Related Articles [Treatment and prognostic analysis of patients with primary esophageal small-cell carcinoma]. Zhonghua Zhong Liu Za Zhi. 2020 Aug 23;42(8):670-675 Authors: Xiayimaierdan Y, Song P, Gao SG Abstract Objective: The study aimed to analyze the clinicopathological features, treatment, and prognosis factors of primary esophageal small-cell carcinoma (PESC). Methods: The clinical records and follow-up data of 100 patients with PESC...
Thu Sep 10, 2020 13:48
Related Articles Subtyping of male breast cancer by PAM50 and immunohistochemistry: a pilot study of a consecutive Danish cohort. APMIS. 2020 Sep;128(9):523-530 Authors: Christensen LG, Lautrup MD, Lyng MB, Möller S, Jylling AMB Abstract Male breast cancer (MBC) is a rare disease that is still to be fully understood. In female breast cancer, molecular subtyping by gene expression has proven its significance. In this study, we characterize a...
Thu Sep 10, 2020 13:48
Related Articles Primary bone lymphoma of the thoracic vertebra in a patient with metastatic lung cancer. Clin Imaging. 2020 Aug;64:119-123 Authors: Li L, Liu G, Zhu L, Li T Abstract We present a rare case of primary diffuse large B-cell lymphoma of the thoracic vertebra in a patient with metastatic lung cancer. PMID: 32438255 [PubMed - indexed for MEDLINE]
Thu Sep 10, 2020 13:48
Related Articles Postoperative Hypoparathyroidism After Total Thyroidectomy in Children. J Surg Res. 2020 08;252:63-68 Authors: Zobel MJ, Long R, Gosnell J, Sosa JA, Padilla BE Abstract BACKGROUND: Postoperative hypocalcemia because of hypoparathyroidism is the most common complication of total thyroidectomy in children. We hypothesized that most children with postoperative hypocalcemia would be eucalcemic by 12 mo and sought to define risk...
Thu Sep 10, 2020 13:48
Related Articles Untreated plasmacytoma of bone containing macroscopic intralesional fat and mimicking intraosseous lipoma: A case report and review of the literature. Clin Imaging. 2020 Aug;64:18-23 Authors: Hansford BG, Hanrahan CJ, Girard N, Silbermann R, Morag Y Abstract Solitary plasmacytoma is a rare form of plasma cell neoplasm defined by local neoplastic accumulation of monoclonal plasma cells in the absence of systemic proliferative...
Thu Sep 10, 2020 13:48
Related Articles Papillary thyroid carcinoma metastasis to a branchial cleft cyst: a case report and review of imaging. Clin Imaging. 2020 Aug;64:1-6 Authors: Cooc A, Chong I, Wang KY, Jiang K, Lincoln CM Abstract Branchial cleft cysts are the most common lesions in the lateral neck with ectopic thyroid tissue found only rarely within these cysts. Over the years, multiple cases of papillary thyroid carcinoma arising from these ectopic thyroid...
Thu Sep 10, 2020 13:48
Related Articles Colorectal cancer with indeterminate pulmonary nodules. Neoplasma. 2020 May;67(3):439-449 Authors: Jiang ZK, Xie YK, Huang JQ, Chen JS Abstract Colorectal cancer (CRC) is one of the most common malignancies with a dismal prognosis. Indeterminate pulmonary nodules (IPNs) are lung nodules with uncertain nature, generally defined as a noncalcified nodule smaller than 10 mm in diameter or solid nodule no greater than 20 mm at maximum...
Thu Sep 10, 2020 13:48
Related Articles Blastic plasmacytoid dendritic cell neoplasm: First retrospective study in the Czech Republic. Neoplasma. 2020 May;67(3):650-659 Authors: Cernan M, Szotkowski T, Hisemova M, Cetkovsky P, Sramkova L, Stary J, Racil Z, Mayer J, Sramek J, Jindra P, Visek B, Zak P, Novak J, Kozak T, Furst T, Papajik T Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with aggressive behavior and poor...
Thu Sep 10, 2020 13:48
Related Articles Gliosarcomas: magnetic resonance imaging findings. Arq Neuropsiquiatr. 2020 02;78(2):112-120 Authors: Fukuda A, Queiroz LS, Reis F Abstract BACKGROUND: Central nervous system (CNS) gliosarcoma (GSM) is a rare primary neoplasm characterized by the presence of glial and sarcomatous components. OBJECTIVE: In this report, we describe the clinical and neuroimaging aspects of three cases of GSM and correlate these aspects...
Thu Sep 10, 2020 13:48
Related Articles Neurologic Immune-Related Adverse Events Associated with Immune Checkpoint Inhibition. Curr Oncol Rep. 2019 11 27;21(12):108 Authors: Pan PC, Haggiagi A Abstract PURPOSE OF REVIEW: This review highlights the spectrum of neurologic adverse events seen with use of immune checkpoint inhibitors (ICIs), their potential mechanisms, the treatments undertaken, and the clinical outcomes. RECENT FINDINGS: The advent of ICIs...
Thu Sep 10, 2020 13:48
Related Articles Management of retropharyngeal lymph node metastasis in oral cancer. Oral Oncol. 2019 12;99:104471 Authors: Oikawa Y, Michi Y, Tsushima F, Tomioka H, Mochizuki Y, Kugimoto T, Osako T, Nojima H, Yokokawa M, Kashima Y, Harada H Abstract OBJECTIVES: Retropharyngeal lymph node (RPLN) metastasis is extremely rare, and prognosis is significantly poor in oral cancer. We retrospectively examined the management of RPLN metastases in...
Thu Sep 10, 2020 13:48
Related Articles NF2-Related Intravestibular Schwannomas: Long-Term Outcomes of Cochlear Implantation. Otol Neurotol. 2020 01;41(1):94-99 Authors: Jia H, Nguyen Y, Hochet B, Smail M, Mosnier I, Wu H, Sterkers O, Kalamarides M, Bernardeschi D Abstract OBJECTIVE: Intravestibular schwannomas (IVS) are uncommon tumors in Neurofibromatosis type 2 (NF2) and are mainly associated with multiple internal auditory meatus (IAM) and cerebellopontine angle...
Thu Sep 10, 2020 13:48
Related Articles Complete response with neoadjuvant avelumab in Merkel cell carcinoma - A case report. Oral Oncol. 2019 12;99:104350 Authors: Abdallah N, Nagasaka M, Chowdhury T, Raval K, Hotaling J, Sukari A Abstract Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin malignancy. We report here a case of localized MCC achieving pathologic complete response upon treatment with avelumab in the neoadjuvant setting. Preclinical...
Thu Sep 10, 2020 13:48
Related Articles Medication related osteonecrosis of jaw in a leukemia patient undergoing systemic arsenic trioxide therapy: A rare case report. Oral Oncol. 2019 12;99:104343 Authors: Kumar M, Vineetha R, Kudva A Abstract Osteonecrosis of the jaw is a potential side effect of certain pharmaceutical agents used in the field of medicine. Early diagnosis and effective management of this condition can be challenging to the clinicians. Bisphosphonates...
Thu Sep 10, 2020 13:48
Related Articles CD19 negative and dim precursor B-lineage acute lymphoblastic leukemias: real-world challenges in a targeted-immunotherapy era. Leuk Lymphoma. 2019 12;60(13):3154-3160 Authors: Bommannan BKK, Arumugam JR, Sundersingh S, Rajan PT, Radhakrishnan V, Sagar TG Abstract Flow cytometric diagnosis and minimal residual disease (MRD) assessment of precursor B-lineage acute lymphoblastic leukemia (B-ALL) are heavily dependent on CD19...
Thu Sep 10, 2020 13:48
Related Articles Recent advances in the systemic treatment of metastatic non-clear cell renal cell carcinomas. Int J Urol. 2019 09;26(9):868-877 Authors: Ito K Abstract There is still no standard treatment for non-clear cell renal cell carcinomas. Sunitinib is the most examined drug because of its effectiveness in retrospective studies and clinical trials, and is the preferred first-line drug in the National Comprehensive Cancer Network guideline....
Thu Sep 10, 2020 13:48
Related Articles Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 Study. Cancer Epidemiol Biomarkers Prev. 2019 07;28(7):1238-1245 Authors: Chen F, Childs EJ, Mocci E, Bracci P, Gallinger S, Li D, Neale RE, Olson SH, Scelo G, Bamlet WR, Blackford AL, Borges M, Brennan P, Chaffee KG, Duggal P, Hassan MJ, Holly EA, Hung RJ, Goggins MG, Kurtz RC, Oberg AL, Orlow I, Yu H, Petersen GM, Risch HA, Klein AP Abstract ...
Thu Sep 10, 2020 13:48
Related Articles Gelatinous bone marrow transformation and emergence of clonal Philadelphia-negative cytogenetic abnormalities with excess blasts in a patient with chronic myeloid leukemia treated with dasatinib. Anticancer Drugs. 2019 04;30(4):416-421 Authors: Hermel DJ, Nael A, Lu YT, Kim J, Brynes RK, Vergara-Lluri M, Akhtari M Abstract Gelatinous bone marrow transformation (GBMT) is a rare pathologic entity of unclear etiology characterized...
Thu Sep 10, 2020 13:48
Related Articles Proton therapy for skull base tumors: A review of clinical outcomes for chordomas and chondrosarcomas. Head Neck. 2019 02;41(2):536-541 Authors: Mercado CE, Holtzman AL, Rotondo R, Rutenberg MS, Mendenhall WM Abstract BACKGROUND: Skull base chordomas and chondrosarcomas are rare tumors traditionally treated by surgical resection and adjuvant radiation therapy (RT). We will discuss data evaluating clinical outcomes of proton...
Thu Sep 10, 2020 13:48
Related Articles Adult type rhabdomyoma presenting as a parathyroid adenoma. Head Neck. 2019 02;41(2):E30-E33 Authors: Lee JP, Blake Sullivan C, Bayon R, Shearer AE, Robinson RA Abstract BACKGROUND: Adult-type rhabdomyoma (ATR) is a rare mesenchymal tumor of skeletal muscle differentiation. Extracardiac ATR occurs most commonly in the head and neck, but do so in a heterogeneous fashion, arising at numerous different locations within this region....
Thu Sep 10, 2020 13:48
Predicting complications of pediatric temporal bone fractures. Int J Pediatr Otorhinolaryngol. 2020 Sep 01;138:110358 Authors: Dedhia RD, Chin OY, Kaufman M, Hsieh TY, Diaz RC, Brodie HA, Funamura JL Abstract OBJECTIVE: Our aim is to characterize complications of pediatric temporal bone fractures and identify predictive risk factors associated with fracture complications. METHODS: A retrospective review was conducted of all temporal...
Thu Sep 10, 2020 13:46
Spontaneous cerebrospinal fluid otorrhea and pneumocephalus on the contralateral side of the previous cranial surgery. Surg Neurol Int. 2020;11:245 Authors: Ohara K, Terao T, Michishita S, Sato K, Sasaki Y, Murayama Y Abstract Background: Cerebrospinal fluid (CSF) leaks and pneumocephalus commonly occur due to head trauma or surgical procedures. Spontaneous CSF (sCSF) leaks, however, occur without any clear etiology and are relatively uncommon....
Thu Sep 10, 2020 13:46
Frontotemporal brain sagging syndrome: Craniospinal hypovolemia secondary to a T6-T7 cerebrospinal fluid-venous fistula. Surg Neurol Int. 2020;11:250 Authors: Ortega-Porcayo LA, Ortega EP, Quiroz-Castro O, Carrillo-Meza RA, Ponce-Gomez JA, Romano-Feinholz S, Alcocer-Barradas V, de Velasco AR, Zazueta MO Abstract Background: The frontotemporal brain sagging syndrome (FTBSS) is defined as an insidious/progressive decline in behavior and executive...
Thu Sep 10, 2020 13:46
Intrathecal Access Through Suboccipital Port in Patients With Spinal Muscular Atrophy and Complex Spines: Case Series and Technical Note. Cureus. 2020 Aug 02;12(8):e9525 Authors: Tran DK, Shah V, Muhonen MG Abstract Introduction Many patients with the spinal muscular atrophy (SMA) have complex spinal anatomy, secondary to thoraco-lumbar spinal fusions. Their fragile musculoskeletal anatomy potentiates limb and joint injury if conventional spinal...
Thu Sep 10, 2020 13:46
Endoscopic endonasal transpterygoid approach for reduction of a lateral recess encephalocele with postoperative cerebrospinal fluid leak. BMJ Case Rep. 2020 Sep 07;13(9): Authors: Khalafallah AM, Ahmed OG, Rowan NR, Mukherjee D PMID: 32900733 [PubMed - in process]
Thu Sep 10, 2020 13:46
Related Articles Lateral Decubitus Digital Subtraction Myelography: Tips, Tricks, and Pitfalls. AJNR Am J Neuroradiol. 2020 01;41(1):21-28 Authors: Kim DK, Brinjikji W, Morris PP, Diehn FE, Lehman VT, Liebo GB, Morris JM, Verdoorn JT, Cutsforth-Gregory JK, Farb RI, Benson JC, Carr CM Abstract Digital subtraction myelography is a valuable diagnostic technique to detect the exact location of CSF leaks in the spine to facilitate appropriate diagnosis...
Thu Sep 10, 2020 13:46
Related Articles Coverage of visible intercostal and lumbar segmental arteries can predict the volume of cerebrospinal fluid drainage in elective endovascular repair of descending thoracic and thoracoabdominal aortic disease: a pilot study. Eur J Cardiothorac Surg. 2019 Apr 01;55(4):646-652 Authors: D'Oria M, Chiarandini S, Pipitone M, Calvagna C, Ziani B Abstract OBJECTIVES: Our goal was to identify anatomical and physiological factors that...
Thu Sep 10, 2020 13:46
Correlations between long-term quality of life and patient needs and concerns following head and neck cancer treatment and the impact of psychological distress. A multicentric cross-sectional study. Eur Arch Otorhinolaryngol. 2020 Sep 08;: Authors: Elaldi R, Roussel LM, Gal J, Scheller B, Chamorey E, Schiappa R, Lasne-Cardon A, Louis MY, Culié D, Dassonville O, Poissonnet G, Saada E, Benezery K, Babin E, Bozec A Abstract OBJECTIVES: To assess...
Thu Sep 10, 2020 13:45
Association between the 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene and sudden sensorineural hearing loss in Caucasian population: a meta-analysis. Eur Arch Otorhinolaryngol. 2020 Sep 08;: Authors: Wei Z, Chang K, Fan C Abstract PURPOSE: To clarify the association between the 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) and sudden sensorineural hearing loss (SSNHL). METHODS: A systematic...
Thu Sep 10, 2020 13:45
Auditory dysfunction in type 2 Stickler Syndrome. Eur Arch Otorhinolaryngol. 2020 Sep 08;: Authors: Alexander P, Gomersall P, Stancel-Lewis J, Fincham GS, Poulson A, Richards A, McNinch A, Baguley DM, Snead M Abstract PURPOSE: To present the extent and site of lesion of auditory dysfunction in a large cohort of individuals with type 2 Stickler Syndrome. Type 2 Stickler Syndrome results from a mutation in the gene coding for α-1 type XI pro-collagen,...
Thu Sep 10, 2020 13:45
Publication date: Available online 10 September 2020Source: Journal of Surgical EducationAuthor(s): Azeem Tariq Malik, Jeffery Kim, Uzair Ahmed, Elizabeth Yu, Safdar N. Khan
Thu Sep 10, 2020 13:44
Combined expression levels of KDM2A and KDM2B correlate with nucleolar size and prognosis in primary breast carcinomas. Histol Histopathol. 2020 Sep 09;:18248 Authors: De Nicola I, Guerrieri AN, Penzo M, Ceccarelli C, De Leo A, Trerè D, Montanaro L Abstract Ribosome biogenesis is a fine-tuned cellular process and its deregulation is linked to cancer progression: tumors characterized by an intense ribosome biogenesis often display a more aggressive...
Thu Sep 10, 2020 13:39
Intragastric balloon insertion and pancreatitis: Case series. Int J Surg Case Rep. 2020 Aug 29;74:263-267 Authors: Alqabandi O, Almutawa Y, AlTarrah D, Alhajeri M, Jamal MH, Almazeedi S Abstract INTRODUCTION: Obesity is a complex multifactorial disease that affects populations worldwide. In Kuwait, the prevalence of obesity is a major public health problem. Intra-Gastric Balloon (IGB) is commonly used as a non-operative strategy among bariatric...
Thu Sep 10, 2020 13:39
Pigmented villonodular synovitis associated with developmental dysplasia of the hip: A case report. Int J Surg Case Rep. 2020 Aug 11;74:260-262 Authors: Asaad SK, Salih KM, Kakamad FH, Salih AM, Mohammed SH Abstract INTRODUCTION: Pigmented villonodular synovitis (PVNS) of the hip joint associated with developmental dysplasia of the hip joint (DDH) is an extremely rare co-presentation. The aim of this study is to report a case of PVNS associated...
Thu Sep 10, 2020 13:39
Conversion from mini bypass to laparoscopic Roux en Y gastric bypass in an emergency setting: Case report and literature review. Int J Surg Case Rep. 2020;75:32-36 Authors: Perez Galaz F, Moedano Rico K, Lopez-Acosta ME, Raffoul Cohen I, Cervantes Gutierrez O, Cuevas Bustos R, Perez Tristan FA, Jafif Cojab M Abstract Introduction: It has been demonstrated that certain technique endpoints are key to the success for the OAGB and RYGB procedures...
Thu Sep 10, 2020 13:39
Internet-Administered Cognitive Behavioral Therapy for Hypersexual Disorder, With or Without Paraphilia(s) or Paraphilic Disorder(s) in Men: A Pilot Study. J Sex Med. 2020 Sep 05;: Authors: Hallberg J, Kaldo V, Arver S, Dhejne C, Piwowar M, Jokinen J, Öberg KG Abstract BACKGROUND: Hypersexual disorder (HD) is a condition in which the individual experiences loss of control over engagement in sexual behaviors, leading to negative effects on various...
Thu Sep 10, 2020 13:38
A blubber gene expression index for evaluating stress in marine mammals. Conserv Physiol. 2020;8(1):coaa082 Authors: Pujade Busqueta L, Crocker DE, Champagne CD, McCormley MC, Deyarmin JS, Houser DS, Khudyakov JI Abstract Evaluating the impacts of anthropogenic disturbance on free-ranging marine mammal populations, many of which are in decline, requires robust diagnostic markers of physiological stress and health. However, circulating levels...
Thu Sep 10, 2020 13:35
Seasonal variation in thermal tolerance of redside dace Clinostomus elongatus. Conserv Physiol. 2020;8(1):coaa081 Authors: Leclair ATA, Drake DAR, Pratt TC, Mandrak NE Abstract Organisms living in environments with oscillating temperatures may rely on plastic traits to sustain thermal tolerance during high temperature periods. Phenotypic plasticity in critical thermal maximum (CTmax) is a powerful thermoregulative strategy that enables organisms...
Thu Sep 10, 2020 13:35
Differing Progression to Posterior Glottic Stenosis in Autoimmune and Idiopathic Subglottic Stenosis
Objectives/Hypothesis We sought to characterize rates of progression to posterior glottic stenosis (PGS) from autoimmune or idiopathic subglottic stenosis. Study Design This was a retrospective review. Methods Patients from a tertiary‐care laryngology practice over a 10‐year period with autoimmune or idiopathic subglottic stenosis (SGS) were included. Patients with a history of prolonged intubation or other causes of iatrogenic stenosis were excluded. PGS was confirmed on videostrobolaryngoscopy...
Wed Sep 09, 2020 17:18
Objective/Hypothesis The objective of this study was to investigate the glottic gap area as a significant marker for the severity of presbyphonia as it relates to patient‐reported outcome measures (Voice Handicap Index‐10 [VHI‐10]) and stroboscopic findings. Study Design Retrospective case‐control study conducted in an academic tertiary voice center. Methods Patients seen at a tertiary voice clinic who were diagnosed with presbyphonia without other organic laryngeal pathology from January...
Wed Sep 09, 2020 17:09
Wed Sep 09, 2020 17:04
Objectives Serial intralesional steroid injection (SILSI) is an emerging treatment for idiopathic subglottic stenosis (ISGS), providing improvement in both subjective symptoms and objective airflow parameters. Little is known about how this airway remodeling affects the voice. This project analyzes subjective voice changes after SILSI and correlates these with airflow parameters. Methods An ISGS database containing voice‐related quality of life (V‐RQOL) and spirometry (peak expiratory flow...
Wed Sep 09, 2020 16:53
Objective Our objective was to gather data that would enable us to suggest more specific guidelines for the management of children with airway disruption. Study Design Retrospective case series with data from five tertiary medical centers. Methods Children younger than 18 years of age with a disrupted airway were enrolled in this series. Data pertaining to age, sex, etiology and location of the disruption, type of injury, previous surgery, presence of air extravasation, management, and...
Wed Sep 09, 2020 16:26
Objectives Outcomes in laryngology focus primarily on patient reported outcome measures (PROMs). The increasing number of questionnaires may lead to survey fatigue. We sought to determine the relationship between the newest questionnaire, Laryngopharyngeal Universal Measure of Perceived Sensation (LUMP), and other laryngology PROMs. Study Design Cross‐sectional study. Methods Patients undergoing laryngology multidisciplinary evaluation prospectively completed laryngology questionnaires....
Wed Sep 09, 2020 14:39
Berberine: a Promising Natural Isoquinoline Alkaloid for Development of Hypolipidemic Drug. Curr Top Med Chem. 2020 Sep 08;: Authors: Li DD, Yu P, Xiao W, Wang ZZ, Zhao LG Abstract Berberine as a representative of isoquinoline alkaloid, exhibits significant hypolipidemic activity both in animal model and clinic trials. Recently, a large number of studies on the lipid-lowering mechanism of berberine, and researches for improving its hypolipidemic...
Thu Sep 10, 2020 13:27
Efficiency of Homology Modeling assisted Molecular Docking in G-protein coupled receptors. Curr Top Med Chem. 2020 Sep 08;: Authors: Bhunia SS, Saxena AK Abstract BACKGROUND: Molecular docking is in regular practice to assess ligand affinity on a target protein crystal structure. In absence of protein crystal structure, the homology modeling or comparative modeling is the best alternative to elucidate the relationship details between a ligand...
Thu Sep 10, 2020 13:27
Indole alkaloids, synthetic dimers and hybrids with potential in vivo anticancer activity. Curr Top Med Chem. 2020 Sep 08;: Authors: Song F, Bian Y, Liu J, Li Z, Zhao L, Fang J, Lai Y, Zhou M Abstract Indole, a heterocyclic organic compound, is one of the most promising heterocycles found in natural and synthetic sources since its derivatives possess fascinating structural diversity and various therapeutic properties. Indole alkaloids, synthetic...
Thu Sep 10, 2020 13:27
Publication date: Available online 10 September 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Richard P. Ramonell, F. Eun-Hyung Lee, Joshua M. Levy, Merin Kuruvilla
Thu Sep 10, 2020 13:26
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Nanhe Lin, Xin Song, Bin Chen, Hao Ye, Youlin Wang, Xi Cheng, Hongxiang Wang
Thu Sep 10, 2020 13:26
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Grasiela Costa Bezerra Barros, Laércia K.D. Paiva Ferreira, Larissa A.M.P. Ferreira, Talissa Mozzini Monteiro, Adriano Francisco Alves, Ramon de Alencar Pereira, Marcia Regina Piuvezam
Thu Sep 10, 2020 13:26
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Luana Heimfarth, Mairim Russo Serafini, Paulo Ricardo Martins-Filho, Jullyana de Souza Siqueira Quintans, Lucindo José Quintans-Júnior
Thu Sep 10, 2020 13:26
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Aliye Bastug, Hurrem Bodur, Serpil Erdogan, Derya Gokcinar, Sumeyye Kazancioglu, Behiye Deniz Kosovali, Bahadır Orkun Ozbay, Gamze Gok, Isil Ozkocak Turan, Gulsen Yilmaz, Canan Cam Gonen, Fatma Meric Yilmaz
Thu Sep 10, 2020 13:26
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Panpan Liu, Yurun Xue, Bin Zheng, Yingran Liang, Jianping Zhang, Jing Shi, Xi Chu, Xue Han, Li Chu
Thu Sep 10, 2020 13:26
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Zhihui Kuang, Jinwu Bai, Licheng Ni, Kai Hang, Jianxiang Xu, Li Ying, Deting Xue, Zhijun Pan
Thu Sep 10, 2020 13:26
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Yun Peng, Yuxuan Song, Jin Ding, Nan Li, Zheyu Zhang, Haitao Wang
Thu Sep 10, 2020 13:26
Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy. iScience. 2020 Aug 20;23(9):101474 Authors: Singh V, Bhoir S, Chikhale RV, Hussain J, Dwyer D, Bryce RA, Kirubakaran S, De Benedetti A Abstract Through in vitro kinase assays and docking studies, we report the synthesis and biological evaluation of a phenothiazine analog J54 with potent TLK1 inhibitory activity for prostate cancer (PCa) therapy. Most...
Thu Sep 10, 2020 13:25
Hispidulin: A promising flavonoid with diverse anti-cancer properties. Life Sci. 2020 Sep 06;:118395 Authors: Liu K, Zhao F, Yan J, Xia Z, Jiang D, Ma P Abstract In recent years, natural products have increasingly attracted more attention because of their potential anticancer activity and low intrinsic toxicity. Hispidulin is a natural flavonoid with a wide range of biological activities, including anti-inflammatory, antifungal, antiplatelet,...
Thu Sep 10, 2020 13:25
Protective Effect of Thymidine on DNA Damage Induced by Hydrogen Peroxide in Human Hepatocellular Cancer Cells. ACS Omega. 2020 Sep 01;5(34):21796-21804 Authors: Li Y, Guo J, Zhang H, Lam CWK, Luo W, Zhou H, Zhang W Abstract Intracellular ribonucleotide (RN) and deoxyribonucleotide (dRN) pool sizes are critical for the fidelity of DNA synthesis. They are likely to be severely perturbed by many factors which disrupt the integrity and stability...
Thu Sep 10, 2020 13:25
Vorinostat-loaded titanium oxide nanoparticles (anatase) induce G2/M cell cycle arrest in breast cancer cells via PALB2 upregulation. 3 Biotech. 2020 Sep;10(9):407 Authors: Abdel-Ghany S, Raslan S, Tombuloglu H, Shamseddin A, Cevik E, Said OA, Madyan EF, Senel M, Bozkurt A, Rehman S, Sabit H Abstract Breast cancer is a group of diseases in which cells divide out of controlled, typically resulting in a mass. Erlotinib is targeted cancer...
Thu Sep 10, 2020 13:25
Sirtuin inhibition and anti-cancer activities of ethyl 2-benzimidazole-5-carboxylate derivatives. Medchemcomm. 2019 Dec 01;10(12):2140-2145 Authors: Yeong KY, Nor Azizi MIH, Berdigaliyev N, Chen WN, Lee WL, Shirazi AN, Parang K Abstract New benzimidazoles were synthesized based on the previously identified sirtuin inhibitor BZD9L1. The compounds were screened for their sirtuin (SIRT1, SIRT2 and SIRT3) inhibitory activities. Compound BZD9Q1...
Thu Sep 10, 2020 13:25
Intravenous Immunoglobulin G Suppresses Heat Shock Protein (HSP)-70 Expression and Enhances the Activity of HSP90 and Proteasome Inhibitors. Front Immunol. 2020;11:1816 Authors: Jones RJ, Singh RK, Shirazi F, Wan J, Wang H, Wang X, Ha MJ, Baljevic M, Kuiatse I, Davis RE, Orlowski RZ Abstract Intravenous immunoglobulin G (IVIgG) is approved for primary immunodeficiency syndromes but may induce anti-cancer effects, and while this has been...
Thu Sep 10, 2020 13:25
DDX39 Overexpression Predicts a Poor Prognosis and Promotes Aggressiveness of Melanoma by Cooperating With SNAIL. Front Oncol. 2020;10:1261 Authors: Xing C, Tian H, Zhang Y, Guo K, Tang Y, Wang Q, Lv L, Wang L Abstract This study aimed to investigate the prognostic value and molecular mechanism of DDX39 and its effector SNAIL in melanoma. First, overexpression of DDX39 in melanoma, which was identified by database analysis, was further...
Thu Sep 10, 2020 13:25
Thymoquinone inhibits the proliferation and invasion of esophageal cancer cells by disrupting the AKT/GSK-3β/Wnt signaling pathway via PTEN upregulation. Phytother Res. 2020 Sep 09;: Authors: Ma J, Zhang Y, Deng H, Liu Y, Lei X, He P, Dong W Abstract Although thymoquinone (TQ) has been reported to exert antitumor activity against various types of human cancers without evident toxicity, limited studies have reported the effects of TQ on...
Thu Sep 10, 2020 13:25
FoxM1 Regulates Proliferation and Apoptosis of Human Neuroblastoma Cell through PI3K/AKT Pathway. Fetal Pediatr Pathol. 2020 Sep 09;:1-16 Authors: Liao J, Jiang L, Wang C, Zhao D, He W, Zhou K, Liang Y Abstract AIM: This study investigated the effect of FoxM1 on the biological behavior of neuroblastoma (NB) cells in vitro and the association between FoxM1 and PI3K/AKT pathways in NB cell lines. Materials and methods: Recombinant plasmid...
Thu Sep 10, 2020 13:25
Aflatoxin B1 Induces Neurotoxicity through Reactive Oxygen Species Generation, DNA Damage, Apoptosis, and S-Phase Cell Cycle Arrest. Int J Mol Sci. 2020 Sep 06;21(18): Authors: Huang B, Chen Q, Wang L, Gao X, Zhu W, Mu P, Deng Y Abstract Aflatoxin B1 (AFB1) is a mycotoxin widely distributed in a variety of food commodities and exhibits strong toxicity toward multiple tissues and organs. However, little is known about its neurotoxicity...
Thu Sep 10, 2020 13:25
Carnosine Impedes PDGF-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells In Vitro and Sprout Outgrowth Ex Vivo. Nutrients. 2020 Sep 03;12(9): Authors: Hwang B, Song JH, Park SL, Kim JT, Kim WJ, Moon SK Abstract Carnosine, a naturally producing dipeptide, exhibits various beneficial effects. However, the possible role of carnosine in vascular disorders associated with pathological conditions, including proliferation...
Thu Sep 10, 2020 13:25
PI3K p110α Blockade Enhances Anti-Tumor Efficacy of Abemaciclib in Human Colorectal Cancer Cells. Cancers (Basel). 2020 Sep 03;12(9): Authors: Lee HJ, Kim KJ, Sung JH, Nam M, Suh KJ, Kim JW, Kim SH, Kim JW, Kim YJ, Lee KW, Lee JS, Kim JH Abstract Targeting cell cycle regulation in colorectal cancer has not been fully evaluated. We investigated the efficacy of the CDK4/6 inhibitor, abemaciclib, and confirmed a synergistic interaction for...
Thu Sep 10, 2020 13:25
In Silico, In Vitro, and In Vivo Antitumor and Anti-Inflammatory Evaluation of a Standardized Alkaloid-Enriched Fraction Obtained from Boehmeria caudata Sw. Aerial Parts. Molecules. 2020 Sep 03;25(17): Authors: Paiva PP, Nunes JHB, Nonato FR, Ruiz ALTG, Zafred RRT, Sousa IMO, Okubo MY, Kawano DF, Monteiro PA, Foglio MA, Carvalho JE Abstract In the context of the cancer-inflammation relationship and the use of natural products as potential...
Thu Sep 10, 2020 13:25
Related Articles Cobalamin Deficiency: Effect on Homeostasis of Cultured Human Astrocytes. Cells. 2019 11 24;8(12): Authors: Rzepka Z, Rok J, Respondek M, Pawlik J, Beberok A, Gryko D, Wrześniok D Abstract Cobalamin deficiency is an important health problem. The major non-hematological symptoms of hypocobalaminemia are nervous system disorders, but the molecular and cellular mechanisms underlying this phenomenon have not yet been fully explained....
Thu Sep 10, 2020 13:25
Related Articles The Evolution of Melanoma - Moving beyond Binary Models of Genetic Progression. J Invest Dermatol. 2020 02;140(2):291-297 Authors: Zeng H, Judson-Torres RL, Shain AH Abstract To date, over 1000 melanocytic neoplasms, spanning all stages of tumorigenesis, have been sequenced, offering detailed views into their -omic landscapes. This has coincided with advances in genetic engineering technologies that allow molecular biologists...
Thu Sep 10, 2020 13:25
Related Articles Asymmetric Centromeres Differentially Coordinate with Mitotic Machinery to Ensure Biased Sister Chromatid Segregation in Germline Stem Cells. Cell Stem Cell. 2019 11 07;25(5):666-681.e5 Authors: Ranjan R, Snedeker J, Chen X Abstract Many stem cells utilize asymmetric cell division (ACD) to produce a self-renewed stem cell and a differentiating daughter cell. How non-genic information could be inherited differentially to establish...
Thu Sep 10, 2020 13:25
To the Editor: The incidence of prostate cancer and its associated mortality vary widely according to race or ethnic background. This association is probably due to the interplay of socioeconomic factors, environmental exposures, and biologic and epigenetic phenomena. Nevertheless, precision…
Thu Sep 10, 2020 03:00
Innate immunity is mediated by different cell types and cell-associated or fluid-phase pattern-recognition molecules and plays a key role in tissue repair and resistance against pathogens. Exposure to selected vaccines, such as bacille Calmette–Guérin (BCG) or microbial components, can increase the…
Thu Sep 10, 2020 03:00
To the Editor: Tumor-induced osteomalacia is a rare paraneoplastic syndrome caused by excessive secretion of fibroblast growth factor 23 (FGF23) by a phosphaturic mesenchymal tumor. Through fibroblast growth factor receptor 1 (FGFR1) signaling, FGF23 decreases renal phosphate reabsorption and…
Wed Sep 09, 2020 03:00
Key points Brachial artery (BA) shear‐mediated dilation is a widely used assessment of vascular function with links to coronary artery health and cardiovascular risk. Cerebral vascular health is often interrogated using cerebrovascular (middle cerebral artery velocity) reactivity to carbon dioxide. We show that endothelium‐dependent diameter (dilator) responses are not significantly related between the internal carotid artery (ICA) and BA; nor are endothelium‐independent responses. Additionally,...
Wed Sep 09, 2020 14:44
Publication date: Available online 9 September 2020Source: CortexAuthor(s): Joana Lourenço, Fani Koukouli, Alberto Bacci
Thu Sep 10, 2020 13:16
Abstract Background Filler injections are widely used for facial rejuvenation. The technique is safe as long as some precautions are respected. In this review we will focus on vascular anatomy in the upper, middle and lower face. Material and Methods We performed a PUBMED research on “facial danger zones” and “filler injections” and “hyaluronic acid” and “vascular compromise” with a focus on the last decade. This is of particular importance since vascular compromise is one of the most severe...
Wed Sep 09, 2020 14:17
Abstract The aim of this questionnaire‐based study was to measure the level of appreciation, practice patterns, and side effects of monopolar radiofrequencytreatment among Korean dermatologists practicingthe most updated monopolar radiofrequency device (Thermage FLXTM, Thermage® Inc., Hayward, CA). According to a total of 52 surveys analyzed, thislatest device (Thermage FLXTM) was consideredmore effective (57.4%), faster with reduced treatment time (66.0%), and more painful (25.5%) compared to Thermage...
Wed Sep 09, 2020 14:15
Abstract The first cases of the coronavirus disease (COVID‐19) appeared in Wuhan, China, in December 2019. COVID‐19 was declared a pandemic in March 2020. Cutaneous manifestations are among the heterogenous clinical features of the disease, and urticaria is one of the most common skin manifestations reported in COVID‐19. We reviewed the literature available regarding COVID‐19‐associated urticaria. A literature search in the PubMed and Scopus databases was conducted, till the cut‐off date of 24th...
Wed Sep 09, 2020 14:14
Abstract The Second Congress of BULSDS was held on 13th March and 13th June 2020 in the Bulgarian capital Sofia. The main topics of the conference were One‐step melanoma surgery (OSMS) and Drug‐induced melanoma. Although this is only the second edition of the conference, the predominant presence of students and young scientists was visibly large, which is rare at professional conferences. The second national conference of BULSDS gave an opportunity to many young scientists to express themselves,...
Wed Sep 09, 2020 14:14
Abstract Purpose This in vitro study was designed to compare bacterial adhesion to zirconia versus lithium disilicate crowns after artificial aging. Materials and Methods Seventy‐five discs were tested in this study: 25 Cr‐Co base metal discs (control), 25 zirconia discs, and 25 lithium disilicate discs. Each sample was polished and glazed appropriately. The discs were subjected to 1000 thermal cycles between 5 and 55°C, whereby samples stayed in the bath for 20 seconds, at each temperature....
Wed Sep 09, 2020 14:16
Canalis Sinuosus: An Anatomic Repair That May Prevent Success of Dental Implants in Anterior Maxilla
Abstract Canalis sinuosus (CS) is a neurovascular canal that corresponds to a small branch of the infraorbital canal. It contains the anterior superior alveolar nerve and vessels, supplying the anterior maxilla. Despite having been described 81 years ago, CS is not recognized by many dental practitioners and may be the cause of unintended injuries during dental procedures. The aims of this study are to report a case of a patient who suffered pain due to exposure of the CS, to provide a comprehensive...
Wed Sep 09, 2020 13:54
Abstract Background Ionizing radiation use for medical diagnostic purposes has substantially increased over the last three decades. Moderate to high doses of radiation are well established causes of cancer, especially for exposure at young ages. However, cancer risk from low-dose medical imaging is debated. Objective To review the literature on cancer...
Thu Sep 10, 2020 03:00
This case report demonstrates pericardial effusion, acute pericarditis, and cardiac tamponade in an otherwise healthy woman who had a positive test result for coronavirus disease 2019. Few case reports have be...
Wed Sep 09, 2020 03:00
Hand-Gesture Recognition Based on EMG and Event-Based Camera Sensor Fusion: A Benchmark in Neuromorphic Computing. Front Neurosci. 2020;14:637 Authors: Ceolini E, Frenkel C, Shrestha SB, Taverni G, Khacef L, Payvand M, Donati E Abstract Hand gestures are a form of non-verbal communication used by individuals in conjunction with speech to communicate. Nowadays, with the increasing use of technology, hand-gesture recognition is considered to...
Thu Sep 10, 2020 13:06
mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration. Front Neurosci. 2020;14:775 Authors: Norwitz NG, Querfurth H Abstract The mechanistic target of rapamycin protein complex, mTORC1, has received attention in recent years for its role in aging and neurodegenerative diseases, such as Alzheimer's disease. Numerous excellent reviews have been written on the pathways and drug targeting of this keystone...
Thu Sep 10, 2020 13:06
Alteration of Brain Gray Matter Density After 24 h of Sleep Deprivation in Healthy Adults. Front Neurosci. 2020;14:754 Authors: Sun J, Zhao R, Yang X, Deng H, Zhu Y, Chen Y, Yuan K, Xi Y, Yin H, Qin W Abstract It has been reported that one night of acute sleep deprivation (SD) could induce brain structural changes at the synaptic and neuronal levels in animal studies, and could lead to white matter microstructure and cortical thickness change...
Thu Sep 10, 2020 13:06
Analyzing and Decoding Natural Reach-and-Grasp Actions Using Gel, Water and Dry EEG Systems. Front Neurosci. 2020;14:849 Authors: Schwarz A, Escolano C, Montesano L, Müller-Putz GR Abstract Reaching and grasping is an essential part of everybody's life, it allows meaningful interaction with the environment and is key to independent lifestyle. Recent electroencephalogram (EEG)-based studies have already shown that neural correlates of natural...
Thu Sep 10, 2020 13:06
Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms. Front Neurosci. 2020;14:730 Authors: Kowalczyk J, Kurach Ł, Boguszewska-Czubara A, Skalicka-Woźniak K, Kruk-Słomka M, Kurzepa J, Wydrzynska-Kuźma M, Biała G, Skiba A, Budzyńska B Abstract Bergapten is a furanocoumarin naturally occurring in the Apiaceae family and it is a well-known photosensitizing agent used in photochemotherapy....
Thu Sep 10, 2020 13:06
Tremor in Vascular Cognitive Impairment Raises the Possibility of Mixed Pathology With Lewy Body Disease. Front Neurosci. 2020;14:781 Authors: Chiu PY, Tzeng RC, Wei CY, Hung GU, Hu CJ Abstract Objectives: Tremor is common in patients with Lewy body disease (LBD) and not rare in normal individuals. Prevalence of tremor in patients with vascular cognitive impairment (VCI) and its association with other comorbidities are seldom studied. The aim...
Thu Sep 10, 2020 13:06
Conductive Hearing Loss Aggravates Memory Decline in Alzheimer Model Mice. Front Neurosci. 2020;14:843 Authors: Kim JS, Lee HJ, Lee S, Lee HS, Jeong YJ, Son Y, Kim JM, Lee YJ, Park MH Abstract The study of cognitive impairment associated with hearing loss has recently garnered considerable interest. Epidemiological data have demonstrated that hearing loss is a risk factor for cognitive decline as a result of aging. However, no previous study...
Thu Sep 10, 2020 13:06
Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics. Front Neurosci. 2020;14:807 Authors: Kelly K, West AB Abstract Genetic studies have identified variants in the LRRK2 gene as important components of Parkinson's disease (PD) pathobiology. Biochemical and emergent biomarker studies have coalesced around LRRK2 hyperactivation in disease. Therapeutics that diminish LRRK2 activity, either with small molecule kinase inhibitors or anti-sense...
Thu Sep 10, 2020 13:06
Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson's Disease. Front Neurosci. 2020;14:689 Authors: Hermann W, Schmitz-Peiffer H, Kasper E, Fauser M, Franke C, Wienecke M, Otto K, Löhle M, Brandt MD, Reichmann H, Storch A Abstract Background: Sleep disturbances and impairment of cognitive function are among the most frequent non-motor symptoms in Parkinson's disease (PD) with negative implications on...
Thu Sep 10, 2020 13:06
Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics. Front Neurosci. 2020;14:816 Authors: Oliva MK, Pérez-Moreno JJ, O'Shaughnessy J, Wardill TJ, O'Kane CJ Abstract Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly mutated in hereditary spastic paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption...
Thu Sep 10, 2020 13:06
Timescales of Evidence Evaluation for Decision Making and Associated Confidence Judgments Are Adapted to Task Demands. Front Neurosci. 2020;14:826 Authors: Harun R, Jun E, Park HH, Ganupuru P, Goldring AB, Hanks TD Abstract Decision making often involves choosing actions based on relevant evidence. This can benefit from focussing evidence evaluation on the timescale of greatest relevance based on the situation. Here, we use an auditory change...
Thu Sep 10, 2020 13:06
Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders. Front Neurosci. 2020;14:764 Authors: Xiao M, Xiao ZJ, Yang B, Lan Z, Fang F Abstract The blood-brain barrier (BBB) is a dynamic but solid shield in the cerebral microvascular system. It plays a pivotal role in maintaining central nervous system (CNS) homeostasis by regulating the exchange of materials between the...
Thu Sep 10, 2020 13:06
Human and Bovine Milk Oligosaccharides Elicit Improved Recognition Memory Concurrent With Alterations in Regional Brain Volumes and Hippocampal mRNA Expression. Front Neurosci. 2020;14:770 Authors: Fleming SA, Mudd AT, Hauser J, Yan J, Metairon S, Steiner P, Donovan SM, Dilger RN Abstract Human milk contains a unique profile of oligosaccharides (OS) and preliminary evidence suggests they impact brain development. The objective of this study...
Thu Sep 10, 2020 13:06
Impact of Brain Surface Boundary Conditions on Electrophysiology and Implications for Electrocorticography. Front Neurosci. 2020;14:763 Authors: Rogers N, Thunemann M, Devor A, Gilja V Abstract Volume conduction of electrical potentials in the brain is highly influenced by the material properties and geometry of the tissue and recording devices implanted into the tissue. These effects are very large in EEG due to the volume conduction through...
Thu Sep 10, 2020 13:06
Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer's Disease. Front Neurosci. 2020;14:862 Authors: Lim JKH, Li QX, He Z, Vingrys AJ, Chinnery HR, Mullen J, Bui BV, Nguyen CTO Abstract Alzheimer's disease is characterized by the aberrant deposition of protein in the brain and is the leading cause of dementia worldwide. Increasingly, there have been reports of the presence of these protein hallmarks in the retina....
Thu Sep 10, 2020 13:06
Rofecoxib Attenuates the Pathogenesis of Amyotrophic Lateral Sclerosis by Alleviating Cyclooxygenase-2-Mediated Mechanisms. Front Neurosci. 2020;14:817 Authors: Zou YH, Guan PP, Zhang SQ, Guo YS, Wang P Abstract Cyclooxygenase-2 (COX-2) is reported to be activated during the course of amyotrophic lateral sclerosis (ALS) development and progression. However, the roles of COX-2 in aggravating ALS and the underlying mechanism have been largely...
Thu Sep 10, 2020 13:06
Pharmaco-fUS for Characterizing Drugs for Alzheimer's Disease - The Case of THN201, a Drug Combination of Donepezil Plus Mefloquine. Front Neurosci. 2020;14:835 Authors: Vidal B, Droguerre M, Valdebenito M, Zimmer L, Hamon M, Mouthon F, Charvériat M Abstract Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer's disease (AD). Beyond the widely described neuronal impact of...
Thu Sep 10, 2020 13:06
Higher Adherence to the Mediterranean Diet Is Associated With Preserved White Matter Integrity and Altered Structural Connectivity. Front Neurosci. 2020;14:786 Authors: Rodrigues B, Coelho A, Portugal-Nunes C, Magalhães R, Moreira PS, Castanho TC, Amorim L, Marques P, Soares JM, Sousa N, Santos NC Abstract The Mediterranean diet (MedDiet) has been associated with cognitive performance. Yet, controlled trials have yielded contradictory results....
Thu Sep 10, 2020 13:06
63 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/09/10PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 10, 2020 13:05
Presentation of Case. Dr. Rachel A. Meyen (Psychiatry): A 64-year-old Haitian-American man was evaluated at the geriatric psychiatry clinic of this hospital for chronic depression, intrusive thoughts, and fear of being poisoned. During the evaluation, the patient described his mood as "not that…
Thu Sep 10, 2020 03:00
Purpose. To analyze retrospectively the clinical efficacy and safety for patients treated with fractionated stereotactic radiation therapy (FSRT) using volumetric modulated arc therapy. Methods. Between 2016 and 2017, 46 patients with solitary brain metastasis who underwent FSRT consisting of 25-40 Gy/5 fractions were recruited in this study. All targets within the same course received different prescriptions according to size. Toxicities were graded according to the Common Terminology Criteria for...
Thu Sep 10, 2020 10:50
The incidence and mortality of lung cancer were extremely high. The present study showed that SRCIN1 was an oncogene in non-small-cell lung cancer (NSCLC). Public dataset analysis showed SRCIN1 was significantly overexpressed in NSCLC samples. Also, we found that NSCLC patients with higher SRCIN1 expression had shorter OS time by analyzing TCGA, Kaplan-Meier Plotter, GSE30219, GSE50081, and GSE19188 databases. Overexpression or knockdown of SRCIN1 significantly induced or reduced A549 and H1299 cell...
Thu Sep 10, 2020 10:50
Osteosarcoma is a malignant tumor that seriously threatens human health. Numerous studies have pointed out the potential of long noncoding RNAs (lncRNAs) as new therapeutic targets for various human cancers. Therefore, we mainly investigate whether there is a new type of lncRNA pathway involved in regulating the development of osteosarcoma. The present study shows the higher expression levels of LINC00511 correlates to a shorter overall survival and disease-free survival time in patients with sarcoma....
Thu Sep 10, 2020 10:50
Background. Colorectal cancer (CRC) is the third most common cancer in the world, and most of them are adenocarcinomas. CRC could be classified as colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) according to the original tumorigenesis position. Increasing evidences indicated that microRNAs (miRNAs) play an important role in the occurrence of multiple tumors. Methods. In this study, we firstly downloaded miRNA (COAD, 8 controls vs. 455 tumors; READ, 3 controls vs. 161 tumors) and mRNA...
Thu Sep 10, 2020 10:20
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