Efficacy of argon‐helium cryoablation andits effects on immune function of patients with neck malignant tumors

Efficacy of argon‐helium cryoablation andits effects on immune function of patients with neck malignant tumors:

Abstract

Objectives

Our study aimedto investigate the clinical efficacy of argon‐helium cryoablation and its effects on the immune function of patients with neck malignant tumors.

Design

Retrospective study.

Setting

Single‐institution academic tertiary care center.

Methods

Totally 180 patients harboring head and neck malignant tumors were divided intothe the argon‐helium cryoablation group(n=150) and the radiotherapy group(n=50). The efficacy of the two groups was compared and the immune function was observed.

Results

The short‐term clinical effect of the argon‐helium cryoablation group was significantly higher than that of the radiotherapy group(P<0.05). After treatment, the CD3+, CD4+, CD8+ and CD4+/CD8+ of the argon‐helium cryoablation group were significantly better than those of the radiotherapy group(P < 0.001). The results of TNF‐ α, IL‐1 β and CRP in the argon‐helium cryoablation group was significantly better than that in the radiotherapy group(P < 0.001).

Conclusion

Argon‐helium cryoablation could effectively improve the immune function, 5‐year survival rate and local remission rate.