On February 4, 2020, the U.S. secretary of health and human services declared that emergency use of diagnostics for SARS-CoV-2 was justified, triggering emergency authority for the Food and Drug Administration (FDA) to grant an emergency use authorization (EUA) for a device if it reasonably…
Wed Sep 09, 2020 03:00
176 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/09/10PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 10, 2020 14:13
New England Journal of Medicine, Ahead of Print.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1018-1027, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 997-999, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1040-1049, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1090-1092, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1009-1017, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1000-1002, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1068-1070, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1067-1068, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1093-1094, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1083-1085, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1078-1080, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1057-1057, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1092-1093, September 2020.
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New England Journal of Medicine, Volume 383, Issue 11, Page 1028-1039, September 2020.
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139 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2020/09/10PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 10, 2020 14:09
The fifth head of quadriceps femoris: for sure? Surg Radiol Anat. 2020 Sep 09;: Authors: Aragonés P, Olewnik Ł, Polguj M, Quinones S, Sanudo J Abstract PURPOSE: The quadriceps femoris has been described as a muscle composed by four heads: rectus femoris, vastus lateralis, vastus medialis and vastus intermedius. Each head fuse with the other ones making up the quadriceps tendon, which inserts into the patella. Nevertheless, there has been...
Thu Sep 10, 2020 14:09
Externally Monitored Versus Conventional Buried Flaps in Laryngopharyngeal Reconstruction. Clin Exp Otorhinolaryngol. 2020 Sep 10;: Authors: Ban MJ, Na G, Ko S, Kim J, Heo NH, Choi EC, Park JH, Kim WS Abstract Objectives: To compare the surgical outcomes of externally monitored and conventional buried flaps with the goal of determining the usefulness of external monitoring of buried flaps. Methods: In this case-control study with propensity...
Thu Sep 10, 2020 14:06
Abstract Aim To assess changes in the position of the mucogingival junction (MGJ) after an apically positioned flap (APF) with collagen matrix performed at sites with or without previous guided bone regeneration (GBR). Materials and Methods Dental implants were placed with or without GBR (group GBR or nonGBR) depending on the available ridge width in 30 patients with a limited width of keratinized mucosa (MGJ placed more coronally than the expected prosthetic margin). An apically positioned...
Thu Sep 10, 2020 14:03
Abstract Objective To determine the positional accuracy of implants placed with a three‐dimensionally printed template having nonmetal sleeves and to determine the contributing factors to observed deviations. Materials and Methods One hundred and eighty‐seven implants placed in 72 patients were analyzed. Presurgical intraoral scans and cone‐beam computed tomography images obtained before and after surgery were superimposed, and vertical, angular, platform, and apex deviations were measured...
Wed Sep 09, 2020 22:49
Diagnosing Myasthenia Gravis With Repetitive Ocular Vestibular Evoked Myogenic Potentials. Front Neurol. 2020;11:861 Authors: Wirth MA, Fierz FC, Valko Y, Weber KP Abstract Timely and accurate diagnosis of myasthenia gravis, particularly in patients with fluctuating, isolated ocular involvement, remains challenging. Serological antibody testing and repetitive nerve stimulation of peripheral muscles usually have low sensitivity in these...
Thu Sep 10, 2020 14:01
39 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Exp Ther Med"[jour] These pubmed results were generated on 2020/09/10PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 10, 2020 13:59
Abstract Hereditary mucoepithelial dysplasia (HMD) is an uncommon autosomal dominant disease affecting skin, mucosae, hair, eyes, and lungs. Prominent clinical features include non‐scarring alopecia, mucosal erythema, perineal erythematous intertrigo, and involvement of the conjunctival mucosa. To date, 20 familial or sporadic HMD cases have been described, most of them originating from Caucasian ethnic groups. In this study, a novel HMD pedigree, including an affected father and his daughter, is...
Wed Sep 09, 2020 18:18
Abstract NFIB (Nuclear Factor I B) haploinsufficiency has recently been identified as a cause of intellectual disability and macrocephaly. Here we describe two patients with pathogenic variants in NFIB. The first is a 6‐year‐old Latino male with developmental delays, mild hypotonia, facial anomalies, and brain magnetic resonance imaging findings comprising mild thinning of the corpus callosum, with more marked thinning of the splenium and blunting of the rostrum and cavum septum pellucidum. Exome...
Wed Sep 09, 2020 18:18
Abstract Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities (IDDFBA) caused by germline de novo variants in FBXO11 was recently recognized as a novel intellectual disability (ID) syndrome through reverse phenotyping after whole‐exome sequencing (WES). Fewer than 50 disease‐causing de novo FBXO11 variants in IDDFBA are reported thus far. Here, we present the first report of a family showing autosomal dominantly inherited IDDFBA, harboring a novel heterozygous...
Wed Sep 09, 2020 14:18
ABSTRACT The multiple pterygium syndromes (MPS) are rare disorders with disease severity ranging from lethal to milder forms. The nonlethal Escobar variant MPS (EVMPS) is characterized by multiple pterygia and arthrogryposis, as well as various additional features including congenital anomalies. The genetic etiology of EVMPS is heterogeneous and the diagnosis has been based either on the detection of pathogenic CHRNG variants (~23% of patients), or suggestive clinical features. We describe four...
Wed Sep 09, 2020 14:18
Abstract Down syndrome (DS) is associated with a complex respiratory phenotype, including obstructive sleep apnea syndrome (OSAS). The study explored parent‐reported prevalence and presentation of OSAS symptoms in children and adolescents with DS in Ireland. It also investigated treatment and compliance in those who have OSAS. A cross‐sectional survey was distributed to parents registered with Down Syndrome Ireland (DSI) (n = 1,343). Data was collated and analyzed using SPSS v23. The response rate...
Wed Sep 09, 2020 14:17
Abstract Genetic diagnosis depends on having available tissue to test. This can be important for many reasons, such as related to familial diagnosis in the case of another pregnancy. When blood or DNA samples from affected family members are not available, accurate prenatal diagnosis may be much more difficult and hence additional effort may be needed to obtain a genetic diagnosis in such families. We report two families with suspected monogenic disorders where attempts were made to establish the...
Wed Sep 09, 2020 14:16
Abstract Bi‐allelic loss‐of‐function variants in LAMC3, encoding extracellular matrix protein laminin gamma 3, represent a rare cause of occipital polymicrogyria with epilepsy, developmental delay and cognitive impairment. So far, only five families have been reported. We now identified a novel, homozygous splice variant in LAMC3 in an individual with an unusual manifestation of cortical malformation. She presented with polymicrogyria in the frontal but not the occipital lobes, with adult‐onset...
Wed Sep 09, 2020 14:15
Clinical features and prognosis of clinical N0 non-small cell lung cancer exceeding 30 mm. Jpn J Clin Oncol. 2020 Sep 09;: Authors: Kagimoto A, Tsutani Y, Handa Y, Mimae T, Miyata Y, Okada M Abstract OBJECTIVES: This study aimed to determine the characteristics, ground glass opacity ratio and prognosis of patients with clinical N0 non-small cell lung cancer tumours exceeding 30 mm in size. METHODS: Patients with clinical N0 non-small...
Thu Sep 10, 2020 13:54
Rathke's cleft cyst with xanthogranulomatous change: A case report and review of the literature. Surg Neurol Int. 2020;11:246 Authors: Sprau A, Mahavadi A, Zhang M, Saste M, Deftos M, Singh H Abstract Background: Rathke's cleft cysts (RCCs) are benign, typically asymptomatic sellar lesions found incidentally in adults, with a dramatically lower incidence in pediatric patients (<18 years). We present a case of RCC with xanthogranulomatous...
Thu Sep 10, 2020 13:53
Calcifying pseudoneoplasm of the neuraxis: A rare case involving the oculomotor nerve. Surg Neurol Int. 2020;11:249 Authors: Huang J, Ghent F, Rodriguez M, Davies M Abstract Background: Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare entity which can occur at intracranial and spinal locations. Clinical presentation is due to local mass effect rather than tissue infiltration. Lesions causing significant symptoms or are showing radiological...
Thu Sep 10, 2020 13:53
Prognostic Value of Cumulative Score Based on Preoperative Fibrinogen and Albumin Level in Skull Base Chordoma. Onco Targets Ther. 2020;13:8337-8346 Authors: Li M, Bai J, Wang S, Zhai Y, Zhang S, Li C, Du J, Zhang Y Abstract Objective: Inflammation and malnutrition have been shown to be correlated with tumor progression and a poor prognosis in various cancers. However, the clinical implications of biomarkers of inflammation and malnutrition...
Thu Sep 10, 2020 13:53
Ultra-short antibiotic prophylaxis guided by preoperative microbiological nasal swabs in endoscopic endonasal skull base surgery. Acta Neurochir (Wien). 2020 Sep 08;: Authors: Ceraudo M, Prior A, Balestrino A, Anania P, Camera M, Fiaschi P, Gatto F, Riccardi N, Zona G, Criminelli Rossi D Abstract PURPOSE: Endoscopic endonasal skull base surgery (EESBS) is a clean-contaminated procedure. Guidelines regarding the antibiotic prophylaxis in EESBS...
Thu Sep 10, 2020 13:53
Related Articles EUFOREA consensus on biologics for CRSwNP with or without asthma. Allergy. 2019 12;74(12):2312-2319 Authors: Fokkens WJ, Lund V, Bachert C, Mullol J, Bjermer L, Bousquet J, Canonica GW, Deneyer L, Desrosiers M, Diamant Z, Han J, Heffler E, Hopkins C, Jankowski R, Joos G, Knill A, Lee J, Lee SE, Mariën G, Pugin B, Senior B, Seys SF, Hellings PW Abstract Novel therapies such as type 2 targeting biologics are emerging treatment...
Thu Sep 10, 2020 13:53
Related Articles Contemporary management of primary parapharyngeal space tumors. Head Neck. 2019 02;41(2):522-535 Authors: López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P, Hanna EY, Rodrigo JP, de Bree R, Quer M, Takes RP, Bradford CR, Shaha AR, Sanabria A, Rinaldo A, Ferlito A Abstract The parapharyngeal space is a complex anatomical area. Primary parapharyngeal tumors are rare tumors and 80% of them are benign. A variety...
Thu Sep 10, 2020 13:53
Trigeminal Neuralgia Secondary to Meningiomas and Vestibular Schwannoma Is Improved after Stereotactic Radiosurgery: A Systematic Review and Meta-Analysis. Stereotact Funct Neurosurg. 2020 Sep 09;:1-11 Authors: Peciu-Florianu I, Régis J, Levivier M, Dedeciusova M, Reyns N, Tuleasca C Abstract INTRODUCTION: Trigeminal neuralgia (TN) secondary to tumors is encountered in up to 6% of patients with facial pain syndromes and is considered to be...
Thu Sep 10, 2020 13:51
No benefit of hydroxychloroquine in COVID-19: Results of Systematic Review and Meta-Analysis of Randomized Controlled Trials". Diabetes Metab Syndr. 2020 Sep 01;14(6):1673-1680 Authors: Pathak DSK, Salunke DAA, Thivari DP, Pandey A, Nandy DK, Harish V K Ratna D, Pandey DS, Chawla DJ, Mujawar DJ, Dhanwate DA, Menon DV Abstract BACKGROUND AND AIMS: Coronavirus pandemic is currently a global public health emergency with no definitive treatment...
Thu Sep 10, 2020 13:51
Evaluating Daratumumab in the Treatment of Multiple Myeloma: Safety, Efficacy and Place in Therapy. Cancer Manag Res. 2020;12:7891-7903 Authors: Dima D, Dower J, Comenzo RL, Varga C Abstract Despite the tremendous advances in the treatment of multiple myeloma, mortality remains significant, highlighting the need for new effective strategies. In recent years, daratumumab, a novel human monoclonal antibody, binding CD38, has dramatically improved...
Thu Sep 10, 2020 13:51
Improving the Efficacy of Tumor Radiosensitization Through Combined Molecular Targeting. Front Oncol. 2020;10:1260 Authors: Hintelmann K, Kriegs M, Rothkamm K, Rieckmann T Abstract Chemoradiation, either alone or in combination with surgery or induction chemotherapy, is the current standard of care for most locally advanced solid tumors. Though chemoradiation is usually performed at the maximum tolerated doses of both chemotherapy and radiation,...
Thu Sep 10, 2020 13:51
Hydrolyzed Protein Formula for Allergy Prevention in Preterm Infants: Follow-Up Analysis of a Randomized, Triple-Blind, Placebo-Controlled Study. Front Pediatr. 2020;8:422 Authors: Di Mauro A, Baldassarre ME, Brindisi G, Zicari AM, Tarantini M, Laera N, Capozza M, Panza R, Salvatore S, Pensabene L, Fanelli M, Laforgia N Abstract Background: Allergic diseases are a major public health burden worldwide. Evidence suggests that early nutrition...
Thu Sep 10, 2020 13:51
Artificial Intelligence to Decode Cancer Mechanism: Beyond Patient Stratification for Precision Oncology. Front Pharmacol. 2020;11:1177 Authors: Patel SK, George B, Rai V Abstract The multitude of multi-omics data generated cost-effectively using advanced high-throughput technologies has imposed challenging domain for research in Artificial Intelligence (AI). Data curation poses a significant challenge as different parameters, instruments,...
Thu Sep 10, 2020 13:51
Progress and Future Trends in PET/CT and PET/MRI Molecular Imaging Approaches for Breast Cancer. Front Oncol. 2020;10:1301 Authors: Ming Y, Wu N, Qian T, Li X, Wan DQ, Li C, Li Y, Wu Z, Wang X, Liu J, Wu N Abstract Breast cancer is a major disease with high morbidity and mortality in women worldwide. Increased use of imaging biomarkers has been shown to add more information with clinical utility in the detection and evaluation of breast cancer....
Thu Sep 10, 2020 13:51
A Field Test of Major Value Frameworks in Chemotherapy of Nasopharyngeal Carcinoma-To Know, Then to Measure. Front Oncol. 2020;10:1076 Authors: Zhang Y, Liu X, Li YQ, Tang LL, Chen L, Ma J Abstract Background: The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) have independently developed their own frameworks to assess the benefits of different cancer treatment options, which have significant...
Thu Sep 10, 2020 13:51
CAR T Cell Therapy for Pediatric Brain Tumors. Front Oncol. 2020;10:1582 Authors: Patterson JD, Henson JC, Breese RO, Bielamowicz KJ, Rodriguez A Abstract Chimeric Antigen Receptor (CAR) T cell therapy has recently begun to be used for solid tumors such as glioblastoma multiforme. Many children with pediatric malignant brain tumors develop extensive long-term morbidity of intensive multimodal curative treatment. Others with certain diagnoses...
Thu Sep 10, 2020 13:51
Predictive Biomarkers of Response to Immunotherapy in Metastatic Renal Cell Cancer. Front Oncol. 2020;10:1644 Authors: Raimondi A, Sepe P, Zattarin E, Mennitto A, Stellato M, Claps M, Guadalupi V, Verzoni E, de Braud F, Procopio G Abstract Introduction: In the last decades, the therapeutic decision-making approach to metastatic renal cell cancer (mRCC) has dramatically changed thanks to the introduction in the treatment scenario of, first,...
Thu Sep 10, 2020 13:51
Safety and Efficacy of Convalescent Plasma to Treat Severe COVID-19: Protocol for the Saudi Collaborative Multi-center Phase II Study. JMIR Res Protoc. 2020 Sep 08;: Authors: Albalawi M, Zaidi SZA, AlShehry N, AlAskar A, Zaidi ARZ, Abdallah RNM, Salam A, AlMozain N, Elgohary G, AlSagheir A, Batarfi K, Alfaraedi A, Khojah O, Al-Ansari R, Radwi G, Alfaraj M, Dayel A, Al Bahrani A, Abdelhameed AN, Alhumaidan H, Al-Otaibi JM, Raizah A, Shatry H, Alsaleh S, AlZahrani...
Thu Sep 10, 2020 13:51
Bioethical considerations for cancer patients care during the COVID-19 pandemic. Future Oncol. 2020 Sep 09;: Authors: Kourie HR, Eid R, Haddad FG, Scheuer M, Tomb R PMID: 32903047 [PubMed - as supplied by publisher]
Thu Sep 10, 2020 13:51
Preventing smoking relapse in patients with cancer: A randomized controlled trial. Cancer. 2020 Sep 09;: Authors: Simmons VN, Sutton SK, Meltzer LR, Martinez U, Palmer AM, Meade CD, Jacobsen PB, McCaffrey JC, Haura EB, Brandon TH Abstract BACKGROUND: Abstaining from smoking after a cancer diagnosis is critical to mitigating the risk of multiple adverse health outcomes. Although many patients with cancer attempt to quit smoking, the majority...
Thu Sep 10, 2020 13:51
Varied functions of immune checkpoints during cancer metastasis. Cancer Immunol Immunother. 2020 Sep 09;: Authors: Safarzadeh A, Alizadeh M, Beyranvand F, Falavand Jozaaee R, Hajiasgharzadeh K, Baghbanzadeh A, Derakhshani A, Argentiero A, Baradaran B, Silvestris N Abstract Immune checkpoints comprise diverse receptors and ligands including costimulatory and inhibitory molecules, which play monumental roles in regulating the immune system. Immune...
Thu Sep 10, 2020 13:51
Phase III study of nivolumab alone or combined with ipilimumab as immunotherapy versus standard of care in resectable head and neck squamous cell carcinoma. Future Oncol. 2020 Sep 09;: Authors: Zech HB, Moeckelmann N, Boettcher A, Muenscher A, Binder M, Vettorazzi E, Bokemeyer C, Schafhausen P, Betz CS, Busch CJ Abstract Locally advanced head and neck squamous cell carcinoma (LA-HNSCC) often requires postoperative chemoradiation with high risk...
Thu Sep 10, 2020 13:51
Health economic impact of a biopsy-based cell cycle gene expression assay in localized prostate cancer. Future Oncol. 2020 Sep 09;: Authors: Gustavsen G, Taylor K, Cole D, Gullet L, Lewine N Abstract Background: Prior studies have established that broader incorporation of active surveillance, guided by additional prognostic tools, may mitigate the growing economic burden of localized prostate cancer in the USA. This study sought to further...
Thu Sep 10, 2020 13:51
Simultaneous integrated boost of intensity-modulated radiation therapy to Stage II-III non-small cell lung cancer with metastatic lymph nodes. Cancer Med. 2020 Sep 09;: Authors: Li QS, Liang N, Ouyang WW, Su SF, Ma Z, Geng YC, Yang WG, Hu YX, Li HQ, Lu B Abstract Local tumor failure remains a major problem after radiation-based nonsurgical treatment for unresectable locally advanced nonsmall cell lung cancer (NSCLC）and inoperable stage II NSCLC....
Thu Sep 10, 2020 13:51
High-Z metal-organic frameworks for X-ray radiation-based cancer theranostics. Chemistry. 2020 Sep 09;: Authors: Neufeld M, Lutzke A, Pratx G, Sun C Abstract X-ray radiation is commonly employed in clinical practice for diagnostic and therapeutic applications. Over the past decade, developments in nanotechnology have led to the use of high-Z elements as the basis for innovative new treatment platforms that enhance the clinical efficacy of X-ray...
Thu Sep 10, 2020 13:51
Targeting CDK9: A novel biomarker in the treatment of endometrial cancer. Oncol Rep. 2020 Sep 01;: Authors: He S, Fang X, Xia X, Hou T, Zhang T Abstract Endometrial cancer is one of the three major malignant tumors of the female reproductive system. Although cyclin‑dependent kinase 9 (CDK9) has a definitive pathogenic role in various types of cancer, little is known concerning its function in endometrial cancer. Our study was conducted to evaluate...
Thu Sep 10, 2020 13:51
Implementation of the three-dimensional printing technology in treatment of bone tumours: a case series. Int Orthop. 2020 Sep 08;: Authors: Jovičić MŠ, Vuletić F, Ribičić T, Šimunić S, Petrović T, Kolundžić R Abstract PURPOSE: With the ability to overcome specific anatomical and pathological challenges, 3D printing technology is setting itself as an important tool in patient-specific orthopaedics, delivering anatomical models, patient-specific...
Thu Sep 10, 2020 13:51
Characterization and registration of 3D ultrasound for use in permanent breast seed implant brachytherapy treatment planning. Brachytherapy. 2020 Sep 05;: Authors: Zhang C, Hilts M, Batchelar D, Orlando N, Gardi L, Fenster A, Crook J Abstract PURPOSE: Permanent breast seed implant (PBSI) brachytherapy is a novel technique for early-stage breast cancer. Computed tomography (CT) images are used for treatment planning and freehand 2D ultrasound...
Thu Sep 10, 2020 13:51
Preoperative nomogram predicting 12-year probability of metastatic renal cancer - evaluation in a contemporary cohort. Urol Oncol. 2020 Sep 05;: Authors: Mano R, Duzgol C, Ganat M, Goldman DA, Blum KA, Silagy AW, Walasek A, Sanchez A, DiNatale RG, Marcon J, Kashan M, Becerra MF, Benfante N, Coleman JA, Kattan MW, Russo P, Akin O, Ostrovnaya I, Hakimi AA Abstract OBJECTIVES: Preoperative models, based on patient and tumor characteristics, predict...
Thu Sep 10, 2020 13:51
Fluorescence imaging in pediatric surgery: State-of-the-art and future perspectives. J Pediatr Surg. 2020 Aug 15;: Authors: Paraboschi I, De Coppi P, Stoyanov D, Anderson J, Giuliani S Abstract BACKGROUND: The employment of fluorescence imaging has gained popularity in many fields of adult surgery where it has demonstrated great potentials to improve both surgical and oncological outcomes while minimizing anesthetic time and lowering health-care...
Thu Sep 10, 2020 13:51
Comparing mutation frequencies for homologous recombination genes in uterine serous and high-grade serous ovarian carcinomas: A case for homologous recombination deficiency testing in uterine serous carcinoma. Gynecol Oncol. 2020 Sep 05;: Authors: Wallbillich JJ, Morris RT, Ali-Fehmi R Abstract OBJECTIVE: To compare the frequencies of somatic homologous recombination (HR) gene mutations identified in next-generation sequencing (NGS) genomic...
Thu Sep 10, 2020 13:51
Immunotherapy in Small Cell Lung Cancer. Cancers (Basel). 2020 Sep 04;12(9): Authors: Esposito G, Palumbo G, Carillio G, Manzo A, Montanino A, Sforza V, Costanzo R, Sandomenico C, La Manna C, Martucci N, La Rocca A, De Luca G, Piccirillo MC, De Cecio R, Botti G, Totaro G, Muto P, Picone C, Normanno N, Morabito A Abstract Small-cell lung cancer (SCLC) is an aggressive tumor type with limited therapeutic options and poor prognosis. Chemotherapy...
Thu Sep 10, 2020 13:51
Definition and Independent Validation of a Proteomic-Classifier in Ovarian Cancer. Cancers (Basel). 2020 Sep 04;12(9): Authors: Kasimir-Bauer S, Roder J, Obermayr E, Mahner S, Vergote I, Loverix L, Braicu E, Sehouli J, Concin N, Kimmig R, Net L, Roder H, Zeillinger R, Aust S, On Behalf Of The Ovcad Ovarian Cancer Diagnosis Initiative Abstract Mass-spectrometry-based analyses have identified a variety of candidate protein biomarkers that might...
Thu Sep 10, 2020 13:51
Pre-Radiotherapy Progression after Surgery of Newly Diagnosed Glioblastoma: Corroboration of New Prognostic Variable. Diagnostics (Basel). 2020 Sep 05;10(9): Authors: Lakomy R, Kazda T, Selingerova I, Poprach A, Pospisil P, Belanova R, Fadrus P, Smrcka M, Vybihal V, Jancalek R, Kiss I, Muckova K, Hendrych M, Knight A, Sana J, Slampa P, Slaby O Abstract BACKGROUND: The aim of this retrospective study is to assess the incidence, localization,...
Thu Sep 10, 2020 13:51
RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling. Cancers (Basel). 2020 Sep 03;12(9): Authors: Scherer D, Dávila López MD, Goeppert B, Abrahamsson S, González Silos RG, Nova I, Marcelain K, Roa JC, Ibberson D, Umu SU, Rounge TB, Roessler S, Bermejo JL Abstract Cancer cell lines allow the identification of clinically relevant alterations and the prediction of drug response. However,...
Thu Sep 10, 2020 13:51
The Optimal Duration of Adjuvant Chemotherapy in Colon Cancer. Cancers (Basel). 2020 Sep 03;12(9): Authors: Collienne M, Arnold D Abstract Adjuvant chemotherapy for colon cancer (UICC stage II and III) has been under investigation over the last 30 years, regarding treatment duration and regimens. In this review, choice of regimen, its duration, possible limitations and future perspectives are discussed. Monotherapy with 5-fluorouracil was followed...
Thu Sep 10, 2020 13:51
Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials. Cancers (Basel). 2020 Sep 03;12(9): Authors: Marinelli D, Mazzotta M, Pizzuti L, Krasniqi E, Gamucci T, Natoli C, Grassadonia A, Tinari N, Tomao S, Sperduti I, Sanguineti G, Botticelli A, Fabbri A, Botti C, Ciliberto G, Barba M, Vici P Abstract Chemotherapy based on the sequential use of anthracyclines...
Thu Sep 10, 2020 13:51
Related Articles Shift Work, Chronotype, and Melatonin Rhythm in Nurses. Cancer Epidemiol Biomarkers Prev. 2019 07;28(7):1177-1186 Authors: Razavi P, Devore EE, Bajaj A, Lockley SW, Figueiro MG, Ricchiuti V, Gauderman WJ, Hankinson SE, Willett WC, Schernhammer ES Abstract BACKGROUND: Previous studies associated night-shift work with melatonin disruption, with mixed evidence regarding the modulating effects of chronotype (i.e., diurnal preference)....
Thu Sep 10, 2020 13:51
Related Articles Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs. Bioorg Med Chem Lett. 2019 07 01;29(13):1549-1554 Authors: Markowska A, Kaysiewicz J, Markowska J, Huczyński A Abstract Chemotherapy is one of the standard methods for the treatment of malignant tumors. It aims to cause lethal damage to cellular structures, mainly DNA. Noteworthy, in recent years discoveries of novel anticancer agents from well-known...
Thu Sep 10, 2020 13:51
Related Articles Proteolysis targeting chimeras (PROTACs) in 'beyond rule-of-five' chemical space: Recent progress and future challenges. Bioorg Med Chem Lett. 2019 07 01;29(13):1555-1564 Authors: Edmondson SD, Yang B, Fallan C Abstract Proteolysis targeting chimeras (PROTACs) are heterobifunctional compounds with molecular weights and other properties that lie outside the classic 'rule-of-five' space. Consequently, PROTACs have unique challenges...
Thu Sep 10, 2020 13:51
Combination of carbon-ion beam and dual tyrosine kinase inhibitor, lapatinib, effectively destroys HER2 positive breast cancer stem-like cells. Am J Cancer Res. 2020;10(8):2371-2386 Authors: Sai S, Kim EH, Vares G, Suzuki M, Yu D, Horimoto Y, Hayashi M Abstract To investigate whether carbon-ion beam alone, or in combination with lapatinib, has a beneficial effect in targeting HER2-positive breast cancer stem-like cells (CSCs) compared to that...
Thu Sep 10, 2020 13:50
Therapeutic Strategies for Human Epidermal Receptor-2 Positive Metastatic Breast Cancer: A Literature Review. Cureus. 2020 Aug 02;12(8):e9522 Authors: Sapna F, Athwal PSS, Kumar M, Randhawa S, Kahlon S Abstract Breast cancer is a frequently occurring malignancy in women. Immunologically, breast cancers can be classified into four subtypes depending on the types of receptors present and their expression profiles. These are estrogen positive,...
Thu Sep 10, 2020 13:50
Advances in the Treatment of Early-Stage HER2-Positive Breast Cancer. Clin Adv Hematol Oncol. 2020 Aug;18(8):482-492 Authors: Sharifi M, Wisinski KB Abstract The management of early-stage human epidermal growth factor receptor 2-positive (HER2+) breast cancer has evolved in recent years, with the current standard being to tailor the intensity of adjuvant treatment to individual risk. Risk-adapted approaches to systemic therapy have been facilitated...
Thu Sep 10, 2020 13:50
Tyrosine kinase inhibitor neratinib attenuates liver fibrosis by targeting activated hepatic stellate cells. Sci Rep. 2020 Sep 08;10(1):14756 Authors: Park YJ, An HT, Park JS, Park O, Duh AJ, Kim K, Chung KH, Lee KC, Oh Y, Lee S Abstract Liver fibrosis, a common outcome of chronic liver disease characterized by excessive accumulation of extracellular matrix (ECM), is a leading cause of mortality worldwide. The tyrosine kinase inhibitor neratinib...
Thu Sep 10, 2020 13:50
Frequency spectrum of rare and clinically relevant markers in multiethnic Indian populations (ClinIndb): A resource for genomic medicine in India. Hum Mutat. 2020 Sep 09;: Authors: Narang A, Uppilli B, Vivekanand A, Naushin S, Yadav A, Singhal K, Shamim U, Sharma P, Zahra S, Mathur A, Seth M, Parveen S, Vats A, Hillman S, Dolma P, Varma B, Jain V, TRISUTRA Ayurgenomics Consortium, Prasher B, Sengupta S, Mukerji M, Faruq M Abstract There have...
Thu Sep 10, 2020 13:48
Rare hypomorphic human variation in the heptahelical domain of SMO contributes to holoprosencephaly phenotypes. Hum Mutat. 2020 Sep 09;: Authors: Nagai-Tanima M, Hong S, Hu P, Carrington B, Sood R, Roessler E, Muenke M Abstract Holoprosencephaly (HPE) is the most common congenital anomaly affecting the forebrain and face in humans and occurs as frequently as 1:250 conceptions or 1:10,000 livebirths. Sonic hedgehog signaling molecule (SHH) is...
Thu Sep 10, 2020 13:48
ICPis -induced autoimmune polyendocrine syndrome type 2: a review of the literature and a protocol for optimal management. J Clin Endocrinol Metab. 2020 Sep 09;: Authors: Shi Y, Shen M, Zheng X, Chen Y, Zhao R, Gu Y, Yang T Abstract CONTEXT: Immune checkpoint inhibitors (ICPis) targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1) and its ligand (PD-L1) are now approved to treat a variety of cancers. However,...
Thu Sep 10, 2020 13:48
Vaginal cuff dehiscence following transvaginal oocyte retrieval: a case report. Fertil Res Pract. 2020;6:16 Authors: O'Connor SK, Ryley DA, Obasiolu CW, Esselen KM, Skiadas CC, Kuohung W Abstract Background: Vaginal cuff dehiscence (VCD) is a rare but potentially serious complication following hysterectomy with an estimated incidence of 0.14-1.4%. There is a wide range of risk factors thought to contribute to VCD, but due to its rare occurrence,...
Thu Sep 10, 2020 13:48
Multiple sclerosis, human herpesvirus 4 and thyroid collision tumor: A case report. Exp Ther Med. 2020 Oct;20(4):3458-3461 Authors: Sirbu AM, Sirbu CA, Eftimie L, Soare AM, Ghinescu MC, Ionita-Radu F Abstract The role of interferon β-1b (IFNβ-1b), used for multiple sclerosis (MS) therapy, in cancer occurrence is uncertain. There is evidence supporting the role of human herpesvirus 4 [Epstein-Barr virus (EBV)] in thyroid cancer and MS. Simultaneous...
Thu Sep 10, 2020 13:48
A Novel Mutation in MYH Gene Associated with Aggressive Colorectal Cancer in a Child: A Case Report and Review of Literature. Onco Targets Ther. 2020;13:8557-8565 Authors: Tian X, Wang Q, Cai W Abstract Colorectal cancer is a rare pediatric tumor. Pediatric patients with colorectal cancer present with more aggressive tumor biology and at later stages of the disease, higher proportions of signet ring and mucinous histology, and less differentiation....
Thu Sep 10, 2020 13:48
Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries. Cancer Manag Res. 2020;12:7569-7578 Authors: Yan F, Shi F, Li X, Yu C, Lin Y, Li Y, Jin M Abstract Objective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries. Methods: The primary origin of PMP was explored by reviewing H&E sections...
Thu Sep 10, 2020 13:48
Laparoscopic left hemicolectomy with regional lymph node navigation and intracorporeal anastomosis for splenic flexure colon cancer. Int Cancer Conf J. 2020 Oct;9(4):170-174 Authors: Itatani Y, Kawada K, Hida K, Deguchi Y, Oshima N, Mizuno R, Wada T, Okada T, Sakai Y Abstract Laparoscopic approaches have become a standard strategy for colon cancer patients who undergo surgical treatment. Complete mesocolic excision (CME) with central vascular...
Thu Sep 10, 2020 13:48
Sister Mary Joseph Nodule as an Initial Presentation of Pancreatic Adenocarcinoma. ACG Case Rep J. 2020 Aug;7(8):e00453 Authors: Vekariya P, Daneti DB, Senthamizh Selvan K, Verma SK, Hamide A, Mohan P Abstract Sister Mary Joseph (SMJ) nodule is a metastatic umbilical nodule seen in primary tumors of the gastrointestinal or genitourinary tract. The stomach and colon are the common gastrointestinal cancers associated with SMJ nodule. The pancreas...
Thu Sep 10, 2020 13:48
Survival Profile and Prognostic Factors for Appendiceal Mixed Neuroendocrine Non-neuroendocrine Neoplasms: A SEER Population-Based Study. Front Oncol. 2020;10:1660 Authors: Zheng M, Li T, Li Y, Zhang T, Zhang L, Ma W, Zhou L Abstract Introduction: Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare form of neuroendocrine neoplasms (NENs). The purpose of this study was to investigate the characteristics and survival profile of...
Thu Sep 10, 2020 13:48
CDK9 as a Valuable Target in Cancer: From Natural Compounds Inhibitors to Current Treatment in Pediatric Soft Tissue Sarcomas. Front Pharmacol. 2020;11:1230 Authors: Cassandri M, Fioravanti R, Pomella S, Valente S, Rotili D, Del Baldo G, De Angelis B, Rota R, Mai A Abstract Cyclin-Dependent Kinases (CDKs) are well-known reliable targets for cancer treatment being often deregulated. Among them, since the transcription-associated CDK9 represents...
Thu Sep 10, 2020 13:48
Evaluation of Risk Factors for Mortality in Febrile Neutropenia. J Infect Dev Ctries. 2020 Aug 31;14(8):886-892 Authors: Ceken S, Gedik H, Iskender G, Demirelli M, Mert D, Yapar Toros G, Yigenoglu TN, Altuntas F, Oksuzoglu B, Ertek M Abstract INTRODUCTION: We aimed to evaluate the epidemiology of infections and factors associated with mortality in patients with febrile neutropenia (FEN). METHODOLOGY: The adult patients, who developed...
Thu Sep 10, 2020 13:48
Expression and Clinical Implications of Leucine-Rich Repeat Containing 15 (LRRC15) in Osteosarcoma. J Orthop Res. 2020 Sep 09;: Authors: Cui J, Dean D, Wei R, Hornicek FJ, Ulmert D, Duan Z Abstract Leucine-rich repeat containing 15 (LRRC15) is a member of the leucine-rich repeat superfamily that is overexpressed in various cancers and associated with higher tumor grade and aggression. Despite its known tumorigenicity, its roles within osteosarcoma...
Thu Sep 10, 2020 13:48
Concurrent minimal change disease and retroperitoneal liposarcoma successfully treated by tumor resection and steroid therapy. CEN Case Rep. 2020 Sep 09;: Authors: Yasui Y, Shibata R, Morita N, Himuro N, Hamauchi A, Watanabe M, Ito K, Yasuno T, Abe Y, Miyake K, Yoshimura F, Hamsaki M, Hisano S, Masutani K, Nakashima H Abstract A 54-year-old Japanese woman developed simultaneous abdominal distension and bilateral leg edema. Her medical history...
Thu Sep 10, 2020 13:48
PI-RADS version 2.1 scoring system is superior in detecting transition zone prostate cancer: a diagnostic study. Abdom Radiol (NY). 2020 Sep 09;: Authors: Wang Z, Zhao W, Shen J, Jiang Z, Yang S, Tan S, Zhang Y Abstract PURPOSE: The studies comparing the versions 2 vs. 2.1 of the Prostate Imaging Reporting and Data System (PI-RADS) are rare. This study aimed to evaluate whether PI-RADS version 2.1 is superior in detecting transition zone prostate...
Thu Sep 10, 2020 13:48
Determination of the migration effect and molecular docking of verteporfin in different subtypes of breast cancer cells. Mol Med Rep. 2020 Sep 02;: Authors: Wei C, Li X Abstract Breast cancer is one of the most aggressive malignant tumors in women. According to the expression differences of estrogen receptor, progesterone receptor, human epidermal growth factor receptor‑2 (HER‑2) and cell proliferation antigen Ki‑67, breast cancer can be divided...
Thu Sep 10, 2020 13:48
A mixed-type intraductal papillary mucinous neoplasm of the pancreas with a histologic combination of gastric and pancreatobiliary subtypes in a 70-year-old woman: a case report. J Med Case Rep. 2020 Sep 09;14(1):146 Authors: Ismail S, Darwisho R, Ali M, Haidar M, Houreih MA, Alshehabi Z Abstract BACKGROUND: Intraductal papillary mucinous neoplasms are rare papillary pancreatic neoplasms arising from major pancreatic ducts, characterized by...
Thu Sep 10, 2020 13:48
Fibronectin and colorectal cancer: signaling pathways and clinical implications. J Recept Signal Transduct Res. 2020 Sep 09;:1-8 Authors: Wang J, Li R, Li M, Wang C Abstract Colorectal cancer (CRC) is the fourth leading cause of cancer deaths worldwide, with poor prognosis mainly related to metastasis. Fibronectin (FN), a vital component of the extracellular matrix (ECM), has been found involved in tumorigenesis and malignant progression in...
Thu Sep 10, 2020 13:48
Current Status and Perspectives of Patient-Derived Models for Ewing's Sarcoma. Cancers (Basel). 2020 Sep 04;12(9): Authors: Kondo T Abstract Patient-derived cancer models, including cell lines, organoids, and xenografts, are indispensable tools in cancer research. These models, which recapitulate molecular features of original tumors, allow studies on the biological significance of cancer-associated genes, antitumor effects of novel agents,...
Thu Sep 10, 2020 13:48
Evaluation of PD-L1 Expression and HPV Genotyping in Anal Squamous Cell Carcinoma. Cancers (Basel). 2020 Sep 04;12(9): Authors: Wessely A, Heppt MV, Kammerbauer C, Steeb T, Kirchner T, Flaig MJ, French LE, Berking C, Schmoeckel E, Reinholz M Abstract Anal squamous cell carcinoma (SCC) is a rare cancer with increasing incidence. Infection with high-risk human papillomavirus (HPV) subtypes is the major cause for its development. We retrospectively...
Thu Sep 10, 2020 13:48
Gallbladder neuroendocrine carcinoma: A single center experience. Medicine (Baltimore). 2020 Sep 04;99(36):e21912 Authors: Chu H, Zhang C, Shi Y, Wu W, Hu Z, Zhang J, Huang D Abstract Gallbladder neuroendocrine carcinoma (GB-NEC) is a group of rare and heterogeneous neoplasms and there are few reports at present.We analyzed the clinical and pathological features of 7 patients with GB-NEC who were admitted to Zhejiang Provincial People's Hospital...
Thu Sep 10, 2020 13:48
Related Articles Follicular dendritic cell sarcoma in the right chest wall: A case report. Medicine (Baltimore). 2020 Aug 28;99(35):e21935 Authors: Xu H, Chen B, Jiang C, Yang Z, Wang K Abstract RATIONALE: Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor that originates from germinal center follicular dendritic cells, and can occur at both nodal and extranodal sites. There are very few described cases of FDCS arising in the...
Thu Sep 10, 2020 13:48
Related Articles [Treatment and prognostic analysis of patients with primary esophageal small-cell carcinoma]. Zhonghua Zhong Liu Za Zhi. 2020 Aug 23;42(8):670-675 Authors: Xiayimaierdan Y, Song P, Gao SG Abstract Objective: The study aimed to analyze the clinicopathological features, treatment, and prognosis factors of primary esophageal small-cell carcinoma (PESC). Methods: The clinical records and follow-up data of 100 patients with PESC...
Thu Sep 10, 2020 13:48
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