Prognostic value of 18F-FDG PET/CT parameters and histopathologic variables in head and neck cancer.

Prognostic value of 18F-FDG PET/CT parameters and histopathologic variables in head and neck cancer.:

Related Articles

Prognostic value of 18F-FDG PET/CT parameters and histopathologic variables in head and neck cancer.

Braz J Otorhinolaryngol. 2019 Dec 10;:

Authors: Aslan H, Cekin G, Pinar E, Yazir M, Imre A, Songu M, Islek A, Aladag I, Oncel IS

Abstract

INTRODUCTION: 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters such as; maximum standardized uptake values, standard metabolic tumor volume and otal lesion glycosis are important prognostic biomarkers in cancers.

OBJECTIVE: To investigate the prognostic value of these parameters in patients with head and neck cancers.

METHODS: We performed a retrospective study including 47 patients with head and neck cancer who underwent18F-fluorodeoxyglucose positron emission tomography/computed tomography prior to treatment. Standard metabolic tumor volume, otal lesion glycosis and standardized uptake were measured for each patient. The prognostic value of quantitative 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters and clinicopathologic variables on disease free survival and overall survival were analyzed.

RESULTS: The median (range) standard metabolic tumor volume and otal lesion glycosis and standardized uptake were 7.63 cm3 (0.6-34.3), 68.9 g (2.58-524.5 g), 13.89 (4.89-33.03 g/mL), respectively. Lymph node metastases and tumour differentiation were significant variables for disease free survival and overall survival, however, all 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters were not associated with disease- free survival and overall survival.

CONCLUSION: Pretreatment quantities positron emission tomography parameters did not predict survival in head and neck cancer.

PMID: 31899125 [PubMed - as supplied by publisher]