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The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor.
Related ArticlesThe allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor. Proc Natl Acad Sci U S A. 2019 Jul 19;: Authors: LeVine MV, Terry DS, Khelashvili G, Siegel ZS, Quick M, Javitch JA, Blanchard SC, Weinstein H Abstract Neurotransmitter:sodium symporters (NSSs) in the SLC6 family terminate neurotransmission by coupling the thermodynamically favorable transport of ions to the thermodynamically unfavorable...
Related ArticlesExposing the inadequacy of redox formalisms by resolving redox inequivalence within isovalent clusters. Proc Natl Acad Sci U S A. 2019 Jul 19;: Authors: Bartholomew AK, Teesdale JJ, Hernández Sánchez R, Malbrecht BJ, Juda CE, Ménard G, Bu W, Iovan DA, Mikhailine AA, Zheng SL, Sarangi R, Wang SG, Chen YS, Betley TA Abstract In this report we examine a family of trinuclear iron complexes by multiple-wavelength, anomalous diffraction (MAD)...
Related ArticlesLabel-free chemical imaging flow cytometry by high-speed multicolor stimulated Raman scattering. Proc Natl Acad Sci U S A. 2019 Jul 19;: Authors: Suzuki Y, Kobayashi K, Wakisaka Y, Deng D, Tanaka S, Huang CJ, Lei C, Sun CW, Liu H, Fujiwaki Y, Lee S, Isozaki A, Kasai Y, Hayakawa T, Sakuma S, Arai F, Koizumi K, Tezuka H, Inaba M, Hiraki K, Ito T, Hase M, Matsusaka S, Shiba K, Suga K, Nishikawa M, Jona M, Yatomi Y, Yalikun Y, Tanaka Y, Sugimura T, Nitta N,...
Related ArticlesVisualizing complex feature interactions and feature sharing in genomic deep neural networks. BMC Bioinformatics. 2019 Jul 19;20(1):401 Authors: Liu G, Zeng H, Gifford DK Abstract BACKGROUND: Visualization tools for deep learning models typically focus on discovering key input features without considering how such low level features are combined in intermediate layers to make decisions. Moreover, many of these methods examine a network's...
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Related ArticlesUnder nutrition, maternal anemia and household food insecurity are risk factors of anemia among preschool aged children in Menz Gera Midir district, Eastern Amhara, Ethiopia: a community based cross-sectional study. BMC Public Health. 2019 Jul 19;19(1):968 Authors: Engidaye G, Melku M, Yalew A, Getaneh Z, Asrie F, Enawgaw B Abstract BACKGROUND: In Ethiopian, the prevalence of anemia among preschool aged children widely varied across regions....
Related ArticlesOutpatient health-seeking behavior of residents in Zhejiang and Qinghai Province, China. BMC Public Health. 2019 Jul 19;19(1):967 Authors: Huang M, Zhang H, Gu Y, Wei J, Gu S, Zhen X, Hu X, Sun X, Dong H Abstract BACKGROUND: The eastern and western regions of China are different in many ways such as socioeconomic characteristics and health resource distribution. This study aimed to explore the outpatient health-seeking behavior and compare...
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Related ArticlesHome-based intervention to test and start (HITS) protocol: a cluster-randomized controlled trial to reduce HIV-related mortality in men and HIV incidence in women through increased coverage of HIV treatment. BMC Public Health. 2019 Jul 19;19(1):969 Authors: Mathenjwa T, Kim HY, Zuma T, Shahmanesh M, Seeley J, Matthews P, Wyke S, McGrath N, Sartorius B, Yapa HM, Adeagbo O, Blandford A, Dobra A, Bäernighausen T, Tanser F Abstract BACKGROUND:...
Endoplasmic reticulum stress: A master regulator of metabolic syndrome. Eur J Pharmacol. 2019 Jul 17;:172553 Authors: Mohan S, R PRM, Brown L, Ayyappan P, G RK Abstract Endoplasmic reticulum (ER) stress, a change in the ER homeostasis, leads to initiation of the unfolded protein response (UPR). The primary functions of the UPR are to restore the ER's physiological activity and coordinate the apoptotic and adaptive responses. Pathophysiological conditions...
Role of serotonin 4 receptor in the growth of hippocampal neurons during the embryonic development in mice. Neuropharmacology. 2019 Jul 17;:107712 Authors: Agrawal L, Vimal SK, Shiga T Abstract Serotonin (5-HT) homeostasis is critical for the brain development which influences neurogenesis, neuronal migration, and circuit formation. Distinctive distribution patterns of serotonin receptors (5-HTRs) in the brain govern various physiological activities....
Related ArticlesTranscriptional Regulation of Zinc Transporters in Human Osteogenic Sarcoma (Saos-2) Cells to Zinc Supplementation and Zinc Depletion. Biol Trace Elem Res. 2019 Jul 19;: Authors: Alluri K, Nair KPM, Kotturu SK, Ghosh S Abstract Bone is a passive storage organ for zinc, which contains about 30% of the total body zinc. However, during extreme zinc deficiency, only a small fraction of zinc is released in contrast to other tissues where zinc...
Related ArticlesClinical promise of next-generation complement therapeutics. Nat Rev Drug Discov. 2019 Jul 19;: Authors: Mastellos DC, Ricklin D, Lambris JD Abstract The complement system plays a key role in pathogen immunosurveillance and tissue homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of inflammatory damage that exacerbates pathology. The clinical merit of targeting the complement system has been established...
Related ArticlesA novel rapamycin analog is highly selective for mTORC1 in vivo. Nat Commun. 2019 Jul 19;10(1):3194 Authors: Schreiber KH, Arriola Apelo SI, Yu D, Brinkman JA, Velarde MC, Syed FA, Liao CY, Baar EL, Carbajal KA, Sherman DS, Ortiz D, Brunauer R, Yang SE, Tzannis ST, Kennedy BK, Lamming DW Abstract Rapamycin, an inhibitor of mechanistic Target Of Rapamycin Complex 1 (mTORC1), extends lifespan and shows strong potential for the treatment...
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Related ArticlesActive thrombin produced by the intestinal epithelium controls mucosal biofilms. Nat Commun. 2019 Jul 19;10(1):3224 Authors: Motta JP, Denadai-Souza A, Sagnat D, Guiraud L, Edir A, Bonnart C, Sebbag M, Rousset P, Lapeyre A, Seguy C, Mathurine-Thomas N, Galipeau HJ, Bonnet D, Alric L, Buret AG, Wallace JL, Dufour A, Verdu EF, Hollenberg MD, Oswald E, Serino M, Deraison C, Vergnolle N Abstract Proteolytic homeostasis is important at mucosal...
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