Protective role of histone deacetylase 4 from ultraviolet radiation‐induced DNA lesions

Protective role of histone deacetylase 4 from ultraviolet radiation‐induced DNA lesions:

Abstract

Ultraviolet B (UVB) exposure is a core factor that leads to skin disease or carcinogenesis through the insufficient repair of DNA lesions. UVB‐induced DNA lesions are mainly removed by the nucleotide excision repair (NER) mechanism. The expression of histone deacetylase 4 (HDAC4) is altered in the skin upon UVB exposure, indicating its possible implication in UVB‐induced DNA lesions repair. Here, we investigated the role of HDAC4 in the NER removal of the main classes of UVB‐induced DNA lesions consisting of cyclobutane pyrimidine dimers and pyrimidine (6‐4) pyrimidone photoproducts (6‐4PPs). We found that UVB irradiation increased HDAC4 expression at both the mRNA and protein levels. HDAC4 interacted with NER factor XPC, which played an important role in effectively removing the UVB‐induced DNA lesions. This study provides an understanding of the HDAC4 function in DNA repair, which will allow the development of efficient strategies to protect the skin from UVR‐induced diseases.