• Journal of Internal Medicine
• Issue Information

  Journal of Internal Medicine

  Thu Sep 26, 2019 02:01
• Evidence supporting the best clinical management of patients with multimorbidity and polypharmacy: a systematic guideline review and expert consensus

  Journal of Internal Medicine

  Thu Sep 26, 2019 02:01
• Annals of Internal Medicine Online First
• Financial Toxicity of Prescription Drugs

  In their article, Luo and colleagues examine variation by pharmacy type and ZIP code in the prices of 6 on-patent and 10 off-patent (generic) prescription drugs throughout the United States in 2015. The editorialist discusses the findings and raises concerns about the data the study used.

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Meat Consumption and Health: Food for Thought

  This issue includes 5 systematic reviews and new recommendations regarding consumption of red and processed meat and health outcomes. The editorialists discuss the findings and the insight they offer regarding why many have not changed their dietary habits despite prior recommendations to reduce meat consumption.

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Prescription Bias in the Treatment of Chronic Systolic Heart Failure

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Unprocessed Red Meat and Processed Meat Consumption: Dietary Guideline Recommendations From the Nutritional Recommendations (NutriRECS) Consortium

  Description:Dietary guideline recommendations require consideration of the certainty in the evidence, the magnitude of potential benefits and harms, and explicit consideration of people's values and preferences. A set of recommendations on red meat and processed meat consumption was developed on the basis of 5 de novo systematic reviews that considered all of these issues.Methods:The recommendations were developed by using the Nutritional Recomme

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Reduction of Red and Processed Meat Intake and Cancer Mortality and Incidence A Systematic Review and Meta-analysis of Cohort Studies

  Background:Cancer incidence has continuously increased over the past few centuries and represents a major health burden worldwide.Purpose:To evaluate the possible causal relationship between intake of red and processed meat and cancer mortality and incidence.Data Sources:Embase, Cochrane Central Register of Controlled Trials, Web of Science, CINAHL, and ProQuest from inception until July 2018 and MEDLINE from inception until April 2019 without la

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Patterns of Red and Processed Meat Consumption and Risk for Cardiometabolic and Cancer Outcomes A Systematic Review and Meta-analysis of Cohort Studies

  Background:Studying dietary patterns may provide insights into the potential effects of red and processed meat on health outcomes.Purpose:To evaluate the effect of dietary patterns, including different amounts of red or processed meat, on all-cause mortality, cardiometabolic outcomes, and cancer incidence and mortality.Data Sources:Systematic search of MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL, Web of Science, an

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Cases in Precision Medicine: Should You Participate in a Study Involving Genomic Sequencing of Your Patients?

  Internists and other physicians may be asked to participate in research studies that include genomic screening of their patients. Because genomic studies can identify many variants with potential clinical or personal implications, physicians should carefully consider the effect of participation on their patients, as well as the time and effort needed for the physicians to interpret the results and decide how best to use the information. Among the

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials

  Background:Few randomized trials have evaluated the effect of reducing red meat intake on clinically important outcomes.Purpose:To summarize the effect of lower versus higher red meat intake on the incidence of cardiometabolic and cancer outcomes in adults.Data Sources:EMBASE, CENTRAL, CINAHL, Web of Science, and ProQuest from inception to July 2018 and MEDLINE from inception to April 2019, without language restrictions.Study Selection:Randomized

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Fool Me Twice? The Reemergence of Rofecoxib and the Orphan Drug Act

  In 2004, rofecoxib was withdrawn from the market after it was associated with increased risks for heart attack and stroke. In 2017, rofecoxib received orphan drug designation as a pain treatment for hemophilic arthropathy, a rare condition. This essay considers the implications of applying the Orphan Drug Act to products like rofecoxib that may be at risk for off-label prescribing after approval.

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Variation in Prescription Drug Prices by Retail Pharmacy Type A National Cross-sectional Study

  Background:Cash prices for prescription drugs vary widely in the United States.Objective:To describe cash price variation by retail pharmacy type for 10 generic and 6 brand-name drugs throughout the United States and stratified by ZIP code.Design:Cross-sectional study.Setting:Drug pricing data from GoodRx, an online tool for comparing drug prices, representing more than 60 000 U.S. pharmacies (fall 2015).Measurements:Cash prices for a 1-month sup

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Red and Processed Meat Consumption and Risk for All-Cause Mortality and Cardiometabolic Outcomes A Systematic Review and Meta-analysis of Cohort Studies

  Background:Dietary guidelines generally recommend limiting intake of red and processed meat. However, the quality of evidence implicating red and processed meat in adverse health outcomes remains unclear.Purpose:To evaluate the association between red and processed meat consumption and all-cause mortality, cardiometabolic outcomes, quality of life, and satisfaction with diet among adults.Data Sources:EMBASE (Elsevier), Cochrane Central Register o

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Health-Related Values and Preferences Regarding Meat Consumption A Mixed-Methods Systematic Review

  Background:A person's meat consumption is often determined by their values and preferences.Purpose:To identify and evaluate evidence addressing health-related values and preferences regarding meat consumption.Data Sources:MEDLINE, EMBASE, Web of Science, Centre for Agriculture and Biosciences Abstracts, International System for Agricultural Science and Technology, and Food Science and Technology Abstracts were searched from inception to July 2018

  Annals of Internal Medicine Online First

  Mon Sep 30, 2019 16:16
• Allergy
• Histamine H4 receptor regulates IL-6 and INF-γ secretion in native monocytes from healthy subjects and patients with allergic rhinitis

  Histamine H1 receptor (H1R) and histamine H4 receptor (H4R) are essential in allergic inflammation. The roles of H4R have been characterized in T cell subsets, whereas the functional properties of H4R in monoc...

  Allergy

  Sun Sep 29, 2019 17:00
• Ear and Hearing - Published Ahead-of-Print
• Modality Effects on Lexical Encoding and Memory Representations of Spoken Words

  Objectives: The present study investigated presentation modality differences in lexical encoding and working memory representations of spoken words of older, hearing-impaired adults. Two experiments were undertaken: a memory-scanning experiment and a stimulus gating experiment. The primary objective of experiment 1 was to determine whether memory encoding and retrieval and scanning speeds are different for easily identifiable words presented i

  Ear and Hearing - Published Ahead-of-Print

  Thu Sep 26, 2019 17:00
• Observations of Distortion Product Otoacoustic Emission Components in Adults With Hearing Loss

  Objectives: Distortion product otoacoustic emissions (DPOAEs) measured in the ear canal are composed of OAEs generated by at least two mechanisms coming from different places in the cochlea. Otoacoustic emission (OAE) models hypothesize that reduction of cochlear gain will differentially impact the components. The purpose of the current experiment was to provide preliminary data about DPOAE components in adults with hearing loss in relation to

  Ear and Hearing - Published Ahead-of-Print

  Thu Sep 26, 2019 17:00
• Plastic, Reconstructive & Aesthetic Surgery
• Reply to: Letter comments on: Time course of improvement after re-repair procedure for VPI management

  We would like to thank the authors, Sell et al. for their well reasoned and referenced comments on our paper and their analysis of our work. To add a bit of background: the inspiration for the paper came after we noticed a subset of previously lost-to-follow-up patients after re-repair procedure who returned to clinic after an interval of greater than six months and upon evaluation, demonstrated significant improvement in VPI without having had a

  Plastic, Reconstructive & Aesthetic Surgery

  Sun Sep 29, 2019 17:00
• radiol anat
• The myodural bridge complex defined as a new functional structure.

  Related ArticlesThe myodural bridge complex defined as a new functional structure. Surg Radiol Anat. 2019 Sep 28;: Authors: Zheng N, Chung BS, Li YL, Liu TY, Zhang LX, Ge YY, Wang NX, Zhang ZH, Cai L, Chi YY, Zhang JF, Samuel OC, Yu SB, Sui HJ Abstract PURPOSE: The connective tissue between suboccipital muscles and the cervical spinal dura mater (SDM) is known as the myodural bridge (MDB). However, t

  radiol anat

  Mon Sep 30, 2019 06:20
• Os calcaneus secundarius, a relevant differential diagnosis to fracture or pseudarthrosis of processus anterior of the calcaneus: a CT morphologic description.

  Related ArticlesOs calcaneus secundarius, a relevant differential diagnosis to fracture or pseudarthrosis of processus anterior of the calcaneus: a CT morphologic description. Surg Radiol Anat. 2019 Sep 28;: Authors: Hennings R, Voigt P, Kahn T, Josten C, Ahrberg AB Abstract PURPOSE: A fracture or a pseudarthrosis of the processus anterior calcanei (PAC) as well as a traumatized Os calcaneus secundar

  radiol anat

  Mon Sep 30, 2019 06:20
• Academic Radiology
• Improved Visualization of Gastric Cancer and Increased Diagnostic Performance in Lesion Depiction and Depth Identification Using Monoenergetic Reconstructions from a Novel Dual-Layer Spectral Detector CT

  Publication date: Available online 30 September 2019Source: Academic RadiologyAuthor(s): Jing-Juan Liu, Wei Liu, Zheng-Yu Jin, Hua-Dan Xue, Yi-Ning Wang, Sheng-Hui Yu, Jin Chen, Yun Wang, Jian-Chun YuRationale and ObjectivesTo determine the optimal keV for the visualization of gastric cancer and to investigate its value in depicting lesions and in identifying depth invasion using virtual monoenergetic images (VMIs) on a novel dual-layer spectral

  Academic Radiology

  Mon Sep 30, 2019 05:32
• ANZ Journal of Surgery
• How to do an extended totally extraperitoneal mesh repair for groin hernias

  This study describes the technique for extended view totally extraperitoneal hernia repair.

  ANZ Journal of Surgery

  Mon Sep 30, 2019 05:17
• Is laparoscopic selective lateral lymph node dissection for locally advanced rectal cancer after neoadjuvant chemoradiotherapy safe?

  Laparoscopic selective lateral lymph node (LLN) dissection for locally advanced rectal cancer with swollen LLNs after preoperative neoadjuvant chemoradiotherapy is a technically complex and challenging procedure for the complicated anatomy of the pelvic sidewall. Our study showed that with the advantage of a minimally invasive approach, laparoscopic total mesorectal excision and selective LLN dissection following preoperative neoadjuvant chemorad

  ANZ Journal of Surgery

  Mon Sep 30, 2019 05:17
• Blame the drain: early post‐operative small bowel obstruction due to drain

  ANZ Journal of Surgery

  Mon Sep 30, 2019 05:16
• Complete excision of large pericardial synovial sarcoma

  ANZ Journal of Surgery

  Mon Sep 30, 2019 05:16
• Focal hair re‐pigmentation associated with melanoma of the scalp

  ANZ Journal of Surgery

  Mon Sep 30, 2019 05:10
• Minimally invasive Venetian blinds ventral hernia repair with botulinum toxin chemical component separation

  Abstract Background Laparoscopic ventral repair is safe, with lower wound infection rates compared with open repair. ‘Venetian blinds’ technique of plication in combination with mesh reinforcement, is totally intra‐corporeal, with hernia defect and sac plication to reduce seroma formation. While laparoscopic suturing of the abdominal wall can represent a technical challenge, pre‐operative botulinum toxin A (BTA) injections as an adjunct can a

  ANZ Journal of Surgery

  Mon Sep 30, 2019 04:54
• Endometriosis: a rare cause of acute appendicitis in pregnancy

  ANZ Journal of Surgery

  Mon Sep 30, 2019 04:54
• New method in treatment of post‐operative air leakage with fresh frozen plasma

  Fresh frozen plasma seems to be suitable in treatment of an air leak after lung resections. The value of the flow displayed on a digital suction device should preferably be below 375 mL/min. There were no undesired events. Abstract Background No consensus regarding the best post‐operative treatment option for air leak has been established. In this study, we evaluate the use of intra‐pleural fresh frozen plasma (FFP) as a promising treatm

  ANZ Journal of Surgery

  Mon Sep 30, 2019 04:53
• Impact of modern media on analgesic requirements during extracorporeal shockwave lithotripsy

  This is a randomized study comparing sound and vision versus control for analgesic requirements and patient satisfaction during non‐anaesthetic shockwave lithotripsy for renal tract stones. Sound appears to be better than vision. Abstract Background In Australia, shockwave lithotripsy (SWL) to treat urinary tract stones is routinely performed with general anaesthesia (GA). We have established a SWL service avoiding GA based outside opera

  ANZ Journal of Surgery

  Mon Sep 30, 2019 04:53
• Surgical treatment results of hepatocellular carcinoma in non‐cirrhotic liver in southern Chile: case series with follow‐up

  Case series of patients who underwent surgery for hepatocellular carcinoma in non‐cirrhotic liver were studies. Averages of tumour diameter, surgical time and hospitalization were 12.0 cm, 114.4 min and 7.2 days, respectively. Post‐operative morbidity was 31.3%. There was no mortality and there were no re‐interventions. The overall actuarial survival at 1, 2 and 3 was 96.8%, 73.4% and 17.3%, respectively. Abstract Background Hepatocellul

  ANZ Journal of Surgery

  Mon Sep 30, 2019 04:52
• Lateral neck metastases in the ipsilateral and contralateral compartments of papillary thyroid carcinoma located in one lobe

  This study was designed to evaluate the clinicopathological features of patients with papillary thyroid carcinoma (PTC) limited to one lobe but with bilateral lateral neck metastasis (BLNM). Although few patients with PTC located in one lobe have BLNM, the contralateral lateral compartment should be carefully evaluated for BLNM in males and in patients with a primary tumour size >2 cm, aggressive subtype of PTC, central node metastasis and Delphi

  ANZ Journal of Surgery

  Mon Sep 30, 2019 04:52
• Appendicectomy mortality: an Australian national audit

  Australia's appendicectomy mortality rate was 0.02%. Post‐operative care in the elderly was found to be poor at times, with room for improvement. Abstract Background Appendicectomy is a safe surgical procedure with minimal risks. Low mortality rates (0.04–0.24%) have been reported from a number of countries. Appendicectomy mortality rates have not been reported in Australia in recent years. The aim of the study was to conduct an appendic

  ANZ Journal of Surgery

  Mon Sep 30, 2019 04:50
• Screening acute cholangitis patients for sepsis

  We evaluated the discriminative powers of the 2018 Tokyo Guidelines for moderate acute cholangitis and systemic inflammatory response criteria as tests in screening for patients with acute cholangitis complicated by haemodynamic instability as a surrogate marker of sepsis. We have found that the systemic inflammatory syndrome criteria outperformed the 2018 Tokyo Guidelines standards as screening tests for sepsis. Positive predictive value of the

  ANZ Journal of Surgery

  Mon Sep 30, 2019 04:50
• Post‐operative complications in patients with a significant post‐operative decrease in γδT cells

  Surgery results in a decreased percentage of γδT lymphocytes in the peripheral human blood which correlates with the number of septic complications. This observation may help to predict post‐operative recovery after gastroabdominal surgery. Abstract Background It has previously been shown that appropriate distribution of immune cells between different tissues and organs of the body is required for proper function of the immune system. Ou

  ANZ Journal of Surgery

  Mon Sep 30, 2019 04:50
• Journal of Neuroscience Methods
• A novel mouse model of contralateral C7 transfer via the pretracheal route: a feasibility study

  Publication date: Available online 29 September 2019Source: Journal of Neuroscience MethodsAuthor(s): Xuan Ye, Yun-Dong Shen, Jun-Tao Feng, Fei Wang, Zheng-Run Gao, Gao-Wei Lei, Ai-Ping Yu, Cheng-Pan Wang, Chun-Min Liang, Wen-Dong XuAbstractBackgroundContralateral seventh cervical nerve transfer (contralateral C7 transfer) is a novel treatment for patients with spastic paralysis, including stroke and traumatic brain injury. However, little is kno

  Journal of Neuroscience Methods

  Mon Sep 30, 2019 05:43
• Spatiotemporal characteristics of neural activity in tibial nerves with carbon nanotube yarn electrodes

  Publication date: Available online 29 September 2019Source: Journal of Neuroscience MethodsAuthor(s): X. Yu, J.Y. Su, J.Y. Guo, X.H. Zhang, R.H. Li, X.Y. Chai, Y. Chen, D.G. Zhang, J.G. Wang, X.H. Sui, D.M. DurandAbstractBackgroundReliable interfacing with peripheral nervous system is essential to extract neural signals. Current implantable peripheral nerve electrodes cannot provide long-term reliable interfaces due to their mechanical mismatch w

  Journal of Neuroscience Methods

  Mon Sep 30, 2019 05:43
• Sleep Medicine
• Pediatric obstructive sleep apnea: beyond adenotonsillectomy

  Publication date: Available online 29 September 2019Source: Sleep MedicineAuthor(s): Almiro J. Machado, Agrício N. Crespo

  Sleep Medicine

  Mon Sep 30, 2019 02:48
• Cancers
• Cancers, Vol. 11, Pages 1477: The YAP1–NMU Axis Is Associated with Pancreatic Cancer Progression and Poor Outcome: Identification of a Novel Diagnostic Biomarker and Therapeutic Target

  Cancers, Vol. 11, Pages 1477: The YAP1–NMU Axis Is Associated with Pancreatic Cancer Progression and Poor Outcome: Identification of a Novel Diagnostic Biomarker and Therapeutic Target Cancers doi: 10.3390/cancers11101477 Authors: Yoo Lee Jun Noh Lee Jung Jung Kim Park Kim Kim Yes-associated protein (YAP)-1 is highly upregulated in pancreatic cancer and associated with tumor progression. Howev

  Cancers

  Sun Sep 29, 2019 17:00
• Cancers, Vol. 11, Pages 1475: The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics

  Cancers, Vol. 11, Pages 1475: The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics Cancers doi: 10.3390/cancers11101475 Authors: Al Bitar Gali-Muhtasib p21cip1/waf1 mediates various biological activities by sensing and responding to multiple stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor suppressor mainly by inhibiting

  Cancers

  Sun Sep 29, 2019 17:00
• Cancers, Vol. 11, Pages 1473: Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy

  Cancers, Vol. 11, Pages 1473: Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy Cancers doi: 10.3390/cancers11101473 Authors: Franz Ralla Weickmann Jung Rochow Stephan Erbersdobler Kilic Fendler Jung Circular RNAs (circRNAs) may act as novel cancer biomarkers. H

  Cancers

  Sun Sep 29, 2019 17:00
• Cancers, Vol. 11, Pages 1474: Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer

  Cancers, Vol. 11, Pages 1474: Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer Cancers doi: 10.3390/cancers11101474 Authors: Ludovic Bretin Aline Pinon Soukaina Bouramtane Catherine Ouk Laurence Richard Marie-Laure Perrin Alain Chaunavel Claire Carrion Frédérique Bregier Vincent Sol Vincent Chaleix David Yannick Leger Bertrand Liagre Photod

  Cancers

  Sun Sep 29, 2019 17:00
• Cancers, Vol. 11, Pages 1476: Exosomal microRNAs from Longitudinal Liquid Biopsies for the Prediction of Response to Induction Chemotherapy in High-Risk Neuroblastoma Patients: A Proof of Concept SIOPEN Study

  Cancers, Vol. 11, Pages 1476: Exosomal microRNAs from Longitudinal Liquid Biopsies for the Prediction of Response to Induction Chemotherapy in High-Risk Neuroblastoma Patients: A Proof of Concept SIOPEN Study Cancers doi: 10.3390/cancers11101476 Authors: Morini Cangelosi Segalerba Marimpietri Raggi Castellano Fruci de Mora Cañete Yáñez Viprey Corrias Carlini Pezzolo Schleiermacher

  Cancers

  Sun Sep 29, 2019 17:00
• Cancers, Vol. 11, Pages 1472: Current Perspectives in Cancer Immunotherapy

  Cancers, Vol. 11, Pages 1472: Current Perspectives in Cancer Immunotherapy Cancers doi: 10.3390/cancers11101472 Authors: Theodoulakis Christofi Stavroula Baritaki Luca Falzone Massimo Libra Apostolos Zaravinos Different immunotherapeutic approaches have proved to be of significant clinical value to many patients with different types of advanced cancer. However, we need more precise immunotherapies and predictive biomarker

  Cancers

  Sun Sep 29, 2019 17:00
• Cancers, Vol. 11, Pages 1471: Lower Extremity Lymphedema in Gynecologic Cancer Patients: Propensity Score Matching Analysis of External Beam Radiation versus Brachytherapy

  Cancers, Vol. 11, Pages 1471: Lower Extremity Lymphedema in Gynecologic Cancer Patients: Propensity Score Matching Analysis of External Beam Radiation versus Brachytherapy Cancers doi: 10.3390/cancers11101471 Authors: Won Ick Chang Hyun-Cheol Kang Hong-Gyun Wu Hak Jae Kim Seung Hyuck Jeon Maria Lee Hee Seung Kim Hyun Hoon Chung Jae Weon Kim Noh Hyun Park Yong Sang Song Kwan-Sik Seo The goal of this st

  Cancers

  Sun Sep 29, 2019 17:00
• Cancers, Vol. 11, Pages 1469: The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses

  Cancers, Vol. 11, Pages 1469: The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses Cancers doi: 10.3390/cancers11101469 Authors: Duygu Sag Zeynep Ozge Ayyildiz Sinem Gunalp Gerhard Wingender Expression of TRAIL (tumor necrosis factor–related apoptosis–inducing ligand) by immune cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly clear that the interaction

  Cancers

  Sun Sep 29, 2019 17:00
• Cancers, Vol. 11, Pages 1470: CNOT2 Is Critically Involved in Atorvastatin Induced Apoptotic and Autophagic Cell Death in Non-Small Cell Lung Cancers

  Cancers, Vol. 11, Pages 1470: CNOT2 Is Critically Involved in Atorvastatin Induced Apoptotic and Autophagic Cell Death in Non-Small Cell Lung Cancers Cancers doi: 10.3390/cancers11101470 Authors: Jihyun Lee Ji Hoon Jung Jisung Hwang Ji Eon Park Ju-Ha Kim Woon Yi Park Jin Young Suh Sung-Hoon Kim Though Atorvastatin has been used as a hypolipidemic agent, its anticancer mechanisms for repurposing are not fully unde

  Cancers

  Sun Sep 29, 2019 17:00