Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)

Paroxysmal strabismus and stridor acquired in childhood: Do not overlook calcemia!:

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Paroxysmal strabismus and stridor acquired in childhood: Do not overlook calcemia!

Arch Pediatr. 2020 Jan 16;:

Authors: Escudier A, Giabicani E, Neven B, Gouache E, Blanchard M, Isapof A, Nougues MC, Freihuber C

Abstract

Hypocalcemia is known to induce stridor but was rarely reported to cause strabismus. We report the case of a 4-year-old girl who presented with paroxysmal stridor and strabismus with diplopia, persisting for several weeks. Severe hypocalcemia (1.25 mmol/L) was finally diagnosed and was related to hypoparathyroidism, which was the first manifestation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in this patient. Strabismus and stridor both resolved after normalization of calcemia. This case report is a rare observation of paroxysmal strabismus caused by hypocalcemia and it highlights the importance of calcium monitoring in any situation of atypical neurological symptoms.

PMID: 31955955 [PubMed - as supplied by publisher]