Abstract Purpose Evidence-based treatment recommendations for external auditory canal (EAC) carcinoma are lacking in available literature. This study aims to evaluate the clinical characteristics and long-term outcomes of EAC carcinoma in a tertiary referral centre in a period of 15 years and identify independent prognostic factors. Methods ...
Thu Sep 10, 2020 07:24
Abstract Background The role of primary tumor resection in patients with distant metastatic laryngeal carcinoma (DMLC) has not been clarified completely. Thus, we used propensity score matching (PSM) and survival analysis to address this issue. Methods The PSM was utilized to avoid selection bias and disproportionate distributions of the confounding...
Thu Sep 10, 2020 07:24
The article ATF5 involved in radioresistance in nasopharyngeal carcinoma by promoting epithelial-to-mesenchymal phenotype transition, written by Yu Shuai, Erxi Fan, Qiuyue Zhong, Guangyong Feng, Qiying Chen, Xiaoxia Gou, Guihai Zhang, was originally published.
Thu Sep 10, 2020 07:24
Abstract Purpose At the time of writing, there is a pandemic affecting virtually every country on Earth. There is considerable discussion amongst clinicians as well as lay people about anosmia and ageusia in COVID-19 sufferers. We aimed to report the results from comprehensive olfactory and gustatory testing in a series of hospital in-patients. Methods ...
Thu Sep 10, 2020 07:24
Abstract Purpose In our previous randomized controlled trial (RCT), comparing adenotonsillectomy (ATE) with adenopharyngoplasty (APP) in children with severe obstructive sleep apnea (OSA), there were no differences in respiratory sleep parameters or quality of life. The purpose of the present report was to evaluate postoperative morbidity from this RCT. Methods ...
Thu Sep 10, 2020 07:24
Abstract Purpose To assess the added value of susceptibility-weighted imaging (SWI) to diffusion-weighted imaging (DWI) in the characterization of parotid gland tumors. Methods Seventy-eight patients with pathologically confirmed parotid gland tumors, who underwent DWI and SWI for pre-surgery evaluation, were enrolled. Apparent diffusion coefficient...
Thu Sep 10, 2020 07:24
Abstract Purpose To propose a cost-effective reproducible barrier method to safely perform endoscopic endonasal surgery during the Covid-19 pandemic. Methods This manuscript highlights the use of a clear, cost-effective disposable plastic sheet that is draped as a tent over the operating area to contain aerolization of particles. This is then...
Thu Sep 10, 2020 07:24
Abstract Background The aim of this study was to analyze the effect of device-dependent factors on epistaxis episodes comparing patients supported with a continuous-flow left ventricular assist device (CF-LVAD) to patients under the same antithrombotic therapy. Methods Patients who underwent CF-LVAD between 2012 and 2018 were reviewed retrospectively...
Thu Sep 10, 2020 07:24
Abstract Purpose SARS-CoV-2 is a new pandemic influenza caused by a coronavirus which main route of transmission is through exhaled droplets that primarily infect the nose and the nasopharynx. The aim of this paper is to evaluate the effect of acetic acid, the active component of vinegar, as a potential disinfectant agent for upper airways. Methods ...
Thu Sep 10, 2020 07:24
Abstract Purpose The aim of the present study was to evaluate the prognostic factors that may affect the success in endoscopic cartilage tympanoplasty and determine the outcomes of endoscopic cartilage tympanoplasty. Methods This study included 312 patients who underwent transcanal endoscopic type I cartilage tympanoplasty. The effects of sex,...
Thu Sep 10, 2020 07:24
Thyroid, Ahead of Print.
Wed Sep 09, 2020 10:00
Thyroid, Ahead of Print.
Wed Sep 09, 2020 10:00
The radiotherapy (RT) workflow is a complex process consisting of several time-consuming steps that have an impact on treatment quality and hence patient outcome. Artificial intelligence (AI) has been proposed as a tool to increase quality, standardisation and acceleration of these steps leading to a more safe and accurate radiation administration by automation and optimization of workflows [1–3]. Especially with the introduction of adaptive radiotherapy (ART), a streamlined workflow is mandatory...
Wed Sep 09, 2020 03:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Wed Sep 09, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Wed Sep 09, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Wed Sep 09, 2020 10:00
In the simpler times before Covid-19, I used to play a game with medical students who joined me in the operating room. "There’s a giant flood coming that will devastate the earth and its inhabitants. You’ve got a big boat in which to preserve human civilization. There’s room for 100 citizens of the…
Wed Sep 09, 2020 03:00
On February 4, 2020, the U.S. secretary of health and human services declared that emergency use of diagnostics for SARS-CoV-2 was justified, triggering emergency authority for the Food and Drug Administration (FDA) to grant an emergency use authorization (EUA) for a device if it reasonably…
Wed Sep 09, 2020 03:00
Stem Cells and Development, Ahead of Print.
Wed Sep 09, 2020 10:00
High Altitude Medicine &Biology, Ahead of Print.
Wed Sep 09, 2020 10:00
Abstract Purpose Severely fractured sleep is mostly portrayed negatively, but investigations in extreme sports show that humans can maintain performance with a minimum of sleep. With two cases of long-lasting extreme sports performances, we demonstrate that severely fragmented sleep does not necessarily lead to a deterioration of physical and cognitive performance. Methods...
Thu Sep 10, 2020 03:00
Related Articles Voice outcome after unilateral ELS type III or bilateral type II resections for T1-T2 glottic carcinoma: Results after 1 year. Head Neck. 2019 06;41(6):1638-1647 Authors: van Loon Y, Hendriksma M, Heijnen BJ, van de Kamp VAH, Hakkesteegt MM, Böhringer S, Langeveld TPM, de Jong MA, Klop WMC, Baatenburg de Jong RJ, Sjögren EV Abstract BACKGROUND: Voice outcome was assessed in patients with extended T1 and limited T2 glottic...
Thu Sep 10, 2020 05:40
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1713941Orbital pathologies can be complex to manage surgically. In this article, we describe some of the most common and relevant approaches to orbital tumours. For each approach we describe the appropriate indications, surgical technique, potential complications, and illustrate a case example.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text
Wed Sep 09, 2020 02:00
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1713849Transcaruncular and transconjunctival approaches are commonly used by ophthalmic plastic surgeons to access various orbital compartments. These approaches are versatile and may be combined with transnasal or transcranial approaches to the orbit to gain optimal access to challenging locations. A major advantage of the transcaruncular and transconjunctival approaches is the lack of a visible skin incision with excellent postoperative cosmesis. As...
Wed Sep 09, 2020 02:00
Sebaceous carcinoma is an aggressive skin cancer with a 5-year overall survival rate of 78% for localized/regional disease and 50% for metastatic disease. The incidence of this cancer has been increasing in the United States for several decades, but the underlying reasons for this increase are unclear. In this article, we review the epidemiology and genetics of sebaceous carcinoma, including recent population data and tumor genomic analyses that provide new insights into underlying tumor biology....
Wed Sep 09, 2020 15:42
Biofuel made from agricultural products has the potential in contribute to a stable supply of fuel for growing energy demands. Some salient plant traits, such as stem diameter and water content, and their relationship to other important biomass-related traits are so far poorly understood. Here, we performed QTL mapping for three stem diameter and two water content traits in a Sorghum bicolor BTx623 x IS3620c recombinant inbred line population of 399 genotypes, and validated the genomic regions identified...
Wed Sep 09, 2020 23:12
Abstract In 1911, the Danish physician Hans Christian Gram (1853–1938) sustained to have found signs of hyperthyroidism in a marble head of a Roman woman that he observed in the Ny Carlsberg Glyptotek in Copenhagen. It could be one of the first examples of a clinical diagnosis of an endocrine disease in an ancient statue.
Thu Sep 10, 2020 03:00
Related Articles The French Cochlear Implant Registry (EPIIC): General indicators. Eur Ann Otorhinolaryngol Head Neck Dis. 2020 Sep 02;: Authors: Gauvrit F, Risoud M, Aubry K, Bordure P, Bozorg-Grayeli A, Deguine O, Eyermann C, Franco-Vidal V, Godey B, Guevara N, Karkas A, Klopp N, Labrousse M, Lebreton JP, Lerosey Y, Lescanne E, Loundon N, Marianowski R, Merklen F, Mezouaghi K, Mom T, Moreau S, Mosnier I, Noël-Petroff N, Parietti C, Piller P, Poncet C, Radafy...
Thu Sep 10, 2020 04:00
Central Brain Tumor Registry of the United States (CBTRUS) reports the incidence rate of malignant CNS tumors in the United States is 23.41 per 100,000, with 48.3% of which are glioblastoma multiforme (GBM) [1]. Treatment for GBM includes maximal surgical resection and radiation therapy (RT) with concomitant and adjuvant temozolomide (TMZ) chemotherapy based on the STUPP trial [2]. Despite the intensive treatment, GBM will eventually develop resistance to RT and TMZ, and most patients will succumb...
Wed Sep 09, 2020 03:00
Background. Interleukin-17 plays important roles in allergic diseases. Several studies proved that leptin promoted Th17 immune responses by inducing RORγt transcription. ILC2 is an important member of the early stage of immune response. Therefore, we aimed to explore the effect of leptin on the IL-17 production by ILC2 in AR in this study. Methods. Fifteen AR patients and fifteen healthy controls were enrolled. Serum leptin levels were measured, and their correlation with the frequency of IL-17+...
Wed Sep 09, 2020 15:05
Inflammation can cause various chronic diseases like inflammatory bowel diseases. Various food protein-derived bioactive peptides (BAPs) with anti-inflammatory activity have the potential to manage these diseases. The aim of this paper is to overview the mechanisms and the molecular targets of BAPs to exert anti-inflammatory activity. In this review, the in vitro and in vivo effects of BAPs on intestinal inflammation are highlighted. The mechanism, pathways, and future perspectives of BAPs as the...
Wed Sep 09, 2020 15:05
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05691
Wed Sep 09, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02051
Wed Sep 09, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02350
Wed Sep 09, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c03050
Wed Sep 09, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01224
Wed Sep 09, 2020 07:00
Abstract Background The clinical predictors and biological mechanisms for localized prostate cancer (PCa) outcomes remain mostly unknown. We aim to evaluate the role of serum immune-checkpoint-related (ICK) proteins and genetic variations in predicting outcomes of localized PCa. Methods We profiled the serum levels of 14 ICK-related proteins (BTLA,...
Wed Sep 09, 2020 03:00
Objectives: A vortex whistle produces a tone which has a frequency proportional to the inlet air flow rate. The objectives of this study were to replicate previous studies demonstrating the use of a vortex whistle as an accurate flow meter, and to assess the degree of relationship between measures of vital capacity (VC) obtained using low-cost methods (vortex whistle and hand-held spirometry) vs. pneumotach-based spirometry.Methodology: A vortex whistle was designed using 3D modeling software and...
Wed Sep 09, 2020 03:00
High exposure to heat and combustion byproducts is associated with health problems and an increased risk of cancer.
Wed Sep 09, 2020 03:00
Straw phonation exercises have been proved to be effective in improving voice quality among persons with voice pathology. The aim of the study was to investigate the effects of straw phonation as a warm-up exercise on maximum phonation duration, acoustic, and perceptual parameters of voice among Speech Language Pathologists.
Wed Sep 09, 2020 03:00
To identify the possible risk factors related to etiology of the minimal associated pathological lesions (MAPLs) of the vocal folds and their impacts on the recurrence of lesion.
Wed Sep 09, 2020 03:00
Frequency range measures in singers reflect their physiological capacity, vocal flexibility, training effects, strengths, and limitations in singing. Since this information is vital for pedagogic and clinical purposes, this study aimed to measure the frequency range in Carnatic singers while singing different aspects of the vocal music.
Wed Sep 09, 2020 03:00
Abstract Purpose At graduation from medical school, competency in otoscopy is often insufficient. Simulation-based training can be used to improve technical skills, but the suitability of the training model and assessment must be supported by validity evidence. The purpose of this study was to collect content validity evidence for a simulation-based test of handheld otoscopy skills. ...
Wed Sep 09, 2020 03:00
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Yongbin Yan, Xianhui Yang, Xiaoxu Sun, Huijuan Zhang, Lingling Liu, Ruiying Ran
Thu Sep 10, 2020 01:22
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Mengjia Sun, Huanjun Wang, Lili Gong, Dongmei Qi, Xiaoming Wang, Yunlun Li, Haiqiang Jiang
Thu Sep 10, 2020 01:22
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Yue Li, Weidong Wu, Weihong Liu, Mingxue Zhou
Thu Sep 10, 2020 01:22
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Natia Tsagareli, Nana Tsiklauri, Irine Kvachadze, Merab G. Tsagareli
Thu Sep 10, 2020 01:22
Publication date: Available online 8 September 2020Source: Brain Research BulletinAuthor(s): Yu-xiang Fei, Jian-ping Zhu, Zhao Bo, Qi-yang Yin, Wei-rong Fang, Yun-man Li
Thu Sep 10, 2020 01:04
Publication date: Available online 8 September 2020Source: Brain Research BulletinAuthor(s): Mahnaz Bayat, Shahrbanoo Zabihi, Narges Karbalaei, Masoud Haghani
Thu Sep 10, 2020 01:04
Multi-fraction high dose-rate brachytherapy (HDR) as monotherapy is a safe and effective treatment option for men with prostate cancer [1,2]. The reported low alpha/beta ratio of prostate cancer, as well as the logistic challenges of delivering multi-fraction HDR brachytherapy, has prompted several investigators to explore single-fraction regimens. Early reports of clinical outcomes after a single dose of 19 Gy seemed to support this notion, with high biochemical control rates being reported [3,4].
Wed Sep 09, 2020 03:00
An exchange of genetic material that occurred when ancient giant viruses infected ancient eukaryotic cells could have caused the nucleus of the eukaryotic cell -- its defining feature -- to form. A novel evolutionary hypothesis opens doors to new discussions on the subject, bringing us one giant step closer to the truth.
Wed Sep 09, 2020 17:03
Background. The microliposome maintenance (MCM) complex, MCM2-7, is revealed to be involved in multiple cellular processes and plays a key role in the development and progression of human cancers. However, the MCM complex remains poorly elaborated in hepatic carcinoma (HCC). Methods. In the study, we found the mRNA and protein level by bioinformatics. We also explored the prognostic value, genetic alteration, interaction network, and functional enrichment of MCM2-7. The MCM expression and correlation...
Wed Sep 09, 2020 14:20
Facial plastic and reconstructive surgeons’ professional lives are first consumed with starting a practice, academic or private, building the practice, and being facial plastic surgeons. We live our lives as experts in our chosen field. However, there are many issues that arise sometimes suddenly to startle us, other times lingering in the background waiting for attention. The articles in this issue of the Facial Plastic Surgery Clinics of North America explore many day-to-day problems that are often...
Wed Sep 09, 2020 03:00
Body dysmorphic disorder and borderline personality disorder are common in esthetic practices and occur in up to 15% of patients. Operating on these patients may not only lead to dissatisfaction but may also worsen their premorbid condition and can induce negative behavior toward the practice. Preventing surgery and referring patients for cognitive therapy is essential. An adequate understanding of these conditions and the available screening tools is indispensable for all esthetic practitioners....
Wed Sep 09, 2020 03:00
Surgical education is under tremendous pressure due to ever-increasing medical knowledge and demands on trainees’ time. They must continually learn more in less time due to work hour limitations, regulations, and electronic medical record demands. Surgical training must become more efficient. There is an unprecedented array of education and training opportunities for resident preparation. The preparation for each case has to be maximal. Preoperative, intraoperative, and postoperative simulation and...
Wed Sep 09, 2020 03:00
Skin resurfacing techniques allow improvement of skin texture and color. This includes the effacement of wrinkles, signs of photoaging, and the softening of scars. Laser resurfacing, chemical peels, and dermabrasion are associated with overlapping risks of complications. The most common of these include infection, hypopigmentation, hyperpigmentation, and scarring. Patient evaluation helps provide treatment that gives the maximal benefit with a minimization of risks. This includes understanding the...
Wed Sep 09, 2020 03:00
Facial plastic surgeons need to be very much more than excellent surgeons. They need to understand and have the ability to bring each patient into the practice family of the surgeon, the administrative and clerical staff, the nurses, the technicians, and the aestheticians. The entire staff must “own” the practice and the patient management philosophy of the surgeon. This article is the author’s philosophy and method of guiding his patients through their journey of rejuvenative facial surgery based...
Wed Sep 09, 2020 03:00
Pneumoblastoma is a rare primary childhood tumor. We report the observation of an infant aged 2 years and 8 months who presented with dry cough and dyspnea. The physical examination found mixed pleural effusion syndrome on the right. The chest X-ray revealed a right pneumothorax. Biology has shown leukocytosis at 16,000/mm3. The CT scan revealed parenchymal air cystic lesions affecting the outer segment of the middle lobe mimicking a pulmonary malformation. Thoracic drainage brought back 100 ml of...
Wed Sep 09, 2020 17:50
The advent of three-dimensional imaging and computer-aided surgical simulation (CASS) have brought about a paradigm shift in surgical planning. The aim of this study was to assess the accuracy of maxillary repositioning surgery using computer-aided design and manufacturing (CAD/CAM) customized titanium surgical guides and fixation plates. Thirty consecutive adult patients, 13 male and 17 female, with a mean age of 29.2 years and 25.5 years, respectively, requiring Le Fort I maxillary osteotomy, with...
Wed Sep 09, 2020 03:00
Drugs targeting the fusion process of viral entry into host cells have been approved for clinical use in the treatment of AIDS. There remains a great need to improve the use of existing drugs for HIV therapy. ...
Tue Sep 08, 2020 03:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02906
Wed Sep 09, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02942
Wed Sep 09, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02121
Wed Sep 09, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02164
Wed Sep 09, 2020 07:00
AbstractPrimary sclerosing encapsulating peritonitis (SEP) is an idiopathic and rare condition characterized by chronic peritoneal inflammation. We describe the case of an intraoperative diagnosis of SEP, presenting as a mimicker of small bowel obstruction. The patient was a 59-year-old male with suspected small bowel obstruction. On exploratory laparotomy, it was noted that there was thick fibrous tissue involving the visceral and parietal peritoneum enveloping grossly dilated loops of small bowel....
Wed Sep 09, 2020 23:34
Researchers studied the evolution of the body sizes of frogs and their tadpoles. They found that the two life stages do not evolve completely independently of each other as previously thought.
Fri Sep 04, 2020 16:29
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08117
Wed Sep 09, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06868
Wed Sep 09, 2020 07:00
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