• Journal of Evolutionary Biology
• Greater opportunities for sexual selection in male than in female obligate brood parasitic birds

  Bateman’s Paradigm predicts reproductive success and the number of mates is positive for males but not for females, resulting in more intense sexual selection on males vs. females. Many studies fail to corroborate this paradigm, potentially due to parental care. We show that in brood parasitic brown‐headed cowbirds (Molothrus ater), which lack parental care in either sex, annual reproductive success increases with the number of mates in males, bu

  Journal of Evolutionary Biology

  Mon Sep 30, 2019 12:00
• Evolutionary Psychiatry
• Genetics and Mental Illness

  With new technology, the long-standing dream of understanding the genetics of psychiatric disorders is finally coming into its own.

  Evolutionary Psychiatry

  Mon Sep 30, 2019 12:23
• Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
• Fe3O4@poly(N-Vinylcaprolactam) Grafted onto Chitosan as New Sorbent for Detection Imatinib mesylate in Biosample Followed by UPLC-MS/MS

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01654F, PaperHamed Sahebi, Seied Mahdi Pourmortazavi, Hamed Zandavar, Somayeh MirsadeghiThe Fe3O4 nanoparticles with chitosan grafted onto poly(N-Vinylcaprolactam) copolymers are synthesized, which showed dual sensitivity to temperature and pH. The nanoparticles were characterized by different techniques and two aspects of...The content of this RSS Feed (c) The Royal Society of Chemistry

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Mon Sep 30, 2019 16:00
• An SDS-PAGE based proteomic approach for N-terminome profiling

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01616C, PaperPrashant Kaushal, Yumi Kwon, Shinyeong Ju, Cheolju LeeInitial sample quantity, solublization, separation, and visualization of proteins or their proteolytically altered products are some of the challenges of currently available solution-based N-termini enrichment methods. We therefore took advantage...The content of this RSS Feed (c) The Royal Society of Chemistry

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Mon Sep 30, 2019 16:00
• Quantitative Detection of Procalcitonin by Electrochemical Immunosensor Based on MoO3/Au@rGO Nanocomposites

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01721F, PaperJianqiao Liu, Li Quan, Xuelian Yu, Lin WangIn this work, a sandwich-type electrochemical immunoseneor for detection of procalcitonin (PCT) is constructed layer-by-layer with a novel label based on MoO3/Au@rGO nanocomposites. The high surface area and electroconductivity of...The content of this RSS Feed (c) The Royal Society of Chemistry

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Mon Sep 30, 2019 16:00
• Profiling embryonic stem cell differentiation by MALDI TOF mass spectrometry: development of a reproducible and robust sample preparation workflow

  Analyst, 2019, Advance ArticleDOI: 10.1039/C9AN00771G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rachel E. Heap, Anna Segarra-Fas, Alasdair P. Blain, Greg M. Findlay, Matthias TrostA fast and robust sample preparation method for MALDI TOF MS analysis of whole mammalian cells and phenotypic profiling of mESCs.To cite this article before page numbers are assigned, use the DOI form of cita

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Sun Sep 29, 2019 16:00
• Separation and characterization of KRas proteins and tryptic peptides using enhanced-fluidity liquid chromatography tandem mass spectrometry

  Analyst, 2019, Advance ArticleDOI: 10.1039/C9AN01454C, PaperJuan Bian, Susan V. OlesikA sensitive method for detecting the K-Ras protein and its mutation was developed using enhanced-fluidity, reversed-phase liquid chromatography-mass spectrometry.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Sun Sep 29, 2019 16:00
• A novel highly sensitive fluorescent probe for bioimaging biothiols and its applications in distinguishing cancer cells from normal cells

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01760G, PaperHanchuang Zhu, Hanming Zhang, Changxu Liang, Caiyun Liu, Pan Jia, Zilu Li, Yamin Yu, Xue Zhang, Baocun Zhu, Wenlong ShengIn recent years, targeting drugs made by physical loading or chemical bonding of drugs on small molecular carriers have shown a very wide application prospect in the field of tumor...The content of this RSS Feed (c) The Royal Society of Chemistry

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Sun Sep 29, 2019 16:00
• Lysosome specific theranostic NO donor inhibits cancer cells by stimuli responsive molecular self-decompostion with an on-demand fluorescence pattern

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01746A, PaperWuyang Hua, Jian Zhao, Xinyi Wang, Sinan Pei, Shaohua GouThe anticancer mechanism of NO is difficult to study due to its short lifetime and high reactivity. Thus a theranostic anticancer NO donor assemblied with NO on-demand release ability, accurate...The content of this RSS Feed (c) The Royal Society of Chemistry

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Sun Sep 29, 2019 16:00
• Cancer
• Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix

  British Journal of Cancer, Published online: 01 October 2019; doi:10.1038/s41416-019-0578-3Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix

  Cancer

  Mon Sep 30, 2019 17:00
• Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix

  Cancer

  Mon Sep 30, 2019 15:08
• Annals of Intensive Care - Latest Articles
• Morpho-functional evaluation of lung aeration as a marker of sickle-cell acute chest syndrome severity in the ICU: a prospective cohort study

  Acute chest syndrome (ACS) is the main cause of morbi-mortality in patients with sickle-cell disease in the intensive care unit (ICU). ACS definition encompasses many types of lung damage, making early detecti...

  Annals of Intensive Care - Latest Articles

  Sun Sep 29, 2019 17:00
• Early prediction of noninvasive ventilation failure in COPD patients: derivation, internal validation, and external validation of a simple risk score

  Early identification of noninvasive ventilation (NIV) failure is a promising strategy for reducing mortality in chronic obstructive pulmonary disease (COPD) patients. However, a risk-scoring system is lacking.

  Annals of Intensive Care - Latest Articles

  Sun Sep 29, 2019 17:00
• The Journal of Pathology
• Issue Information

  The Journal of Pathology

  Wed Sep 25, 2019 08:33
• Corrigendum

  The Journal of Pathology

  Wed Sep 25, 2019 08:33
• Evolutionary Biology News -- ScienceDaily
• Biologists track the invasion of herbicide-resistant weeds into southwestern Ontario

  A team led by biologists have identified the ways in which herbicide-resistant strains of the invasive common waterhemp weed have emerged in fields of soy and corn in southwestern Ontario. The resistance, first detected in 2010, spread thanks to two mechanisms: either pollen and seeds of resistant plants were physically dispersed by wind, water and other means, or resistance appeared through the spontaneous emergence of mutations that then spread

  Evolutionary Biology News -- ScienceDaily

  Mon Sep 30, 2019 15:09
• Brave new world: Simple changes in intensity of weather events 'could be lethal'

  Faced with extreme weather events and unprecedented environmental change, animals and plants are scrambling to catch up -- with mixed results. A new model helps to predict the types of changes that could drive a given species to extinction.

  Evolutionary Biology News -- ScienceDaily

  Mon Sep 30, 2019 10:15
• Clinical Cancer Research Online First Articles
• Selective progesterone receptor modulators in early stage breast cancer: a randomized, placebo-controlled Phase II window of opportunity trial using telapristone acetate.

  Background: Selective progesterone receptor modulators (SPRMs) show preclinical activity against hormone-sensitive breast cancer, but have not been tested in patients with early, treatment-naïve tumors. Methods: In a double-blind pre-surgical window trial of oral telapristone acetate (TPA) 12 mg daily vs. placebo, 70 early stage breast cancer patients were randomized 1:1 (stratified by menopause) and treated for 2-10 weeks. The primary endpoint

  Clinical Cancer Research Online First Articles

  Mon Sep 30, 2019 06:28
• Correlation of tumor burden in sentinel lymph nodes with tumor burden in non-sentinel lymph nodes and survival in cutaneous melanoma

  Background: In patients with cutaneous melanoma (CM), metastasis in a non-sentinel lymph node (non-SLN) is a strong independent adverse prognostic factor. However, patients with a tumor-involved SLN no longer routinely undergo completion lymph node dissection (CLND). We hypothesized that SLN tumor burden may predict non-SLN tumor burden. Methods: We compared tumor burden parameters between SLN and non-SLN in patients with CM who underwent SLN bio

  Clinical Cancer Research Online First Articles

  Mon Sep 30, 2019 06:28
• Journal of Biophotonics
• Label‐free spectroscopic tissue characterization using fluorescence excitation‐scanning spectral imaging

  ABSTRACT Spectral imaging approaches provide new possibilities for measuring and discriminating fluorescent molecules in living cells and tissues. These approaches often employ tunable filters and robust image processing algorithms to identify many fluorescent labels in a single image set. Here, we present results from a novel spectral imaging technology that scans the fluorescence excitation spectrum, demonstrating that excitation‐scanning hype

  Journal of Biophotonics

  Mon Sep 30, 2019 08:03
• Rapid Diagnosis of Infection Etiology in Febrile Pediatric Oncology Patients Using Infrared Spectroscopy of Leukocytes

  Abstract Rapid diagnosis of the etiology of infection is highly important for an effective treatment of the infected patients. Bacterial and viral infections are serious diseases that can cause death in many cases. The human immune system deals with many viral and bacterial infections that cause no symptoms and pass quietly without treatment. However, oncology patients undergoing chemotherapy have a very weak immune system caused by leukopenia,

  Journal of Biophotonics

  Mon Sep 30, 2019 08:01
• Head & Neck
• Prognostic implications of human papillomavirus status and p16 expression in laryngeal squamous cell carcinoma

  Abstract Background The purpose of this study was to investigate significance of HPV16 DNA/p16 for survival of patients with laryngeal squamous cell carcinoma (LSCC). Methods HPV16 DNA and p16 status in 812 LSCC patients were determined. The survival was performed using Kaplan‐Meier estimates and Cox model. Results Compared with HPV negativity, adjusted HRs for HPV16 positivity were 0.57, 95% CI, 0.38 to 0.87; 0.60, 0.40 to 0.88;

  Head & Neck

  Mon Sep 30, 2019 07:08
• Annals of Internal Medicine Current Issue
• Correction: Withholding Biologics to Optimize Surgical Outcomes

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Annals On Call - Ablating Atrial Fibrillation in Patients With Heart Failure

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• The Ins and Outs of Microplastics

  Schwabl and colleagues begin to address the fate of ingested microplastics by examining whether they can be detected in human stool. The editorialists discuss the findings and the priorities for future research.

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Annals Graphic Medicine - Dr. Mom: What I Learned at Grand Rounds

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C Virus Infection in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2018 Clinical Practice Guideline

  Description:The Kidney Disease: Improving Global Outcomes (KDIGO) 2018 clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is an extensive update of KDIGO's 2008 guideline on HCV infection in CKD. This update reflects the major advances since the introduction of direct-acting antivirals (DAAs) in the management of HCV infection in the CKD populat

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Asthma

  This review provides an evidence-based guide for the diagnosis, evaluation, and treatment of patients with asthma. It addresses typical questions that arise in the clinic-based care of patients with asthma and provides a basic and comprehensive resource for asthma care.

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Medicare Part D Spending on Single-Enantiomer Drugs Versus Their Racemic Precursors

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Endorse

  Like many things in life, change occurs slowly, at times imperceptibly.

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Correction: Implementation of SI Units for Clinical Laboratory Data

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• To What Target Hemoglobin A 1c Level Would You Treat This Patient With Type 2 Diabetes? Grand Rounds Discussion From Beth Israel Deaconess Medical Center

  In the United States, 9.4% of all adults—and 25% of those older than 65 years—have diabetes. Diabetes is the leading cause of blindness and end-stage renal disease and contributes to both microvascular and macrovascular complications. The management of patients with type 2 diabetes (T2D) is a common and important activity in primary care internal medicine practice. Measurement of hemoglobin A1c (HbA1c) provides an estimate of mean blood sugar lev

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Old Habits Die Hard: Antipsychotics for Treatment of Delirium

  Nikooie and colleagues systematically reviewed the evidence on treatment of delirium, particularly focusing on antipsychotics. The editorial discusses the findings, why we need to abandon old habits of using antipsychotics to treat delirium, and priorities for future research.

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• My Grandmother, the Doctor

  Born in 1925, Iris Smith grew up in a time when doctors were men.

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Antipsychotics for Preventing Delirium in Hospitalized Adults A Systematic Review

  Background:Delirium is an acute disorder marked by impairments in attention and cognition, caused by an underlying medical problem. Antipsychotics are used to prevent delirium, but their benefits and harms are unclear.Purpose:To conduct a systematic review evaluating the benefits and harms of antipsychotics for prevention of delirium in adults.Data Sources:PubMed, Embase, CENTRAL, CINAHL, and PsycINFO from inception through July 2019, without res

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Correction: Omalizumab in Severe Allergic Asthma

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Annals for Educators - 1 October 2019

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Patent Foramen Ovale and Ischemic Stroke in Patients With Pulmonary Embolism

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Inadequate Health Care in U.S. Prisons

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Patent Foramen Ovale and Ischemic Stroke in Patients With Pulmonary Embolism

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Annals Graphic Medicine - Child's Pose

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Relationship Between Poor Olfaction and Mortality

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Local Area Variation in Morbidity Among Low-Income, Older Adults in the United States A Cross-sectional Study

  Background:Recent studies have reported that low-income adults living in more affluent areas of the United States have longer life expectancies. Less is known about the relationship between the affluence of a geographic area and morbidity of the low-income population.Objective:To evaluate the association between the prevalence of chronic conditions among low-income, older adults and the economic affluence of a local area.Design:Cross-sectional as

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Relationship Between Poor Olfaction and Mortality

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Detection of Various Microplastics in Human Stool A Prospective Case Series

  Background:Microplastics are ubiquitous in natural environments. Ingestion of microplastics has been described in marine organisms, whereby particles may enter the food chain.Objective:To examine human feces for the presence of microplastics to determine whether humans involuntarily ingest them.Design:Prospective case series in which participants completed a food diary and sampled stool according to step-by-step instructions.Setting:Europe and As

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Raising the Bar for Procedural Competency Among Hospitalists

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Antipsychotics for Treating Delirium in Hospitalized Adults A Systematic Review

  Background:Delirium is common in hospitalized patients and is associated with worse outcomes. Antipsychotics are commonly used; however, the associated benefits and harms are unclear.Purpose:To conduct a systematic review evaluating the benefits and harms of antipsychotics to treat delirium in adults.Data Sources:PubMed, Embase, CENTRAL, CINAHL, and PsycINFO from inception to July 2019 without language restrictions.Study Selection:Randomized cont

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Raising the Bar for Procedural Competency Among Hospitalists

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Cardiac and Neuromuscular Features of Patients With LMNA -Related Cardiomyopathy

  Background:Mutations in the LMNA (lamin A/C) gene have been associated with neuromuscular and cardiac manifestations, but the clinical implications of these signs are not well understood.Objective:To learn more about the natural history of LMNA-related disease.Design:Observational study.Setting:13 clinical centers in Italy from 2000 through 2018.Patients:164 carriers of an LMNA mutation.Measurements:Detailed cardiologic and neurologic evaluation

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Hypertension

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Vibrio vulnificus Infections From a Previously Nonendemic Area

  Annals of Internal Medicine Current Issue

  Mon Sep 30, 2019 15:48
• Cancer
• Western States Show Biggest Increase in Early‐Onset Colorectal Cancer

  Cancer

  Thu Sep 26, 2019 10:27
• Rethinking a common surgery technique for early cervical cancer

  Cancer

  Thu Sep 26, 2019 10:27
• Issue Information

  Cancer

  Thu Sep 26, 2019 10:27
• Oncogenesis - nature.com science feeds
• Aberrant HER3 ligand heregulin-expressing head and neck squamous cell carcinoma is resistant to anti-EGFR antibody cetuximab, but not second-generation EGFR-TKI

  Oncogenesis, Published online: 30 September 2019; doi:10.1038/s41389-019-0164-9Aberrant HER3 ligand heregulin-expressing head and neck squamous cell carcinoma is resistant to anti-EGFR antibody cetuximab, but not second-generation EGFR-TKI

  Oncogenesis - nature.com science feeds

  Sun Sep 29, 2019 17:00
• Aberrant HER3 ligand heregulin-expressing head and neck squamous cell carcinoma is resistant to anti-EGFR antibody cetuximab, but not second-generation EGFR-TKI

  Oncogenesis - nature.com science feeds

  Sun Sep 29, 2019 17:00