Reliability assessment on intravascular photoacoustic imaging of lipid: Ex vivo animal and human sample validation

Reliability assessment on intravascular photoacoustic imaging of lipid: Ex vivo animal and human sample validation:

ABSTACT

Although the lipid‐detecting IVPA imaging system has been developed in resolution, speed and catheter size, there is no parameterization study of the reliability on the IVPA imaging for lipid diagnosis. Here, the sensitivity, specificity and accuracy were calculated to assess the reliability of the IVPA imaging of lipid. Abdominal aortas from 6 rabbits with atherosclerosis, were subjected to the IVPA imaging and Oil Red O staining, and 75 groups of IVPA as well as corresponding histological images were obtained. Similarly, 125 groups of IVPA and histological results were obtained from 5 human carotid plaque samples. The sensitivity, specificity, and accuracy, calculated from the statistical data, were 96.8%, 83.3%, 94.6% and 97.3%, 72.7%, 95.2%, respectively. The numerical values of sensitivity, specificity and accuracy demonstrated the reliability of IVPA imaging on distinguishing the lesions vessel with lipid‐rich plaque, which provided the foundation for IVPA translation to clinical application.

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