Antibiotics, Vol. 9, Pages 594: The Current Status of the Alternative Use to Antibiotics in Poultry Production: An African Perspective Antibiotics doi: 10.3390/antibiotics9090594 Authors: Letlhogonolo Andrew Selaledi Zahra Mohammed Hassan Tlou Grace Manyelo Monnye Mabelebele Over the years the growth and health of food-producing animals have been enhanced by the use of antibiotics. These have helped reduce on-farm mortalities, lower incidences of diseases and more importantly...
03:00
Antibiotics, Vol. 9, Pages 593: Synergistic Effects of Bacteriocin from Lactobacillus panis C-M2 Combined with Dielectric Barrier Discharged Non-Thermal Plasma (DBD-NTP) on Morganella sp. in Aquatic Foods Antibiotics doi: 10.3390/antibiotics9090593 Authors: Chengjun Shan Han Wu Jianzhong Zhou Wenjing Yan Jianhao Zhang Xiaoli Liu In this paper, Lactocin C-M2(C-M2) was used together with a new non-thermal technology, non-thermal plasma sterilization (NTPS), to inactive the...
Thu Sep 10, 2020 03:00
Antibiotics, Vol. 9, Pages 592: Phytochemical Composition and In Vitro Antimicrobial Activity of Essential Oils from the Lamiaceae Family against Streptococcus agalactiae and Candida albicans Biofilms Antibiotics doi: 10.3390/antibiotics9090592 Authors: Ramona Iseppi Roberta Tardugno Virginia Brighenti Stefania Benvenuti Carla Sabia Federica Pellati Patrizia Messi The antimicrobial activity of different essential oils (EOs) from the Lamiaceae family was evaluated on...
Thu Sep 10, 2020 03:00
Antibiotics, Vol. 9, Pages 591: NSAIDs as a Drug Repurposing Strategy for Biofilm Control Antibiotics doi: 10.3390/antibiotics9090591 Authors: Cláudia Leão Anabela Borges Manuel Simões Persistent infections, usually associated with biofilm-producing bacteria, are challenging for both medical and scientific communities. The potential interest in drug repurposing for biofilm control is growing due to both disinvestment in antibiotic R&D and reduced efficacy of the available...
Thu Sep 10, 2020 03:00
Antibiotics, Vol. 9, Pages 590: Methicillin-Resistant Macrococcus bohemicus Encoding a Divergent SCCmecB Element Antibiotics doi: 10.3390/antibiotics9090590 Authors: Geoffrey Foster Gavin K. Paterson A methicillin-resistant Macrococcus isolate from canine otitis, H889678/16/1, was whole-genome sequenced using HiSeq technology to identify the species, antimicrobial resistance determinates and their genomic context. H889678/16/1 belonged to the newly described species Macrococcus bohemicus....
Thu Sep 10, 2020 03:00
Antibiotics, Vol. 9, Pages 589: Is Only Clarithromycin Susceptibility Important for the Successful Eradication of Helicobacter pylori? Antibiotics doi: 10.3390/antibiotics9090589 Authors: Young Min Kim Kyoung Hwa Lee Jie-Hyun Kim Soon Young Park Young Goo Song Se Yeon Jeon Hyojin Park Resistance to clarithromycin and other antibiotics included in the eradication regimen, such as amoxicillin and metronidazole, is important for Helicobacter pylori (H. pylori) eradication....
Wed Sep 09, 2020 03:00
Antioxidants, Vol. 9, Pages 852: Oxidative Stress: Concept and Some Practical Aspects Antioxidants doi: 10.3390/antiox9090852 Authors: Helmut Sies Oxidative stress is defined as “an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage”. This Commentary presents basic features of this global concept which has attracted interest in biology and medicine. The term “antioxidants”...
Thu Sep 10, 2020 03:00
Antioxidants, Vol. 9, Pages 851: Synthetic vs. Natural Hydroxytyrosol for Clean Label Lamb Burgers Antioxidants doi: 10.3390/antiox9090851 Authors: Martínez-Zamora Ros Nieto Clean labelling refers to consumers’ desire for manufacturers to be more transparent in the way their products are made and sourced. Natural antioxidants (spices, herbs, fruits, or vegetables) have been proven to offer the same functionality as their synthetic counterparts, with the advantage of...
Thu Sep 10, 2020 03:00
Antioxidants, Vol. 9, Pages 848: Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes Antioxidants doi: 10.3390/antiox9090848 Authors: Teresa Vezza Zaida Abad-Jiménez Miguel Marti-Cabrera Milagros Rocha Víctor Manuel Víctor The rising prevalence of obesity and type 2 diabetes (T2D) is a growing concern worldwide. New discoveries in the field of metagenomics and clinical research have revealed that the gut microbiota plays a key...
Thu Sep 10, 2020 03:00
Antioxidants, Vol. 9, Pages 850: Low Molecular Weight Dextran Sulfate (ILB®) Administration Restores Brain Energy Metabolism Following Severe Traumatic Brain Injury in the Rat Antioxidants doi: 10.3390/antiox9090850 Authors: Giacomo Lazzarino Angela Maria Amorini Nicholas M. Barnes Lars Bruce Alvaro Mordente Giuseppe Lazzarino Valentina Di Pietro Barbara Tavazzi Antonio Belli Ann Logan Traumatic brain injury (TBI) is the leading cause of death and disability...
Thu Sep 10, 2020 03:00
Antioxidants, Vol. 9, Pages 849: Insights into the Oxidative Stress Response of Salmonella enterica serovar Enteritidis Revealed by the Next Generation Sequencing Approach Antioxidants doi: 10.3390/antiox9090849 Authors: Xiaoying Liu Misara Omar Juan E. Abrahante Kakambi V. Nagaraja Sinisa Vidovic As a facultative intracellular pathogen, Salmonella Enteritidis must develop an effective oxidative stress response to survive exposure to reactive oxygen species within the host....
Thu Sep 10, 2020 03:00
Antioxidants, Vol. 9, Pages 847: The Antioxidant Activities of Betula etnensis Rafin. Ethanolic Extract Exert Protective and Anti-diabetic Effects on Streptozotocin-Induced Diabetes in Rats Antioxidants doi: 10.3390/antiox9090847 Authors: Giuseppe Antonio Malfa Barbara Tomasello Rosaria Acquaviva Alfonsina La Mantia Francesco Pappalardo Monica Ragusa Marcella Renis Claudia Di Giacomo Pathophysiological mechanisms correlating diabetes mellitus with associated complications...
Thu Sep 10, 2020 03:00
Antioxidants, Vol. 9, Pages 845: Mature Twin Neonates Exhibit Oxidative Stress via Nitric Oxide Synthase Dysfunctionality: A Prognostic Stress Marker in the Red Blood Cells and Umbilical Cord Vessels Antioxidants doi: 10.3390/antiox9090845 Authors: Payal Chakraborty Krisztina N. Dugmonits Hajnalka Orvos Edit Hermesz Intrauterine hypoxic condition increases the generation of reactive oxygen species and fetal oxidative stress. Multiple pregnancy always bears an additional oxidative...
Thu Sep 10, 2020 03:00
Antioxidants, Vol. 9, Pages 846: Beneficial Effects of Glucagon-Like Peptide-1 (GLP-1) in Diabetes-Induced Retinal Abnormalities: Involvement of Oxidative Stress Antioxidants doi: 10.3390/antiox9090846 Authors: Hugo Ramos Patricia Bogdanov Joel Sampedro Jordi Huerta Rafael Simó Cristina Hernández Background: Hyperglycemia-induced oxidative stress plays a key role in diabetic complications, including diabetic retinopathy. The main goal of this study was to assess whether...
Thu Sep 10, 2020 03:00
Antioxidants, Vol. 9, Pages 844: An Anthocyanin-Enriched Extract from Vaccinium uliginosum Improves Signs of Skin Aging in UVB-Induced Photodamage Antioxidants doi: 10.3390/antiox9090844 Authors: Kyungae Jo Gi Yeon Bae Kyoungwon Cho Sung Sun Park Hyung Joo Suh Ki-Bae Hong Accumulating evidence indicates that botanical extracts affect skin biophysical parameters, such as hydration, transepidermal water loss (TEWL), melanin index, erythema index, and wrinkle development....
Wed Sep 09, 2020 03:00
Antioxidants, Vol. 9, Pages 843: Yuzu and Hesperidin Ameliorate Blood-Brain Barrier Disruption during Hypoxia via Antioxidant Activity Antioxidants doi: 10.3390/antiox9090843 Authors: Bo Kyung Lee Soo-Wang Hyun Yi-Sook Jung Yuzu and its main component, hesperidin (HSP), have several health benefits owing to their anti-inflammatory and antioxidant properties. We examined the effects of yuzu and HSP on blood–brain barrier (BBB) dysfunction during ischemia/hypoxia in an...
Wed Sep 09, 2020 03:00
Antioxidants, Vol. 9, Pages 842: Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway Antioxidants doi: 10.3390/antiox9090842 Authors: Sakiko Nishikawa Yasumichi Inoue Yuka Hori Chiharu Miyajima Daisuke Morishita Nobumichi Ohoka Shigeaki Hida Toshiaki Makino Hidetoshi Hayashi Kurarinone, a flavonoid isolated from the roots of Sophora flavescens, was suggested to exert potent antioxidant and immunosuppressive effects. However,...
Wed Sep 09, 2020 03:00
Atmosphere, Vol. 11, Pages 970: Apportioning Smoke Impacts of 2018 Wildfires on Eastern Sierra Nevada Sites Atmosphere doi: 10.3390/atmos11090970 Authors: Sean Mueller Leland Tarnay Susan O’Neill Sean Raffuse The summer of 2018 saw intense smoke impacts on the eastern side of the Sierra Nevada in California, which have been anecdotally ascribed to the closest wildfire, the Lions Fire. We examined the role of the Lions Fire and four other, simultaneous large wildfires on smoke...
03:00
Atmosphere, Vol. 11, Pages 968: Vortex Initialization in the NCEP Operational Hurricane Models Atmosphere doi: 10.3390/atmos11090968 Authors: Liu Zhang Tong Zhang Liu Wang Zhu Zhang Xu Trahan Bernardet Mehra Tallapragada This paper describes the vortex initialization (VI) currently used in NCEP operational hurricane models (HWRF and HMON, and possibly HAFS in the future). The VI corrects the background fields for hurricane models: it consists...
Thu Sep 10, 2020 03:00
Atmosphere, Vol. 11, Pages 969: Impact of Urbanization on the Predictions of Urban Meteorology and Air Pollutants over Four Major North American Cities Atmosphere doi: 10.3390/atmos11090969 Authors: Shuzhan Ren Craig A. Stroud Stephane Belair Sylvie Leroyer Rodrigo Munoz-Alpizar Michael D. Moran Junhua Zhang Ayodeji Akingunola Paul A. Makar The sensitivities of meteorological and chemical predictions to urban effects over fourmajor North American cities are investigated...
Thu Sep 10, 2020 03:00
Atmosphere, Vol. 11, Pages 967: Characterization of Urban Greening in a District of Lecce (Southern Italy) for the Analysis of CO2 Storage and Air Pollutant Dispersion Atmosphere doi: 10.3390/atmos11090967 Authors: Riccardo Buccolieri Elisa Gatto Michela Manisco Fabio Ippolito Jose Luis Santiago Zhi Gao This paper is devoted to the assessment of urban greening effects on two important ecosystem services, i.e., air quality and CO2 storage, including the corresponding economic...
Thu Sep 10, 2020 03:00
Atmosphere, Vol. 11, Pages 966: Tornadoes in Romania—from Forecasting and Warning to Understanding Public’s Response and Expectations Atmosphere doi: 10.3390/atmos11090966 Authors: Andrei Andrei Huştiu Cheval Antonescu Significant progress in tornado research and management can be claimed over the last few decades worldwide. However, tornado forecasting and warning continue to be permanent challenges for most European national meteorological services because they require...
Thu Sep 10, 2020 03:00
Atmosphere, Vol. 11, Pages 965: Modeling Evaporation of Water Droplets as Applied to Survival of Airborne Viruses Atmosphere doi: 10.3390/atmos11090965 Authors: Dombrovsky Fedorets Levashov Kryukov Bormashenko Nosonovsky Many viruses, such as coronaviruses, tend to spread airborne inside water microdroplets. Evaporation of the microdroplets may result in a reduction of their contagiousness. However, the evaporation of small droplets is a complex process involving...
Thu Sep 10, 2020 03:00
Atmosphere, Vol. 11, Pages 963: Urban Spatial Patterns and Heat Exposure in the Mediterranean City of Tel Aviv Atmosphere doi: 10.3390/atmos11090963 Authors: Moshe Mandelmilch Michal Ferenz Noa Mandelmilch Oded Potchter This study aims to examine the effect of urban spatial patterns on heat exposure in the city of Tel Aviv using multiple methodologies, Local Climate Zones (LCZ), meteorological measurements, and remote sensing. A Local Climate Zone map of Tel Aviv was created...
Thu Sep 10, 2020 03:00
Atmosphere, Vol. 11, Pages 964: Rainfall Trends and Extremes in Saudi Arabia in Recent Decades Atmosphere doi: 10.3390/atmos11090964 Authors: Almazroui The observed records of recent decades show increased economic damage associated with flash flooding in different regions of Saudi Arabia. An increase in extreme rainfall events may cause severe repercussions for the socio-economic sectors of the country. The present study investigated the observed rainfall trends and associated extremes...
Thu Sep 10, 2020 03:00
Atmosphere, Vol. 11, Pages 962: Analysis of Separation Distances under Varying Odour Emission Rates and Meteorology: A WWTP Case Study Atmosphere doi: 10.3390/atmos11090962 Authors: Marco Ravina Salvatore Bruzzese Deborah Panepinto Mariachiara Zanetti A wide variability of odour impact criteria is found around the world. The objective of this research work was to evaluate the influence of the uncertainties related to some individual stages of odour impact assessment in the application...
Thu Sep 10, 2020 03:00
Atmosphere, Vol. 11, Pages 961: Influence of Ammonium Sulfate Seed Particle on Optics and Compositions of Toluene Derived Organic Aerosol in Photochemistry Atmosphere doi: 10.3390/atmos11090961 Authors: Tingting Lu Mingqiang Huang Weixiong Zhao Changjin Hu Xuejun Gu Weijun Zhang Aromatic secondary organic aerosol (SOA) particles are known to contribute to radiative forcing and light absorption of atmosphere. However, the complex refractive index (CRI), single-scattering...
Thu Sep 10, 2020 03:00
Atmosphere, Vol. 11, Pages 960: The Spatio—Temporal Variation of Pacific Blocking Frequency within Winter Months and Its Relationship with Surface Air Temperature Atmosphere doi: 10.3390/atmos11090960 Authors: Mingxiang Gao Shuangyan Yang Tim Li The spatio–temporal evolution of the Pacific blocking frequency (PBF) that is based on a two–dimensional blocking index is investigated during the recent 40–winter (1979/80–2018/19) months (December–January–February)....
Wed Sep 09, 2020 03:00
Behavioral Sciences, Vol. 10, Pages 137: A Review on the Role of the Neuroscience of Flow States in the Modern World Behavioral Sciences doi: 10.3390/bs10090137 Authors: Joshua Gold Joseph Ciorciari Flow states have been shown to help people reach peak performance, yet this elusive state is not easily attained. The review describes the current state of literature on flow by addressing the environmental influences as well as the cognitive and neurocognitive elements that underlie the...
Wed Sep 09, 2020 03:00
Beverages, Vol. 6, Pages 56: Bottle Conditioning: Technology and Mechanisms Applied in Refermented Beers Beverages doi: 10.3390/beverages6030056 Authors: Kateřina Štulíková Jan Novák Jakub Vlček Jan Šavel Petr Košin Pavel Dostálek Bottle conditioning refers to a method of adding fermenting wort or yeast suspension in sugar solution into beer in its final package. Additionally denoted as bottle refermentation, this technique has been originally developed to assure beer...
Wed Sep 09, 2020 03:00
Bioengineering, Vol. 7, Pages 108: Formulation and Characterization of Alginate Dialdehyde, Gelatin, and Platelet-Rich Plasma-Based Bioink for Bioprinting Applications Bioengineering doi: 10.3390/bioengineering7030108 Authors: Lakshmi T. Somasekharan Naresh Kasoju Riya Raju Anugya Bhatt Layer-by-layer additive manufacturing process has evolved into three-dimensional (3D) “bio-printing” as a means of constructing cell-laden functional tissue equivalents. The...
Wed Sep 09, 2020 03:00
Bioengineering, Vol. 7, Pages 107: Sonodelivery in Skeletal Muscle: Current Approaches and Future Potential Bioengineering doi: 10.3390/bioengineering7030107 Authors: Richard E. Decker Zachary E. Lamantia Todd S. Emrick Marxa L. Figueiredo There are currently multiple approaches to facilitate gene therapy via intramuscular gene delivery, such as electroporation, viral delivery, or direct DNA injection with or without polymeric carriers. Each of these methods has benefits, but...
Wed Sep 09, 2020 03:00
Biology, Vol. 9, Pages 282: Oxidative Stress and Reproductive Function in the Aging Male Biology doi: 10.3390/biology9090282 Authors: Paulina Nguyen-Powanda Bernard Robaire With the delay of parenthood becoming more common, the age at which men father children is on the rise. While the effects of advanced maternal age have been well documented, only recently have studies started to focus on the impact of advanced paternal age (APA) in the context of male reproduction. As men age,...
03:00
Biology, Vol. 9, Pages 281: TIP_finder: An HPC Software to Detect Transposable Element Insertion Polymorphisms in Large Genomic Datasets Biology doi: 10.3390/biology9090281 Authors: Simon Orozco-Arias Nicolas Tobon-Orozco Johan S. Piña Cristian Felipe Jiménez-Varón Reinel Tabares-Soto Romain Guyot Transposable elements (TEs) are non-static genomic units capable of moving indistinctly from one chromosomal location to another. Their insertion polymorphisms may cause beneficial...
Wed Sep 09, 2020 03:00
Biology, Vol. 9, Pages 280: Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients Biology doi: 10.3390/biology9090280 Authors: Amany Magdy Beshbishy Helal F. Hetta Diaa E. Hussein Abdullah A. Saati Christian C. Uba Nallely Rivero-Perez Adrian Zaragoza-Bastida Muhammad Ajmal Shah Tapan Behl Gaber El-Saber Batiha Overweight and obesity are defined as an unnecessary accumulation of fat, which poses a risk to health....
Wed Sep 09, 2020 03:00
Biomedicines, Vol. 8, Pages 342: Algae Polyphenolic Compounds and Modern Antibacterial Strategies: Current Achievements and Immediate Prospects Biomedicines doi: 10.3390/biomedicines8090342 Authors: Natalya N. Besednova Boris G. Andryukov Tatyana S. Zaporozhets Sergey P. Kryzhanovsky Tatyana A. Kuznetsova Ludmila N. Fedyanina Ilona D. Makarenkova Tatyana N. Zvyagintseva The increasing drug resistance of pathogenic microorganisms raises concern worldwide and necessitates...
03:00
Biomedicines, Vol. 8, Pages 341: Potential for Novel Biomarkers in Diabetes-Associated Chronic Kidney Disease: Epigenome, Metabolome, and Gut Microbiome Biomedicines doi: 10.3390/biomedicines8090341 Authors: Lecamwasam Elif I. Ekinci Saffery Karen M. Dwyer Diabetes-associated chronic kidney disease is a pandemic issue. Despite the globalincrease in the number of individuals with this chronic condition together with increasingmorbidity and mortality, there are currently...
Thu Sep 10, 2020 03:00
Biomedicines, Vol. 8, Pages 340: Using Ex Vivo Porcine Jejunum to Identify Membrane Transporter Substrates: A Screening Tool for Early—Stage Drug Development Biomedicines doi: 10.3390/biomedicines8090340 Authors: Yvonne E. Arnold Yogeshvar N. Kalia Robust, predictive ex vivo/in vitro models to study intestinal drug absorption by passive and active transport mechanisms are scarce. Membrane transporters can significantly impact drug uptake and transporter-mediated drug–drug...
Thu Sep 10, 2020 03:00
Biomedicines, Vol. 8, Pages 339: Molecular Mechanisms of KDELC2 on Glioblastoma Tumorigenesis and Temozolomide Resistance Biomedicines doi: 10.3390/biomedicines8090339 Authors: Yu-Ling Tsai Hsin-Han Chang Ying-Chuan Chen Yu-Chan Chang Ying Chen Wen-Chiuan Tsai The activation of the Notch pathway induces glioblastoma (GBM) development. Since KDEL (Lys-Asp-Glu-Leu) containing 2 (KDELC2) is involved in the Notch pathway, the detailed mechanism is still undetermined. The Cancer...
Thu Sep 10, 2020 03:00
Biomedicines, Vol. 8, Pages 338: Potent Small-Molecule Inhibitors Targeting Acetylated Microtubules as Anticancer Agents Against Triple-Negative Breast Cancer Biomedicines doi: 10.3390/biomedicines8090338 Authors: Ahreum Kwon Gwi Bin Lee Taein Park Jung Hoon Lee Panseon Ko Eunae You Jin Hee Ahn Soo Hyun Eom Sangmyung Rhee Woo Keun Song Microtubules are one of the major targets for anticancer drugs because of their role in cell proliferation and migration. However,...
Wed Sep 09, 2020 03:00
Biomedicines, Vol. 8, Pages 337: Association between Serum Zinc and Calcification Propensity (T50) in Patients with Type 2 Diabetes Mellitus and In Vitro Effect of Exogenous Zinc on T50 Biomedicines doi: 10.3390/biomedicines8090337 Authors: Shinya Nakatani Katsuhito Mori Mika Sonoda Kozo Nishide Hideki Uedono Akihiro Tsuda Masanori Emoto Tetsuo Shoji Zinc inhibits vascular calcification in vivo and in vitro. Patients with type 2 diabetes mellitus show hypozincemia...
Wed Sep 09, 2020 03:00
Biomedicines, Vol. 8, Pages 336: Anthocyanins, Vibrant Color Pigments, and Their Role in Skin Cancer Prevention Biomedicines doi: 10.3390/biomedicines8090336 Authors: Zorița Diaconeasa Ioana Știrbu Jianbo Xiao Nicolae Leopold Zayde Ayvaz Corina Danciu Huseyin Ayvaz Andreea Stǎnilǎ Mǎdǎlina Nistor Carmen Socaciu Until today, numerous studies evaluated the topic of anthocyanins and various types of cancer, regarding the anthocyanins’ preventative and...
Wed Sep 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1308: Transient Unfolding and Long-Range Interactions in Viral BCL2 M11 Enable Binding to the BECN1 BH3 Domain Biomolecules doi: 10.3390/biom10091308 Authors: Arvind Ramanathan Akash Parvatikar Srinivas C. Chennubhotla Yang Mei Sangita C. Sinha Viral BCL2 proteins (vBCL2s) help to sustain chronic infection of host proteins to inhibit apoptosis and autophagy. However, details of conformational changes in vBCL2s that enable binding to BH3Ds remain...
03:00
Biomolecules, Vol. 10, Pages 1306: Mesenchymal Stem Cells as a Promising Cell Source for Integration in Novel In Vitro Models Biomolecules doi: 10.3390/biom10091306 Authors: Ann-Kristin Afflerbach Mark D. Kiri Tahir Detinis Ben M. Maoz The human-relevance of an in vitro model is dependent on two main factors—(i) an appropriate human cell source and (ii) a modeling platform that recapitulates human in vivo conditions. Recent years have brought substantial advancements...
Thu Sep 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1307: Effects of New NSAID-CAI Hybrid Compounds in Inflammation and Lung Fibrosis Biomolecules doi: 10.3390/biom10091307 Authors: Laura Lucarini Mariaconcetta Durante Silvia Sgambellone Cecilia Lanzi Elisabetta Bigagli Ozlem Akgul Emanuela Masini Claudiu T. Supuran Fabrizio Carta Pulmonary fibrosis is a severe lung disease with progressive worsening of dyspnea, characterized by chronic inflammation and remodeling of lung parenchyma....
Thu Sep 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1305: From Seeds to Fibrils and Back: Fragmentation as an Overlooked Step in the Propagation of Prions and Prion-Like Proteins Biomolecules doi: 10.3390/biom10091305 Authors: Cristóbal Marrero-Winkens Charu Sankaran Hermann M. Schätzl Many devastating neurodegenerative diseases are driven by the misfolding of normal proteins into a pathogenic abnormal conformation. Examples of such protein misfolding diseases include Alzheimer’s disease, Parkinson’s...
Thu Sep 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1304: The Usefulness of Diagnostic Panels Based on Circulating Adipocytokines/Regulatory Peptides, Renal Function Tests, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Diagnosis and Prognosis of Type 2 Diabetes Mellitus with Obesity Biomolecules doi: 10.3390/biom10091304 Authors: Katarzyna Komosinska-Vassev Olga Gala Krystyna Olczyk Agnieszka Jura-Półtorak Paweł Olczyk The quantitative analysis of selected regulatory...
Wed Sep 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1303: Vitamin K in Vertebrates’ Reproduction: Further Puzzling Pieces of Evidence from Teleost Fish Species Biomolecules doi: 10.3390/biom10091303 Authors: Silvia Beato Francisco Javier Toledo-Solís Ignacio Fernández Vitamin K (VK) is a fat-soluble vitamin that vertebrates have to acquire from the diet, since they are not able to de novo synthesize it. VK has been historically known to be required for the control of blood coagulation, and more recently,...
Wed Sep 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1302: Quantitative Lipidomic Analysis of Osteosarcoma Cell-Derived Products by UHPLC-MS/MS Biomolecules doi: 10.3390/biom10091302 Authors: Sara Casati Chiara Giannasi Mauro Minoli Stefania Niada Alessandro Ravelli Ilaria Angeli Veronica Mergenthaler Roberta Ottria Pierangela Ciuffreda Marica Orioli Anna T. Brini Changes in lipid metabolism are involved in several pathological conditions, such as cancer. Among lipids, eicosanoids...
Wed Sep 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1301: An In Vitro Comparison of the Neurotrophic and Angiogenic Activity of Human and Canine Adipose-Derived Mesenchymal Stem Cells (MSCs): Translating MSC-Based Therapies for Spinal Cord Injury Biomolecules doi: 10.3390/biom10091301 Authors: Ibtesam R. T. Al Delfi Chelsea R. Wood Louis D. V. Johnson Martyn D. Snow John F. Innes Peter Myint William E. B. Johnson The majority of research into the effects of mesenchymal stem cell (MSC) transplants...
Wed Sep 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1299: Control of Transcription Initiation by Biased Thermal Fluctuations on Repetitive Genomic Sequences Biomolecules doi: 10.3390/biom10091299 Authors: Masahiko Imashimizu Yuji Tokunaga Ariel Afek Hiroki Takahashi Nobuo Shimamoto David B. Lukatsky In the process of transcription initiation by RNA polymerase, promoter DNA sequences affect multiple reaction pathways determining the productivity of transcription. However, the question of how...
Wed Sep 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1300: Association Between Dietary Flavonoids Intake and Cognitive Function in an Italian Cohort Biomolecules doi: 10.3390/biom10091300 Authors: Justyna Godos Filippo Caraci Sabrina Castellano Walter Currenti Fabio Galvano Raffaele Ferri Giuseppe Grosso Background: Diet is one of the leading factors contributing to the prevalence of non-communicable diseases, including neurodegenerative disorders. Dietary polyphenols, antioxidant components...
Wed Sep 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1298: Pharmacological Effects of Agastache rugosa against Gastritis Using a Network Pharmacology Approach Biomolecules doi: 10.3390/biom10091298 Authors: Hyeon-Hwa Nam Joong Sun Kim Jun Lee Young Hye Seo Hyo Seon Kim Seung Mok Ryu Goya Choi Byeong Cheol Moon A Yeong Lee Agastache rugosa is used as a Korean traditional medicine to treat gastric diseases. However, the active ingredients and pharmacological targets of A. rugosa are unknown....
Wed Sep 09, 2020 03:00
Biosensors, Vol. 10, Pages 121: Biomolecules and Electrochemical Tools in Chronic Non-Communicable Disease Surveillance: A Systematic Review Biosensors doi: 10.3390/bios10090121 Authors: Ana Lúcia Morais Patrícia Rijo María Belén Batanero Bataner Hernán Marisa Nicolai Over recent three decades, the electrochemical techniques have become widely used in biological identification and detection, because it presents optimum features for efficient and sensitive molecular detection...
Thu Sep 10, 2020 03:00
Biosensors, Vol. 10, Pages 120: LipiSensors: Exploiting Lipid Nanoemulsions to Fabricate Ionophore-Based Nanosensors Biosensors doi: 10.3390/bios10090120 Authors: Alexandra L. Dailey Meredith D. Greer Tyler Z. Sodia Megan P. Jewell Tabitha A. Kalin Kevin J. Cash Ionophore-based nanosensors (IBNS) are tools that enable quantification of analytes in complex chemical and biological systems. IBNS methodology is adopted from that of bulk optodes where an ion exchange event...
Thu Sep 10, 2020 03:00
Biosensors, Vol. 10, Pages 119: Exploiting Laser-Ablation ICP-MS for the Characterization of Salt-Derived Bismuth Films on Screen-Printed Electrodes: A Preliminary Investigation Biosensors doi: 10.3390/bios10090119 Authors: Carlo Dossi Gilberto Binda Damiano Monticelli Andrea Pozzi Sandro Recchia Davide Spanu The use of insoluble bismuth salts, typically BiPO4, is known to be a viable alternative to classical Bi3+ ion electrochemical reduction for the preparation of bismuth...
Wed Sep 09, 2020 03:00
Biosensors, Vol. 10, Pages 118: Electrochemiluminescence Biosensors Using Screen-Printed Electrodes Biosensors doi: 10.3390/bios10090118 Authors: Emiliano Martínez-Periñán Cristina Gutiérrez-Sánchez Tania García-Mendiola Encarnación Lorenzo Electrogenerated chemiluminescence (also called electrochemiluminescence (ECL)) has become a great focus of attention in different fields of analysis, mainly as a consequence of the potential remarkably high sensitivity and wide dynamic range....
Wed Sep 09, 2020 03:00
Brain Sciences, Vol. 10, Pages 628: The Possible Neuroprotective Effect of Silymarin against Aluminum Chloride-Prompted Alzheimer’s-Like Disease in Rats Brain Sciences doi: 10.3390/brainsci10090628 Authors: Hanaa R. Aboelwafa Attalla F. El-kott Eman M. Abd-Ella Hany N. Yousef Alzheimer’s disease (AD) is a worldwide rapidly growing neurodegenerative disease. Here, we elucidated the neuroprotective effects of silymarin (SM) on the hippocampal tissues of aluminum chloride...
03:00
Brain Sciences, Vol. 10, Pages 627: Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study Brain Sciences doi: 10.3390/brainsci10090627 Authors: Kyoung Bo Lee Seong Hoon Lim Geun-Young Park Sun Im Patients with stroke are known to manifest a decreased cough force, which is associated with an increased risk of aspiration. Specific brain lesions have been linked to impaired reflexive coughing. However, few studies have investigated...
Thu Sep 10, 2020 03:00
Brain Sciences, Vol. 10, Pages 626: Whole-Brain Models to Explore Altered States of Consciousness from the Bottom Up Brain Sciences doi: 10.3390/brainsci10090626 Authors: Rodrigo Cofré Rubén Herzog Pedro A.M. Mediano Juan Piccinini Fernando E. Rosas Yonatan Sanz Perl Enzo Tagliazucchi The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity...
Thu Sep 10, 2020 03:00
Brain Sciences, Vol. 10, Pages 625: Corpus Callosum Agenesis: An Insight into the Etiology and Spectrum of Symptoms Brain Sciences doi: 10.3390/brainsci10090625 Authors: Jagoda Hofman Michał Hutny Karolina Sztuba Justyna Paprocka Brain hemispheres are connected by commissural structures, which consist of white matter fiber tracts that spread excitatory stimuli to various regions of the cortex. This allows an interaction between the two cerebral halves. The largest commissure...
Wed Sep 09, 2020 03:00
Brain Sciences, Vol. 10, Pages 624: The Anatomical and Functional Heterogeneity of the Mediodorsal Thalamus Brain Sciences doi: 10.3390/brainsci10090624 Authors: Ioana Antoaneta Georgescu Daniela Popa Leon Zagrean The mediodorsal nucleus (MD) represents just one piece of a complex relay structure situated within the brain, called the thalamus. MD is characterized by its robust interconnections with other brain areas, especially with limbic-related structures. Given the close anatomo-functional...
Wed Sep 09, 2020 03:00
Brain Sciences, Vol. 10, Pages 623: Serum BDNF’s Role as a Biomarker for Motor Training in the Context of AR-Based Rehabilitation after Ischemic Stroke Brain Sciences doi: 10.3390/brainsci10090623 Authors: Ekaterina S. Koroleva Ivan V. Tolmachev Valentina M. Alifirova Anastasiia S. Boiko Lyudmila A. Levchuk Anton J. M. Loonen Svetlana A. Ivanova Background: brain-derived neurotrophic factor (BDNF) may play a role during neurorehabilitation following ischemic stroke....
Wed Sep 09, 2020 03:00
Cancers, Vol. 12, Pages 2591: Improved Progression-Free Long-Term Survival of a Nation-Wide Patient Population with Metastatic Melanoma Cancers doi: 10.3390/cancers12092591 Authors: Anne Vest Soerensen Eva Ellebaek Lars Bastholt Henrik Schmidt Marco Donia Inge Marie Svane Approval of immune checkpoint-inhibitors (ICIs) and BRAF-inhibitors has revolutionized the treatment of metastatic melanoma. Although these drugs have improved overall survival (OS) in clinical trials,...
03:00
Cancers, Vol. 12, Pages 2589: How Should We Assign Large Infiltrative Hepatocellular Carcinomas for Staging? Cancers doi: 10.3390/cancers12092589 Authors: Lee Lee Seo Goh Kim Yim Han Lee Choi Kim Keum An Park Seo Yim Kim Yu Kim Jeen Chun Lee Kim Um Infiltrative gross morphology of hepatocellular carcinoma (HCC) is known to be associated with poor prognosis, but this is not considered for staging....
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2587: Plasma Nucleosomes in Primary Breast Cancer Cancers doi: 10.3390/cancers12092587 Authors: Michal Mego Katarina Kalavska Marian Karaba Gabriel Minarik Juraj Benca Tatiana Sedlackova Paulina Gronesova Dana Cholujova Daniel Pindak Jozef Mardiak Peter Celec When cells die, nucleosomes composed of DNA and histone proteins enter the extracellular space and end eventually in the circulation. In plasma, they might serve as a nonspecific...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2586: Synergistic Anti-Tumor Activity by Targeting Multiple Signaling Pathways in Ovarian Cancer Cancers doi: 10.3390/cancers12092586 Authors: Wei Wen Ernest S. Han Thanh H. Dellinger Leander X. Lu Jun Wu Richard Jove John H. Yim More effective therapy is needed to improve the survival of patients with advanced and recurrent ovarian cancer. Preclinical and early clinical studies with single molecular targeted agents have shown limited antitumor...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2588: RAS Subcellular Localization Inversely Regulates Thyroid Tumor Growth and Dissemination Cancers doi: 10.3390/cancers12092588 Authors: Yaiza García-Ibáñez Garcilaso Riesco-Eizaguirre Pilar Santisteban Berta Casar Piero Crespo RAS mutations are the second most common genetic alteration in thyroid tumors. However, the extent to which they are associated with the most aggressive phenotypes is still controversial. Regarding their malignancy, the majority...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2579: Cathepsin Inhibition Modulates Metabolism and Polarization of Tumor-Associated Macrophages Cancers doi: 10.3390/cancers12092579 Authors: Diana Oelschlaegel Tommy Weiss Sadan Seth Salpeter Sebastian Krug Galia Blum Werner Schmitz Almut Schulze Patrick Michl Stroma-infiltrating immune cells, such as tumor-associated macrophages (TAM), play an important role in regulating tumor progression and chemoresistance. These effects are mostly conveyed...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2584: Adjuvant Chemotherapy for Stage II Colon Cancer Cancers doi: 10.3390/cancers12092584 Authors: Sara Elena Rebuzzi Guido Pesola Valentino Martelli Alberto Felice Sobrero In stage II colon cancer management, surgery alone has shown a high cure rate (about 80%), and the role of adjuvant chemotherapy is still a matter of debate. Patients with high-risk features (T4, insufficient nodal sampling, grading, etc.) have a poorer prognosis and, usually, adjuvant...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2583: Temozolomide-Induced RNA Interactome Uncovers Novel LncRNA Regulatory Loops in Glioblastoma Cancers doi: 10.3390/cancers12092583 Authors: Sabrina Fritah Arnaud Muller Wei Jiang Ramkrishna Mitra Mohamad Sarmini Monika Dieterle Anna Golebiewska Tao Ye Eric Van Dyck Christel Herold-Mende Zhongming Zhao Francisco Azuaje Simone P. Niclou Resistance to chemotherapy by temozolomide (TMZ) is a major cause of glioblastoma (GBM)...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2581: Exhaustion of Protective Heat Shock Response Induces Significant Tumor Damage by Apoptosis after Modulated Electro-Hyperthermia Treatment of Triple Negative Breast Cancer Isografts in Mice Cancers doi: 10.3390/cancers12092581 Authors: Lea Danics Csaba András Schvarcz Pedro Viana Tamás Vancsik Tibor Krenács Zoltán Benyó Tamás Kaucsár Péter Hamar Modulated electro-hyperthermia (mEHT) is a complementary antitumor therapy applying capacitive...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2582: Isolation and Characterization of Two Novel Colorectal Cancer Cell Lines, Containing a Subpopulation with Potential Stem-Like Properties: Treatment Options by MYC/NMYC Inhibition Cancers doi: 10.3390/cancers12092582 Authors: Jan Schulte am Esch Beatrice Ariane Windmöller Johannes Hanewinkel Jonathan Storm Christine Förster Ludwig Wilkens Martin Krüger Barbara Kaltschmidt Christian Kaltschmidt Cancer stem cells (CSC) are crucial mediators...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2580: FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State Cancers doi: 10.3390/cancers12092580 Authors: Athanasios Blanas Anouk Zaal Irene van der Haar Àvila Maxime Kempers Laura Kruijssen Mike de Kok Marko A. Popovic Joost C. van der Horst Sandra J. van Vliet Cancer stem cells (CSCs) are located in dedicated niches, where they remain inert to chemotherapeutic drugs and drive metastasis. Although plasticity in the...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2585: Uncommon Site of Metastasis and Prolonged Survival in Patients with Anaplastic Thyroid Carcinoma: A Systematic Review of the Literature Cancers doi: 10.3390/cancers12092585 Authors: Aurora Mirabile Matteo Biafora Leone Giordano Gianluigi Arrigoni Maria Giulia Cangi Italo Dell’Oca Francesca Lira Luce Davide Di Santo Andrea Galli Michele Tulli Renata Mellone Davide Valsecchi Vanesa Gregorc Mario Bussi Anaplastic thyroid...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2576: Amino Acids Regulate Cisplatin Insensitivity in Neuroblastoma Cancers doi: 10.3390/cancers12092576 Authors: Venugopal Gunda Anup S. Pathania Srinivas Chava Philip Prathipati Nagendra K. Chaturvedi Don W. Coulter Manoj K. Pandey Donald L. Durden Kishore B. Challagundla Neuroblastoma are pediatric, extracranial malignancies showing alarming survival prognosis outcomes due to their resilience to current aggressive treatment regimens,...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2577: A Modern Approach to Endometrial Carcinoma: Will Molecular Classification Improve Precision Medicine in the Future? Cancers doi: 10.3390/cancers12092577 Authors: Simone Marnitz Till Walter Birgid Schömig-Markiefka Tobias Engler Stefan Kommoss Sara Yvonne Brucker Endometrial cancer has been histologically classified as either an estrogen-dependent cancer with a favorable outcome or an estrogen-independent cancer with a worse prognosis. These...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2575: Interleukin-15 after Near-Infrared Photoimmunotherapy (NIR-PIT) Enhances T Cell Response against Syngeneic Mouse Tumors Cancers doi: 10.3390/cancers12092575 Authors: Yasuhiro Maruoka Aki Furusawa Ryuhei Okada Fuyuki Inagaki Hiroaki Wakiyama Takuya Kato Tadanobu Nagaya Peter L. Choyke Hisataka Kobayashi Near infrared photoimmunotherapy (NIR-PIT) is a newly developed and highly selective cancer treatment that employs a monoclonal antibody...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2578: Influence of Target Location, Size, and Patient Age on Normal Tissue Sparing- Proton and Photon Therapy in Paediatric Brain Tumour Patient-Specific Approach Cancers doi: 10.3390/cancers12092578 Authors: Mikaela Dell’Oro Michala Short Puthenparampil Wilson Chia-Ho Hua Melissa Gargone Thomas E. Merchant Eva Bezak Background: Proton radiotherapy produces superior dose distributions compared to photon radiotherapy, reducing side effects. Differences...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2573: N-MYC Downstream Regulated Gene 4 (NDRG4), a Frequent Downregulated Gene through DNA Hypermethylation, plays a Tumor Suppressive Role in Esophageal Adenocarcinoma Cancers doi: 10.3390/cancers12092573 Authors: Longlong Cao Tianling Hu Heng Lu Dunfa Peng The incidence of esophageal adenocarcinoma (EAC) has been rising dramatically in the past few decades in the United States and Western world. The N-myc downregulated gene 4 (NDRG4) belongs to the...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2574: Mitochondrial Metabolism, Contact Sites and Cellular Calcium Signaling: Implications for Tumorigenesis Cancers doi: 10.3390/cancers12092574 Authors: Roberta Peruzzo Roberto Costa Magdalena Bachmann Luigi Leanza Ildikò Szabò Mitochondria are organelles that are mainly involved in the generation of ATP by cellular respiration. In addition, they modulate several intracellular functions, ranging from cell proliferation and differentiation to cell...
Thu Sep 10, 2020 03:00
Cancers, Vol. 12, Pages 2571: Acute Radiation Colitis after Preoperative Short-Course Radiotherapy for Rectal Cancer: A Morphological, Immunohistochemical and Genetic Study Cancers doi: 10.3390/cancers12092571 Authors: Magda Zanelli Alessia Ciarrocchi Giovanni De Petris Maurizio Zizzo Massimo Costantini Alessandra Bisagni Federica Torricelli Davide Nicoli Dafne Ramundo Stefano Ricci Andrea Palicelli Francesca Sanguedolce Stefano Ascani Carolina Castro...
Wed Sep 09, 2020 03:00
Cancers, Vol. 12, Pages 2572: Transcriptional Spatial Profiling of Cancer Tissues in the Era of Immunotherapy: The Potential and Promise Cancers doi: 10.3390/cancers12092572 Authors: Sanjna Nilesh Nerurkar Denise Goh Chun Chau Lawrence Cheung Pei Qi Yvonne Nga Jeffrey Chun Tatt Lim Joe Poh Sheng Yeong Intratumoral heterogeneity poses a major challenge to making an accurate diagnosis and establishing personalized treatment strategies for cancer patients. Moreover, this...
Wed Sep 09, 2020 03:00
Cancers, Vol. 12, Pages 2570: Plasma Treatment Limits Human Melanoma Spheroid Growth and Metastasis Independent of the Ambient Gas Composition Cancers doi: 10.3390/cancers12092570 Authors: Sybille Hasse Tita Meder Eric Freund Thomas von Woedtke Sander Bekeschus Melanoma skin cancer is still a deadly disease despite recent advances in therapy. Previous studies have suggested medical plasma technology as a promising modality for melanoma treatment. However, the efficacy of...
Wed Sep 09, 2020 03:00
Cancers, Vol. 12, Pages 2569: The Value of Serum MicroRNA Expression Signature in Predicting Refractoriness to Bortezomib-Based Therapy in Multiple Myeloma Patients Cancers doi: 10.3390/cancers12092569 Authors: Paweł Robak Izabela Dróżdż Dariusz Jarych Damian Mikulski Edyta Węgłowska Monika Siemieniuk-Ryś Małgorzata Misiewicz Konrad Stawiski Wojciech Fendler Janusz Szemraj Piotr Smolewski Tadeusz Robak Bortezomib is the first-in-class proteasome inhibitor,...
Wed Sep 09, 2020 03:00
Cancers, Vol. 12, Pages 2568: Evaluation of Cognitive Function in Trials Testing New-Generation Hormonal Therapy in Patients with Prostate Cancer: A Systematic Review Cancers doi: 10.3390/cancers12092568 Authors: Laura Marandino Francesca Vignani Consuelo Buttigliero Teresa Gamba Andrea Necchi Marcello Tucci Massimo Di Maio In patients with prostate cancer, earlier use and longer duration of new-generation hormonal therapy (NGHT), added to androgen deprivation therapy,...
Wed Sep 09, 2020 03:00
Cancers, Vol. 12, Pages 2567: The Landscape of CAR-T Cell Clinical Trials against Solid Tumors—A Comprehensive Overview Cancers doi: 10.3390/cancers12092567 Authors: Niels Schaft CAR-T cells showed great potential in the treatment of patients with hematologic tumors. However, the clinical efficacy of CAR-T cells against solid tumors lags behind. To obtain a comprehensive overview of the landscape of CAR-T cell clinical trials against this type of cancer, this review summarizes all the...
Wed Sep 09, 2020 03:00
Cancers, Vol. 12, Pages 2566: Exosomes: A Source for New and Old Biomarkers in Cancer Cancers doi: 10.3390/cancers12092566 Authors: Mariantonia Logozzi Davide Mizzoni Rossella Di Raimo Stefano Fais Clinical oncology needs reliable tumor biomarkers to allow a follow-up of tumor patients who do not necessarily need invasive approaches. To date, the existing biomarkers are not sufficiently reliable, and many of them have generated more problems than facilitating the commitment...
Wed Sep 09, 2020 03:00
Cancers, Vol. 12, Pages 2562: The Treatment of Heterotopic Human Colon Xenograft Tumors in Mice with 5-Fluorouracil Attached to Magnetic Nanoparticles in Combination with Magnetic Hyperthermia Is More Efficient than Either Therapy Alone Cancers doi: 10.3390/cancers12092562 Authors: Mohammad Dabaghi Rainer Quaas Ingrid Hilger Magnetic nanoparticles (MNPs) have shown promising features to be utilized in combinatorial magnetic hyperthermia and chemotherapy. Here, we assessed if a...
Wed Sep 09, 2020 03:00
Cancers, Vol. 12, Pages 2564: Biomimetic Magnetite Nanoparticles as Targeted Drug Nanocarriers and Mediators of Hyperthermia in an Experimental Cancer Model Cancers doi: 10.3390/cancers12092564 Authors: Francesca Oltolina Ana Peigneux Donato Colangelo Nausicaa Clemente Annarita D’Urso Guido Valente Guillermo R. Iglesias Concepcion Jiménez-Lopez Maria Prat Biomimetic magnetic nanoparticles mediated by magnetosome proteins (BMNPs) are potential innovative tools...
Wed Sep 09, 2020 03:00
Cancers, Vol. 12, Pages 2563: Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant? Cancers doi: 10.3390/cancers12092563 Authors: Sena Turkdogan Marc Pusztaszeri Veronique-Isabelle Forest Michael P. Hier Richard J. Payne The Bethesda classification system for thyroid fine needle aspirate (FNA) is used to predict the risk of malignancy and to guide the management of thyroid nodules. We postulated that thyroid malignancies...
Wed Sep 09, 2020 03:00
Cancers, Vol. 12, Pages 2565: Targeted Therapies for Epstein-Barr Virus-Associated Lymphomas Cancers doi: 10.3390/cancers12092565 Authors: Yonggang Pei Josiah H. Y. Wong Erle S. Robertson The Epstein-Barr virus (EBV) is the first human tumor virus identified that can transform quiescent B lymphocytes into lymphoblastoid cell lines (LCLs) in vitro. EBV can establish asymptomatic life-long persistence and is associated with multiple human malignancies, including non-Hodgkin lymphoma...
Wed Sep 09, 2020 03:00
Cells, Vol. 9, Pages 2074: Alterations in Progesterone Receptor Isoform Balance in Normal and Neoplastic Breast Cells Modulates the Stem Cell Population Cells doi: 10.3390/cells9092074 Authors: María Sol Recouvreux María Inés Diaz Bessone Agustina Taruselli Laura Todaro María Amparo Lago Huvelle Rocío G. Sampayo Mina J. Bissell Marina Simian To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used...
03:00
Cells, Vol. 9, Pages 2073: Osteoblast-Osteoclast Communication and Bone Homeostasis Cells doi: 10.3390/cells9092073 Authors: Jung-Min Kim Chujiao Lin Zheni Stavre Matthew B. Greenblatt Jae-Hyuck Shim Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell-to-cell contact or through...
Thu Sep 10, 2020 03:00
Cells, Vol. 9, Pages 2070: Dynamic High-Sensitivity Quantitation of Procollagen-I by Endogenous CRISPR-Cas9 NanoLuciferase Tagging Cells doi: 10.3390/cells9092070 Authors: Ben C. Calverley Karl E. Kadler Adam Pickard The ability to quantitate a protein of interest temporally and spatially at subcellular resolution in living cells would generate new opportunities for research and drug discovery, but remains a major technical challenge. Here, we describe dynamic, high-sensitivity...
Thu Sep 10, 2020 03:00
Cells, Vol. 9, Pages 2071: Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer Cells doi: 10.3390/cells9092071 Authors: Jihane Boustani Valentin Derangère Aurélie Bertaut Olivier Adotevi Véronique Morgand Céline Charon-Barra François Ghiringhelli Céline Mirjolet In locally advanced rectal cancer, radiotherapy (RT) followed by surgery have improved locoregional control, but distant recurrences remain frequent. Although checkpoint inhibitors...
Thu Sep 10, 2020 03:00
Cells, Vol. 9, Pages 2067: Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis † Cells doi: 10.3390/cells9092067 Authors: Silvia González-Ramos Victoria Fernández-García Miriam Recalde Cristina Rodríguez José Martínez-González Vicente Andrés Paloma Martín-Sanz Lisardo Boscá Atherothrombosis, the main cause of acute coronary syndromes (ACS), is characterized by the rupture of the atherosclerotic plaque followed...
Thu Sep 10, 2020 03:00
Cells, Vol. 9, Pages 2072: Tsc1 Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells Cells doi: 10.3390/cells9092072 Authors: Maria V. Guijarro Laura S. Danielson Marta Cañamero Akbar Nawab Carolina Abrahan Eva Hernando Glyn D. Palmer TSC1 is a tumor suppressor that inhibits cell growth via negative regulation of the mammalian target of rapamycin complex (mTORC1). TSC1 mutations are associated with Tuberous Sclerosis Complex (TSC), characterized...
Thu Sep 10, 2020 03:00
Cells, Vol. 9, Pages 2065: Using High-Content Screening to Generate Single-Cell Gene-Corrected Patient-Derived iPS Clones Reveals Excess Alpha-Synuclein with Familial Parkinson’s Disease Point Mutation A30P Cells doi: 10.3390/cells9092065 Authors: Peter Barbuti Paul Antony Bruno Santos François Massart Gérald Cruciani Claire Dording Jonathan Arias Jens Schwamborn Rejko Krüger The generation of isogenic induced pluripotent stem cell (iPSC) lines using CRISPR-Cas9...
Thu Sep 10, 2020 03:00
Cells, Vol. 9, Pages 2068: Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma Cells doi: 10.3390/cells9092068 Authors: Andra S. Martinikova Monika Burocziova Miroslav Stoyanov Libor Macurek Genome integrity is protected by the cell-cycle checkpoints that prevent cell proliferation in the presence of DNA damage and allow time for DNA repair. The transient checkpoint arrest together with cellular senescence represent an intrinsic...
Thu Sep 10, 2020 03:00
Cells, Vol. 9, Pages 2066: ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart Cells doi: 10.3390/cells9092066 Authors: Bianca A. Meyer Shirin Doroudgar Endoplasmic reticulum (ER) stress is a result of conditions that imbalance protein homeostasis or proteostasis at the ER, for example ischemia, and is a common event in various human pathologies, including the diseased heart. Cardiac integrity and function depend on the active secretion of mature...
Thu Sep 10, 2020 03:00
Cells, Vol. 9, Pages 2064: Breast Cancer Subtypes Underlying EMT-Mediated Catabolic Metabolism Cells doi: 10.3390/cells9092064 Authors: Eunae Sandra Cho Nam Hee Kim Jun Seop Yun Sue Bean Cho Hyun Sil Kim Jong In Yook Efficient catabolic metabolism of adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide phosphate (NADPH) is essentially required for cancer cell survival, especially in metastatic cancer progression. Epithelial–mesenchymal transition...
Thu Sep 10, 2020 03:00
Cells, Vol. 9, Pages 2069: Autologous, Non-Invasively Available Mesenchymal Stem Cells from the Outer Root Sheath of Hair Follicle Are Obtainable by Migration from Plucked Hair Follicles and Expandable in Scalable Amounts Cells doi: 10.3390/cells9092069 Authors: Hanluo Li Federica Francesca Masieri Marie Schneider Tina Kottek Sebastian Hahnel Kensuke Yamauchi Danilo Obradović Jong-Keun Seon Sook Jung Yun Rubén A. Ferrer Sandra Franz Jan-Christoph Simon Bernd...
Thu Sep 10, 2020 03:00
Cells, Vol. 9, Pages 2062: Formation of βTC3 and MIN6 Pseudoislets Changes the Expression Pattern of Gpr40, Gpr55, and Gpr119 Receptors and Improves Lysophosphatidylcholines-Potentiated Glucose-Stimulated Insulin Secretion Cells doi: 10.3390/cells9092062 Authors: Anna Drzazga Eliza Cichońska Maria Koziołkiewicz Edyta Gendaszewska-Darmach The impaired spatial arrangement and connections between cells creating islets of Langerhans as well as altered expression of G protein-coupled...
Wed Sep 09, 2020 03:00
Cells, Vol. 9, Pages 2063: Targeted Activation of T Cells with IL-2-Coupled Nanoparticles Cells doi: 10.3390/cells9092063 Authors: Verena K. Raker Christian Becker Katharina Landfester Kerstin Steinbrink Interleukin-2 (IL-2) is a T cell growth factor particularly required in regulatory T cell maintenance and memory T cell responses. High-dose IL-2 treatment was the first FDA-approved immunotherapy for cancer, while low-dose IL-2 administration has shown promise in allograft...
Wed Sep 09, 2020 03:00
Cells, Vol. 9, Pages 2059: Annexin A2 Egress during Calcium-Regulated Exocytosis in Neuroendocrine Cells Cells doi: 10.3390/cells9092059 Authors: Marion Gabel Cathy Royer Tamou Thahouly Valérie Calco Stéphane Gasman Marie-France Bader Nicolas Vitale Sylvette Chasserot-Golaz Annexin A2 (AnxA2) is a calcium- and lipid-binding protein involved in neuroendocrine secretion where it participates in the formation and/or stabilization of lipid micro-domains required for...
Wed Sep 09, 2020 03:00
Cells, Vol. 9, Pages 2057: Fibrotic Changes and Endothelial-to-Mesenchymal Transition Promoted by VEGFR2 Antagonism Alter the Therapeutic Effects of VEGFA Pathway Blockage in a Mouse Model of Choroidal Neovascularization Cells doi: 10.3390/cells9092057 Authors: Franco Aparecido Rossato Yu Su Ashley Mackey Yin Shan Eric Ng Many patients with wet age-related macular degeneration do not respond well to anti- vascular endothelial growth factor A (VEGFA) therapy for choroidal neovascularization...
Wed Sep 09, 2020 03:00
Cells, Vol. 9, Pages 2060: Novel Insights into Beta 2 Adrenergic Receptor Function in the rd10 Model of Retinitis Pigmentosa Cells doi: 10.3390/cells9092060 Authors: Maurizio Cammalleri Massimo Dal Monte Rosario Amato Dominga Lapi Paola Bagnoli Background: In retinitis pigmentosa (RP), inherited rod death is followed by cone loss and blindness. Why cones die is still a matter of consideration. Here, we investigate the pathogenic role of the sympathetic transmission in the...
Wed Sep 09, 2020 03:00
Cells, Vol. 9, Pages 2058: Evaluation of Priming Efficiency of Forskolin in Tissue-Specific Human Mesenchymal Stem Cells into Dopaminergic Neurons: An In Vitro Comparative Study Cells doi: 10.3390/cells9092058 Authors: Manisha Singh Pardeep Kumar Vaishnav Amit Kumar Dinda Sujata Mohanty Background: Human mesenchymal stem cells (hMSC) can be derived from various tissue sources and differentiated into dopaminergic (DAergic) neurons using various types of inducers. There are several...
Wed Sep 09, 2020 03:00
Cells, Vol. 9, Pages 2061: Nucleic Acid-Based Approaches for Tumor Therapy Cells doi: 10.3390/cells9092061 Authors: Simone Hager Frederic Julien Fittler Ernst Wagner Matthias Bros Within the last decade, the introduction of checkpoint inhibitors proposed to boost the patients’ anti-tumor immune response has proven the efficacy of immunotherapeutic approaches for tumor therapy. Furthermore, especially in the context of the development of biocompatible, cell type targeting...
Wed Sep 09, 2020 03:00
Cells, Vol. 9, Pages 2056: Precision Medicine: Steps along the Road to Combat Human Cancer Cells doi: 10.3390/cells9092056 Authors: Samuel F. Nassar Khadir Raddassi Baljit Ubhi Joseph Doktorski Ahmad Abulaban The diagnosis and treatment of diseases such as cancer is becoming more accurate and specialized with the advent of precision medicine techniques, research and treatments. Reaching down to the cellular and even sub-cellular level, diagnostic tests can pinpoint specific,...
Wed Sep 09, 2020 03:00
Children, Vol. 7, Pages 133: COVID-19: Neurological Considerations in Neonates and Children Children doi: 10.3390/children7090133 Authors: Carl E. Stafstrom Lauren L. Jantzie The ongoing worldwide pandemic of the novel human coronavirus SARS-CoV-2 and the ensuing disease, COVID-19, has presented enormous and unprecedented challenges for all medical specialists. However, to date, children, especially neonates, have been relatively spared from the devastating consequences of this infection....
Thu Sep 10, 2020 03:00
Children, Vol. 7, Pages 132: Patterns of Urinary Neutrophil Gelatinase-Associated Lipocalin and Acute Kidney Injury in Neonates Receiving Cardiopulmonary Bypass Children doi: 10.3390/children7090132 Authors: Kathleen G. Brennan Elvira Parravicini John M. Lorenz David A. Bateman Elevated urinary neutrophil gelatinase-associated lipocalin (uNGAL) predicts acute kidney injury (AKI) in children following cardiopulmonary bypass (CPB) during cardiac surgery, but little is known about...
Wed Sep 09, 2020 03:00
Clean Technol., Vol. 2, Pages 377-391: Waste Recovery through Thermochemical Conversion Technologies: A Case Study with Several Portuguese Agroforestry By-Products Clean Technologies doi: 10.3390/cleantechnol2030023 Authors: Leonel J. R. Nunes Liliana M. E. F. Loureiro Letícia C. R. Sá Hugo F. C. Silva Agroforestry waste stores a considerable amount of energy that can be used. Portugal has great potential to produce bioenergy. The waste generated during agricultural production...
Thu Sep 10, 2020 03:00
Dentistry Journal, Vol. 8, Pages 105: Family Influences on Caries in Grenada Dentistry Journal doi: 10.3390/dj8030105 Authors: Danielle Mitnick Ashley Dills Amy M. Smith Slep Richard E. Heyman Jill Giresi If high-conflict family environments are cariogenic across cultures, and can be studied in cultures where both these environments and cariogenic dental practices are particularly prevalent, this would afford the opportunity to examine how these two pathways of risk might...
Wed Sep 09, 2020 03:00
Diagnostics, Vol. 10, Pages 683: Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome Diagnostics doi: 10.3390/diagnostics10090683 Authors: Elena G. Kornetova Alexander N. Kornetov Irina A. Mednova Olga A. Lobacheva Valeria I. Gerasimova Viktoria V. Dubrovskaya Ivan V. Tolmachev Arkadiy V. Semke Anton J. M. Loonen Nikolay A. Bokhan Svetlana A. Ivanova In this study, we aim...
Thu Sep 10, 2020 03:00
Diagnostics, Vol. 10, Pages 682: Monostotic Fibrous Dysplasia Mimicking Metastasis in the Femoral Neck on Bone Scintigraphy and 18F-FDG PET/CT Diagnostics doi: 10.3390/diagnostics10090682 Authors: Wei-Liang Hung Hung-Yen Chan Ni-Chun Kuo Hung-Pin Chan A 51-year-old woman who had lung adenocarcinoma was found to have a high uptake area over the right femoral neck by means of bone scintigraphy, suggesting a suspicious bony metastasis. 18F-FDG PET/CT was arranged, and showed an...
Thu Sep 10, 2020 03:00
Diagnostics, Vol. 10, Pages 680: Establishment of CTPA Local Diagnostic Reference Levels with Noise Magnitude as a Quality Indicator in a Tertiary Care Hospital Diagnostics doi: 10.3390/diagnostics10090680 Authors: Hanif Haspi Harun Muhammad Khalis Abdul Karim Mohd Amiruddin Abd Rahman Hairil Rashmizal Abdul Razak Iza Nurzawani Che Isa Faeezah Harun This study aimed to establish the local diagnostic reference levels (LDRLs) of computed tomography pulmonary angiography...
Wed Sep 09, 2020 03:00
Diagnostics, Vol. 10, Pages 681: Association of Radiation Doses and Cancer Risks from CT Pulmonary Angiography Examinations in Relation to Body Diameter Diagnostics doi: 10.3390/diagnostics10090681 Authors: Hanif Haspi Harun Muhammad Khalis Abdul Karim Zulkifly Abbas Mohd Amir Abdul Rahman Akmal Sabarudin Kwan Hoong Ng In this study, we aimed to estimate the probability of cancer risk induced by CT pulmonary angiography (CTPA) examinations concerning effective body diameter....
Wed Sep 09, 2020 03:00
Diagnostics, Vol. 10, Pages 679: Coronary Microvascular Dysfunction and the Role of Noninvasive Cardiovascular Imaging Diagnostics doi: 10.3390/diagnostics10090679 Authors: Muhammad Talha Ayub Dinesh Kalra Patients with coronary microvascular dysfunction (CMD) have significantly higher rates of cardiovascular events, including hospitalization for heart failure, sudden cardiac death, and myocardial infarction (MI). In CMD, several pathophysiological changes lead to functional and structural...
Wed Sep 09, 2020 03:00
Diagnostics, Vol. 10, Pages 678: Self-Collected versus Healthcare Worker-Collected Swabs in the Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 Diagnostics doi: 10.3390/diagnostics10090678 Authors: Johan H. Therchilsen Christian von Buchwald Anders Koch Susanne Dam Nielsen Daniel B. Rasmussen Rebekka Faber Thudium Nikolai S. Kirkby Daniel E. T. Raaschou-Pedersen Johan S. Bundgaard Kasper Iversen Henning Bundgaard Tobias Todsen The aim of...
Wed Sep 09, 2020 03:00
Diversity, Vol. 12, Pages 349: Tuber mesentericum and Tuber aestivum truffles: New Insights Based on Morphological and Phylogenetic Analyses Diversity doi: 10.3390/d12090349 Authors: Giorgio Marozzi Gian Maria Niccolò Benucci Edoardo Suriano Nicola Sitta Lorenzo Raggi Hovirag Lancioni Leonardo Baciarelli Falini Emidio Albertini Domizia Donnini Tuber aestivum, one of the most sought out and marketed truffle species in the world, is morphologically similar to...
Thu Sep 10, 2020 03:00
Diversity, Vol. 12, Pages 348: Conservation Biogeography of Tenebrionid Beetles: Insights from Italian Reserves Diversity doi: 10.3390/d12090348 Authors: Simone Fattorini The species-area relationship (SAR), the latitudinal gradient, the peninsula effect, and the elevational gradient are widespread biogeographical patterns. Using data from Italian reserves, these patterns were tested for tenebrionids and used as a framework to calculate expected extinction rates following area loss....
Thu Sep 10, 2020 03:00
Environments, Vol. 7, Pages 70: Industrial Energy Transitions and the Dynamics of Innovation Systems: The Swedish Pulp and Paper Industry, 1970–2010 Environments doi: 10.3390/environments7090070 Authors: Kristina Söderholm Patrik Söderholm This article provides a sectoral innovation system perspective of the development of energy efficient and clean process technologies in the Swedish pulp and paper industry. Specifically, the analysis elaborates the importance of knowledge development,...
Thu Sep 10, 2020 03:00
Epigenomes, Vol. 4, Pages 22: Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology Epigenomes doi: 10.3390/epigenomes4030022 Authors: Maria J. Barrero The contribution of the non-coding genome to disease and its therapeutic potential have been largely unexplored. Recently, several epigenetic drugs developed for cancer treatment have been described to mediate therapeutic effects through the reactivation of the expression of transposable elements in cancer...
Thu Sep 10, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου