffering from malignant melanoma, although their onset severely worsens both prognosis and quality of life. Extracellular vesicles (EVs) including...
Related ArticlesEstimation of immune cell content in tumor using single-cell RNA-seq reference data. BMC Cancer. 2019 Jul 19;19(1):715 Authors: Yu X, Chen YA, Conejo-Garcia JR, Chung CH, Wang X Abstract BACKGROUND: The rapid development of single-cell RNA sequencing (scRNA-seq) provides unprecedented opportunities to study the tumor ecosystem that involves a heterogeneous mixture of cell types. However, the majority of previous and current studies related...
Related ArticlesClinical Applications of Circulating Tumour DNA in Pancreatic Adenocarcinoma. J Pers Med. 2019 Jul 18;9(3): Authors: Loft M, Lee B, Tie J, Gibbs P Abstract Pancreatic adenocarcinoma remains one of the most aggressive cancers with an ongoing dismal survival rate despite some recent advances in treatment options. This is largely due to the typically late presentation and limited effective therapeutic options in advanced disease. There are...
Related ArticlesPrevalence and characteristics of positional obstructive sleep apnea (POSA) in patients with severe OSA. Sleep Breath. 2019 Jul 20;: Authors: Oksenberg A, Gadoth N, Töyräs J, Leppänen T Abstract PURPOSE: We assessed the prevalence of positional patients (PPs) and the main predictors of positional dependency in severe obstructive sleep apnea (OSA). A simulated effect of positional therapy (PT) vs. continuous positive airway pressure (CPAP)...
Related ArticlesTonsillar follicular large B-cell lymphoma with IRF4 rearrangement causing sleep apnoea. J Clin Pathol. 2019 Jul 19;: Authors: Yu YT, Sakata S, Takeuchi K, Medeiros LJ, Chang KC PMID: 31324665 [PubMed - as supplied by publisher]
Related ArticlesA modified park bench position: the "Dormeuse" position. Acta Neurochir (Wien). 2019 Jul 19;: Authors: Spena G, Guerrini F, Grimod G Abstract BACKGROUND: Because of the restricted volume of the cisternal space, proper patient positioning on the operating table is of utmost importance during surgery by retrosigmoid approaches. Three positions are commonly used: supine, with the head rotated to the side contralateral to the lesion; the...
Related ArticlesRadiomics approach for prediction of recurrence in skull base meningiomas. Neuroradiology. 2019 Jul 19;: Authors: Zhang Y, Chen JH, Chen TY, Lim SW, Wu TC, Kuo YT, Ko CC, Su MY Abstract PURPOSE: A subset of skull base meningiomas (SBM) may show early progression/recurrence (P/R) as a result of incomplete resection. The purpose of this study is the implementation of MR radiomics to predict P/R in SBM. METHODS: From October 2006...
Cat flu: Broad spectrum polymeric antivirals. Antiviral Res. 2019 Jul 17;:104563 Authors: Synowiec A, Gryniuk I, Pachota M, Strzelec Ł, Roman O, Kłysik-Trzciańska K, Zając M, Drebot I, Gula K, Andruchowicz A, Rajfur Z, Szczubiałka K, Nowakowska M, Pyrc K Abstract Feline herpesvirus type 1 (FHV-1) and feline calicivirus (FCV) are considered as main causes of feline upper respiratory tract disease and the most common clinical manifestations include rhinotracheitis,...
An investigation of the effects of procalcitonin testing on antimicrobial prescribing in respiratory tract infections in an Irish university hospital setting: a feasibility study. J Antimicrob Chemother. 2019 Jul 19;: Authors: O'Riordan F, Shiely F, Byrne S, O'Brien D, Palmer B, Dahly D, O'Connor TM, Curran D, Fleming A Abstract BACKGROUND: Diagnostic uncertainty and a high prevalence of viral infections present unique challenges for antimicrobial prescribing...
Related ArticlesInfluenza virus-related critical illness: pathophysiology and epidemiology. Crit Care. 2019 Jul 19;23(1):258 Authors: Kalil AC, Thomas PG Abstract Influenza virus affects the respiratory tract by direct viral infection or by damage from the immune system response. In humans, the respiratory epithelium is the only site where the hemagglutinin (HA) molecule is effectively cleaved, generating infectious virus particles. Virus transmission...
Related ArticlesUnderstanding the influence of parent-clinician communication on antibiotic prescribing for children with respiratory tract infections in primary care: a qualitative observational study using a conversation analysis approach. BMC Fam Pract. 2019 Jul 19;20(1):102 Authors: Cabral C, Horwood J, Symonds J, Ingram J, Lucas PJ, Redmond NM, Kai J, Hay AD, Barnes RK Abstract BACKGROUND: Acute respiratory tract infections (RTI) in children are...
Related ArticlesVirtual surgical planning in fibula free flap head and neck reconstruction: A systematic review and meta-analysis. J Plast Reconstr Aesthet Surg. 2019 Jul 02;: Authors: Tang NSJ, Ahmadi I, Ramakrishnan A Abstract BACKGROUND: The traditional approach to head and neck reconstruction is considered challenging, requiring a subjective assessment of an often-complex defect followed by careful modelling of a bony flap to match this. The introduction...
Related ArticlesImproved survival of older patients with advanced breast cancer due to an increase in systemic treatments: a population-based study. Breast Cancer Res Treat. 2019 Jul 19;: Authors: de Glas N, Bastiaannet E, de Boer A, Siesling S, Liefers GJ, Portielje J Abstract PURPOSE: The number of older patients with breast cancer is rapidly increasing. A previous study showed that between 1990 and 2005, the survival of older patients with breast...
Related ArticlesSubtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells. Nat Commun. 2019 Jul 19;10(1):3201 Authors: Wang XD, Hu R, Ding Q, Savage TK, Huffman KE, Williams N, Cobb MH, Minna JD, Johnson JE, Yu Y Abstract Pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC), is a particularly aggressive malignancy. The lineage-specific transcription factors Achaete-scute homolog 1 (ASCL1), NEUROD1 and...
Related ArticlesA novel 18F-labeled PSMA ligand for PET/CT imaging of prostate cancer patients: First-in-man observational study and clinical experience with 18F-JK-PSMA-7 during the first year of application. J Nucl Med. 2019 Jul 19;: Authors: Dietlein F, Hohberg M, Kobe C, Zlatopolskiy BD, Krapf P, Endepols H, Täger P, Hammes J, Heidenreich A, Neumaier B, Drzezga A, Dietlein M Abstract In preclinical trials, the recently developed tracer 18F-JK-PSMA-7...
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