Recent years have provided multiple modalities being promoted for improvement of facial appearance, including facial rhytid removal or smoothing, facial lesion correction, scar improvement, and general tightening and skin rejuvenation. Evaluation of the effectiveness of these techniques in addition to insightful selection of the appropriate equipment and treatment technology can be challenging to the contemporary facial plastic surgeon. This issue of Facial Plastic Surgery Clinics of North America...
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One of the greatest challenges in the progression of aesthetic medicine lies in providing treatments with long-term results that are also minimally invasive and safe. Keeping up with this demand are developments in autologous therapies such as adipose-derived stem cells, stromal vascular fraction, microfat, nanofat, and platelet therapies, which are being shown to deliver satisfactory results. Innovations in more traditional cosmetic therapies, such as botulinum toxin, fillers, and thread lifts,...
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Pulsed light has proven its usefulness, effectiveness, and versatility in treating a multitude of skin problems, delaying skin aging, maintaining healthy skin, and as an adjunct to a cosmetic surgical practice in the treatment of postsurgical scars. Practitioners contemplating adding a pulsed light device to their practice should choose a device that has at least 4 important features: a large spot size, variable-sized smaller spot adaptors, pulse rates of at least 1 pulse per second, a wide range...
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Energy-based skin rejuvenation has, like other forms of aesthetic treatments, the capability of achieving desirable end results. These end results must be balanced with the degree and duration of morbidity, which affect recovery from treatment. Renuvion skin resurfacing protocols include a free hand approach and we describe our preferred approach of pulsing and fractionating the helium plasma resurfacing energy.
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Microneedle radiofrequency (RF) is a breakthrough in targeting skin laxity and rhytids that provides direct in situ delivery, impedance measurements, temperature measurements, energy delivery controls, and targeting of various skin depths to achieve desired clinical outcomes. Microneedle RF controls penetration depth and delivery to specified temperatures and impedance measurements, ensuring significantly improved efficacy in the treatment of mild-to-moderate rhytids and skin laxity of the face and...
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Beauty of the face is dependent on many factors, measurable and intangible. The concept of a beautiful face varies from era to era and culture to culture. Maintenance, improvement, and creation of beautiful skin benefit from procedures, prescriptive topicals, cosmeceuticals, and cosmetics. Current science and art are children of the efforts of previous practitioners of past generations. A thorough understanding of how the skin ages is necessary for choosing the appropriate therapeutic approach to...
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Photodynamic therapy is the combination of the initial application of a photosensitive chemical on the skin and then using typically a blue filter light of varying spectrums. This treatment protocol has been more useful and functional than other chemical peels and lasers for a variety of conditions. There has been efficacy in antiviral treatments, such as herpetic lesions; malignant cancers of the head and neck; and lung, bladder, and skin cancers. It has been tested for prostate cancers, cervical...
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In the 2000s, there was a significant expansion in technology that was described as “nonablative.” These devices featured several different wavelengths and technologies. What they shared in common was the goal of delivering improvement in skin appearance while minimizing downtime and complications. Most of the “less-invasive” devices relied on the advent of fractional technology. This was the design feat of having multiple very small laser pulses delivered in a gridlike fashion and allowed for a...
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The process of obtaining blood biologics, including platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), can be complicated and expensive and is influenced by many vendors and proprietary techniques. The indications for PRP/PRF use remain controversial, and complicated or expensive modes of generating this biologic may lead to many facial plastic surgeons to pass on the use of these potentially useful agents. The lack of standardization of PRP procurement also has led to difficulties in assessing...
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The use of microneedling with or without radiofrequency continues to expand in aesthetics. There are now many different devices available that have multiple indications, unique protocols, and low side effect profiles.
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Objectives This study was conducted to investigate the dose‐response characteristics of radioiodine on salivary glands and to investigate the mechanism responsible for radioiodine‐induced salivary glands toxicity. Methods Twenty‐four mice were divided into six groups: 0, 0.05, 0.10, 0.20, 0.40, and 0.80 mCi/20 g mouse, administered orally. Mortalities were noted 12 months after radioiodine administration. Body weights, gland weights, salivary lag times, flow rates, and changes in 99mTc pertechnetate...
Mon Nov 25, 2019 15:46
Objective To compare pain control (opioid consumption and postsurgical pain scores) in head and neck (H&N) free flap reconstruction patients who undergo traditional means of postoperative analgesia including use of opioids versus a novel protocol that includes ketamine and gabapentin. Methods Single‐institution retrospective cohort study. Results Eighty‐six patients who underwent H&N free flap reconstruction from 2015 to 2018 were included. Forty‐three patients were in the control...
Mon Nov 25, 2019 15:44
Objectives/Hypothesis To investigate long‐term complications of newer reconstructive palate surgery techniques. Study Design Retrospective case‐series analysis. Methods Retrospective six‐country clinical study of OSA patients who had nose and palate surgery. Results There were 217 patients, mean age = 43.9 ± 12.5 years, mean body mass index = 25.9 ± 4.7, mean preoperative apnea‐hypopnea index [AHI] = 30.5 ± 19.1, follow‐up 41.3 months. A total of 217 palatal procedures were performed,...
Mon Nov 25, 2019 15:34
Objectives Analyze risk factors affecting length of stay (LOS) for patients presenting with deep neck space infections including care by medical versus surgical team. Methods This is a retrospective chart review from January 2005 through May 2018 at the University of Kentucky analyzing factors related to deep neck space abscesses. Patients included adults >18 years old admitted for deep neck space infections undergoing surgical intervention. This study compared effects of treatment on a...
Mon Nov 25, 2019 15:25
Introduction Drug‐induced sleep endoscopy (DISE) is used to assess site of obstruction for patients in a pharmacologically induced sleep‐like state. It is traditionally performed in the operating room (OR), however, no data exists regarding the feasibility of this intervention outside the OR in children. The objective is to compare the safety of DISE performed in the MRI induction room to those performed in the OR. Methods Prospective case‐series of patients undergoing DISE in the MRI induction...
Mon Nov 25, 2019 15:24
Objectives/Hypothesis The purpose of this study was to investigate the impact of dysphagia definition on the incidence and overall prevalence of dysphagia in patients with unilateral vocal fold paralysis (UVP) stratified by etiology. Study Design Retrospective medical chart review. Methods Data was collected from the records of individuals diagnosed with UVP from 2013 to 2018, including patient demographics, dysphagia questionnaire total scores, clinical evaluation dysphagia symptoms,...
Mon Nov 25, 2019 15:18
Purpose:Circulating tumor cells (CTCs) serve as noninvasive tumor biomarkers in many types of cancer. Our aim was to detect CTCs from patients with neuroblastoma for use as predictive and pharmacodynamic biomarkers.Experimental Design:We collected matched blood and bone marrow samples from 40 patients with neuroblastoma to detect GD2+/CD45– neuroblastoma CTCs from blood and disseminated tumor cells (DTCs) from bone marrow using the Imagestream Imaging flow cytometer (ISx). In six cases, circulating...
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Purpose: Pancreatic cancer remains one of the most lethal cancers and late detection renders most tumors refractory to conventional therapies. Development of cancer prophylaxis may be the most realistic option for improving the mortality of this disease. Here we develop a novel individualized prophylactic and therapeutic vaccination regimen using induced pluripotent stem cells (iPSCs), gene editing and tumor-targeted replicating oncolytic viruses. Experimental Design: We created a Virus-Infected,...
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Analytical ChemistryDOI: 10.1021/acs.analchem.9b04901
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01303
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03578
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03996
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03776
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03778
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04189
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04206
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02871
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03316
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04065
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04122
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03726
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03943
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03636
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03861
Mon Nov 25, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03920
Mon Nov 25, 2019 07:00
Horm Metab ResDOI: 10.1055/a-1023-4181A lack of vitamin D seems to be related to autoimmune diseases including autoimmune thyroiditis (AIT). This study intends to determine the correlation between improvement of 25-hydroxyvitamin D [25(OH)D] levels and AIT in patients from an outpatient endocrine clinic in Frankfurt, Germany. This study included 933 patients with thyroid peroxidase antibodies (anti-TPO-Ab) ≥34 kIU/l, including most patients with clear AIT due to a concurrent sonographic evidence...
Mon Nov 25, 2019 01:00
Nature Communications, Published online: 26 November 2019; doi:10.1038/s41467-019-13458-xPublisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
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Nature Communications, Published online: 25 November 2019; doi:10.1038/s41467-019-13179-1Swimming bacteria perform collective motion at high cell density, yet it is unclear how this behaviour affects their ability to follow substance gradients in the environment. Here, Colin et al. address this question by studying motion of Escherichia coli in controlled chemical gradients.
Mon Nov 25, 2019 02:00
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