Redox thermodynamics of B-class dye-decolorizing peroxidases. J Inorg Biochem. 2019 Jul 11;199:110761 Authors: Pfanzagl V, Bellei M, Hofbauer S, Laurent CVFP, Furtmüller PG, Oostenbrink C, Battistuzzi G, Obinger C Abstract With >5000 annotated genes dye-decolorizing peroxidases (DyPs) represent a heme b peroxidase family of broad functional diversity. Bacterial B-class DyPs are poor peroxidases of unknown physiological function. Hydrogen peroxide...
Related ArticlesEffect of vagus nerve stimulation on blood glucose concentration in epilepsy patients - Importance of stimulation parameters. Physiol Rep. 2019 Jul;7(14):e14169 Authors: Stauss HM, Daman LM, Rohlf MM, Sainju RK Abstract In previous animal experiments, we demonstrated that cervical vagus nerve stimulation (VNS) inhibits pancreatic insulin secretion, thereby raises blood glucose levels, and impairs glucose tolerance through afferent signaling....
Related ArticlesModel-based estimation of lowest observed effect concentration from replicate experiments to identify potential biomarkers of in vitro neurotoxicity. Arch Toxicol. 2019 Jul 19;: Authors: Calderazzo S, Tavel D, Zurich MG, Kopp-Schneider A Abstract A paradigm shift is occurring in toxicology following the report of the National Research Council of the USA National Academies entitled "Toxicity testing in the 21st Century: a vision and strategy"....
Related ArticlesAnalysis of lncRNA-miRNA-mRNA Interactions in Hyper-proliferative Human Pulmonary Arterial Smooth Muscle Cells. Sci Rep. 2019 Jul 19;9(1):10533 Authors: Chinnappan M, Gunewardena S, Chalise P, Dhillon NK Abstract We previously reported enhanced proliferation of smooth muscle cells on the combined exposure of HIV proteins and cocaine leading to the development of HIV-pulmonary arterial hypertension. Here, we attempt to comprehensively...
Related ArticlesActive thrombin produced by the intestinal epithelium controls mucosal biofilms. Nat Commun. 2019 Jul 19;10(1):3224 Authors: Motta JP, Denadai-Souza A, Sagnat D, Guiraud L, Edir A, Bonnart C, Sebbag M, Rousset P, Lapeyre A, Seguy C, Mathurine-Thomas N, Galipeau HJ, Bonnet D, Alric L, Buret AG, Wallace JL, Dufour A, Verdu EF, Hollenberg MD, Oswald E, Serino M, Deraison C, Vergnolle N Abstract Proteolytic homeostasis is important at mucosal...
Related ArticlesMolecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor. Nat Commun. 2019 Jul 19;10(1):3225 Authors: Basak S, Gicheru Y, Kapoor A, Mayer ML, Filizola M, Chakrapani S Abstract Serotonin receptor (5-HT3AR) is the most common therapeutic target to manage the nausea and vomiting during cancer therapies and in the treatment of irritable bowel syndrome. Setrons, a class of competitive antagonists, cause functional inhibition...
Related ArticlesIdentification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch. Neuron. 2019 Jul 10;: Authors: Pan H, Fatima M, Li A, Lee H, Cai W, Horwitz L, Hor CC, Zaher N, Cin M, Slade H, Huang T, Xu XZS, Duan B Abstract Lightly stroking the lips or gently poking some skin regions can evoke mechanical itch in healthy human subjects. Sensitization of mechanical itch and persistent spontaneous itch are intractable symptoms in chronic...
Related ArticlesAdvantages of prophylactic versus conventionally scheduled heart failure therapy in an experimental model of doxorubicin-induced cardiomyopathy. J Transl Med. 2019 Jul 19;17(1):229 Authors: Lódi M, Priksz D, Fülöp GÁ, Bódi B, Gyöngyösi A, Nagy L, Kovács Á, Kertész AB, Kocsis J, Édes I, Csanádi Z, Czuriga I, Kisvárday Z, Juhász B, Lekli I, Bai P, Tóth A, Papp Z, Czuriga D Abstract BACKGROUND: Chemotherapy-induced left ventricular dysfunction...
Related ArticlesArachidonic Acid Evokes an Increase in Intracellular Ca2+ Concentration and Nitric Oxide Production in Endothelial Cells from Human Brain Microcirculation. Cells. 2019 Jul 09;8(7): Authors: Berra-Romani R, Faris P, Negri S, Botta L, Genova T, Moccia F Abstract It has long been known that the conditionally essential polyunsaturated arachidonic acid (AA) regulates cerebral blood flow (CBF) through its metabolites prostaglandin E2 and epoxyeicosatrienoic...
Related ArticlesInfluence of Equimolar Doses of Beetroot Juice and Sodium Nitrate on Time Trial Performance in Handcycling. Nutrients. 2019 Jul 18;11(7): Authors: Flueck JL, Gallo A, Moelijker N, Bogdanov N, Bogdanova A, Perret C Abstract This study aimed to investigate the influence of a single dose of either beetroot juice (BR) or sodium nitrate (NIT) on performance in a 10 km handcycling time trial (TT) in able-bodied individuals and paracyclists....
Related ArticlesMass media representation of suicide in a high suicide state in India: an epidemiological comparison with suicide deaths in the population. BMJ Open. 2019 Jul 18;9(7):e030836 Authors: Armstrong G, Vijayakumar L, Pirkis J, Jayaseelan M, Cherian A, Soerensen JB, Arya V, Niederkrotenthaler T Abstract OBJECTIVES: Suicide rates in India are among the highest in the world, equating to over 200 000 suicides annually. Reports of suicides are...
Related ArticlesDirect and indirect costs of families with a child with acute lymphoblastic leukaemia in an academic hospital in China: a cross-sectional survey. BMJ Open. 2019 Jul 18;9(7):e030511 Authors: Ren Y, Li X Abstract OBJECTIVES: To estimate the direct and indirect costs in families with a child with acute lymphoblastic leukaemia (ALL) in China. DESIGN: A single-site, cross-sectional survey of primary caregiver of a child with ALL was...
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