GastrointestDisord, Vol. 2, Pages 1-2: Acknowledgement to Reviewers of Gastrointestinal Disorders in 2019 Gastrointestinal Disorders doi: 10.3390/gidisord2010001 Authors: Gastrointestinal Disorders Editorial Office The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process over the past 12 months, regardless of whether the papers are finally published or not [...]
Mon Jan 20, 2020 02:00
Geriatrics, Vol. 5, Pages 4: Assessment and Management of Dysphagia in Acute Stroke: An Initial Service Review of International Practice Geriatrics doi: 10.3390/geriatrics5010004 Authors: Fairfield Smithard The international approach to the assessment and management of dysphagia in the acute phase post stroke is little studied. A questionnaire was sent to clinicians in stroke services that explored the current practice in dysphagia screening, assessment, and management within the...
Tue Jan 21, 2020 02:00
Healthcare, Vol. 8, Pages 23: Information Technology and Medical Technology Personnel’s Perception Regarding Segmentation of Medical Devices: A Focus Group Study Healthcare doi: 10.3390/healthcare8010023 Authors: Johansson Jönsson Ivarsson Christiansson Objective: Segmentation is one way of improving data protection. The aim of this study was to investigate Information Technology (IT) and Medical Technology (MT) personnel’s perception in relation to ongoing segmentation...
Tue Jan 21, 2020 02:00
Healthcare, Vol. 8, Pages 22: Investigating the Temporal Relationships between Symptoms and Nebuliser Adherence in People with Cystic Fibrosis: A Series of N-of-1 Observations Healthcare doi: 10.3390/healthcare8010022 Authors: Martin Arden Porritt Wildman Naughton Treatment adherence in adults with cystic fibrosis (CF) is poor. One of the reasons identified for lack of adherence to nebulised treatments is that patients may not experience any immediate relief in their...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 704: Enhancement of Chromium (VI) Reduction in Microcosms Amended with Lactate or Yeast Extract: A Laboratory-Scale Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030704 Authors: Ancona Campanale Tumolo De Paola Ardito Volpe Uricchio A laboratory-scale study was carried out to evaluate the groundwater bioremediation potential of hexavalent chromium (Cr(VI)), taking into account the chromate...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 702: System Approaches to Water, Sanitation, and Hygiene: A Systematic Literature Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030702 Authors: Valcourt Javernick-Will Walters Linden Endemic issues of sustainability in the water, sanitation, and hygiene (WASH) sector have led to the rapid expansion of ‘system approaches’ for assessing the multitude of interconnected factors that affect...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 701: The Association of Knowledge, Attitudes and Access with Park Use before and after a Park-Prescription Intervention for Low-Income Families in the U.S. International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030701 Authors: Razani Hills Thompson Rutherford We conducted secondary data analyses of pooled data from a clinical trial that prescribed park visits to children and their caregivers in a low-income, urban setting....
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 703: Knowledge and Practice of Preventive Measures for Oral Health Care among Male Intermediate Schoolchildren in Abha, Saudi Arabia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030703 Authors: Al-Qahtani Razak Khan The aims of this study were to evaluate oral health knowledge and assess the practice of preventive measures for oral health care among intermediate schoolchildren in Abha, Saudi Arabia. Information...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 699: Low-Cost Robotic Guide Based on a Motor Imagery Brain–Computer Interface for Arm Assisted Rehabilitation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030699 Authors: Quiles Suay Candela Chio Jiménez Álvarez-Kurogi Motor imagery has been suggested as an efficient alternative to improve the rehabilitation process of affected limbs. In this study, a low-cost robotic guide is implemented so that linear...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 698: Association Between Mycotoxin Exposure and Dietary Habits in Colorectal Cancer Development Among a Polish Population: A Study Protocol International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030698 Authors: Przybyłowicz Arłukowicz Danielewicz Morze Gajęcka Zielonka Fotschki Sawicki Colorectal cancer (CRC) is one of the most common and lethal types of cancer worldwide. The developing of this disease...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 700: Spatiotemporal Analysis of the Population Risk of Congenital Microcephaly in Pernambuco State, Brazil International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030700 Authors: Alexander Souza Rodrigues Braga Sá Bezerra Turchi Martelli Since an outbreak in Brazil, which started in 2015, Zika has been recognized as an important cause of microcephaly. The highest burden of this outbreak was in northeast Brazil,...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 696: Influence of Nutritional Education on the Diet and Nutritional Behaviors of Elderly Women at the University of the Third Age International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030696 Authors: Michalczyk Zajac-Gawlak Zając Pelclová Roczniok Langfort Background: The objective of this study was to evaluate the diet composition, body fat content, and physical activity (PA), considering blood lipid levels...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 697: Alcohol Outlet Density and Deprivation in Six Towns in Bergrivier Municipality before and after Legislative Restrictions International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030697 Authors: Bowers Davids London Introduction. In 2016, after the Western Cape Liquor Act was enacted, alcohol outlets were mapped in the six towns from a previous 2008 study to determine: 1) alcohol outlet density; 2) the association between...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 694: The ARTEMIS Center: An Environmental Health Prevention Platform Dedicated to Reproduction International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030694 Authors: Delva Manangama Brochard Teysseire Sentilhes In France, a new approach is being developed through the ARTEMIS Center, which is a prevention platform for environmental health dedicated to reproduction. The objective is to describe the clinical management...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 693: The Perceptions of Trauma, Complaints, Somatization, and Coping Strategies among Syrian Refugees in Germany—A Qualitative Study of an At-Risk Population International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030693 Authors: Zbidat Georgiadou Borho Erim Morawa Background: A high prevalence of mental distress, especially posttraumatic stress disorder, has been widely confirmed among refugees. In order to establish...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 692: Parental Attachment, Adult-Child Romantic Attachment, and Marital Satisfaction: An Examination of Cultural Context in Taiwanese and Thai Heterosexual Couples International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030692 Authors: Huang Sirikantraporn Pichayayothin Turner-Cobb Relationship dynamics between married couples can differ considerably, with varying impacts on relationship satisfaction. However, very limited...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 695: Cost-Effectiveness of “Tele-Square Step Exercise” for Falls Prevention in Fibromyalgia Patients: A Study Protocol International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030695 Authors: Carlos-Vivas Pérez-Gómez Delgado-Gil Campos-López Granado-Sánchez Rojo-Ramos Muñoz-Bermejo Barrios-Fernandez Mendoza-Muñoz Prado-Solano Garcia-Gordillo Adsuar Background: Women with fibromyalgia (FM)...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 690: Cognitive-Affective Change Mechanisms in Personalized Normative Feedback via the Articulated Thoughts in Simulated Situations Paradigm International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030690 Authors: Hummer Hatch Davison The research explored explanatory mechanisms of change for a personalized normative feedback (PNF) intervention, through an adapted application of the Articulated Thoughts in Simulated Situation...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 689: Inflammatory Biomarkers, Microbiome, Depression, and Executive Dysfunction in Alcohol Users International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030689 Authors: Rodríguez-Rabassa López Sánchez Hernández Rodríguez Rodríguez-Santiago Orengo Green Yamamura Rivera-Amill Alcohol-related disorders (ARD) are highly prevalent among Latin American-Caribbean countries. Mental disorders are common...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 688: A Systematic Review of Beef Meat Quantitative Microbial Risk Assessment Models International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030688 Authors: Tesson Federighi Cummins de Oliveira Mota Guillou Boué Each year in Europe, meat is associated with 2.3 million foodborne illnesses, with a high contribution from beef meat. Many of these illnesses are attributed to pathogenic bacterial contamination and inadequate...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 691: Examining the Process of Modal Choice for Everyday Travel Among Older People International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030691 Authors: Ryan Modal choice is a prominent concept within transport studies. However, the term is often used quite loosely, with little known about the factors lying behind the choice, the alternatives available to a person, and whether the person had a ‘choice’ to begin...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 681: Adhering to the 2017 Dutch Physical Activity Guidelines: A Trend over Time 2001–2018 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030681 Authors: Duijvestijn van den Berg Wendel-Vos Recently, new physical activity (PA) guidelines were adopted in the Netherlands consisting of two components: (1) addressing duration of moderate and vigorous PA, (2) bone and muscle strengthening activities. The aim of this study...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 686: Bidirectional Associations across Time between Entitativity, Positive Affect, Generosity, and Religiousness in Adolescents Training with a Religiously Affiliated Charity Marathon Team International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030686 Authors: Schnitker Shubert Houltberg Fernandez Numerous studies have established that participation in regular physical activity provides physical, cognitive, and affective...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 685: Six-Step Model of Nature-Based Therapy Process International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030685 Authors: Oh Shin Khil Kim Several studies have confirmed that the natural environment has psychophysiological healing effects. However, few studies have investigated the healing process involved in the effect of the natural environment. To date, no theoretical model on the nature-based therapy process has...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 682: Evacuate or Stay? A Typhoon Evacuation Decision Model in China Based on the Evolutionary Game Theory in Complex Networks International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030682 Authors: Sun Zhang Su The Chinese Government has played an important role in organizing the evacuation of typhoon disasters, and in-depth analysis of individual behavioral decisions is a prerequisite for adopting an effective emergency...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 684: Removal of Hydrogen Sulfide in Septic Tanks for Treating Black Water via an Immobilized Media of Sulfur-Oxidizing Bacteria International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030684 Authors: Kang Namgung Cho Yoo Lee Ji In South Korea, the installation of septic tanks for treating black water (STBW) is regulated even in sewage treatment areas to prevent the black water deposition in combined sewers. STBWs...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 683: Associations of Socioeconomic Status, Parental Smoking and Parental E-Cigarette Use with 10–11-Year-Old Children’s Perceptions of Tobacco Cigarettes and E-Cigarettes: Cross Sectional Analysis of the CHETS Wales 3 Survey International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030683 Authors: Moore Angel Gray Copeland Van Godwin Segrott Hallingberg Background: This study examines primary schoolchildren’s...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 687: Distribution and Removal of Pharmaceuticals in Liquid and Solid Phases in the Unit Processes of Sewage Treatment Plants International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030687 Authors: Park Kim Hong Lee Chung Jeong Kim In this study, we analyzed 27 pharmaceuticals in liquid and solid phase samples collected from the unit processes of four different sewage treatment plants (STPs) to evaluate their...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 680: Experience of Stress Assessed by Text Messages and Its Association with Objective Workload—A Longitudinal Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030680 Authors: Arapovic-Johansson Wåhlin Hagberg Kwak Axén Björklund Jensen Exploring stress trajectories in detail and over a long time may give valuable information in terms of both understanding and practice. We followed a group of...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 678: Regional Influenza Prediction with Sampling Twitter Data and PDE Model International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030678 Authors: Wang Xu Kang Wang Wang Avram The large volume of geotagged Twitter streaming data on flu epidemics provides chances for researchers to explore, model, and predict the trends of flu cases in a timely manner. However, the explosive growth of data from social media makes...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 679: Nickel: Human Health and Environmental Toxicology International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030679 Authors: Genchi Carocci Lauria Sinicropi Catalano Nickel is a transition element extensively distributed in the environment, air, water, and soil. It may derive from natural sources and anthropogenic activity. Although nickel is ubiquitous in the environment, its functional role as a trace element...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 677: Perceptions of the Use of Alcohol and Drugs after Sudden Bereavement by Unnatural Causes: Analysis of Online Qualitative Data International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030677 Authors: Drabwell Eng Stevenson King Osborn Pitman Bereavement is associated with an increased risk of psychiatric morbidity and all-cause mortality, particularly in younger people and after unnatural deaths. Substance...
Tue Jan 21, 2020 02:00
IJERPH, Vol. 17, Pages 676: Preparation and Characterization of Fe-Mn Binary Oxide/Mulberry Stem Biochar Composite Adsorbent and Adsorption of Cr(VI) from Aqueous Solution International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030676 Authors: Liang Xu Zhu Chen Deng Yan He This study details the preparation of Fe-Mn binary oxide/mulberry stem biochar composite adsorbent (FM-MBC) from mulberry stems via the multiple activation by...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 712: Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy International Journal of Molecular Sciences doi: 10.3390/ijms21030712 Authors: Sirufo Suppa Ginaldi De Martinis : Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 710: The Flagellar Gene Regulates Biofilm Formation and Mussel Larval Settlement and Metamorphosis International Journal of Molecular Sciences doi: 10.3390/ijms21030710 Authors: Liang Zhang Peng Zhu Yoshida Osatomi Yang Biofilms are critical components of most marine systems and provide biochemical cues that can significantly impact overall community composition. Although progress has been made in the bacteria–animal interaction,...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 709: The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control International Journal of Molecular Sciences doi: 10.3390/ijms21030709 Authors: Manzano-López Monje-Casas The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 708: An Update on the Progress of Isolation, Culture, Storage, and Clinical Application of Human Bone Marrow Mesenchymal Stem/Stromal Cells International Journal of Molecular Sciences doi: 10.3390/ijms21030708 Authors: Chu Phuong Tien Tran Thanh Quang Truong Pham Ngoc Chu-Dinh Kushekhar Bone marrow mesenchymal stem/stromal cells (BMSCs), which are known as multipotent cells, are widely used in the treatment of various diseases...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 707: Nuclear Integrants of Organellar DNA Contribute to Genome Structure and Evolution in Plants International Journal of Molecular Sciences doi: 10.3390/ijms21030707 Authors: Guo-Jun Zhang Ran Dong Li-Na Lan Shu-Fen Li Wu-Jun Gao Hong-Xing Niu The transfer of genetic material from the mitochondria and plastid to the nucleus gives rise to nuclear integrants of mitochondrial DNA (NUMTs) and nuclear integrants of plastid DNA (NUPTs). This frequently...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 711: Chemically Crosslinked Bispecific Antibodies for Cancer Therapy: Breaking from the Structural Restrictions of the Genetic Fusion Approach International Journal of Molecular Sciences doi: 10.3390/ijms21030711 Authors: Ueda Umetsu Nakanishi Hashikami Nakazawa Hattori Asano Kumagai Antibodies are composed of structurally and functionally independent domains that can be used as building blocks to construct different types of chimeric...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 705: Extremely Low Leakage Expression Systems Using Dual Transcriptional-Translational Control for Toxic Protein Production International Journal of Molecular Sciences doi: 10.3390/ijms21030705 Authors: Kato Expression systems for highly toxic protein genes must be conditional and suppress leakage expression to almost zero because even faint leakage expression may kill host cells, inhibit host growth, and cause loss of plasmids containing the toxic protein genes....
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 704: Mechanisms and Treatment of Light-Induced Retinal Degeneration-Associated Inflammation: Insights from Biochemical Profiling of the Aqueous Humor International Journal of Molecular Sciences doi: 10.3390/ijms21030704 Authors: Chistyakov Baksheeva Tiulina Goriainov Azbukina Gancharova Arifulin Komarov Chistyakov Tikhomirova Zamyatnin Philippov Senin Sergeeva Zernii Ocular inflammation contributes to the pathogenesis...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 703: Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics International Journal of Molecular Sciences doi: 10.3390/ijms21030703 Authors: Mouchlis Melagraki Zacharia Afantitis Aging-associated neurodegenerative diseases, which are characterized by progressive neuronal death and synapses loss in human brain, are rapidly growing affecting millions of people globally. Alzheimer’s...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 699: Review—Current Concepts in Inflammatory Skin Diseases Evolved by Transcriptome Analysis: In-Depth Analysis of Atopic Dermatitis and Psoriasis International Journal of Molecular Sciences doi: 10.3390/ijms21030699 Authors: Julius Schwingen Mustafa Kaplan Florian C. Kurschus During the last decades, high-throughput assessment of gene expression in patient tissues using microarray technology or RNA-Seq took center stage in clinical research. Insights into...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 700: Potential Clinical Implications of miR-1 and miR-21 in Heart Disease and Cardioprotection International Journal of Molecular Sciences doi: 10.3390/ijms21030700 Authors: Kura Kalocayova Devaux Bartekova The interest in non-coding RNAs, which started more than a decade ago, has still not weakened. A wealth of experimental and clinical studies has suggested the potential of non-coding RNAs, especially the short-sized microRNAs (miRs), to be used as...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 706: The Effect of Transcription Factor MYB14 on Defense Mechanisms in Vitis quinquangularis-Pingyi International Journal of Molecular Sciences doi: 10.3390/ijms21030706 Authors: Luo Wang Bai Li Chen Xu Zhang Duan In the current study, we identified a transcription factor, MYB14, from Chinese wild grape, Vitis quinquangularis-Pingyi (V. quinquangularis-PY), which could enhance the main stilbene contents and expression of stilbene biosynthesis...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 701: Neuroinflammation and Neurogenesis in Alzheimer’s Disease and Potential Therapeutic Approaches International Journal of Molecular Sciences doi: 10.3390/ijms21030701 Authors: Sung Lin Liu Su Tsai In adult brain, new neurons are generated throughout adulthood in the subventricular zone and the dentate gyrus; this process is commonly known as adult neurogenesis. The regulation or modulation of adult neurogenesis includes various intrinsic pathways...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 698: Biopolymers-Based Materials Containing Silver Nanoparticles as Active Packaging for Food Applications–A Review International Journal of Molecular Sciences doi: 10.3390/ijms21030698 Authors: Kraśniewska Galus Gniewosz Packaging is an integral part of food products, allowing the preservation of their quality. It plays an important role, protecting the packed product from external conditions, maintaining food quality, and improving properties of the packaged...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 697: Current Status of AMOEBA–IL: A Multipolar/Polarizable Force Field for Ionic Liquids International Journal of Molecular Sciences doi: 10.3390/ijms21030697 Authors: Erik Antonio Vázquez-Montelongo José Enrique Vázquez-Cervantes G. Andrés Cisneros Computational simulations of ionic liquid solutions have become a useful tool to investigate various physical, chemical and catalytic properties of systems involving these solvents. Classical molecular dynamics...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 702: The TUSC2 Tumour Suppressor Inhibits the Malignant Phenotype of Human Thyroid Cancer Cells via SMAC/DIABLO Protein International Journal of Molecular Sciences doi: 10.3390/ijms21030702 Authors: Mariniello Orlandella Stefano Iervolino Smaldone Luciano Cervone Munciguerra Esposito Mirabelli Salvatore Thyroid carcinoma is the most common endocrine cancer and includes different forms. Among these, anaplastic thyroid carcinoma...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 692: The Roles of FoxO Transcription Factors in Regulation of Bone Cells Function International Journal of Molecular Sciences doi: 10.3390/ijms21030692 Authors: Ma Su Yin Lin Wang Gao Patil War Qadir Tian Qian Forkhead box class O family member proteins (FoxOs) are evolutionarily conserved transcription factors for their highly conserved DNA-binding domain. In mammalian species, all the four FoxO members, FoxO1, FoxO3, FoxO4,...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 695: Protective Effects of [6]-Gingerol Against Chemical Carcinogens: Mechanistic Insights International Journal of Molecular Sciences doi: 10.3390/ijms21030695 Authors: Furlan Bren [6]-Gingerol from ginger has received considerable attention as a potential cancer therapeutic agent because of its chemopreventive and chemotherapeutic effects, as well as its safety. In the current study, we examined [6]-gingerol as a natural scavenger of nine ultimate chemical...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 694: Use of 3D Organoids as a Model to Study Idiopathic Form of Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21030694 Authors: Chlebanowska Tejchman Sułkowski Skrzypek Majka Organoids are becoming particularly popular in modeling diseases that are difficult to reproduce in animals, due to anatomical differences in the structure of a given organ. Thus, they are a bridge between the in vitro and in vivo models. Human...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 693: Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA) International Journal of Molecular Sciences doi: 10.3390/ijms21030693 Authors: Seelinger Otterlei To prevent replication fork collapse and genome instability under replicative stress, DNA damage tolerance (DDT) mechanisms have evolved. The RAD5 homologs, HLTF (helicase-like transcription...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 696: The Emerging Role of Mechanosensitive Piezo Channels in Migraine Pain International Journal of Molecular Sciences doi: 10.3390/ijms21030696 Authors: Della Pietra Mikhailov Giniatullin Recently discovered mechanosensitive Piezo channels emerged as the main molecular detectors of mechanical forces. The functions of Piezo channels range from detection of touch and pain, to control of the plastic changes in different organs. Recent studies suggested the...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 691: Identification and Pilot Evaluation of Salivary Peptides from Anopheles albimanus as Biomarkers for Bite Exposure and Malaria Infection in Colombia International Journal of Molecular Sciences doi: 10.3390/ijms21030691 Authors: Londono-Renteria Drame Montiel Vasquez Tobón-Castaño Taylor Vizcaino Lenhart Insect saliva induces significant antibody responses associated with the intensity of exposure to bites and the risk of disease in...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 690: Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles International Journal of Molecular Sciences doi: 10.3390/ijms21030690 Authors: Sutunkova Solovyeva Chernyshov Klinova Gurvich Shur Shishkina Zubarev Privalova Katsnelson Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 688: Production of Extracellular Matrix Proteins in the Cytoplasm of E. coli: Making Giants in Tiny Factories International Journal of Molecular Sciences doi: 10.3390/ijms21030688 Authors: Sohail Gaikwad Khadka Saaranen Ruddock Escherichia coli is the most widely used protein production host in academia and a major host for industrial protein production. However, recombinant production of eukaryotic proteins in prokaryotes has challenges. One of...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 689: Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma International Journal of Molecular Sciences doi: 10.3390/ijms21030689 Authors: Pires-Afonso Niclou Michelucci Abstract: Cancer heterogeneity and progression are subject to complex interactions between neoplastic cells and their microenvironment, including the immune system. Although glioblastomas (GBMs) are classified as ‘cold tumours’ with...
Tue Jan 21, 2020 02:00
IJMS, Vol. 21, Pages 687: The Probiotic BB12 Induces MicroRNAs Involved in Antigen Processing and Presentation in Porcine Monocyte-Derived Dendritic Cells International Journal of Molecular Sciences doi: 10.3390/ijms21030687 Authors: Bravo-Parra Arenas-Padilla Brcenas-Preciado Hernández Mata-Haro MicroRNAs (miRNAs) mediate the regulation of gene expression. Several reports indicate that probiotics induce miRNA-mediated immunomodulation at different levels, such as cytokine...
Tue Jan 21, 2020 02:00
IJNS, Vol. 6, Pages 4: Newborn Screening for Pompe Disease in Illinois: Experience with 684,290 Infants International Journal of Neonatal Screening doi: 10.3390/ijns6010004 Authors: Burton Charrow Hoganson Fleischer Grange Braddock Hitchins Hickey Christensen Groeppner Shryock Smith Shao Basheeruddin Statewide newborn screening for Pompe disease began in Illinois in 2015. As of 30 September 2019, a total of 684,290 infants had been...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 303: Comparison between Micro-Computed Tomography and Cone-Beam Computed Tomography in the Assessment of Bone Quality and a Long-Term Volumetric Study of the Augmented Sinus Grafted with an Albumin Impregnated Allograft Journal of Clinical Medicine doi: 10.3390/jcm9020303 Authors: Kivovics Szabó Németh Iványi Trimmel Szmirnova Orhan Mijiritsky Szabó Dobó-Nagy The purpose of our study was to compare micromorphometric data obtained...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 295: Role and Mechanism of LIF in Oral Squamous Cell Carcinoma Progression Journal of Clinical Medicine doi: 10.3390/jcm9020295 Authors: Lin Wu Li Yang Illescas Ralda Chang Background: Metastasis is a severe problem in patients with oral squamous cell carcinoma (OSCC), which is the fifth most common cancer worldwide. Leukemia inhibitory factor (LIF) has been studied in different cancers, while the role of LIF in OSCC remains unclear. Methods: LIF...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 301: Affinity-Enhanced CTC-Capturing Hydrogel Microparticles Fabricated by Degassed Mold Lithography Journal of Clinical Medicine doi: 10.3390/jcm9020301 Authors: Lee Maeng Kim Roh Hwang Kim Hwang Bong Technologies for the detection and isolation of circulating tumor cells (CTCs) are essential in liquid biopsy, a minimally invasive technique for early diagnosis and medical intervention in cancer patients. A promising method for CTC capture,...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 298: Improved Left Atrial Function in CRT Responders: A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9020298 Authors: Bytyçi Bajraktari Lindqvist Henein Cardiac resynchronization therapy (CRT) is associated with reverse left atrial (LA) remodeling. The aim of this meta-analysis was to assess the relationship between clinical response to CRT and LA function changes. We conducted a systematic search of all electronic databases...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 297: Obstructive Sleep Apnea in Neurodegenerative Disorders: Current Evidence in Support of Benefit from Sleep Apnea Treatment Journal of Clinical Medicine doi: 10.3390/jcm9020297 Authors: Lajoie Lafontaine Kimoff Kaminska Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurrent upper airway obstruction during sleep resulting in intermittent hypoxemia and sleep fragmentation. Research has recently increasingly focused on the impact...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 296: The Effect of the Paleolithic Diet vs. Healthy Diets on Glucose and Insulin Homeostasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Journal of Clinical Medicine doi: 10.3390/jcm9020296 Authors: Jamka Kulczyński Juruć Gramza-Michałowska Stokes Walkowiak Recently, the Paleolithic diet became popular due to its possible health benefits. Several, albeit not all, studies suggested that the consumption of the Paleolithic...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 302: VEGFR2 Blockade Improves Renal Damage in an Experimental Model of Type 2 Diabetic Nephropathy Journal of Clinical Medicine doi: 10.3390/jcm9020302 Authors: Lavoz Rodrigues-Diez Plaza Carpio Egido Ruiz-Ortega Mezzano The absence of optimal treatments for Diabetic Nephropathy (DN) highlights the importance of the search for novel therapeutic targets. The vascular endothelial growth factor receptor 2 (VEGFR2) pathway is activated in experimental...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 292: Adjustable Versus Nonadjustable Sutures in Strabismus Surgery—Who Benefits the Most? Journal of Clinical Medicine doi: 10.3390/jcm9020292 Authors: Gawęcki Background: Adjustable sutures have been used in strabismus surgery for more than 40 years, but controversy remains regarding their application. This review sought to analyze studies comparing the efficacy of adjustable sutures (AS) and nonadjustable sutures (NAS) in the treatment of different ocular deviations....
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 299: Increased Diagnostic Accuracy of Adnexal Tumors with A Combination of Established Algorithms and Biomarkers Journal of Clinical Medicine doi: 10.3390/jcm9020299 Authors: Lycke Ulfenborg Kristjansdottir Sundfeldt Ovarian cancer is the most lethal gynecologic cancer. Pre-diagnostic testing lacks sensitivity and specificity, and surgery is often the only way to secure the diagnosis. Exploring new biomarkers is of great importance, but the rationale of...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 291: Manipulating the Perceived Shape and Color of a Virtual Limb Can Modulate Pain Responses Journal of Clinical Medicine doi: 10.3390/jcm9020291 Authors: Matamala-Gomez Nierula Donegan Slater Sanchez-Vives Changes in body representation may affect pain perception. The effect of a distorted body image, such as the telescoping effect in amputee patients, on pain perception, is unclear. This study aimed to investigate whether distorting an embodied...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 294: Clinical Implications of Estimating Glomerular Filtration Rate with Three Different Equations Among Older People. Preliminary Results of the Project “Screening for Chronic Kidney Disease among Older People across Europe (SCOPE)” Journal of Clinical Medicine doi: 10.3390/jcm9020294 Authors: Corsonello Roller-Wirnsberger Wirnsberger Ärnlöv Carlsson Tap Mattace-Raso Formiga Moreno-Gonzalez Weingart Sieber Kostka Guligowska...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 293: Female Specific Association of Low Insulin-Like Growth Factor 1 (IGF1) Levels with Increased Risk of Premature Mortality in Renal Transplant Recipients Journal of Clinical Medicine doi: 10.3390/jcm9020293 Authors: Klont Kieneker Gomes-Neto Stam ten Hacken Kema van Beek van den Berg Horvatovich Bischoff Bakker Associations between insulin-like growth factor 1 (IGF1) and mortality have been reported to be female specific...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 300: Genetic Landscape of Nonobstructive Azoospermia and New Perspectives for the Clinic Journal of Clinical Medicine doi: 10.3390/jcm9020300 Authors: Cerván-Martín Castilla Palomino-Morales Carmona Nonobstructive azoospermia (NOA) represents the most severe expression of male infertility, involving around 1% of the male population and 10% of infertile men. This condition is characterised by the inability of the testis to produce sperm cells, and it is...
Tue Jan 21, 2020 02:00
JCM, Vol. 9, Pages 290: Differences in Aortopathy in Patients with a Bicuspid Aortic Valve with or without Aortic Coarctation Journal of Clinical Medicine doi: 10.3390/jcm9020290 Authors: Duijnhouwer van den Hoven Merkx Schokking van Kimmenade Kempers Dijk de Boer Roos-Hesselink Objective: The combination of aortic coarctation (CoA) and bicuspid aortic valve (BAV) is assumed to be associated with a higher risk of ascending aortic dilatation and type A...
Tue Jan 21, 2020 02:00
JoF, Vol. 6, Pages 17: Acknowledgement to Reviewers of Journal of Fungi in 2019 Journal of Fungi doi: 10.3390/jof6010017 Authors: Journal of Fungi Editorial Office The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process over the past 12 months, regardless of whether the papers are finally published or not [...]
Tue Jan 21, 2020 02:00
JPM, Vol. 10, Pages 4: Identification and Characterization of BTD Gene Mutations in Jordanian Children with Biotinidase Deficiency Journal of Personalized Medicine doi: 10.3390/jpm10010004 Authors: AL-Eitan Alqa’qa’ Amayreh Khasawneh Aljamal Al-Abed Haddad Rawashdeh Jaradat Haddad Biotinidase deficiency is an autosomal recessive metabolic disorder whose diagnosis currently depends on clinical symptoms and a biotinidase enzyme assay. This study aimed...
Tue Jan 21, 2020 02:00
Life, Vol. 10, Pages 7: Physicochemical Foundations of Life that Direct Evolution: Chance and Natural Selection are not Evolutionary Driving Forces Life doi: 10.3390/life10020007 Authors: Auboeuf The current framework of evolutionary theory postulates that evolution relies on random mutations generating a diversity of phenotypes on which natural selection acts. This framework was established using a top-down approach as it originated from Darwinism, which is based on observations made...
Tue Jan 21, 2020 02:00
Medicina, Vol. 56, Pages 49: Pregnancy and Multiple Sclerosis: An Update on the Disease Modifying Treatment Strategy and a Review of Pregnancy’s Impact on Disease Activity Medicina doi: 10.3390/medicina56020049 Authors: Varytė Zakarevičienė Ramašauskaitė Laužikienė Arlauskienė Pregnancy rates are rapidly increasing among women of reproductive age diagnosed with multiple sclerosis (MS). Through pre-conception, pregnancy and post-partum periods, there is a need for disease...
Tue Jan 21, 2020 02:00
Medicina, Vol. 56, Pages 50: Influence of Different Repair Acrylic Resin and Thermocycling on the Flexural Strength of Denture Base Resin Medicina doi: 10.3390/medicina56020050 Authors: AlQahtani Haralur Background and Objectives: Fractured acrylic denture base is a common occurrence in clinical practice. The effective denture repair procedure is cost-effective, time conserving, and results in lesser time without denture for the patient. Along with various reinforcements and surface...
Tue Jan 21, 2020 02:00
Medicina, Vol. 56, Pages 48: Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer Medicina doi: 10.3390/medicina56020048 Authors: Lee Bae Jung Background and Objectives: RAD51 plays an essential role in DNA repair via homologous recombination. RAD51 facilitates strand transfer between interrupted sequences and their undamaged homologies. Therefore, we studied the RAD51 mRNA expression levels in colorectal cancer (CRC), and evaluated the clinicopathological...
Tue Jan 21, 2020 02:00
Medicina, Vol. 56, Pages 47: Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research Medicina doi: 10.3390/medicina56020047 Authors: Janion Szczepańska Nowakowska-Zajdel Strzelczyk Copija Background and objectives: Ample evidence indicates that oxidative stress, including complex lipid peroxidation processes, may play a significant role in the pathogenesis of colorectal cancer. The goal of this study...
Tue Jan 21, 2020 02:00
Medicines, Vol. 7, Pages 7: The Use of Medicinal Plants in Maceió, Northeastern Brazil: An Ethnobotanical Survey Medicines doi: 10.3390/medicines7020007 Authors: Cerqueira Correia Santos Lemos Silva Barreto Background: The purpose of this study was to record and analyze the knowledge of medicinal plant use in the community in urban areas of Maceió city, Brazil. Methods: A total of 113 patients from the basic healthcare unit were assessed. Results: Approximately...
Tue Jan 21, 2020 02:00
Metabolites, Vol. 10, Pages 42: Dexamethasone-Induced Perturbations in Tissue Metabolomics Revealed by Chemical Isotope Labeling LC-MS analysis Metabolites doi: 10.3390/metabo10020042 Authors: Dahabiyeh Malkawi Wang Colak Mujamammi Sabi Li Dasouki Abdel Rahman Dexamethasone (Dex) is a synthetic glucocorticoid (GC) drug commonly used clinically for the treatment of several inflammatory and immune-mediated diseases. Despite its broad range of indications,...
Tue Jan 21, 2020 02:00
Microorganisms, Vol. 8, Pages 147: First mecC and mecA Positive Livestock-Associated Methicillin Resistant Staphylococcus aureus (mecC MRSA/LA-MRSA) from Dairy Cattle in Malaysia Microorganisms doi: 10.3390/microorganisms8020147 Authors: Aklilu Hui Ying Livestock associated Methicillin resistant Staphylococcus aureus (S. aureus) (LA-MRSA) was reported to be zoonotic and may transmit to farmers and veterinarians. The objectives of this study were to investigate the occurrence of...
Tue Jan 21, 2020 02:00
Microorganisms, Vol. 8, Pages 149: Cysteine-Capped Hydrogels Incorporating Copper as Effective Antimicrobial Materials against Methicillin-Resistant Staphylococcus aureus Microorganisms doi: 10.3390/microorganisms8020149 Authors: Yang Huang Chuang Herr Hsieh Huang Huang Methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA) has become an alarming threat to public health, and infected soft tissue. Antibiotics are commonly used to treat skin infection with...
Tue Jan 21, 2020 02:00
Microorganisms, Vol. 8, Pages 148: The Control of Intestinal Inflammation: A Major Objective in the Research of Probiotic Strains as Alternatives to Antibiotic Growth Promoters in Poultry Microorganisms doi: 10.3390/microorganisms8020148 Authors: Tarradas Tous Esteve-Garcia Brufau The reduction of antimicrobial resistance is a major challenge for the scientific community. In a few decades, infections by resistant bacteria are forecasted to be the main cause of death in the...
Tue Jan 21, 2020 02:00
Microorganisms, Vol. 8, Pages 146: ZnO Modulates Swine Gut Microbiota and Improves Growth Performance of Nursery Pigs When Combined with Peptide Cocktail Microorganisms doi: 10.3390/microorganisms8020146 Authors: Wei Tsai Knapp Bottoms Deng Story Maxwell Zhao Zinc has been very efficacious in reducing post-weaning diarrhea, whereas animal-derived peptides are suggested to improve the growth performance of weaned piglets. However, the combined effect of zinc...
Tue Jan 21, 2020 02:00
Microorganisms, Vol. 8, Pages 145: Detection of Specific Antibodies against Toscana Virus among Blood Donors in Northeastern Italy and Correlation with Sand Fly Abundance in 2014 Microorganisms doi: 10.3390/microorganisms8020145 Authors: Morini Calzolari Rossini Pascarelli Porcellini Randi Re Albieri Bonilauri Bellini Ayhan Charrel Varani Toscana virus (TOSV) is a Phlebovirus transmitted by phlebotomine sand flies and is an important etiological...
Tue Jan 21, 2020 02:00
Microorganisms, Vol. 8, Pages 144: Recurrent Vulvovaginal Candidiasis: An Immunological Perspective Microorganisms doi: 10.3390/microorganisms8020144 Authors: Rosati Bruno Jaeger ten Oever Netea Vulvovaginal candidiasis (VVC) is a widespread vaginal infection primarily caused by Candida albicans. VVC affects up to 75% of women of childbearing age once in their life, and up to 9% of women in different populations experience more than three episodes per year, which is...
Tue Jan 21, 2020 02:00
Molecules, Vol. 25, Pages 454: Optimization of Ultrasound-Assisted Extraction Condition for Phenolic Compounds, Antioxidant Activity, and Epigallocatechin Gallate in Lipid-Extracted Microalgae Molecules doi: 10.3390/molecules25030454 Authors: Gam Yi Kim Kim Lipid-extracted microalgae (LEM, Tetraselmis KCTC 12236BP), a solid waste by-product obtained from algal biodiesel production, is typically considered a rich source of antioxidant compounds, including phenolic compounds....
Tue Jan 21, 2020 02:00
Molecules, Vol. 25, Pages 453: Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson’s Disease Molecules doi: 10.3390/molecules25030453 Authors: Kelly Joers Tansey McKernan Dowd Parkinson’s disease is a neurodegenerative disorder, the motor symptoms of which are associated classically with Lewy body formation and nigrostriatal degeneration. Neuroinflammation has been implicated in the progression of this...
Tue Jan 21, 2020 02:00
Molecules, Vol. 25, Pages 450: Synthesis of a New Series of Nitrogen/Sulfur Heterocycles by Linking Four Rings: Indole; 1,2,4-Triazole; Pyridazine; and Quinoxaline Molecules doi: 10.3390/molecules25030450 Authors: Boraei Sarhan Yousuf Barakat A new series of nitrogen and sulfur heterocyclic systems were efficiently synthesized by linking the following four rings: indole; 1,2,4-triazole; pyridazine; and quinoxaline hybrids. The strength of the acid that catalyzes the condensation...
Tue Jan 21, 2020 02:00
Molecules, Vol. 25, Pages 452: Proteomic Analysis of Saccharomyces cerevisiae Response to Oxidative Stress Mediated by Cocoa Polyphenols Extract Molecules doi: 10.3390/molecules25030452 Authors: Peláez-Soto Roig Martínez-Culebras Fernández-Espinar Gil The present study addressed the protective effects against oxidative stress (OS) of a cocoa powder extract (CPEX) on the protein expression profile of S. cerevisiae. A proteomic analysis was performed after culture preincubation...
Tue Jan 21, 2020 02:00
Molecules, Vol. 25, Pages 451: Novel Peptide CM 7 Targeted c-Met with Antitumor Activity Molecules doi: 10.3390/molecules25030451 Authors: Xia Wang Liu Wang Gao Li Qi An Xu Anomalous changes of the cell mesenchymal–epithelial transition factor (c-Met) receptor tyrosine kinase signaling pathway play an important role in the occurrence and development of human cancers, including gastric cancer. In this study, we designed and synthesized a novel...
Tue Jan 21, 2020 02:00
Molecules, Vol. 25, Pages 455: Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies Molecules doi: 10.3390/molecules25030455 Authors: Chowdhury Sripathy Webster Park Lao Hsu Loe Bedalov Simon Genetic ablation as well as pharmacological inhibition of sirtuin 2 (SIRT2), an NAD+-dependent protein deacylase, have therapeutic effects in various cancers and neurodegenerative diseases. Previously, we described...
Tue Jan 21, 2020 02:00
Molecules, Vol. 25, Pages 446: Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata Molecules doi: 10.3390/molecules25030446 Authors: Yusheng Zhao Yue Zhang Hui Kong Meiling Zhang Jinjun Cheng Juan Luo Yan Zhao Huihua Qu High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study...
Tue Jan 21, 2020 02:00
Molecules, Vol. 25, Pages 456: Cinnamic Derivatives as Antitubercular Agents: Characterization by Quantitative Structure–Activity Relationship Studies Molecules doi: 10.3390/molecules25030456 Authors: Teixeira Ventura Gomes Gomes Martins Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains one of the top ten causes of death worldwide and the main cause of mortality from a single infectious agent. The upsurge of multi- and extensively-drug resistant tuberculosis...
Tue Jan 21, 2020 02:00
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