Objectives. To assess the expression and clinical value of miR-19 in gastrointestinal malignancy. Setting. Embase, Web of Science, PubMed, and other databases were retrieved to screen out relevant studies until December 31, 2019. Participants. Gastrointestinal cancer patients with the description of miR-19 expression, as well as the correlation between miR-19 and clinicopathological characteristics or prognosis. Main Outcome Measures. Pooled odds ratio (OR) or hazard ratio (HR) with 95% confidence...
Thu Sep 10, 2020 09:20
136 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: head and neck These pubmed results were generated on 2020/09/10PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 10, 2020 13:03
Decoding the covert shift of spatial attention from electroencephalographic signals permits reliable control of a brain-computer interface. J Neural Eng. 2020 Sep 09;: Authors: Reichert C, Dürschmid S, Bartsch MV, Hopf JM, Heinze HJ, Hinrichs H Abstract OBJECTIVE: One of the main goals of brain-computer interfaces (BCI) is to restore communication abilities in patients. BCIs often use event-related potentials (ERPs) like the P300 which signals...
Thu Sep 10, 2020 13:02
"When" and "what" did you see? A novel fMRI-based visual decoding framework. J Neural Eng. 2020 Sep 09;: Authors: Wang C, Yan H, Huang W, Li J, Yang J, Li R, Zhang L, Li L, Zhang J, Zuo Z, Chen H Abstract OBJECTIVE: Visual perception decoding plays an important role in understanding our visual systems. Recent functional magnetic resonance imaging (fMRI) studies have made great advances in predicting the visual content of the single stimulus...
Thu Sep 10, 2020 13:02
Publication date: Available online 9 September 2020Source: Journal of Human EvolutionAuthor(s): Indrė Žliobaitė
Thu Sep 10, 2020 13:01
Value in Interventional Radiology: Achieving High Quality Outcomes at a Lower Cost. Radiology. 2020 Sep 08;:203407 Authors: White SB PMID: 32903151 [PubMed - as supplied by publisher]
Thu Sep 10, 2020 13:01
High-Spatial-Resolution CT Offers New Opportunities for Discovery in the Lung. Radiology. 2020 Sep 08;:203473 Authors: Lynch DA, Oh AS PMID: 32903150 [PubMed - as supplied by publisher]
Thu Sep 10, 2020 13:01
Dissecting the Natural History of Blunt Cerebrovascular Injury. Radiology. 2020 Sep 08;:203358 Authors: Talbott JF PMID: 32903149 [PubMed - as supplied by publisher]
Thu Sep 10, 2020 13:01
42 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/09/10PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 10, 2020 13:01
Publication date: Available online 9 September 2020Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): K. Allepot, A. Mojallal, B. Gerenton
Thu Sep 10, 2020 13:00
FOXL2 somatic mutation occurs in a high percentage of ovarian adult granulosa cell tumors and DICER1 mutations in a high proportion of Sertoli-Leydig cell tumors. These mutations have only been studied in a limited number of juvenile granulosa cell tumors (JGCTs), and their occurrence and frequency in these neoplasms is controversial. We aimed to determine the frequency of FOXL2 and DICER1 mutations in a large cohort of 50 JGCTs, and to evaluate the prognostic impact of these mutations. A FOXL2 hotspot...
Tue Sep 08, 2020 03:00
Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder composed of Langerhans cells admixed with reactive mononuclear and granulocytic cells, associated with prominent eosinophils. LCH is considered a neoplasm, driven in most cases by oncogenic RAS/RAF/MEK/ERK pathway mutations. The disease predominantly affects children. Urinary system involvement has rarely been reported in a multisystem disease setting. We describe 7 patients who presented with LCH occurring within (6 cases) or after...
Tue Sep 08, 2020 03:00
Switch/sucrose nonfermenting complex subunits, such as BRG1, INI1, and ARID1B, are inactivated in a subset of endometrial undifferentiated carcinoma and dedifferentiated carcinoma (DC). Limited information is currently available on their prevalence in other subtypes or the nosological status of endometrial carcinoma with their deficiencies. This study immunohistochemically examined the expression status of BRG1, INI1, and ARID1B using 570 archived cases of endometrial carcinoma and carcinosarcoma...
Tue Sep 08, 2020 03:00
Background: Pseudocarcinomatous squamous hyperplasia (PSH) within the bone is uncommon and closely mimics well-differentiated squamous cell carcinoma (SCC). It arises from cutaneous or mucosal surfaces and grows directly into the bone. This study analyzes a large series of PSH and discusses the clinicopathologic features that facilitate its distinction from SCC. Design: Cases were identified from the surgical pathology files between 1985 and 2020. Results: The 31 cases included...
Tue Sep 08, 2020 03:00
Secondary involvement of the uterine cervix by nongynecologic neoplasms is rare accounting for 50.5) (P=0.01). Mean time to identification of cervical metastases was
Tue Sep 08, 2020 03:00
Nonmetastatic, castration-resistant prostate cancer is defined by rising levels of serum prostate-specific antigen (PSA) and an absence of detectable metastases on conventional imaging in patients receiving androgen-deprivation therapy. Patients with nonmetastatic, castration-resistant prostate…
Thu Sep 10, 2020 03:00
With a prevalence of 17.1 cases per 100,000 males, hemophilia A is the most frequent inherited disorder of blood coagulation. After the adoption of prophylactic replacement therapy with factor VIII administered intravenously 3 or 4 times per week, patients’ life expectancy has become very close to…
Thu Sep 10, 2020 03:00
On February 13, 2020, the Food and Drug Administration (FDA) announced that it had requested that the manufacturer of Belviq and Belviq XR (lorcaserin and extended-release lorcaserin) voluntarily withdraw the products from the U.S. market. The agency’s request was based on its assessment of…
Thu Sep 10, 2020 03:00
Familial adenomatous polyposis is a rare, autosomal dominant, hereditary colorectal cancer syndrome that is most commonly caused by pathogenic germline variants in the adenomatous polyposis coli (APC) gene. In its classic presentation, familial adenomatous polyposis is characterized by progressive…
Thu Sep 10, 2020 03:00
Severe hemophilia A (defined as Prophylaxis with factor VIII products that have an extended half-life has advanced the treatment of severe hemophilia, in part by improving the control of bleeding, joint health, and quality of life, and by reducing treatment burden. However, residual burden still…
Thu Sep 10, 2020 03:00
In the last 12 years several synthetic strategies have been developed that provide access to [ n ]cycloparaphenylenes ([ n ]CPPs) and related conjugated nanohoops. A number of potential applications have emerged, including optoelectronic devices and their use as templates for carbon nanomaterials and in supramolecular chemistry. To tune the structural or optoelectronic properties of carbon nanohoops beyond the size‐dependent effect known for [ n ]CPPs , a variety of aromatic rings other than...
Wed Sep 09, 2020 22:00
Nature provides answers for efficient transport of water by using Aquaporins AQPs as the translocation relays. Artificial Water Channels biomimicking natural AQPs, can be used for both selective and fast transport of water. Here, we use complementary synthetic methods, X‐ray structural data, transport assays to quantify the transport performances of peralkyl‐carboxylate‐pillar[5]arenes dimers in bilayer membranes. They are able to transport ~107 water molecules/channel/second, within one order of...
Wed Sep 09, 2020 20:18
Direct H ydroxylation of benzene to phenol with high yield and selectivity has been the goal of phenol industrial production . P hotocatalysis can serve as a competitive method to realize the h ydroxylation of benzene to phenol owing to its cost‐effective and environmental friendliness, however it is still a forbidding challenge to obtain good yield, high selectivity and high atom availability meanwhile. Here we show a series of supramolecular catalysts based on alkoxohexavanadate anions and quinolinium...
Wed Sep 09, 2020 19:54
Selective hydrogenation of C=O against the conjugated C=C in cinnamaldehyde (CAL) is indispensable to produce cinnamyl alcohol (COL), nonetheless, challenged by the low selectivity and the need to use organic solvents. Herein, for the first time, we report the use of Fe‐Co alloy nanoparticles (NPs) on N‐doped carbon support as a selective hydrogenation catalyst to efficiently convert CAL to COL. The resultant catalyst with the optimized Fe/Co ratio of 0.5 can achieve an exceptional COL selectivity...
Wed Sep 09, 2020 19:08
We have rationally designed a new class of alkyne‐tethered oximes, and applied them into an unprecedented iron‐catalyzed radical relay protocol for the rapid assembly of a wide array of structurally new and interesting fused pyridines. This method showcases broad substrate scope and good functional group tolerance, and can be applied for a few biologically active molecules. In addition, the fused pyridines can be diversely functionalized through various simple transformations, such as cyclization,...
Wed Sep 09, 2020 18:18
With the increasing popularity and burgeoning progress of space technology, the development of ultralow temperature flexible functional materials is a great challenge for human beings. Herein, we reported a highly emissive organic crystal combining with ultralow temperature elasticity and self‐waveguide (when a crystal is excited, it emits light from itself and travels through the crystal to the other end) based on a simple single‐benzene emitter. This crystal displayed excellent elastic bending...
Wed Sep 09, 2020 17:53
Apyrase represents an important family of extracellular enzymes that catalyze the hydrolysis of high‐energy phosphate bonds (HEPBs) in ATP and ADP, thereby modulating many physiological processes and driving life activities. Here, we report an unexpected discovery that cerium‐based metal‐organic frameworks (Ce‐MOFs) of UiO‐66(Ce) possess intrinsic apyrase‐like activity for the intervention of ATP/ADP‐related physiological processes. The abundant Ce(III)/Ce(IV) couple sites of Ce‐MOFs endow them with...
Wed Sep 09, 2020 17:48
We report here a guest‐reaction induced mitosis‐like host transformation from a known Pd 4 L 2 cage 1 to a conjoined Pd 6 L 3 twin‐cage 2 featuring two separate cavities. The encapsulation of 1‐hydroxymethyl‐2‐naphthol ( G1 ), a known ortho ‐quinone methide ( o ‐QMs) precursor, within the hydrophobic cavity of cage 1 is found crucial to realize the cage to twin‐cage conversion. Confined G1 molecules within the nanocavity undergo self‐coupling dimerization reaction to form 2,2'‐dihydroxy‐1,1'‐dinaphthylmethane...
Wed Sep 09, 2020 17:25
The quantitative and comprehensive description of the internal dynamics of proteins is critical for understanding their function. Nanoparticle‐assisted 15 N NMR spin relaxation is a new method that uses a simple read‐out allowing the observation of ps ‐ μs dynamics of proteins when transiently interacting with the surface of nanoparticles. The method is applied here to the widely studied protein human ubiquitin in the presence of anionic and cationic silica nanoparticles (SNP) of different size....
Wed Sep 09, 2020 17:24
Diiron(IV)‐oxo species are proposed to effect the cleavage of strong C–H bonds by nonheme diiron enzymes such as soluble methane monooxygenase (sMMO) and fatty acid desaturases. However, synthetic mimics of such diiron(IV) oxidants are rare. Herein we report the reaction of (TPA*)Fe II ( 1 ) (TPA* = tris(3,5‐dimethyl‐4‐methoxypyridyl‐2‐methyl)amine) in CH 3 CN with 4 equiv. CAN and 200 equiv. HClO 4 at 20 °C to form a complex with an [Fe IV 2 (µ‐O) 2 ] 4+ core. CAN and HClO 4...
Wed Sep 09, 2020 17:24
Closing the carbon dioxide (CO 2 ) cycle by transforming it into fuel in order to mitigate its accumulation in the atmosphere is one of the most important challenges of our fossil‐fuel‐dependent society. [1–6] This solution was inspired by nature itself where green plants efficiently capture sunlight to convert CO 2 and water into various hydrocarbons and O 2 by photosynthesis. [7,8] After eons of evolution, the different steps of capture, activation, and transformation of the thermodynamically...
Wed Sep 09, 2020 17:24
Herein, we report the discovery of a toroidal inorganic cluster of Zirconium(IV) oxysulfate of unprecedented size with the formula Zr 70 (SO 4 ) 58 (O/OH) 146 ·x(H 2 O) (Zr 70 ), which displays different packing of ring units and thus several polymorphic crystal structures. The ring entity measures over 3 nm across, has an inner cavity of 1 nm and displays a pseudo 10‐fold rotational symmetry of Zr 6 octahedra bridged by an additional Zr in the outer rim of the ring. Depending of co‐crystallizing...
Wed Sep 09, 2020 14:40
The asymmetric synthesis of β 2,2 ‐amino acids remains a formidable challenge in organic synthesis. We report here a novel organocatalytic enantioselective aminomethylation of ketenes with stable and readily available N,O‐acetals, providing β 2,2 ‐amino esters bearing an all‐carbon quaternary stereogenic center in high enantiomeric ratios with a catalytic amount of chiral phosphoric acid. Typically, this transformation probably proceeds through an asymmetric counter‐anion‐directed catalysis....
Wed Sep 09, 2020 14:34
The first total synthesis of a hexacyclic ent ‐kaurane diterpenoid alkaloid, liangshanone, has been completed. Its intricate cage‐like framework was assembled through several key transformations including an oxidative dearomatization/Diels‐Alder (OD/DA) cycloaddition sequence, a tandem alkene cleavage/ Mannich cyclization, a Robinson‐type annulation, and an intramolecular aldol reaction. Notably, an organocatalytic enantio‐selective α‐hydroxymethylation process allowed the preparation of the enantioenriched...
Wed Sep 09, 2020 14:33
Small‐pore zeolites such as chabazite (CHA) are excellent candidates for the selective separation of CO 2 , however, the current synthesis involves several steps and the use of organic structure‐directing agent (OSDA), increasing their cost and energy requirements. Here we report the synthesis of small‐pore zeolite crystals (aluminosilicate) with CHA‐type framework structure by direct synthesis in a colloidal suspension containing a mixture of inorganic cations only (Na + , K + and Cs + )....
Wed Sep 09, 2020 14:30
We describe the synthesis of compounds exhibiting gallium–phosphorus double bonds. The stability of these species is dependent on the saturation of the phosphanyl moiety, and the saturated variant behaves as a frustrated Lewis pair that is capable of activating H2 and forms a 1:1 adduct with CO2. Abstract Phosphagallenes (1 a/1 b) featuring double bonds between phosphorus and gallium were synthesized by reaction of (phosphanyl)phosphaketenes with the gallium carbenoid Ga(Nacnac) (Nacnac=HC[C(Me)N(2,6‐i‐Pr2C6H3)]2)....
Wed Sep 09, 2020 14:29
The reversible migration of hydrogen atoms from methyl groups of the ubiquitous C5Me5 (Cp*) ligand to the RhI center in [(η5‐C5Me5)Rh(PMe3)2] is demonstrated, revealing the potential role of Cp* as a proton shuttle by a route that was previously restricted to early transition metals. The incorporation of bulky and electrophilic gold fragments allows the isolation of key bimetallic species in support of the reversible C−H activation at Cp*. Abstract The use of cyclopentadienyl ligands in...
Wed Sep 09, 2020 14:29
Layered lithium‐rich materials are promising cathode materials for the development of next‐generation high‐energy‐density lithium‐ion batteries. Understanding the principles of the performance degradation mechanisms is a prerequisite for progress in this area. In this Minireview, recent research on the material structure and reaction mechanisms of layered lithium‐rich manganese‐based cathode materials is discussed. Abstract Layered lithium‐rich cathode materials have attracted extensive...
Wed Sep 09, 2020 14:29
Topochemical modifications at the reducing end of nanocellulose are a new trend in cellulose materials research. The chemistry is aldehyde‐specific and exploits the inherent directionality of the chains in the cellulose I crystal bearing aldehyde groups exclusively on one end. This Review discusses challenges related to end‐specific modifications and highlights the opportunities for nanocellulose materials. Abstract Native plant cellulose has an intrinsic supramolecular structure. Consequently,...
Wed Sep 09, 2020 14:28
Surface acoustic waves (SAWs) are dynamic lattice distortions, which can be excited on piezoelectric materials. Since many years a promotion of the catalytic activity and selectivity by SAWs is known, but no mechanistic understanding is established yet. We quantify the effect that SAWs have on the electronic and geometric structure of a model catalyst, providing a basis for discussing the promotion mechanism of SAWs in catalytic surface reactions. Abstract Surface acoustic waves (SAW) allow...
Wed Sep 09, 2020 14:27
The para‐selective arylation of sulfonate, phosphonate, and phenol derivatives bearing 2,6‐disubstitution patterns and a suitable meta‐directing group is achieved by using Pd and norbornene cooperative catalysis. The present protocol enables the synthesis of hexa‐substituted arenes by sequential regioselective C−H functionalization. Abstract Biaryl compounds are extremely important structural motifs in natural products, biologically active components and pharmaceuticals. Selective synthesis...
Wed Sep 09, 2020 14:27
Highly active Ni3C branched particles are demonstrated and their selective electrocatalytic conversion of methanol to formate is probed by using advanced in situ infrared spectroscopy combined with nuclear magnetic resonance spectroscopy. Abstract A methanol economy will be favored by the availability of low‐cost catalysts able to selectively oxidize methanol to formate. This selective oxidation would allow extraction of the largest part of the fuel energy while concurrently producing a...
Wed Sep 09, 2020 14:27
Chiral crystals of ϵ‐Zn(OH)2 were crystallized from supersaturated aqueous solutions in the presence of l‐ or d‐arginine and chiral discrimination was observed during the crystallization. A new method for identifying chirality in crystals by using electron paramagnetic resonance (EPR) has also been developed. Abstract Many inorganic materials can form crystals, but little is known about their enantioselective crystallization. Herein, we report on the enantioselective crystallization of...
Wed Sep 09, 2020 14:24
Carbon dioxide was electroreduced to 1‐butanol on oxide‐derived copper. The reaction mechanism was determined to proceed through a combination of electrochemical and chemical steps, some of which require contrasting conditions. This example highlights limitations in one‐pot synthesis and provides a case for utilizing independently optimized sequential reactors in a tandem system to build complex molecules from low molecular‐weight feedstocks. Abstract The electroreduction of carbon dioxide...
Wed Sep 09, 2020 14:22
A chiral‐label‐free surface‐enhanced Raman scattering (SERS) strategy is proposed for recognizing and identifying various types of chiral small aromatic molecules with satisfactory sensitivity and discrimination capabilities. Fingerprint information about molecular specific structure and its chiral information can be acquired synchronously from a single SERS spectrum accessibly. Abstract A versatile and robust chiral discrimination strategy for small aromatic compounds is of significant...
Wed Sep 09, 2020 14:22
The conserved histidines (HisA2, HisB1 and HisB2), influenced by adjacent residues (HisB1+1, HisB2+1 and waterkeeper residue), are responsible for the hydroxylase activity. Starting from a catechol oxidase (CO) a tyrosinase (TYR) with monophenolase activity well within the range of naturally occurring plant TYRs has been designed. Abstract Tyrosinases (TYRs) catalyze the hydroxylation of phenols and the oxidation of the resulting o‐diphenols to o‐quinones, while catechol oxidases (COs)...
Wed Sep 09, 2020 14:22
Spin ice‐like magnetic relaxation was found in a two‐dimensional network of MnIII salen‐type single‐molecule magnets with S T=4. The spin ice‐like behavior was a consequence of the competition between the ferromagnetic interaction and local noncollinear magnetic anisotropies on the single‐molecule magnets. Abstract Spin ice is an exotic type of magnetism displayed by bulk rare‐earth pyrochlore oxides. We discovered a spin ice‐like magnetic relaxation of [{Mn(saltmen)}4{Mn(CN)6}](ClO4)⋅13 H2O...
Wed Sep 09, 2020 14:22
The treatment of a trifluoroacetimidoyl chloride (TFAIC) with the carbenoid iodomethyllithium results in the chemoselective formation of a bis‐trifluoromethyl‐β‐diketiminate. This sequential two‐events strategy involves the homologation of the imine surrogate followed by the lithiation of the intermediate operated by the same carbenoid and attack of a second TFAIC unit. Abstract The selective formal insertion (homologation) of a carbon unit bridging the two trifluoroacetamidoyl chlorides...
Wed Sep 09, 2020 14:21
Optical chirality sensing has attracted a lot of interest due to its potential in high‐throughput screening in chirality analysis. It requires a molecular sensor to convert the chirality of analytes into optical signals. Although many molecular sensors have been reported, the ones with a wide substrate scope remain to be developed. Herein, we report that the amide naphthotube‐based chirality sensors have an unprecedented wide scope for chiroptical sensing of cryptochiral molecules. The substrates...
Wed Sep 09, 2020 14:05
Scanning electrochemical microscopy was developed as a direct nanomachining technique on semiconductor wafers through a close‐loop of current feedback to the positioning system. Arbitrary 3D microstructure were translated into a spatially distributed current and fabricated. Abstract Scanning electrochemical microscopy (SECM) is one of the most important instrumental methods of modern electrochemistry due to its high spatial and temporal resolution. We introduced SECM into nanomachining...
Wed Sep 09, 2020 14:00
Pd‐P nanostructures are efficient electrocatalysts for selective semihydrogenation (deuteration) of terminal and internal alkynes using H2O (D2O) as the H (D) source at a lower potential via an adsorbed atomic hydrogen (H*ads) addition pathway. P‐doping causes enhanced specific adsorption of alkynes and promoted intrinsic activity for producing H*ads from water electrolysis. Abstract We reported a selective semihydrogenation (deuteration) of numerous terminal and internal alkynes using...
Wed Sep 09, 2020 13:59
The cross‐electrophile coupling has become a powerful tool for C–C bond formation, but its potential for forging the C–Si bond remains unexplored. Here we report a cross‐electrophile Csp 2 –Si coupling reaction of vinyl/aryl electrophiles with vinyl chlorosilanes. This new protocol offers an approach for facile and precise synthesis of organosilanes with high molecular diversity and complexity from readily available materials. The reaction proceeds under mild and non‐basic conditions, demonstrating...
Wed Sep 09, 2020 13:43
It is an enormous challenge to achieve the highly efficient organic room‐temperature phosphorescence (RTP) with long lifetime. Here we demonstrated that by bridging the carbazole and halogenated phenyl ring with methylene linker, a type of RTP phosphors CzBX (X = Cl, Br) shows high phosphorescence efficiency ( Ф Ph ), up to 38% for CzBBr with a lifetime of 220 ms, which is much higher than that of compounds CzPX (X = Cl, Br) with C‐N bond as a linker ( Ф Ph < 1%). Single crystal analysis...
Wed Sep 09, 2020 13:37
We report the synthesis of new helical polymeric structures having alternating cis and trans double bonds and chiral amino acid side chains by metathesis cyclopolymerization. The polymer helicity, which is generated by the interaction between fluorenylmethyloxycarbonyl (Fmoc) groups in the side chains, is dramatically affected by solvents. A thorough experimental and theoretical analysis including nuclear magnetic resonance, atomic force microscopy, and density functional theory and molecular...
Wed Sep 09, 2020 13:37
Breathing process involves inhalation and exhalation of different gases in animals. The gas exchange of the breathing process plays a critical role in maintaining the physiological functions of living organisms. Although artificial breathing materials exhibiting volume expansion and contraction upon alternate exposure to different gases have been well explored, those being able to realize the gas exchange remain elusive. Herein, we report breathing micelles (BM) capable of inhaling nitric oxide (NO)...
Wed Sep 09, 2020 13:35
In this study we report the identification of a novel class of ligands for palladium‐catalyzed C(sp3)–H activation that enables the direct alkynylation of free carboxylic acid substrates. In contrast to previous synthetic methods, no introduction/removal of an exogenous directing group is required. A broad scope of acids including both α‐quaternary and challenging α‐non‐quaternary can be used as substrates. Additionally, the alkynylation in the distal γ‐position is reported. Finally, this study encompasses...
Tue Sep 08, 2020 22:00
The Journal of Antibiotics, Published online: 10 September 2020; doi:10.1038/s41429-020-00368-0Discovery and characterization of a cytochalasan biosynthetic cluster from the marine-derived fungus Aspergillus flavipes CNL-338
Thu Sep 10, 2020 03:00
Dimethylsulfoniopropionate (DMSP), an osmolyte produced by oceanic phytoplankton and bacteria, is primarily degraded by bacteria belonging to the Roseobacter lineage and other marine Alphaproteobacteria via DMSP-dependent demethylase A protein (DmdA). To date, the evolutionary history of DmdA gene family is unclear. Some studies indicate a common ancestry between DmdA and GcvT gene families and a co-evolution between Roseobacter and the DMSP-producing-phytoplankton around 250 million years ago (Mya)....
Thu Sep 10, 2020 03:00
Background This study aimed to analyze the clinical outcomes associated with patients with recurrent/metastatic head and neck squamous cell carcinoma (RM HNSCC) who received cetuximab-based chemotherapy in a real-world clinical setting. Methods Clinical data were extracted from RM HNSCC patients diagnosed between 2016 and 2019. Kaplan–Meier survival estimates and Cox proportional hazards model were used for survival...
Thu Sep 10, 2020 03:00
Background Infants under 6 months (U6M) contribute a significant proportion of the burden and mortality of severe malnutrition globally. Evidence of underlying aetiology in this population is sparse, but it is known that the group includes ex-preterm and low birthweight (LBW) infants. They represent a unique population given their dependence on breastmilk or a safe, secure alternative. Nutrition agencies and health providers struggle to make programming decisions on which interventions...
Thu Sep 10, 2020 03:00
Abstract Background Virtual implant planning systems integrate (cone beam-) computed tomography data to assess bone quantity and virtual models for the design of the implant-retained prosthesis and drill guides. Five commercially available systems for virtual implant planning were examined regarding the modalities of integration of radiographic data, virtual dental models and the design of drill guides for guided implant surgery....
Thu Sep 10, 2020 03:00
Background: Distinguishing optic disc edema from pseudopapilledema is a common, sometimes challenging clinical problem. Advances in spectral-domain optical coherence tomography (SD-OCT) of the optic nerve head (ONH) has proven to be a cost effective, noninvasive, outpatient procedure that may help. At its core are tools that quantify the thickness of the retinal nerve fiber layer (RNFL) and ganglion cell–inner plexiform layer (GC-IPL). The SD-OCT also provides a set of tools that may be qualitatively...
Fri Sep 04, 2020 03:00
Publication date: Available online 9 September 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Hooman Shafaee, Erfan Bardideh, Mohammad Sadegh Nazari, Reza Asadi, Bahareh Shahidi, Abdolrasoul Rangrazi
Thu Sep 10, 2020 12:21
Abstract Brain activity during natural walking outdoors can be captured using mobile electroencephalography (EEG). However, EEG recorded during gait is confounded with artifacts from various sources, possibly obstructing the interpretation of brain activity patterns. Currently, there is no consensus on how the amount of artifact present in these recordings should be quantified, nor is there a systematic description of gait artifact properties. In the current study, we expand several features into...
Wed Sep 09, 2020 17:30
Abstract Background Coronavirus disease 2019 (COVID‐19) is a global health emergency. Despite the widely hypothesized role of a cytokine storm in disease severity, no study thus far has explored the association between immunosuppression and disease severity in patients hospitalized with COVID‐19. Objective This study aims to examine the association between the use of immunosuppressant medication and outcomes of patients hospitalized with COVID‐19. Methods Nine hundred...
Wed Sep 09, 2020 13:28
Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics. Typically, classical...
Thu Sep 10, 2020 03:00
Background To the authors' knowledge, race‐based differences in efficacy for the treatment of patients with advanced non–small cell lung cancer (NSCLC) have not been studied to date due to the underrepresentation of patients of minority backgrounds in pivotal trials. In the current study, the authors examined real‐world differences in outcome in a diverse patient population. Methods The authors retrospectively analyzed the clinical outcomes of patients with advanced NSCLC who were treated...
Wed Sep 09, 2020 16:00
Background Abstaining from smoking after a cancer diagnosis is critical to mitigating the risk of multiple adverse health outcomes. Although many patients with cancer attempt to quit smoking, the majority relapse. The current randomized controlled trial evaluated the efficacy of adapting an evidence‐based smoking relapse prevention (SRP) intervention for patients with cancer. Methods The trial enrolled 412 patients newly diagnosed with cancer who had recently quit smoking. Participants were...
Wed Sep 09, 2020 16:00
Abstract Low‐grade serous ovarian carcinoma (LGSOC) is associated with a poor response to existing chemotherapy, highlighting the need to perform comprehensive genomic analysis and identify new therapeutic vulnerabilities. The data presented here represents the largest genetic study of LGSOC to date (n = 71), analysing 127 candidate genes derived from whole exome sequencing cohorts to generate mutation and copy‐number variation data. Additionally, immunohistochemistry was performed on our LGSOC...
Wed Sep 09, 2020 15:24
ABSTRACT ObjectiveTo explore reasons for variations in anxiety in women testing positive for human papillomavirus (HPV) with normal cytology at routine HPV primary cervical cancer screening.MethodsIn‐depth interviews were conducted with 30 women who had tested HPV‐positive with normal cytology, including 15 with low‐to‐normal anxiety and 15 with high anxiety. Data were analysed using Framework Analysis to compare themes between low and high anxiety groups.ResultsSeveral HPV‐related themes were shared...
Wed Sep 09, 2020 20:24
Abstract Background An association between alopecia areata (AA) and atopic dermatitis (AD) has been reported in previous studies. However, the temporality of this relationship remains unclear based on prior cross‐sectional and case‐control studies. Objective This study aimed to investigate the bidirectional association between AA and AD. Methods Participants were recruited from the National Health Insurance Research Database of Taiwan. In analysis 1, we included 12,022 AA patients...
Wed Sep 09, 2020 21:39
There are nine herpesviruses known to infect humans, of which Epstein–Barr virus (EBV) is the most widely distributed (>90% of adults infected). This ubiquitous virus is implicated in a variety of cancers and autoimmune diseases. Previous analyses of the EBV genome revealed numerous regions with evidence of generating unusually stable and conserved RNA secondary structures and led to the discovery of a novel class of EBV non-coding (nc)RNAs: the stable intronic sequence (sis)RNAs. To gain a better...
Thu Sep 10, 2020 03:00
3D view of the anal canal comparing a child in the control (top) to anorectal malformation (bottom) group at rest. Abstract Background Pathophysiology of fecal incontinence (FI) in children with anorectal malformations (AM) is not well understood. Standard or high‐resolution anorectal manometry (ARM) does not identify radial asymmetry or localize abnormal sphincter function. 3D high‐definition anorectal manometry (HDARM) provides detailed topographic and 3D pressure gradient representation...
Wed Sep 09, 2020 16:26
Wed Sep 09, 2020 14:33
Abstract EVIDENCE, an automated variant prioritization system, has been developed to facilitate whole exome sequencing analyses. This study investigated the diagnostic yield of EVIDENCE in patients with suspected genetic disorders. DNA from 330 probands (age range, 0‐68 years) with suspected genetic disorders were subjected to whole exome sequencing. Candidate variants were identified by EVIDENCE and confirmed by testing family members and/or clinical reassessments. EVIDENCE reported...
Wed Sep 09, 2020 14:19
Abstract Conventional next‐generation sequencing methods, used in most gene panels, cannot separate maternally and paternally derived sequence information of distant variants. In recessive diseases, two or more equally plausible causative variants with unsolved phase information prevent accurate molecular diagnosis. In reality, close relatives might be unavailable for segregation analysis. Here, we utilized whole genome linked‐read sequencing to assign variants to haplotypes in two patients...
Wed Sep 09, 2020 14:18
Abstract Osteogenesis imperfecta (OI) is a relatively common genetic skeletal disorder with an estimated frequency of 1 in 20 000 worldwide. The manifestations are diverse and although individually rare, the several different forms contribute to the production of a significant number of affected individuals with considerable morbidity and mortality. During the last decade, there have been extensive molecular investigations into the etiology of OI and these advances have direct relevance...
Wed Sep 09, 2020 13:42
Abstract For decades, the approach to clinical care has involved the assessment of a fairly small set of patients' signs and symptoms, sampled over a short period of time with limited attention given to individual variations in aetiology and pathophysiology. Subsequently, a therapy is assigned predominantly with a "one shoe fits all" approach. Precision medicine approaches are now starting to change ways to test, treat and develop new therapies for allergic and immunological disorders. (Figure 1).
Wed Sep 09, 2020 17:23
Wed Sep 09, 2020 13:31
Abstract Allergic rhinitis (AR) is an upper airway disease with high prevalence in the world, and therefore needs to be thoroughly investigated and treated accordingly. Although the mechanisms underlying the pathology and treatment of AR have been widely studied, many aspects of AR are still unclear and warrant further investigations. The purpose of the present review was therefore to report recently published papers, which highlight the novel mechanisms and treatments of AR. These include role...
Wed Sep 09, 2020 13:31
Abstract Sleep is severely impaired in patients with Alzheimer's disease. Amyloid‐β deposition in the brain of Alzheimer's disease patients is a key event in its pathogenesis and is associated with disrupted sleep, even before the appearance of cognitive decline. Because soluble amyloid‐β oligomers are the key mediators of synaptic and cognitive dysfunction in Alzheimer's disease and impair long‐term memory in rodents, the first aim of this study was to test the hypothesis that amyloid‐β oligomers...
Wed Sep 09, 2020 14:27
The purpose of this study was to develop an effective method of reducing metal artifacts in cochlear implant (CI) electrodes.
Wed Sep 09, 2020 03:00
Background Bacterial vaginosis (BV) is one of the most common vaginal infections worldwide. It is associated with the presence of a dense polymicrobial biofilm on the vaginal epithelium, formed mainly by Gardnerella species. The biofilm also contains other anaerobic species, but little is known about their role in BV development. Aim To evaluate the influence of different culture media on the planktonic and biofilm growth of six cultivable anaerobes frequently associated with BV, namely...
Thu Sep 10, 2020 03:00
Background Numerous studies have utilized machine-learning techniques to predict the early onset of type 2 diabetes mellitus. However, fewer studies have been conducted to predict an appropriate diagnosis code for the type 2 diabetes mellitus condition. Further, ensemble techniques such as bagging and boosting have likewise been utilized to an even lesser extent. The present study aims to identify appropriate diagnosis codes for type 2 diabetes mellitus patients by means of building a multi-class...
Thu Sep 10, 2020 03:00
Abstract Background Understanding the anatomical morphology of the root canal is key for successful root canal treatment. The aims of this case presentation are to report a unique case of root canal treatment involving five root canals in the mandibular first premolar and to highlight the importance of variation in root canals of mandibular first premolars in clinical practice. ...
Thu Sep 10, 2020 03:00
Abstract Background The Oral Health Impact Profile-14 (OHIP-14) questionnaire assesses quality of life related to people’s perception of oral disorders on their well-being. However, a translated and validated Danish version of OHIP-14 is not yet available. The purpose of this pilot study was to translate and cross-culturally adapt the English version of the OHIP-14 into Danish (OHIP-14-DK). In addition,...
Thu Sep 10, 2020 03:00
Abstract Background Greater auricular nerve (GAN) sacrifice can alter sensation; however, the impact on quality of life (QoL) is unclear. Objective The aim of this study was to evaluate patients' QoL following GAN sacrifice versus preservation. Methods Patients who underwent parotidectomy from 2010 to 2019 at a single institution completed two QoL surveys. Results between GAN‐sacrificed versus preserved cohorts and short (≤ 1 year) versus long‐term (> 1 year) follow‐up were compared....
Wed Sep 09, 2020 13:50
The cover image is based on the Original Article Thermal imaging for microvascular free tissue transfer monitoring: Feasibility study using a low cost, commercially available mobile phone imaging system by Annika Meyer MD et al., https://doi.org/10.1002/hed.26350.
Tue Sep 08, 2020 22:51
Pheochromocytoma metastasizing to the ovary is extremely rare. We report the case of a 59-year-old woman who underwent right adrenal pheochromocytoma resection 14 years ago and remained asymptomatic until recently when she complained of palpitation, perspiration, and hypertension. 18F-FDG PET/CT revealed a left adnexal mass with increased activity, which was later surgically removed and pathologically confirmed as ovarian metastasis of pheochromocytoma. Received for publication July 8, 2020;...
Tue Sep 08, 2020 03:00
Yolk sac tumor (YST) is a rare and highly malignant germ cell tumor that is extremely rare in the nasal region. Herein, we present a case of biopsy-proven nasal YST admixed with transitional cell carcinoma in a 58-year-old woman. Complementary 18F-FDG PET/CT revealed the only FDG-avid mass in the right nasal cavity. This case indicates that YST could occur in the nasal region primarily, and 18F-FDG PET/CT is a useful tool to distinguish between primary and metastatic lesions. Received for publication...
Tue Sep 08, 2020 03:00
A 60-year-old woman, previously treated for breast cancer, was referred to gastroenterologists due to persistent abdominal distension. 18F-FDG PET/CT revealed multiple abnormal foci at the skeleton including the bilateral ilium, peritoneum, and omentum. 68Ga-FAPI PET/CT was performed for further detecting the primary lesion, which showed a greater number of bone metastases and higher uptake in peritoneal carcinomatoses than 18F-FDG. Biopsy at the left ilium and omentum indicated metastases from breast...
Tue Sep 08, 2020 03:00
A 65-year-old woman with known breast cancer presented with lower back pain over 1 month. Multiple sclerotic foci of increased tracer uptake in the bones were noted on the 99mTc-MDP bone scintigraphy and SPECT/CT images, suggesting osteoblastic metastasis. Unexpectedly, symmetric 99mTc-MDP activity was visualized in the soft tissue near the umbilical area, corresponding to the sites of insulin injection. Received for publication May 17, 2020; revision accepted July 20, 2020. Conflict of interest...
Tue Sep 08, 2020 03:00
Renal melanoma is rare. We present a case with FDG-avid melanoma arising from renal allograft. This case indicates that melanoma can occur in the allograft, and it should be considered as a differential diagnosis of focal abnormal FDG uptake in the renal allograft. Received for publication June 22, 2020; revision accepted July 20, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Pengcheng Ran, MM, Department of Nuclear Medicine, The Second Affiliated...
Tue Sep 08, 2020 03:00
We present a case with a pancreatic neuroendocrine tumor and extensive tumor thrombosis in portal venous system. The tumor was first identified on contrast-enhanced CT and later confirmed using 68Ga-DOTATATE and 68Ga-NODAGA-LM3 PET/CT. Both tracers demonstrated similar pattern with higher tumor affinity and tumor-to-background ratio using 68Ga-NODAGA-LM3. Received for publication April 27, 2020; revision accepted July 17, 2020. Conflicts of interest and sources of funding: none declared....
Tue Sep 08, 2020 03:00
When the “Standards for Establishing and Sustaining Healthy Work Environments” set forth by the American Association of Critical-Care Nurses are met in a health care system, there is enhanced safety and quality care for the patient, better job satisfaction, and less turnover by the staff. The American Association of Critical-Care Nurses started the Beacon Award for Excellence not only to recognize those who have such high standards but also to encourage units who already have achieved this distinction...
Tue Sep 08, 2020 03:00
Purpose PET is a useful tool for detecting the presence and extent of brain tau accumulation. However, most first-generation tau PET tracers are limited for high off-target binding and detection of tau in non-Alzheimer disease (AD). This study evaluated potential clinical applications of 18F-PI-2620 as a novel PET tracer with a high binding affinity for tau deposition in AD and non-AD tauopathies. Methods Twenty-six participants diagnosed with either mild cognitive impairment, probable...
Tue Sep 08, 2020 03:00
A 55-year-old woman underwent FDG PET/CT to evaluate a pancreatic mass. The images showed elevated FDG activity in the uncinated process of the pancreas, suggestive of malignancy. However, pathological examination from the resected lesion demonstrated pancreatic schwannoma. Received for publication June 16, 2020; revision accepted June 19, 2020. Conflicts of interest and sources of funding: This work was sponsored in part by the National Natural Science Foundation of China (grant 81571713),...
Tue Sep 08, 2020 03:00
A 69-year-old man with a history of back pain, urinary obstruction, and deep vein thrombosis of both lower extremities 4 years earlier was diagnosed with rectal neuroendocrine tumor, grade 2, Ki-67 index 3%. 68Ga-DOTANOC PET/CT images showed a left pelvic mass extended to the lumen of the inferior vena cava with a high affinity for somatostatin receptor. A tubular focus of radiotracer accumulation after the course of inferior vena cava with filling defect was suggestive of tumor thrombus. Received...
Tue Sep 08, 2020 03:00
We report the 18F-FDG PET/CT appearance of abdominal actinomycosis in a 48-year-old immunocompetent woman with a history of laparoscopic cystojejunostomy for pancreatic pseudocyst previously. 18F-FDG PET/CT demonstrated multiple hypermetabolism in the liver, spleen, cystojejunostomy anastomosis, greater omentum, and umbilical region. Actinomycosis was verified by biopsy. Hepatosplenic actinomycosis secondary to cystojejunostomy is extremely rare and easily to be misdiagnosed. PET/CT is helpful for...
Tue Sep 08, 2020 03:00
Most executives new to a health care organization should have introductory and development programs during their first year, which should include networking opportunities, special projects to improve skills, independent or assigned course work, multiple types of assessments, and periodic discussions regarding expectations about their work and their progress in achieving them. It is preferable for the organization and the new executive to have information from outside sources about how a person in...
Tue Sep 08, 2020 03:00
Primary hepatoid adenocarcinoma of the gallbladder is rare. A 67-year-old woman presented with right upper quadrant abdominal pain with elevated α-fetoprotein level. Abdominal ultrasound and MRI showed a tumor in the gallbladder with normal liver. FDG PET/CT showed increased FDG uptake of the gallbladder tumor with retroperitoneal lymph node metastasis. Cholecystectomy was performed. Primary hepatoid adenocarcinoma of the gallbladder was confirmed by histopathology. Received for publication July...
Tue Sep 08, 2020 03:00
Autoimmune encephalitis is a diverse group of neuropsychiatric disorders, which are difficult to diagnose clinically. The disorder presents acutely or subacutely with alteration of consciousness, cognitive decline, seizures, and abnormal movements. Autoantibodies are directed against intracellular antigens or extracellular domains of cell surface proteins, critical for neuronal excitability. 18F-FDG PET/CT has been used to diagnose the metabolic derangement in the brain due to various antibodies....
Tue Sep 08, 2020 03:00
A 51-year-old woman with a history of sarcomatoid hepatocellular carcinoma, status post resection, underwent FDG PET/CT. In addition to abnormal activity elsewhere, the images showed focal activity in the isthmus of the thyroid, suggestive of malignant involvement, and diffuse mild activity in the left lobe of the thyroid, suggestive of thyroiditis. After a 10-week anti–PD-1 pembrolizumab therapy, the follow-up FDG PET/CT scan demonstrated much more intense activity in both the isthmus and the left...
Tue Sep 08, 2020 03:00
Aim The aim of this study was to evaluate if integrating whole-body PET/CT with CT colonography (PET/CTC) improves the preoperative diagnosis of obstructive colorectal cancer (CRC). Methods We prospectively included 47 consecutive patients (18 women and 29 men; mean age, 71 ± 14 years) suspected of having CRC by optical colonoscopy, which was not completed due to obstructive masses. To perform PET/CTC, a small caliber Foley catheter was inserted to distend the colon with CO2 insufflations....
Tue Sep 08, 2020 03:00
We report the case of a 64-year-old woman with musculoskeletal pain and elevated serum parathyroid hormone who had undergone parathyroidectomy for primary hyperparathyroidism 4 years earlier. An 18F-choline PET/CT scan was performed and incidentally showed an intense uptake in a right upper lobe pulmonary nodule and in the right hilar, mediastinal, and cervical lymph nodes. Histopathological analysis confirmed the diagnosis of a small cell lung cancer. Clinical symptoms and recurrent hyperparathyroidism...
Tue Sep 08, 2020 03:00
A 40-year-old woman with follicular thyroid cancer underwent a systemic PET/CT evaluation before operation and then received total thyroidectomy and radioactive 131I ablation therapy. Posttreatment imaging of 131I whole-body scan with SPECT/CT showed that metastasis on the spleen-stomach space coexists with mimicking subcutaneous metastasis, considering their level of 131I accumulation and morphological changes on PET/CT. However, histopathology confirmed the subcutaneous lesion of fibrous hyperplasia...
Tue Sep 08, 2020 03:00
The heterogeneity of even “well-defined” type 2 (T2) asthma is reflected by the absence of uniform response to T2 blockade despite recruitment of subjects with a strong T2 signal. Fractional exhaled nitric oxide (FeNO) is a biomarker elevated in uncontrolled T2-asthma secondary to IL-13 induced nitric oxide synthase expression in the airway epithelium. While FeNO is reduced by anti-IgE and anti-IL-4/13 therapies(1-5), it did not change in studies with mepolizumab, suggesting the absence of modulation...
Wed Sep 09, 2020 03:00
Abstract Purpose To estimate the clinical and functional results of patients who underwent distinctive types of open reduction and internal fixation of ZMC fractures, with particular emphasis on malar height and vertical dystopia. Materials and methods A randomized clinical trial was conducted from August 2016 to October 2019 in which 40 adult patients...
Thu Sep 10, 2020 03:00
Impaired naming is a ubiquitous symptom in all types of aphasia, which often adversely impacts independence, quality of life, and recovery of affected individuals. Previous research has demonstrated that namin...
Wed Sep 09, 2020 03:00
Summary Background Treatment options for pancreatic ductal adenocarcinoma (PDAC) are limited and checkpoint blockade inhibitors have been disappointing in this disease. Pegilodecakin has demonstrated single agent anti-tumor activity in immune-sensitive tumors. Phase 1 and preclinical data indicate synergy of pegilodecakin with 5-FU and platins. We assessed the safety and activity of pegilodecakin+FOLFOX in patients with PDAC. Methods IVY (NCT02009449) was an open-label phase 1b...
Thu Sep 10, 2020 03:00
Abstract Background Oral lichen planus (OLP) is a relatively common mucocutaneous disorder, and its causative factors and pathogenesis are not fully understood. Existing studies on the association between hematinic deficiencies and OLP are limited and inconsistent. The aim of this study was to assess the hematinic deficiencies in a cohort of OLP patients and evaluate the correlation between hematinic deficiencies and OLP. ...
Thu Sep 10, 2020 03:00
Many of the risk factors for Birth Related Brachial Plexus Injury (BRBPI) such as maternal gestational diabetes and macrosomia, are known to vary between demographic groups. Socioeconomic differences are known to influence access to healthcare, including elective Caesarean section rates and access to consultant Obstetricians, which could impact rates of BRBPI. This study aims to explore whether BRBPI is affected by demographic factors.
Wed Sep 09, 2020 03:00
Abstract Sinonasal angiectatic polyp is an uncommon condition with features that masquerade various pathologies like hemangioma, angiofibroma, inverted papilloma, malignancy. We report a case of a left-sided vascular nasal mass, which on examination and investigations suggested cavernous hemangioma of the left maxillary sinus, whereas histopathology post-excision revealed angiectatic polyp.
Thu Sep 10, 2020 03:00
Abstract To observe and compare the functional outcome in term of hearing gain in ossiculoplasty with autologous incus and Teflon made TORP/PORP in cases of chronic otitis media (COM) with ossicular disruption. 60 patients of COM between age of 11–50 years who had ossicular disruption were included in the study. They were divided into two groups of 30 patients/ group: group 1 included those patients who had mucosal COM and group 2 included those who had squamous COM. They were...
Thu Sep 10, 2020 03:00
Objectives: Small studies suggest that a new entity of high-grade (HG) (G3, by Ki-67 or mitotic index) well-differentiated (histologically) gastrointestinal neuroendocrine tumors (NETs) exists, but prognosis and characteristics are unknown. We further characterized demographics and prognosis of patients with colorectal G3 NETs. Materials and Methods: We used the Surveillance Epidemiology and End Results (SEER) database to study colorectal NETs diagnosed from 2000 to 2015. We evaluated...
Tue Sep 08, 2020 03:00
No abstract available
Tue Sep 08, 2020 03:00
Future Oncology, Ahead of Print.
Wed Sep 09, 2020 10:42
Future Oncology, Ahead of Print.
Wed Sep 09, 2020 04:54
Future Oncology, Ahead of Print.
Wed Sep 09, 2020 04:01
Abstract Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII) have been identified as predictors of treatment response in a variety of cancers. We conducted a retrospective analysis to investigate the usefulness of NLR, PLR and SII at baseline and at 6 weeks post-treatment as predictors of response to anti-PD-1/PD-L1 antibody treatment in small cell lung cancer (SCLC). Data of 41 SCLC patients receiving immunotherapy...
Thu Sep 10, 2020 03:00
To the Editor: Tumor-induced osteomalacia is a rare paraneoplastic syndrome caused by excessive secretion of fibroblast growth factor 23 (FGF23) by a phosphaturic mesenchymal tumor. Through fibroblast growth factor receptor 1 (FGFR1) signaling, FGF23 decreases renal phosphate reabsorption and…
Wed Sep 09, 2020 03:00
Babywearing may be as old as humankind, but it still garners controversy as a parenting tool. New research may help push forward the idea that it's not just about convenience.
Thu Sep 10, 2020 07:30
Abstract Purpose Adenotonsillectomy is the first-line treatment for pediatric obstructive sleep apnea (OSA). However, although completely resolved OSA after adenotonsillectomy, some children still showed persistence of mouth breathing. Therefore, we attempted to identify risk factors for residual mouth breathing in children with OSA after successful adenotonsillectomy. ...
Thu Sep 10, 2020 07:24
Abstract Purpose Revision surgery for correcting benign laryngotracheal stenosis is challenging and it gets complicated in patients with comorbidities. To improve results in such cases, we describe a new technique of stabilizing the trachea by splinting it to the clavicle on both sides. Methods Retrospective case series. ...
Thu Sep 10, 2020 07:24
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