Abstract Suprahyoid muscle activation and tongue pressure force play a critical role for swallowing function. In addition, dysphagia limit is one of most important factors indicating swallowing efficiency. The purpose of this study was to compare the effects of 8-week training sessions of three different exercises including chin tuck against resistance (CTAR), Shaker exercises and chin tuck exercise with theraband on suprahyoid muscle activity, anterior tongue pressure and dysphagia...
Mon Nov 25, 2019 02:00
Mon Nov 25, 2019 12:58
Abstract Histories of cash-crop agriculture in Senegal’s peanut basin have foregrounded the sway of market forces—an economic story of supply and demand staging metropolitan industrial needs, commercial entrepreneurialism, and profitable returns with both planned and unplanned developments. The political connivance between commercial crops and French rule is also well documented. The relentless expansion of peanut cultivation in Senegal’s hinterland was promoted by colonial policies...
Mon Nov 25, 2019 02:00
Abstract Background Attention deficit hyperactivity disorder (ADHD) is defined as childhood neurobehavioural disorder. Due to short attention span, oral hygiene and dental treatment of such individuals can be challenging. Aim of this study was to evaluate the oral health of children and adolescents with and without ADHD living in residential care in rural Rhineland-Palatinate, Germany. ...
Mon Nov 25, 2019 02:00
New Findings •What is the central question of this study? This study investigated the effect of an elevated baseline blood flow, via either high‐dose intra‐arterial infusion of adenosine or adenosine triphosphate, on the rapid onset vasodilatory response to a single forearm muscle contraction. •What is the main finding and its importance? The peak response to a single contraction is unaffected by augmented baseline blood flow, and thus is likely due to a feedforward vasodilatory mechanism....
Sun Nov 24, 2019 19:03
Sun Nov 24, 2019 21:56
Abstract Purpose of Review Over the last decade, there has been a spark in innovation in the development of therapies for food allergy. Herein, we describe the background and recent advances for food-specific immunotherapies including epicutaneous (EPIT), sublingual (SLIT), and subcutaneous (SCIT). Recent Findings Studies have progressed most...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1865: Gene Therapy for Liver Cancers: Current Status from Basic to Clinics Cancers doi: 10.3390/cancers11121865 Authors: Kamimura Yokoo Abe Terai The liver is a key organ for metabolism, protein synthesis, detoxification, and endocrine function, and among liver diseases, including hepatitis, cirrhosis, malignant tumors, and congenital disease, liver cancer is one of the leading causes of cancer-related deaths worldwide. Conventional therapeutic options...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1867: Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation Cancers doi: 10.3390/cancers11121867 Authors: Kostadinova Shive Anthony Circulating autotaxin (ATX) is elevated in persons with liver disease, particularly in the setting of chronic hepatitis C virus (HCV) and HCV/HIV infection. It is thought that plasma ATX levels are, in part, attributable to impaired liver clearance...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1864: Identifying Biomarkers to Pair with Targeting Treatments within Triple Negative Breast Cancer for Improved Patient Stratification Cancers doi: 10.3390/cancers11121864 Authors: Tovey Cheang The concept of precision medicine has been around for many years and recent advances in high-throughput sequencing techniques are enabling this to become reality. Within the field of breast cancer, a number of signatures have been developed to molecularly sub-classify...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1866: Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells Cancers doi: 10.3390/cancers11121866 Authors: Tsubaki Takeda Noguchi Jinushi Seki Morii Shimomura Imano Satou Nishida RAS and BRAF-mutated colorectal cancers are associated with resistance to chemotherapy and poor prognosis, highlighting the need for new therapeutic strategies. Although these cancers sometimes...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1863: IL-8 Released from Human Pancreatic Cancer and Tumor-Associated Stromal Cells Signals through a CXCR2-ERK1/2 Axis to Induce Muscle Atrophy Cancers doi: 10.3390/cancers11121863 Authors: Callaway Delitto Patel Nosacka D’Lugos Delitto Deyhle Trevino Judge Judge Tumor-derived cytokines are known to drive the catabolism of host tissues, including skeletal muscle. However, our understanding of the specific cytokines that initiate...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1862: Minimal Effect of Bevacizumab Treatment on Residual Vestibular Schwannomas after Partial Resection in Young Neurofibromatosis Type 2 Patients Cancers doi: 10.3390/cancers11121862 Authors: Isabel Gugel Lan Kluwe Julian Zipfel Christian Teuber Marcos Tatagiba Victor-Felix Mautner Martin Ulrich Schuhmann Florian Grimm Hearing-preserving partial resection of neurofibromatosis type 2 (NF2) associated vestibular schwannomas (VS) is a preferred...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1860: Automated Gleason Scoring and Tumor Quantification in Prostate Core Needle Biopsy Images Using Deep Neural Networks and Its Comparison with Pathologist-Based Assessment Cancers doi: 10.3390/cancers11121860 Authors: Han Suk Ryu Min-Sun Jin Jeong Hwan Park Sanghun Lee Joonyoung Cho Sangjun Oh Tae-Yeong Kwak Junwoo Isaac Woo Yechan Mun Sun Woo Kim Soohyun Hwang Su-Jin Shin Hyeyoon Chang The Gleason grading system, currently...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1861: Cachexia and Sarcopenia in Older Adults with Cancer: A Comprehensive Review Cancers doi: 10.3390/cancers11121861 Authors: Richard F. Dunne Kah Poh Loh Grant R. Williams Aminah Jatoi Karen M. Mustian Supriya G. Mohile Cancer cachexia is a syndrome characterized by weight loss with accompanying loss of muscle and/or fat mass and leads to impaired patient function and physical performance and is associated with a poor prognosis. It is prevalent...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1859: The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic Cancer Cancers doi: 10.3390/cancers11121859 Authors: Nesrin Hasan Nita Ahuja Pancreatic cancer is an aggressive cancer with low survival rates. Genetic and epigenetic dysregulation has been associated with the initiation and progression of pancreatic tumors. Multiple studies have pointed to the involvement of aberrant chromatin modifications in driving tumor behavior. ATP-dependent...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1856: Incidental Use of Beta-Blockers Is Associated with Outcome of Metastatic Colorectal Cancer Patients Treated with Bevacizumab-Based Therapy: A Single-Institution Retrospective Analysis of 514 Patients Cancers doi: 10.3390/cancers11121856 Authors: Ondrej Fiala Pavel Ostasov Ondrej Sorejs Vaclav Liska Tomas Buchler Alexandr Poprach Jindrich Finek Background: Beta-adrenergic signalling plays an important role in several cancer-related processes,...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1857: Racial Differences in Immunological Landscape Modifiers Contributing to Disparity in Prostate Cancer Cancers doi: 10.3390/cancers11121857 Authors: Jeronay King Thomas Hina Mir Neeraj Kapur Shailesh Singh Prostate cancer affects African Americans disproportionately by exhibiting greater incidence, rapid disease progression, and higher mortality when compared to their Caucasian counterparts. Additionally, standard treatment interventions do not achieve...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1855: Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope Cancers doi: 10.3390/cancers11121855 Authors: Lucia Salvioni Maria Antonietta Rizzuto Jessica Armida Bertolini Laura Pandolfi Miriam Colombo Davide Prosperi Starting with the enhanced permeability and retention (EPR) effect discovery, nanomedicine has gained a crucial role in cancer treatment. The advances in the field have led to the approval of nanodrugs with improved safety...
Mon Nov 25, 2019 02:00
Cancers, Vol. 11, Pages 1858: FoxO3a as a Positive Prognostic Marker and a Therapeutic Target in Tamoxifen-Resistant Breast Cancer Cancers doi: 10.3390/cancers11121858 Authors: Michele Pellegrino Pietro Rizza Ada Donà Alessandra Nigro Elena Ricci Marco Fiorillo Ida Perrotta Marilena Lanzino Cinzia Giordano Daniela Bonofiglio Rosalinda Bruno Federica Sotgia Michael P. Lisanti Diego Sisci Catia Morelli Background: Resistance to endocrine treatments...
Mon Nov 25, 2019 02:00
Publication date: Available online 24 November 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Yolande Ikala Openda, Pinar Sen, Muthumuni Managa, Tebello NyokongAbstractThis work reports on the synthesis and characterization of novel acetophenone substituted phthalocyanines along with the self-assembled nanoconjugates formed via π-π stacking interaction between the synthesized unmetalated (2), zinc (3) and indium (4) phthalocyanines and graphene quantum dots (GQDs) to form 2@GQDs, 3@GQDs...
Mon Nov 25, 2019 18:43
Erratum zu: HNO 2019 https://doi.org/10.1007/s00106-019-00771-6 Die Autorin weist darauf hin, dass die Abb. 4 „Test-Retest-Reliabilität in Abhängigkeit vom Schalldruckpegel pro Lautkomponente“ mit den falschen Daten publiziert wurde. Nachstehend finden Sie die Abb. 4 mit den exakten Daten.
Mon Nov 25, 2019 02:00
Publication date: Available online 24 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): R.Y. Kannan, A. Hills, M.J. Shelley, B. Bisase, K. Kapoor, P. Norris, C. NdukaAbstractThe best outcomes after injury to the facial nerve are seen after immediate direct coaptation, but in practice, this happens infrequently. We ask whether late repair (between 3 weeks and 18 months) is comparable to immediate repair. In this prospective observational study over a two-year period...
Mon Nov 25, 2019 18:18
Nature Chemistry, Published online: 25 November 2019; doi:10.1038/s41557-019-0366-yGene-circuit-based sensors have, to date, largely relied on optical proteins (such as green fluorescent protein) to report the output, which limits the signalling bandwidth. Now, an electrochemical output has been developed and integrated with cell-free gene circuits. This approach enables multiplexing of sensors and introduces the possibility of electronic-based logic, memory and response elements to synthetic biology.
Mon Nov 25, 2019 02:00
Nature Chemistry, Published online: 25 November 2019; doi:10.1038/s41557-019-0369-8DNA is capable of self-assembling into a wide range of user-defined structures and so can be used as a scaffold to arrange binding motifs with nanometre precision. Now, DNA has been used to accurately display aptamers that fit the repeated epitope pattern of a dengue viral antigen to produce a nanostructure that can be a potent viral inhibitor or a fluorescent sensor.
Mon Nov 25, 2019 02:00
Nature Chemistry, Published online: 25 November 2019; doi:10.1038/s41557-019-0353-3Despite the potential of fluorinated compounds in pharmaceuticals and agrochemicals, the formation of C–F bonds remains challenging. It has now been shown that aryl sulfonium salts, which can be made by site-selective C–H functionalization, have advantageous photoredox reactivity compared to conventional (pseudo)halides and can be used for late-stage C–H fluorination.
Mon Nov 25, 2019 02:00
Nature Chemistry, Published online: 25 November 2019; doi:10.1038/s41557-019-0367-xSinglet fission produces two low-energy triplet excitons that are difficult to dissociate into free charges. Now, separate optima in charge yield have been observed as a function of driving force for singlet and triplet excitons in pentacene. At optimal driving forces, the triplet-exciton dissociation rate is at least five orders of magnitude smaller than the singlet-exciton dissociation rate.
Mon Nov 25, 2019 02:00
Nature Chemistry, Published online: 25 November 2019; doi:10.1038/s41557-019-0372-0High electrical conductivities in metal–organic frameworks—attractive for applications in sensing and energy storage—typically arise in layered MOFs from metal–ligand bonds with strong covalent character. Now, lanthanide-based MOFs have shown high out-of-plane conductivities originating instead from the π-stacking of organic ligands.
Mon Nov 25, 2019 02:00
Nature Chemistry, Published online: 25 November 2019; doi:10.1038/s41557-019-0376-9The broad infrared spectrum of water in the OH stretching region shows how significantly a water molecule is distorted when within a hydrogen-bonding network; it also raises the question of what the spectrum of a single OH oscillator would be. Now, the spectral signatures of isolated OH oscillators embedded in cold water cages have been measured using vibrational spectroscopy.
Mon Nov 25, 2019 02:00
Nature Chemistry, Published online: 25 November 2019; doi:10.1038/s41557-019-0365-zOwing to the electropositive character of aluminium it is difficult to prepare Al anions; the few that exist are supported by nitrogen ligands. Now, a dialkyl-alumanyl anion has been synthesized that features a polar Al–K bond. This anion reacts as a very strong base that deprotonates benzene, and undergoes nucleophilic substitution reactions.
Mon Nov 25, 2019 02:00
42 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Asian Pac J Cancer Prev"[jour] These pubmed results were generated on 2019/11/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Nov 25, 2019 17:54
42 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Asian Pac J Cancer Prev"[jour] These pubmed results were generated on 2019/11/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Nov 25, 2019 13:56
Publication date: Available online 24 November 2019Source: International ImmunopharmacologyAuthor(s): Shutao Zhang, Shicheng Huo, Hui Li, Haozheng Tang, Bin'en Nie, Xinhua Qu, Bing YueAbstractPostmenopausal osteoporosis is one of the most common types of osteoporosis resulting from estrogen deficiency in elderly women. Nonsteroidal anti-inflammatory drugs (NSAIDs) are important drugs for pain relief in patients with osteoporosis. In this study, we report for the first time that flufenamic acid, a...
Mon Nov 25, 2019 17:13
Publication date: Available online 24 November 2019Source: International ImmunopharmacologyAuthor(s): Jing Zheng, Lijuan Zhu, Iong Iok In, Yilan Chen, Ning Jia, Weiping ZhuAbstractBackgroundRheumatoid arthritis (RA) is a chronic autoimmune disease closely correlated to synovial tissue inflammation. Exosomes are known to transfer microRNAs (miRNAs) between cells and have been validated as the vehicles for delivery of therapeutic molecules.Aim and scopeThe current study was set to examine the functional...
Mon Nov 25, 2019 17:13
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