Antibodies, Vol. 9, Pages 2: Antibody Conjugates-Recent Advances and Future Innovations Antibodies doi: 10.3390/antib9010002 Authors: Donmienne Leung Jacqueline M. Wurst Tao Liu Ruben M. Martinez Amita Datta-Mannan Yiqing Feng Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past 30 years. Clinical success rates of antibodies have exceeded expectations, resulting in heavy investment in biologics discovery and development in addition...
Wed Jan 08, 2020 02:00
Antioxidants, Vol. 9, Pages 58: Anti-Inflammatory, Antioxidant, and Microbiota-Modulating Effects of Camellia Oil from Camellia brevistyla on Acetic Acid-Induced Colitis in Rats Antioxidants doi: 10.3390/antiox9010058 Authors: Wu Tung Chen Lee Lin Yen Altering the microbiota by the daily diet is highly associated with improved human health. Studies confirms the gastrointestinal protective and anti-inflammatory effects of camellia oil; however, the benefits in gut...
Wed Jan 08, 2020 02:00
Antioxidants, Vol. 9, Pages 57: Strenuous Acute Exercise Induces Slow and Fast Twitch-Dependent NADPH Oxidase Expression in Rat Skeletal Muscle Antioxidants doi: 10.3390/antiox9010057 Authors: Juliana Osório Alves Leonardo Matta Pereira Igor Cabral Coutinho do Rêgo Monteiro Luiz Henrique Pontes dos Santos Alex Soares Marreiros Ferraz Adriano Cesar Carneiro Loureiro Crystianne Calado Lima José Henrique Leal-Cardoso Denise Pires Carvalho Rodrigo Soares Fortunato Vânia...
Wed Jan 08, 2020 02:00
Antioxidants, Vol. 9, Pages 56: Changes in Plasma Fatty Acids, Free Amino Acids, Antioxidant Defense, and Physiological Stress by Oleuropein Supplementation in Pigs Prior to Slaughter Antioxidants doi: 10.3390/antiox9010056 Authors: Ana I. Rey Almudena de-Cara Luis Calvo Patricia Puig Teresa Hechavarría Olive tree leaves are characterized for having not only a potent antioxidant power but also effects on glucose and lipid metabolism. The impact of the individual oleuropein...
Wed Jan 08, 2020 02:00
Antioxidants, Vol. 9, Pages 55: Novel N,N′-Disubstituted Acylselenoureas as Potential Antioxidant and Cytotoxic Agents Antioxidants doi: 10.3390/antiox9010055 Authors: Ana Carolina Ruberte Sandra Ramos-Inza Carlos Aydillo Irene Talavera Ignacio Encío Daniel Plano Carmen Sanmartín Selenium compounds are pivotal in medicinal chemistry for their antitumoral and antioxidant properties. Forty seven acylselenoureas have been designed and synthesized following a fragment-based...
Wed Jan 08, 2020 02:00
Antioxidants, Vol. 9, Pages 54: Sangiovese cv Pomace Seeds Extract-Fortified Kefir Exerts Anti-Inflammatory Activity in an In Vitro Model of Intestinal Epithelium Using Caco-2 Cells Antioxidants doi: 10.3390/antiox9010054 Authors: Gabriele Carullo Paolo Governa Umile Gianfranco Spizzirri Marco Biagi Fabio Sciubba Gianluca Giorgi Monica Rosa Loizzo Maria Enrica Di Cocco Francesca Aiello Donatella Restuccia Inflammatory bowel disease and food allergies are a...
Wed Jan 08, 2020 02:00
Atmosphere, Vol. 11, Pages 75: Atmospheric Density and Temperature Vertical Profile Retrieval for Flight-Tests with a Rayleigh Lidar On-Board the French Advanced Test Range Ship Monge Atmosphere doi: 10.3390/atmos11010075 Authors: Wing Martic Hauchecorne Porteneuve Keckhut Courcoux Yung Retailleau Cocuron The Advanced Test Range Ship Monge (ATRSM) is dedicated to in-flight measurementsduring the re-entry phase of ballistic missiles test flights. Atmospheric...
Wed Jan 08, 2020 02:00
Atmosphere, Vol. 11, Pages 76: Numerical Modeling of the Natural and Manmade Factors Influencing Past and Current Changes in Polar, Mid-Latitude and Tropical Ozone Atmosphere doi: 10.3390/atmos11010076 Authors: Smyshlyaev Galin Blakitnaya Jakovlev A chemistry–climate model of the lower and middle atmosphere is used to compare the role of natural and anthropogenic factors in the observed variability of stratospheric ozone. Numerical experiments have been carried...
Wed Jan 08, 2020 02:00
Atmosphere, Vol. 11, Pages 74: Regional Differences of Primary Meteorological Factors Impacting O3 Variability in South Korea Atmosphere doi: 10.3390/atmos11010074 Authors: Yeomin Jeong Hwa Woon Lee Wonbae Jeon Surface ozone (O3) is a harmful pollutant and effective strategies must be developed for its reduction. In this study, the impact of meteorological factors on the annual O3 variability for South Korea were analyzed. In addition, the regional differences of meteorological...
Wed Jan 08, 2020 02:00
Atmosphere, Vol. 11, Pages 73: Comparison of Atmospheric Mercury Speciation at a Coastal and an Urban Site in Southeastern Texas, USA Atmosphere doi: 10.3390/atmos11010073 Authors: Travis Griggs Lei Liu Robert W. Talbot Azucena Torres Xin Lan Sixteen months of continuous measurements and the analysis of atmospheric mercury (gaseous elemental mercury GEM, gaseous oxidized mercury GOM, and particulate bound mercury PBM) under urban and coastal settings were conducted in Southeastern...
Wed Jan 08, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 29: Involvement in Physical Fights among School Attending Adolescents: A Nationally Representative Sample from Kuwait Behavioral Sciences doi: 10.3390/bs10010029 Authors: Masood Ali Shaikh Anne P. Abio Adebola A. Adedimeji Michael Lowery Wilson Background: Interpersonal violence in school settings is an important public health problem worldwide. This study investigated the individual and social correlates for being involved in a physical fight...
Wed Jan 08, 2020 02:00
Beverages, Vol. 6, Pages 3: Designing New Yeasts for Craft Brewing: When Natural Biodiversity Meets Biotechnology Beverages doi: 10.3390/beverages6010003 Authors: Fabrizio Iattici Martina Catallo Lisa Solieri Beer is a fermented beverage with a history as old as human civilization. Ales and lagers are by far the most common beers; however, diversification is becoming increasingly important in the brewing market and the brewers are continuously interested in improving and extending...
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Biology, Vol. 9, Pages 15: Protein Deimination and Extracellular Vesicle Profiles in Antarctic Seabirds Biology doi: 10.3390/biology9010015 Authors: Phillips Kraev Lange Pelagic seabirds are amongst the most threatened of all avian groups. They face a range of immunological challenges which seem destined to increase due to environmental changes in their breeding and foraging habitats, affecting prey resources and exposure to pollution and pathogens. Therefore, the identification...
Wed Jan 08, 2020 02:00
Biomolecules, Vol. 10, Pages 113: The Ovarian Transcriptome of Reproductively Aged Multiparous Mice: Candidate Genes for Ovarian Cancer Protection Biomolecules doi: 10.3390/biom10010113 Authors: Ulises Urzúa Carlos Chacón Maximiliano Norambuena Luis Lizama Sebastián Sarmiento Esther Asaki John I Powell Sandra Ampuero In middle-aged women, the decline of ovarian follicle reserve below a critical threshold marks menopause, leading to hormonal, inflammatory, and metabolic...
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Biomolecules, Vol. 10, Pages 112: Molecular Insight into Stereoselective ADME Characteristics of C20-24 Epimeric Epoxides of Protopanaxadiol by Docking Analysis Biomolecules doi: 10.3390/biom10010112 Authors: Wenna Guo Zhiyong Li Meng Yuan Geng Chen Qiao Li Hui Xu Xin Yang Chirality is a common phenomenon, and it is meaningful to explore interactions between stereoselective bio-macromolecules and chiral small molecules with preclinical and clinical significance. Protopanaxadiol-type...
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Biomolecules, Vol. 10, Pages 111: TLR2 and TLR4 Surface and Gene Expression in White Blood Cells after Fasting and Oral Glucose, Lipid and Protein Challenges: Influence of Obesity and Sex Hormones Biomolecules doi: 10.3390/biom10010111 Authors: M. Ángeles Martínez-García Miriam Ojeda-Ojeda Eulalia Rodríguez-Martín María Insenser Samuel Moncayo Francisco Álvarez-Blasco Manuel Luque-Ramírez Héctor F. Escobar-Morreale We studied if macronutrients of the diet have different...
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Biomolecules, Vol. 10, Pages 110: Electrochemical Sensing Fabricated with Ta2O5 Nanoparticle-Electrochemically Reduced Graphene Oxide Nanocomposite for the Detection of Oxytetracycline Biomolecules doi: 10.3390/biom10010110 Authors: Magesa Wu Dong Tian Li Vianney Buza Liu He A novel tantalum pentoxide nanoparticle-electrochemically reduced graphene oxide nanocomposite-modified glassy carbon electrode (Ta2O5-ErGO/GCE) was developed for the detection of...
Wed Jan 08, 2020 02:00
Biomolecules, Vol. 10, Pages 109: Production of Polyhydroxyalkanoates by Two Halophilic Archaeal Isolates from Chott El Jerid Using Inexpensive Carbon Sources Biomolecules doi: 10.3390/biom10010109 Authors: Ben Abdallah Karray Sayadi The large use of conventional plastics has resulted in serious environmental problems. Polyhydroxyalkanoates represent a potent replacement to synthetic plastics because of their biodegradable nature. This study aimed to screen bacteria and archaea...
Wed Jan 08, 2020 02:00
Biomolecules, Vol. 10, Pages 107: The Unique Lipidomic Signatures of Saccharina latissima Can Be Used to Pinpoint Their Geographic Origin Biomolecules doi: 10.3390/biom10010107 Authors: Monteiro Rey Melo Moreira Arbona Skjermo Forbord Funderud Raposo Kerrison Perrineau Gachon Domingues Calado Domingues The aquaculture of macroalgae for human consumption and other high-end applications is experiencing unprecedented development in...
Wed Jan 08, 2020 02:00
Biomolecules, Vol. 10, Pages 108: Benzimidazole Containing Acetamide Derivatives Attenuate Neuroinflammation and Oxidative Stress in Ethanol-Induced Neurodegeneration Biomolecules doi: 10.3390/biom10010108 Authors: Muhammad Imran Lina Tariq Al Kury Humaira Nadeem Fawad Ali Shah Muzaffar Abbas Shagufta Naz Arif-ullah Khan Shupeng Li Oxidative stress-induced neuroinflammation is the prominent feature of neurodegenerative disorders, and is characterized by a gradual...
Wed Jan 08, 2020 02:00
Biomolecules, Vol. 10, Pages 106: Olive Oil Oleogel Formulation Using Wax Esters Derived from Soybean Fatty Acid Distillate Biomolecules doi: 10.3390/biom10010106 Authors: Papadaki Kopsahelis Freire Mandala Koutinas Oleogelation is an emerging technology to structure oils, which can be widely used to substitute saturated and trans fats. Extra virgin olive oil is widely recognized for its high nutritional value, but its utilization in oleogel production is currently limited....
Wed Jan 08, 2020 02:00
Biomolecules, Vol. 10, Pages 105: Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression Biomolecules doi: 10.3390/biom10010105 Authors: Raghad Khalid AL-Ishaq Anthony J. Overy Dietrich Büsselberg Gastrointestinal (GI) cancer is a prevailing global health disease with a high incidence rate which varies by region. It is a huge economic burden on health care providers. GI cancer affects different organs in the body such as the gastric...
Wed Jan 08, 2020 02:00
Brain Sciences, Vol. 10, Pages 36: How the Brain Understands Spoken and Sung Sentences Brain Sciences doi: 10.3390/brainsci10010036 Authors: Rossi Gugler Rungger Galvan Zorowka Seebacher The present study investigates whether meaning is similarly extracted from spoken and sung sentences. For this purpose, subjects listened to semantically correct and incorrect sentences while performing a correctness judgement task. In order to examine underlying neural mechanisms,...
Wed Jan 08, 2020 02:00
Brain Sciences, Vol. 10, Pages 35: Expression and Localization of Kv1.1 and Kv3.1b Potassium Channels in the Cochlear Nucleus and Inferior Colliculus after Long-Term Auditory Deafferentation Brain Sciences doi: 10.3390/brainsci10010035 Authors: Clara M. Poveda Maria L. Valero Marianny Pernia Juan C. Alvarado David K. Ryugo Miguel A. Merchan Jose M. Juiz Deafness affects the expression and distribution of voltage-dependent potassium channels (Kvs) of central auditory...
Wed Jan 08, 2020 02:00
Brain Sciences, Vol. 10, Pages 34: Perspectives on Deep Brain Stimulation and Its Earlier Use for Parkinson’s Disease: A Qualitative Study of US Patients Brain Sciences doi: 10.3390/brainsci10010034 Authors: Laura Y. Cabrera Karen Kelly-Blake Christos Sidiropoulos Background: Deep brain stimulation (DBS) is being used earlier than was previously the case in the disease progression in people with Parkinson’s disease (PD). To explore preferences about the timing of DBS,...
Wed Jan 08, 2020 02:00
Cancers, Vol. 12, Pages 159: Cortactin: A Major Cellular Target of the Gastric Carcinogen Helicobacter pylori Cancers doi: 10.3390/cancers12010159 Authors: Irshad Sharafutdinov Steffen Backert Nicole Tegtmeyer Cortactin is an actin binding protein and actin nucleation promoting factor regulating cytoskeletal rearrangements in nearly all eukaryotic cell types. From this perspective, cortactin poses an attractive target for pathogens to manipulate a given host cell to their own benefit....
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Cancers, Vol. 12, Pages 157: Socio-Demographic Disparities in Gastric Adenocarcinoma: A Population-Based Study Cancers doi: 10.3390/cancers12010157 Authors: Navpreet Rana Rohit Gosain Riccardo Lemini Chong Wang Emmanuel Gabriel Turab Mohammed Beas Siromoni Sarbajit Mukherjee Background: Gastric cancer is one of the leading causes of cancer-related mortality worldwide, accounting for 8.2% of cancer-related deaths. The purpose of this study was to investigate the geographic...
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Cancers, Vol. 12, Pages 156: Multimodal Assessment Shows a Mostly Preserved Cognitive Status in Incidentally Discovered Low Grade Gliomas: A Single Institution Study Cancers doi: 10.3390/cancers12010156 Authors: Ilaria Guarracino Tamara Ius Enrico Pegolo Daniela Cesselli Miran Skrap Barbara Tomasino Incidentally discovered low-grade gliomas (iLGGs) are poorly reported in the literature. Still less is known about iLGG patients’ neuropsychological profile: It is...
Wed Jan 08, 2020 02:00
Cancers, Vol. 12, Pages 150: TYK2 in Tumor Immunosurveillance Cancers doi: 10.3390/cancers12010150 Authors: Karjalainen Shoebridge Krunic Simonović Tebb Macho-Maschler Strobl Müller We review the history of the tyrosine kinase 2 (TYK2) as the founding member of the Janus kinase (JAK) family and outline its structure-function relation. Gene-targeted mice and hereditary defects of TYK2 in men have established the biological and pathological functions of TYK2...
Wed Jan 08, 2020 02:00
Cancers, Vol. 12, Pages 154: Targeting Glucose Transporters for Breast Cancer Therapy: The Effect of Natural and Synthetic Compounds Cancers doi: 10.3390/cancers12010154 Authors: Barbosa Martel Reprogramming of cellular energy metabolism is widely accepted to be a cancer hallmark. The deviant energetic metabolism of cancer cells-known as the Warburg effect-consists in much higher rates of glucose uptake and glycolytic oxidation coupled with the production of lactic acid, even in...
Wed Jan 08, 2020 02:00
Cancers, Vol. 12, Pages 153: The Regulation of the Metastatic Cascade by Physical Activity: A Narrative Review Cancers doi: 10.3390/cancers12010153 Authors: van Doorslaer de ten Ryen Deldicque The purpose of this narrative review is to provide an overview of the currently available knowledge about the mechanisms by which physical activity may affect metastatic development. The search terms exercise [Title/Abstract] AND metastasis [Title/Abstract] returned 222 articles on PUBMED...
Wed Jan 08, 2020 02:00
Cancers, Vol. 12, Pages 151: Imaging of Colorectal Liver Metastases: New Developments and Pending Issues Cancers doi: 10.3390/cancers12010151 Authors: Renzulli Clemente Ierardi Pettinari Tovoli Brocchi Peta Cappabianca Carrafiello Golfieri Computed tomography (CT), magnetic resonance imaging (MRI), and 18-fluorideoxyglucose positron emission tomography (18FDG-PET) are historically the most accurate imaging techniques for diagnosing liver metastases....
Wed Jan 08, 2020 02:00
Cancers, Vol. 12, Pages 152: Prediction of Postoperative Clinical Outcomes in Resected Stage I Non-Small Cell Lung Cancer Focusing on the Preoperative Glasgow Prognostic Score Cancers doi: 10.3390/cancers12010152 Authors: Lindenmann Fink-Neuboeck Taucher Pichler Posch Brcic Smolle Koter Smolle Smolle-Juettner Background: The Glasgow Prognostic Score (GPS), which consists of albumin and C-reactive protein (CRP), may predict overall survival (OS) in...
Wed Jan 08, 2020 02:00
Cancers, Vol. 12, Pages 155: Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer? Cancers doi: 10.3390/cancers12010155 Authors: Del Cornò Gessani Conti β-glucans represent a heterogeneous group of naturally occurring and biologically active polysaccharides found in many kinds of edible mushrooms, baker’s yeast, cereals and seaweeds, whose health-promoting effects have been known since ancient times. These compounds can...
Wed Jan 08, 2020 02:00
Cancers, Vol. 12, Pages 148: Epigenetic Silencing of Ubiquitin Specific Protease 4 by Snail1 Contributes to Macrophage-Dependent Inflammation and Therapeutic Resistance in Lung Cancer Cancers doi: 10.3390/cancers12010148 Authors: Chao-Yang Lai Da-Wei Yeh Chih-Hao Lu Yi-Ling Liu Yu-Chen Chuang Jhen-Wei Ruan Cheng-Yuan Kao Li-Rung Huang Tsung-Hsien Chuang There is a positive feedback loop driving tumorigenesis and tumor growth through coordinated regulation of epigenetics,...
Wed Jan 08, 2020 02:00
Cancers, Vol. 12, Pages 149: Prediction of Drug Efficacy in Colon Cancer Preclinical Models Using a Novel Ranking Method of Gene Expression Cancers doi: 10.3390/cancers12010149 Authors: Justine Fritz Olivier Lefebvre Aurore Fernandez Jordane Schmidt Dominique Bagnard The presence of stromal cells in tumors is altering the significance of molecular profiling when using standard methods of gene expression quantification. We developed a novel normalization method to rank target...
Wed Jan 08, 2020 02:00
Cancers, Vol. 12, Pages 147: Roles of TrkC Signaling in the Regulation of Tumorigenicity and Metastasis of Cancer Cancers doi: 10.3390/cancers12010147 Authors: Wook Jin Tropomyosin receptor kinase (Trk) C contributes to the clinicopathology of a variety of human cancers, and new chimeric oncoproteins containing the tyrosine kinase domain of TrkC occur after fusion to the partner genes. Overexpression of TrkC and TrkC fusion proteins was observed in patients with a variety of cancers,...
Wed Jan 08, 2020 02:00
Cancers, Vol. 12, Pages 146: Neurocognitive Decline Following Radiotherapy: Mechanisms and Therapeutic Implications Cancers doi: 10.3390/cancers12010146 Authors: Simonetta Pazzaglia Giovanni Briganti Mariateresa Mancuso Anna Saran The brain undergoes ionizing radiation (IR) exposure in many clinical situations, particularly during radiotherapy for malignant brain tumors. Cranial radiation therapy is related with the hazard of long-term neurocognitive decline. The detrimental...
Wed Jan 08, 2020 02:00
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