- BioMed Research International
- Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat ModelIntroduction. Ca2+ regulatory excitation-contraction coupling properties are key topics of interest in the development of work-related muscle myalgia and may constitute an underlying cause of muscle pain and loss of force generating capacity. Method. A well-established rat model of high repetition high force (HRHF) work was used to investigate if such exposure leads to an increase in cytosolic Ca2+ concentration ([Ca2+]i) and changes in sarcoplas
- Establishment and Initial Testing of a Medium-Sized, Surgically Feasible Animal Model for Brucellar Spondylodiscitis: A Preliminary StudyBrucellar spondylodiscitis, the most prevalent and significant osteoarticular presentation of human Brucellosis, is difficult to diagnose and usually yields irreversible neurologic deficits and spinal deformities. However, no animal models of Brucellar spondylodiscitis exist, allowing for preclinical investigations. The present study investigated whether intraosseous injection of attenuated Brucella melitensis vaccine into rabbits’ lumbar vertebr
- Health Risk Assessment of Heavy Metals from Smoked Corbicula fluminea Collected on Roadside Vendors at Kelantan, MalaysiaCorbicula fluminea serves as traditional food to the local people in Kelantan, Malaysia. Concerns regarding river contamination, smoking method, and associated adverse effects on public health had been increasing. Hence, this study aims to measure the level of heavy metals (Cd, Cu, Mn, Pb, and Zn) and assess human health risk in C. fluminea consumption at Kelantan. Heavy-metal analysis was done using flame atomic absorption spectrophotometry, whi
- Antibacterial Effect of Curcumin against Clinically Isolated Porphyromonas gingivalis and Connective Tissue Reactions to Curcumin Gel in the Subcutaneous Tissue of RatsThe aim of this study was to find the antibacterial potential of curcumin against Porphyromonas gingivalis and connective tissue responses to curcumin gel in the subcutaneous tissue of rats. The sample consisted of subgingival plaque collected from patients with chronic periodontitis. The P. gingivalis clinically isolated strain was confirmed by anaerobic culture, morphology, biochemical tests (Vitek ANC Kit), and PCR (16S rDNA). Minimum inhibito
- Spica Prunellae Extract Enhances Fluorouracil Sensitivity of 5-Fluorouracil-Resistant Human Colon Carcinoma HCT-8/5-FU Cells via TOP2α and miR-494The use of 5-fluorouracil (5-FU) has been proven benefits, but it also has adverse events in colorectal cancer (CRC) chemotherapy. In this study, we explored the mechanism of 5-FU resistance by bioinformatics analysis of the NCBI public dataset series GSE81005. Fifteen hub genes were screened out of 582 different expressed genes. Modules of the hub genes in protein-protein interaction networks gathered to TOP2α showed a decrease in HCT-8 cells bu
- Resting Level of Insulin-Like Growth Factor-1 Is Not at Play in Cardiac Enlargement in Endurance-Trained AdolescentsPurpose. The study aimed to investigate resting levels of several selected growth and metabolic hormones in a group of 24 endurance-trained adolescents (aged 13–19 years) compared with 24 untrained age- and sex-matched controls, and to investigate if increased cardiac dimensions were related to these hormones at rest with emphasis on insulin-like growth factor-1 (IGF-1). Methods. The hormones (cortisol, IGF-1, IGF-2, follicle-stimulating hormone,
- NEJM : Research
- Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal CancerThe BRAF V600E mutation occurs in approximately 10% of patients with metastatic colorectal cancer, with recent estimates ranging from as low as 5% to as high as 21%. This mutation identifies a distinct subtype of colorectal cancer that has a poor prognosis. Initial standard chemotherapy for BRAF…
- Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate CancerProstate cancer is the second leading cause of cancer-related death among men in the United States and the third leading cause of cancer-related death in Europe. Four different classes of medical treatments have prolonged survival among patients with metastatic castration-resistant prostate cancer,…
- allergy
- Focusing on Children.Related ArticlesFocusing on Children. Immunol Allergy Clin North Am. 2019 Nov;39(4):xiii-xiv Authors: Stukus DR PMID: 31563193 [PubMed - in process]
- Pediatric Allergy: The Key to an Evolving Renaissance in Our Specialty.Related ArticlesPediatric Allergy: The Key to an Evolving Renaissance in Our Specialty. Immunol Allergy Clin North Am. 2019 Nov;39(4):xi-xii Authors: Tilles SA PMID: 31563192 [PubMed - in process]
- How Dr Google Is Impacting Parental Medical Decision Making.Related ArticlesHow Dr Google Is Impacting Parental Medical Decision Making. Immunol Allergy Clin North Am. 2019 Nov;39(4):583-591 Authors: Stukus DR Abstract The Internet has forever changed the manner in which we communicate with one another and gather information. Patients and the general public are using online search engines to look for information pertaining to their own health as well as the h
- Asthma Self-management: It's Not One Size Fits All.Related ArticlesAsthma Self-management: It's Not One Size Fits All. Immunol Allergy Clin North Am. 2019 Nov;39(4):573-582 Authors: Ulrich L, Palacios S Abstract Asthma exacerbations are a significant cause of health care use and mortality. Home management strategies may be effective in managing many exacerbations before presentation to a health care institution. This article focuses on the variety of
- It's Time to Start Phenotyping Our Patients with Asthma.Related ArticlesIt's Time to Start Phenotyping Our Patients with Asthma. Immunol Allergy Clin North Am. 2019 Nov;39(4):561-572 Authors: Duffey H, Anderson WC Abstract Advances in the management of pediatric asthma, including biologics, offer practitioners the ability to tailor therapies to individual patients. However, asthma treatment guidelines have not kept up with current studies. This review exp
- Vocal Cord Dysfunction: The Spectrum Across the Ages.Related ArticlesVocal Cord Dysfunction: The Spectrum Across the Ages. Immunol Allergy Clin North Am. 2019 Nov;39(4):547-560 Authors: Petrov AA Abstract Vocal cord dysfunction (VCD) is an upper airway disorder characterized by exaggerated and transient glottic constriction causing respiratory and laryngeal symptoms. Although the origin of VCD symptoms is in the upper airway, it is frequently misdiagno
- What to Do with an Abnormal Newborn Screen for Severe Combined Immune Deficiency.Related ArticlesWhat to Do with an Abnormal Newborn Screen for Severe Combined Immune Deficiency. Immunol Allergy Clin North Am. 2019 Nov;39(4):535-546 Authors: Chong HJ, Maurer S, Heimall J Abstract Newborn screening for severe combined immunodeficiency has been implemented in all 50 states. This screening identifies newborns with T-cell lymphopenia. After an abnormal screening, additional testing i
- Tips and Tricks for Controlling Eczema.Related ArticlesTips and Tricks for Controlling Eczema. Immunol Allergy Clin North Am. 2019 Nov;39(4):521-533 Authors: Raveendran R Abstract Eczema is a chronic, relapsing, and remitting disease that can affect patients from infancy through adulthood. Severity of eczema ranges from mild to severe and can be plagued with recurrent flares. These flares can be difficult to treat and may require use of d
- Atopic Dermatitis Is a Barrier Issue, Not an Allergy Issue.Related ArticlesAtopic Dermatitis Is a Barrier Issue, Not an Allergy Issue. Immunol Allergy Clin North Am. 2019 Nov;39(4):507-519 Authors: Kraft MT, Prince BT Abstract Atopic dermatitis (AD) is a chronic, relapsing disease that typically manifests in childhood and improves with age. Studies have demonstrated that the presence of AD increases the risk of developing food allergy, allergic rhinitis, and
- Moving Past "Avoid All Nuts": Individualizing Management of Children with Peanut/Tree Nut Allergies.Related ArticlesMoving Past "Avoid All Nuts": Individualizing Management of Children with Peanut/Tree Nut Allergies. Immunol Allergy Clin North Am. 2019 Nov;39(4):495-506 Authors: Schroer B, Bjelac J Abstract It has been common practice to tell patients with allergy to peanut or tree nuts to avoid all nuts. Evidence that unnecessary avoidance of peanuts and eggs is associated with increased risk for
- Oral Food Challenges in Infants and Toddlers.Related ArticlesOral Food Challenges in Infants and Toddlers. Immunol Allergy Clin North Am. 2019 Nov;39(4):481-493 Authors: Greiwe J Abstract Oral food challenges (OFCs) are an indispensable tool for accurately diagnosing clinically relevant food allergy. Despite perceived concerns, data suggest OFCs, including infant OFCs, are both safe and practical in the clinical setting. The benefits of OFCs ca
- Managing Younger Siblings of Food Allergic Children.Related ArticlesManaging Younger Siblings of Food Allergic Children. Immunol Allergy Clin North Am. 2019 Nov;39(4):469-480 Authors: Agnihotri NT, Lei DK, Gupta RS Abstract Current guidelines state that there is insufficient evidence to recommend testing siblings of food allergic children before introduction of potential allergic foods, but the topic continues to remain controversial. Although the pro
- Implementation of Early Peanut Introduction Guidelines: It Takes a Village.Related ArticlesImplementation of Early Peanut Introduction Guidelines: It Takes a Village. Immunol Allergy Clin North Am. 2019 Nov;39(4):459-467 Authors: Mikhail IJ Abstract A landmark study showed that early peanut introduction in high-risk infants, defined as infants with moderate to severe atopic dermatitis or egg allergy, reduced the risk of developing peanut allergy. Since this trial, many inte
- It's Not Mom's Fault: Prenatal and Early Life Exposures that Do and Do Not Contribute to Food Allergy Development.Related ArticlesIt's Not Mom's Fault: Prenatal and Early Life Exposures that Do and Do Not Contribute to Food Allergy Development. Immunol Allergy Clin North Am. 2019 Nov;39(4):447-457 Authors: Abrams EM, Chan ES Abstract Thus far, the most effective strategy for the prevention of food allergy is early introduction of allergenic solids to at-risk infants. Early skin moisturization may have a role in
- European Review » Uncategorized
- MicroRNA-524-5p suppresses cell proliferation and promotes cell apoptosis in gastric cancer by regulating CASP3OBJECTIVE: To investigate miR-524-5p expression in gastric cancer (GC) tissues and the regulatory mechanism of miR-524-5p on biological behaviors of GC cell lines, such as proliferation, cell apoptosis and cycle.MATERIALS AND METHODS: The expression of miR-524-5p was detected in 48 paired of GC tissue samples and matched adjacent tissues, and also detected in GC cell lines by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).
- Correlation of serum vitamin A, D, and E with recurrent respiratory infection in childrenOBJECTIVE: To investigate the correlation of serum vitamin A, D, and E levels with a recurrent respiratory infection (RRI) in children.PATIENTS AND METHODS: The medical records of 422 children with RRI (a study group) in Cangzhou Central Hospital from January 2015 to December 2018 were retrospectively analyzed (the study group was divided into an active group and a stable group). Further 100 healthy children who underwent physical examination at
- European Review » Infectious Diseases
- Effectiveness of the new generation transcatheter aortic valve in the real life studies. Review and meta-analysisOBJECTIVE: The aim of the meta-analysis was to assess post-procedural outcome of the new generation of transcatheter aortic valve implantation (TAVI) devices, focusing on the transfemoral and balloon-expandable SAPIEN 3 (Edwards Lifesciences Inc., Irvine, CA, USA), the self-expanding CoreValveTM Evolut series R and PRO (R/PRO)TM (Medtronic Inc., Minneapolis, MN, USA) and ACURATE neo transcatheter aortic valve (Symetis SA, a Boston Scientific comp
- MicroRNA-708-5p regulates mycobacterial vitality and the secretion of inflammatory factors in Mycobacterium tuberculosis-infected macrophages by targeting TLR4OBJECTIVE: Tuberculosis (TB), a major public health problem worldwide, is induced by Mycobacterium tuberculosis (M.tb) infection. Macrophages serve as the cellular home in immunoreaction against M.tb infection, which is tightly adjusted by host microRNAs (miRNAs) expression. The purpose of this research was to investigate the function mechanism of miR-708-5p in mycobacterial vitality and immunoreaction in human macrophages (HTP-1 and U937 cells)
- Regulatory effect of lncRNA NKILA on autophagy induced by sepsis kidney injuryOBJECTIVE: The aim of this study was to investigate the regulatory effect of long non-coding RNA (lncRNA) NKILA on autophagy in sepsis-induced kidney injury.MATERIALS AND METHODS: Sepsis model was successfully established in rats by cecal ligation and puncture (CLP). Hematoxylin and eosin (HE) staining was performed to evaluate the pathological lesions in rat kidney tissues. Subsequently, serum samples of sepsis rats were collected. The levels of
- European Review » Neurology
- Influence of LncRNA-MALAT1 on neuronal apoptosis in rats with cerebral infarction through regulating the ERK/MAPK signaling pathwayOBJECTIVE: To investigate the regulatory effect of long non-coding ribonucleic acid (lncRNA)-metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) on the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway, and to explore its influence on neuronal apoptosis in rats with cerebral infarction.MATERIALS AND METHODS: A total of 45 adult male Sprague-Dawley rats were randomly divided into sham g
- Group housing with young mice relieves Alzheimer’s disease behaviors in aging miceOBJECTIVE: Due to the increase in human life expectancy, a higher number of individuals are experiencing age-related cognitive impairments. Therefore, it is important to investigate the methods to tackle the effects of aging.MATERIALS AND METHODS: The mice were divided into the following groups: the aging mice (male, 20 months) and young mice (male, 2 months) were pairing-housed together in the same cage and lasted for at least one month (Aging-Y
- Influence of miR-34a on cerebral neuronal apoptosis in rats with cerebral ischemia reperfusion through the Notch1 signaling pathwayOBJECTIVE: To explore the influence and the underlying mechanism of micro-ribonucleic acid (miR)-34a on cerebral neuronal apoptosis in rats with cerebral ischemia-reperfusion (CIR).MATERIALS AND METHODS: 60 adult male Wistar rats were randomly divided into 3 groups: Sham group, CIR group and miR-34a knockdown group. The rat model of CIR was established using the suture occlusion method. The expression level of miR-34a in lesion tissues in the thr
- pubmed: "world neurosurg"[jo...
- Rescue cerebral revascularization in patients with progressive steno-occlusive ischemia of the anterior intracranial circulation.Related ArticlesRescue cerebral revascularization in patients with progressive steno-occlusive ischemia of the anterior intracranial circulation. World Neurosurg. 2019 Sep 26;: Authors: Steinberg JA, Rennert RC, Ravina K, Strickland BA, Russin JJ Abstract BACKGROUND: Despite the failure of two randomized controlled trials assessing the utility of bypass for steno-occlusive cerebrovascular disease, a
- pubmed: cell cycle arrest
- Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells.Related ArticlesKnockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells. Mol Cells. 2019 Sep 30;42(9):628-636 Authors: Ma C, Zu X, Liu K, Bode AM, Dong Z, Liu Z, Kim DJ Abstract Altered genetic features in cancer cells lead to a high rate of aerobic glycolysis and metabolic reprogramming that is essential for increased cancer
- Nitidine chloride induces S phase cell cycle arrest and mitochondria-dependent apoptosis in HaCaT cells and ameliorates skin lesions in psoriasis-like mouse models.Related ArticlesNitidine chloride induces S phase cell cycle arrest and mitochondria-dependent apoptosis in HaCaT cells and ameliorates skin lesions in psoriasis-like mouse models. Eur J Pharmacol. 2019 Sep 26;:172680 Authors: Yang XG, Jiang BW, Jing QQ, Li WJ, Tan LP, Bao YL, Song ZB, Yu CL, Liu L, Liu YC, Li YX Abstract Psoriasis is a common dermatosis causing considerable inconvenience to 4% of th
- pubmed: future oncology
- Post-coital bleeding: What is the incidence of significant gynaecological pathology in women referred for colposcopy?Related ArticlesPost-coital bleeding: What is the incidence of significant gynaecological pathology in women referred for colposcopy? Sex Reprod Healthc. 2019 Sep 23;22:100462 Authors: Godfrey MAL, Nikolopoulos M, Povolotskaya N, Chenoy R, Wuntakal R Abstract OBJECTIVE: To evaluate the incidence of underlying serious gynaecological pathology in women referred to colposcopy with post-coital bleeding.
- Comprehensive Prognostication in Critically Ill Pediatric Hematopoietic Cell Transplant Patients: Results from Merging the Center for International Blood and Marrow Transplant Research (CIBMTR) and Virtual Pediatric Systems (VPS) Registries.Related ArticlesComprehensive Prognostication in Critically Ill Pediatric Hematopoietic Cell Transplant Patients: Results from Merging the Center for International Blood and Marrow Transplant Research (CIBMTR) and Virtual Pediatric Systems (VPS) Registries. Biol Blood Marrow Transplant. 2019 Sep 26;: Authors: Zinter MS, Logan BR, Fretham C, Sapru A, Abraham A, Aljurf MD, Arnold SD, Artz A, Auletta JJ, Chhabra S, Copel
- A Consensus Molecular Classification of Muscle-invasive Bladder Cancer.Related ArticlesA Consensus Molecular Classification of Muscle-invasive Bladder Cancer. Eur Urol. 2019 Sep 25;: Authors: Kamoun A, Reyniès A, Allory Y, Sjödahl G, Gordon Robertson A, Seiler R, Hoadley KA, Groeneveld CS, Al-Ahmadie H, Choi W, Castro MAA, Fontugne J, Eriksson P, Mo Q, Kardos J, Zlotta A, Hartmann A, Dinney CP, Bellmunt J, Powles T, Malats N, Chan KS, Kim WY, McConkey DJ, Black PC, Dyrskjøt L, Höglund M,
- A systematic review and meta-analysis of clinician-reported versus patient-reported outcomes of radiation dermatitis.Related ArticlesA systematic review and meta-analysis of clinician-reported versus patient-reported outcomes of radiation dermatitis. Breast. 2019 Sep 19;: Authors: Lam E, Yee C, Wong G, Popovic M, Drost L, Pon K, Vesprini D, Lam H, Aljabri S, Soliman H, DeAngelis C, Chow E Abstract Radiation dermatitis is a common adverse effect of radiotherapy (RT) in breast cancer patients. Although radiation derm
- Circulating cell-free tumor DNA analysis in pediatric cancers.Related ArticlesCirculating cell-free tumor DNA analysis in pediatric cancers. Mol Aspects Med. 2019 Sep 25;: Authors: Andersson D, Fagman H, Dalin MG, Ståhlberg A Abstract Analysis of circulating cell-free tumor DNA (ctDNA) has shown promising results within several clinical applications, including cancer detection, mutation profiling, treatment monitoring and early detection of relapse. Here, we di
- pubmed: "am j case rep"[jour...
- A 10-Year Old Girl with Resistant Hypertension without Significant Indication of an Underlying Renal Cell Carcinoma, Misdiagnosed as Malaria.Related ArticlesA 10-Year Old Girl with Resistant Hypertension without Significant Indication of an Underlying Renal Cell Carcinoma, Misdiagnosed as Malaria. Am J Case Rep. 2019 Sep 29;20:1434-1439 Authors: Ogunmola OJ, Onyema C, Babatunde Bakare TI, Olabinri EO, Bamigboye-Taiwo OT, Adaje AO, Lawal OA Abstract BACKGROUND Blood pressure (BP) is not routinely screened in children in clinical practice.
- pubmed: "int j surg case rep...
- Peritoneal carcinomatosis of unknown primary site may be an undiagnosed appendiceal adenocarcinoma. A case series.Related ArticlesPeritoneal carcinomatosis of unknown primary site may be an undiagnosed appendiceal adenocarcinoma. A case series. Int J Surg Case Rep. 2019 Sep 18;63:65-68 Authors: Sugarbaker PH Abstract BACKGROUND: Peritoneal carcinomatosis is sometimes diagnosed by cytology or by biopsy, but routine radiologic and endoscopic workup may not reveal a primary site. This clinical condition is called a
- Porto-mesenteric vein thrombosis following laparoscopic sleeve gastrectomy for morbid obesity: Case series and literature review.Related ArticlesPorto-mesenteric vein thrombosis following laparoscopic sleeve gastrectomy for morbid obesity: Case series and literature review. Int J Surg Case Rep. 2019 Sep 18;63:59-64 Authors: Alenazi NA, Ahmad KS, Essa MS, Alrushdan MS, Al-Shoaibi AM Abstract BACKGROUND: Portal vein thrombosis is a rare and a potentially lethal complication of Laparoscopic sleeve gastrectomy. In this series, we
- Mesenteric Castleman's disease mimicking neuroendocrine tumour.Related ArticlesMesenteric Castleman's disease mimicking neuroendocrine tumour. Int J Surg Case Rep. 2019 Sep 18;63:56-58 Authors: Bhogal RH, Wotherspoon A, Khan AK Abstract INTRODUCTION: Castleman's disease is a rare entity and is a benign hyperplastic enlargement of lymph nodes. It can occur anywhere within the body but only approximately 50 cases of mesenteric Castleman's disease have been reporte
- Secondary psoas abscess after an open cholecystectomy and a common bile duct exploration.Related ArticlesSecondary psoas abscess after an open cholecystectomy and a common bile duct exploration. Int J Surg Case Rep. 2019 Aug 31;63:53-55 Authors: Alvarado MU, Colindres CA, Pinto LJ, Padilla CG, Reyes CE Abstract BACKGROUND: A psoas abscess presents a diagnostic challenge, due to its rarity, non-specific clinical manifestations and wide range of etiologies. CASE REPORT: We describ
- Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a patient with peritoneal carcinomatosis from a pancreatic cystadenocarcinoma: A case report.Related ArticlesCytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a patient with peritoneal carcinomatosis from a pancreatic cystadenocarcinoma: A case report. Int J Surg Case Rep. 2019 Sep 17;63:48-52 Authors: Lin SD, Soucisse ML, Lansom J, Morris DL Abstract INTRODUCTION: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a well-estab
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Δευτέρα 30 Σεπτεμβρίου 2019
- BioMed Research International
- NEJM : Research
- allergy
- European Review » Uncategorized
- European Review » Infectious Diseases
- European Review » Neurology
- pubmed: "world neurosurg"[jo...
- pubmed: cell cycle arrest
- pubmed: future oncology
- pubmed: "am j case rep"[jour...
- pubmed: "int j surg case rep...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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