Duodenal Ulceration in a Child with Coeliac Disease

Diagnostics, Vol. 10, Pages 31: Duodenal Ulceration in a Child with Coeliac Disease:

Diagnostics, Vol. 10, Pages 31: Duodenal Ulceration in a Child with Coeliac Disease

Diagnostics doi: 10.3390/diagnostics10010031

Authors:
Polina S. Lototskaya
Marina A. Manina
Aleksandr S. Tertychnyy
Andrey A. Zamyatnin
Svetlana I. Erdes


Coeliac disease (CD) is a gluten-dependent inflammatory disease of the small bowel that affects up to 1% of the global population. Herein, the presence of ulcers, erosions, or strictures in the duodenum for non-advanced cases of CD is a rarity. Case report: We present a clinical case of a 17-year-old girl, who from the age of 9, had suffered from erosive Helicobacter pylori (HP)-associated gastritis and erosive duodenitis. At 16, she was diagnosed with a duodenal ulcer, complicated by cicatricial deformity of the bulb. While an atypical course in the development of the disease had led to the initial delay in diagnosis, a serum study and an intestinal biopsy confirmed CD. Discussion: A recent study found an elevated rate of peptic ulcer disease in patients with CD. From literature searches, comorbid HP infection and CD have indeed been widely reported, whereas cases highlighting the prevalence of CD-associated peptic ulcers have been observed and reported in only a few instances. Consequently, greater awareness is warranted and must be exercised for identifying the origins of ulcerative lesions that may be CD-related or -derived.