Abstract Rationale F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsychopharmacology 44(11):1917–1924, 2019). Objective...
02:00
Abstract Rationale Phosphodiesterase 10A inhibitor TAK-063 has shown effects that suggest efficacy in schizophrenia treatment. Objective This randomized, double-blind, placebo-controlled, incomplete-crossover study investigated effects of single oral administration of TAK-063 on ketamine-induced changes in blood oxygen level-dependent (BOLD) signal in healthy...
02:00
Abstract Rationale There is limited understanding regarding how various e-cigarette flavorings may influence the behavior of non-regular e-cigarette users who are regular cigarette smokers. Objectives To assess differences in nicotine delivery, puffing topography, subjective effects, and user satisfaction from different flavored e-liquids. ...
02:00
Abstract Rationale Whereas the effect of the sex steroid 17-beta-estradiol (E2) on dopaminergic (DA) transmission in the nucleus accumbens (NAc) is well evidenced in female rats, studies in humans are inconsistent. Moreover, linear and inverted u-shaped dose response curves have been observed for E2’s effects on hippocampal plasticity, but the shape of dose response curves for E2’s effects on the NAc is much less characterized. ...
02:00
After publication of this paper, the authors determined an error in Fig. 4. Below is the correct Fig. 4.
Mon Nov 25, 2019 02:00
The reversion-inducing cysteine-rich protein with kazal motifs (RECK) gene was described as a tumor suppressor gene two decades ago. Recently, novel alternatively spliced products of this gene have been identified. Of these, the transcript variant 3 (RECKVar3) was shown to display tumor-facilitating effects in astrocytoma cells in vitro, with a higher RECKVar3/canonical RECK expression ratio being correlated with lower survival rates of patients. However, the regulatory mechanisms through which the...
Mon Nov 18, 2019 02:00
Histone posttranslational modifications (PTMs) have been shown to be dysregulated in multiple cancers including melanoma and as they are abundant and easily detectable, they make ideal biomarkers. The aim of this study was to identify histone PTMs that could be potential biomarkers for melanoma diagnosis. Previously, we utilized mass spectrometry to identify histone PTMs that were dysregulated in matched melanoma cell lines and found two modifications, H3 lysine 27 trimethylation (histone H3) and...
Mon Nov 18, 2019 02:00
Combined BRAF and MEK inhibition is one of the first-line treatment strategies for patients with advanced BRAF-mutant melanoma. Sarcoid-like reactions (SLRs) have occasionally been described with melanoma systemic treatments such as immunotherapy or the BRAF inhibitor vemurafenib, but very few cases have been reported with dabrafenib and trametinib. Our aim was to better characterize SLR induced by this combination. We conducted a monocentric retrospective observational study among patients treated...
Mon Nov 18, 2019 02:00
We report a case in which a renal transplant recipient with metastatic melanoma had an excellent response to treatment with second line programmed cell death protein 1 (PD-1) inhibitor therapy, pembrolizumab. Acute cellular allograft rejection on initiation of PD-1 inhibitor was successfully reversed with methylprednisolone. By converting the patient to sirolimus and giving predose prednisolone, pembrolizumab was continued with stable renal function and an excellent oncological response. This case...
Mon Nov 18, 2019 02:00
Background. Lactate has been widely used as a risk indicator of outcomes in critically ill patients due to its ready measurement and good predictive ability. However, the interconnections between lactate metabolism and glucose metabolism have not been sufficiently explored, yet. In this study, we aimed to investigate whether glucose levels could influence the predictive ability of lactate and design a more comprehensive strategy to assess the in-hospital mortality of critically ill patients. Methods....
09:05
Here is brief video case report on a case of CNS Toxoplasmosis by Dr Sumer SethiFamous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com
09:01
Abstract Introduction Nepal has made considerable progress on improving child survival during the Millennium Development Goal period, however, further progress will require accelerated reduction in neonatal mortality. Neonatal survival is one of the priorities for Sustainable Development Goals 2030. This paper examines the trends, equity gaps and factors associated with neonatal mortality between 2001 and 2016 to assess the likelihood...
02:00
Abstract Background This study aimed to elucidate the correlation between gene amplification, protein expression of receptor tyrosine kinase, and prognosis of patients with oral squamous cell carcinoma (OSCC) using immunohistochemistry (IHC) and next‐generation sequencing data. Methods We evaluated data pertaining to 208 patients with OSCC using IHC for epidermal growth factor receptor (EGFR) and mesenchymal‐epithelial transition factor (MET). Results High expressions of EGFR and...
Mon Nov 25, 2019 12:04
נציגים מהאקדמיה ללשון העברית וענף הכדורגל בחרו חלופה בעברית למונח הלועזי VAR בשלהי עונת הכדורגל של שנת תשע"ח–תשע"ט (2018–2019) הצטרפה ישראל למדינות שעברו לשיטת שיפוט באמצעות VAR – ראשי תיבות של Video Assistant Referee. נוהל שקבע איגוד השופטים מורה כי שופט ליגת העל, עוזר לשופט ומפעיל טכני יעקבו אחר התנהלות משחק הכדורגל באמצעות מצלמות הפרוסות לאורך המגרש, ויתריעו לפני השופט במגרש על בעיית שיפוט באחד מארבעה מצבים: (1( עבירה שהובילה לשער; (2) החלטה על בעיטת עונשין; (3) אירוע המחייב כרטיס אדום; (4)...
07:00
Opinion statement Advanced basal cell carcinoma (BCC) represents a small proportion of BCCs that are not amenable to standard therapies due to lack of efficacy, high recurrence risk, and excessive morbidity. Implication of the Sonic hedgehog (Shh) pathway in the development of BCC has led to the development of systemic Shh pathway inhibitors, providing patients with advanced BCCs new treatment options and improved survival. There are currently two Food and Drug Administration...
02:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
07:12
Abstract Background Several articles have recently reported that certain colon microbiota can improve the efficacy of cancer immunotherapy. To develop new treatment strategies, including immunotherapy for colorectal cancer (CRC), we evaluated the correlations between subpopulations of tumor-infiltrating immune cells (TIICs) and intestinal microbiota in CRC. Methods ...
02:00
Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
06:17
The 5' untranslated region (5’ UTR) of eukaryotic mRNA plays important role in translation. Here we report the function of the 5' UTR mRNA of S-adenosylmethionine synthetase (sam1) in translational modulation in the presence of SAM in fission yeast Schizosaccharomyces pombe. Reporter assays, binding and chemical probing experiments and mutational analysis show that the 5' UTR mRNA of sam1 binds to SAM to effect translation. Translational modulation is dependent on a tertiary structure transition...
Mon Nov 25, 2019 18:09
The expression and distribution of a protein can provide critical information about its function in a cell. For some neuronal proteins this information may include neurotransmitter (NT) usage and sites of NT release. However, visualizing the expression of a protein within a given neuron is often challenging because most neurons are intricately intermingled with numerous other neurons, making individual neuronal expression difficult to discern, especially since many neuronal genes are expressed at...
00:07
Many breeds of modern cattle are naturally horned, and for sound husbandry management reasons the calves frequently undergo procedures to physically remove the horns by disbudding or dehorning. These procedures are however a welfare concern. Selective breeding for polledness - absence of horns - has been effective in some cattle breeds but not in others (Bos indicus genotypes) due in part to the complex genetics of horn phenotype. To address this problem different approaches to genetic testing...
00:07
Peroxisomes are subcellular organelles that are essential for proper function of eukaryotic cells. In addition to being the sites of a variety of oxidative reactions, they are crucial regulators of lipid metabolism. Peroxisome loss or dysfunction leads to multi-system diseases in humans that strongly affect the nervous system. In order to identify previously unidentified genes and mechanisms that impact peroxisomes, we conducted a genetic screen on a collection of lethal mutations on the X chromosome...
00:07
Akirin, a conserved metazoan protein, functions in muscle development in flies and mice. However, this was only tested in the rodent and fly model systems. Akirin was shown to act with chromatin remodeling complexes in transcription and was established as a downstream target of the NFkB pathway. Here we show a role for Caenorhabditis elegans Akirin/AKIR-1 in the muscle and body length regulation through a different pathway. Akirin localizes to somatic tissues throughout the body of C. elegans, including...
00:07
We report a case of a 71-year-old male with a history of BPH who presented with flank pain, fever, chills, abdominal pain, and nausea. He had a dental cleaning 1 month prior to admission and flosses daily. Laboratory data revealed both urine and blood cultures to be positive for streptococcus sanguinis. Computed tomography revealed a 10 mm right ureteral stone, and an ultrasound demonstrated moderate right hydronephrosis. He underwent an ureteroscopy with stent placement. A transesophageal echocardiogram...
05:05
Abstract Purpose: To investigate the role of vagus nerve activation in the protective effects of hypercapnia in ventilator-induced lung injury (VILI) rats. Methods: Male Sprague-Dawley rats were randomized to either high-tidal volume or low-tidal volume ventilation (control) and monitored for 4h. The high-tidal volume group was further divided into either a vagotomy or sham-operated group and each surgery group was further divided into two subgroups: normocapnia and hypercapnia. Injuries were assessed...
04:56
Abstract Purpose: To investigate the effect of mesenteric lymph drainage on the spleen injury and the expressions of inflammatory cytokines in splenic tissue in mice following hemorrhagic shock. Methods: Male C57 mice were randomly divided into the sham shock, shock and shock+drainage groups. The mice in both shock and shock+drainage groups suffered femoral artery bleeding, maintained mean arterial pressure (MAP) of 40±2 mmHg for 90 min, and were resuscitated. And mesenteric lymph drainage was...
04:56
Abstract Purpose: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, was investigated in the present study for its possible healing effect on calvarial defects with bone grafts. Methods: Wistar male rats (n = 30) were divided into 3 groups: 1) the control (defect) group (n = 10), 2) defect and graft group (n = 10), and 3) defect, graft, and G. lucidum treated group (n = 10). The G. lucidum was administered to the rats at 20 mL/kg...
04:56
Sun Nov 24, 2019 16:17
Nitrogen plasma skin regeneration (PSR) initiated the use of cold atmospheric plasma (CAP) in skin rejuvenation over a decade ago. Helium gas CAP is already in widespread use worldwide for many surgical applications, whereas its use in skin rejuvenation is now emerging as a viable tool for treatment of facial rhytidosis. Animal studies comparing these CAPs suggest that observed differences in skin tissue interaction result from differences in plasma generation and in energy deposition wherein greater...
04:43
Facial aging is a combination of descent of facial tissues, atrophy of fat compartments, bony remodeling, and photoaging/chronologic changes of the skin. Photoaging of the skin is clinically and histologically distinct from the genetically programmed aging process. Photoaging is due to UV-A and UV-B–generated free radicals that cause DNA mutations, structural and enzymatic protein alterations, and lipid peroxidation.
04:43
Fractional CO2 procedures are an established, safe and effective armamentarium for managing skin rejuvenation and scarring. Very short-pulse-duration devices offer a very high ablated volume/ablated surface ratio, inducing a controlled thermal damage. With this kind of device, each procedure can be customized on the features of the skin of each patient. The same device can be used to treat severe burn scars. With a very deep fractional procedure on a scar tissue, immediate relaxation of the tension...
04:43
Picosecond laser technology was cleared by Food and Drug Administration in 2012 and enhanced our ability to clear both benign pigmentation and dermal ink through a photomechanical impact created in the tissue. This impact created is greater than comparative nanotechnology and can be accomplished with lower fluences and smaller pulse durations. The addition of a diffractive lens array (FOCUS lens) has created a new category in skin rejuvenation by stimulating elastin and collagen through photomechanical...
04:43
FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA
04:43
With modern medicine increasing both the average life span and quality of life, there has been a greater demand for treatment of age-related skin changes. As many new options in skin resurfacing are developed annually, it is chemical peeling that has withstood the trials of time and scrutiny. The different variations of chemoexfoliation have been used for rhytids, actinic damage, lentigos, and dyschromias. This article describes the most recent knowledge about chemical peeling, and exposes previously...
04:43
Having beautiful skin has been a constant desire through the ages, and the history of skin improvement, including cosmetics, dates to ancient Egypt nearly 6000 years ago.1 My interest in skin care started with my residency training at Baylor College of Medicine. At that time, most commercial skin-care improvement products existed in cosmetics, and not much was available for prescription skin-care and medical practice. The laser era was in its infancy. Retin A was introduced for acne treatment in...
04:43
Techniques for Hair Restoration
04:43
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου