• Journal of Voice
• Acoustic Voice Quality Index as a Potential Tool for Voice Screening

  To diminish the risk of voice disorders in people who are highly dependent on their voices, such as teachers, vocal screening is important already at the beginning of such individuals’ professional studies. A reliable, specified screening tool is needed. The Acoustic Voice Quality Index (AVQI) has been found to differentiate normal voices from abnormal voices and to serve as a treatment outcome measure. This study investigated whether AVQI could

  Journal of Voice

  Sun Sep 29, 2019 17:00
• Medgadget
• Using FibroScan in The Clinic: Interview with Dr. Stephen A. Harrison

  EchoSens creates non-invasive liver diagnosis medical devices. The company’s line of products, called FibroScan, work by measuring the speed of ultrasound waves as they move through liver tissue. This measurement can tell us about the state of the liver. For example, ultrasound waves move faster through fibrotic/scarred livers. EchoSens recently appointed Dominique Legros as their new global CEO, and we recently spoke about his plans for growth i

  Medgadget

  Mon Sep 30, 2019 11:07
• Loop-X Surgical Imaging Robot Unveiled

  Brainlab, out of Germany, just unveiled its flagship Loop-X mobile intraoperative imaging robot specifically designed for spinal surgical procedures. Developed by medPhoton, an Austrian company, the device is now the core of Brainlab’s imaging offerings. The device offers 2D and 3D intraprocedural imaging, moving as necessary along with the surgical workflow and staying out of the way of clinicians and robotic instruments. Its actions can

  Medgadget

  Mon Sep 30, 2019 09:15
• Temporary Medical Tattoos of Anatomy, Injuries, Pathologies

  Part of the difficulty in training the public in how to respond to medical emergencies is that many don’t understand the human anatomy below the skin. Moreover, knowing what different conditions actually look like on the body is another problem. Knowing where arteries run and where muscles connect to bone, as well as how bruises, infections, and orthopedic injuries appear, can be helpful in recognizing and addressing common maladies. Eliz

  Medgadget

  Mon Sep 30, 2019 08:34
• New Chip for Microwave Imaging of Body

  Today’s clinicians are limited to a few imaging modalities, primarily X-ray, CT, MRI, and ultrasound. Microwaves, in principle, can also be used as a useful way to look inside the body. Microwave radiation is non-ionizing, so should be safer than X-rays, but in practice microwave imagers, because of the electronics inside, have remained bulky tabletop devices. Not only have they been impractical for imaging the body, the electronics inside conven

  Medgadget

  Mon Sep 30, 2019 07:33
• Synchron Announces First Successful Clinical Implantation of Stentrode

  Synchron, a spin-off from the University of Melbourne in Australia, has announced the first successful implantation of the Stentrode minimally invasive neural interface device in a person. The device is part of the Synchron brain-computer interface and combines the minimally invasive delivery of a vascular stent with the functionality of a neural implant. The company hopes that the device could unlock a range of capabilities, including givi

  Medgadget

  Mon Sep 30, 2019 05:33
• Angewandte Chemie International Edition
• Aluminium‐Mediated Carbon Dioxide Reduction by an Isolated Monoalumoxane Anion

  The deoxygenative conversion of carbon dioxide to carbon monoxide is promoted by the aluminyl anion [Al(NON Ar )] – (NON Ar = [O(SiMe 2 NAr) 2 ] 2– , Ar  = 2,6‐ i Pr 2 C 6 H 3 ). The reaction proceeds via the isolable monoalumoxane anion [Al(NON Ar )(O)] – , containing a terminal aluminum‐oxygen bond. This species reacts with a second equivalent of carbon dioxide to afford the carbonate [Al(NON Ar )(CO 3 )] – , and

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 12:53
• PolyMOF Nanoparticles: Dual Roles of a Multivalent polyMOF Ligand in Size Control and Surface Functionalization

  A simple strategy was developed to access functional MOF NPs in one pot, using a multi‐valent polyMOF ligand that possesses a polymer block for surface functionalization and a coordination block with tunable multivalency for size control. Uniform polyMOF‐5 NPs and polyUiO‐66 NPs with sizes down to 20 nm were produced, displaying exceptional structural and colloidal stability upon exposure to ambient conditions for up to 7 months. Abstract M

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 12:00
• Exploring the Trans‐Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor

  An accurate, rapid, and cost‐effective biosensing strategy for the quantification of disease biomarkers is vital for the development of early‐diagnostic point‐of‐care systems, benefiting overall human health.The recent discovery of the trans‐cleavage activity of CRISPR type V effectors makes CRISPR a potential high‐accuracy sensing system. In this study, we report the first CRISPR Cas12a (cpf1) based electrochemical biosensor (E‐CRISPR), which is

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 10:04
• Asymmetric Synthesis of Chiral Sulfoximines via the S‐Alkylation of Sulfinamides

  Innovation in drug discovery critically depends on the development of new bioisosteric groups. Chiral sulfoximines, which contain a tetrasubstituted sulfur atom that bears one nitrogen, one oxygen, and two different carbon substituents, represent an emerging chiral bioisostere in medicinal chemistry. Chiral sulfoximines are conventionally prepared via the stereospecific nitrene transfer reaction to chiral sulfoxides; however, the number of readil

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 09:49
• Diastereodivergent Asymmetric 1,3‐Dipolar Cycloaddition of Azomethine Ylides and β‐Fluoroalkyl Vinylsulfones: Low Copper(II) Catalyst Loading and Theoretical Studies

  A familiar ring: The commercially available chiral Cu(OAc)2/(S)‐tol‐BINAP catalyst is effective in the asymmetric 1,3‐dipolar cycloaddition of fluoroalkylated building blocks and azomethine ylides. The reaction is enantio‐ and diastereoselective. Notably, both exo‐ and exo′‐pyrrolidine derivatives can be accessed. Abstract A CuII‐catalyzed asymmetric 1,3‐dipolar cycloaddition using β‐fluoroalkyl alkenyl arylsulfones as dipolarophiles and gl

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 09:07
• Molecular Pivot‐Hinge Installation to Evolve Topology in Rare‐Earth Metal–Organic Frameworks

  Molecular pivot‐hinge installation is introduced as a linker desymmetrization strategy to evolve the topology of rare‐earth metal–organic frameworks (MOFs), where a pivot group is placed in the center of a linker similar to a hinge. By tuning the composition of pivot groups and steric hindrances of the substituents on various linker rotamers, MOFs with various topologies can be obtained. Abstract Linker desymmetrization has been witnessed a

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 09:07
• Synergistically Interactive Pyridinic‐N–MoP Sites: Identified Active Centers for Enhanced Hydrogen Evolution in Alkaline Solution

  The effect of the dopant: In the electrocatalyst comprising MoP nanoparticles encapsulated by nitrogen‐doped carbon, the sites where MoP interacts with pyridinic N (but not pyrrolic N or graphitic N) lead to increased electron density on the nitrogen‐doped carbon, as well as optimized adsorption of H* and OH*, all of which help to accelerate the hydrogen evolution reaction in alkaline media. Abstract For electrocatalysts for the hydrogen ev

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 09:07
• Water‐Mediated Synthesis of a Superionic Halide Solid Electrolyte

  A superionic conductor, Li3InCl6, with room‐temperature Li+ conductivity of 2.04×10−3 S cm−1, is prepared by a facile and scalable water‐mediated synthesis route. The reversible conversion between Li3InCl6 and Li3InCl6⋅2 H2O makes it stable against air and humidity, thus ensuring the high ionic conductivity is recovered after conversion. Abstract To promote the development of solid‐state batteries, polymer‐, oxide‐, and sulfide‐based solid‐

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 09:07
• H2‐Acceptorless Dehydrogenative Boration and Transfer Boration of Alkenes Enabled by Zirconium Catalyst

  The first facile and direct H2‐acceptorless dehydrogenative boration of alkenes was achieved at room temperature in less than 10 min. Mechanistic studies revealed a reversible reaction pathway, which suggested the application of the zirconium catalyst as a “shuttle catalyst” for transfer boration, thus avoiding the use of relatively sensitive borane reagents. Abstract The first example of an efficient and direct dehydrogenative boration of

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 09:05
• Before and After Photoshop: Recursive Fraud in the Age of Digital Reproducibility

  “Word‐processing software, SCIgen, or Photoshop have increased fraudulent output, but … they have also changed the very form of fraud. Photoshop and similar tools are thus enabling something that is categorically new: recursive fraud, that is, the serial digital reproduction and dissemination of more fraud.” Read more in the Guest Editorial by M. Biagioli.

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 09:05
• Direct Arylation of α‐Amino C(sp3)‐H Bonds by Convergent Paired Electrolysis

  It's electrifying! A convergent paired electrolysis method to synthesize benzylic amines through direct arylation of tertiary amines and benzonitrile derivatives without stoichiometric oxidants and metals is reported. This electrocatalytic approach makes full use of the anodic and cathodic reactions and provides a new perspective for the cross‐coupling of anodically and cathodically generated species. Abstract A metal‐free convergent paired

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 09:04
• Oxysulfide Semiconductors for Photocatalytic Overall Water Splitting with Visible Light

  A Y2Ti2O5S2 oxysulfide photocatalyst that is activated and stabilized by Rh/Cr2O3 and IrO2 co‐catalysts achieves efficient photocatalytic overall water splitting when irradiated with 600 nm visible light. The band gap of Y2Ti2O5S2 is a narrow 1.9 eV because Y 3d contributes to the valence band maximum. This Highlight discusses this recent innovation in sulfide‐based photocatalytic materials. Key: conduction (CB) and valence (VB) bands, hydrogen (

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 09:03
• Catalytic Difunctionalization of Unactivated Alkenes with Unreactive Hexamethyldisilane through Regeneration of Silylium Ions

  A metal‐free, intermolecular syn ‐addition of hexamethyldisilane across simple alkenes is reported. The catalytic cycle is initiated and propagated by the transfer of a methyl group from the disilane to a silylium‐ion‐like intermediate, corresponding to the (re)generation of the silylium‐ion catalyst. The key feature of the reaction sequence is the cleavage of the Si–Si bond in a 1,3‐silyl shift from silicon to carbon. A central intermediate of

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 07:36
• Radical Monofluoroalkylative Alkynylation of Olefins by Docking‐Migration Strategy

  The radical‐mediated monofluoroalkylative alkynylation of alkenes is disclosed for the first time. The reaction demonstrates a remarkably broad substrate scope in which both activated and unactivated alkenes are suitable materials. Concurrent incorporation of an alkynyl and a monofluoroalkyl groups into alkenes proceeds through the docking‐migration sequence, affording a vast array of valuable fluoroalkyl‐substituted alkynes. Many complex natural

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 05:45
• Photolabile Semiconducting Polymer Nanotransducer for Near‐infrared Regulation of CRISPR/Cas9 Gene Editing

  Noninvasive regulation of CRISPR/Cas9 gene editing is conducive to understanding of gene function and development of gene therapy; however, it remains challenging. Herein, a photolabile semiconducting polymer nanotransducer (pSPN) is synthesized to not only act as the gene vector to deliver CRISPR/Cas9 plasmids into cells but also behave as the photoregulator to remotely activate gene editing. pSPN comprise a single‐oxygen (1O2) generating backbo

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 05:44
• Sequential Cross‐Coupling/Annulation of ortho‐Vinyl Bromobenzenes with Aromatic Bromides for the Synthesis of Polycyclic Aromatic Compounds

  Palladium catalysis: A sequential cross‐coupling/annulation of ortho‐vinyl bromobenzenes with aromatic bromides is realized in a direct and modular approach to access polycyclic aromatic compounds. A C(vinyl), C(aryl)‐palladacycle species is proposed as the key intermediate. High chemo‐ and regioselectivity, broad substrate scope, and excellent functional group tolerance are observed for this transformation. Abstract A sequential cross‐coup

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 05:02
• Chiral‐Organotin‐Catalyzed Kinetic Resolution of Vicinal Amino Alcohols

  A valuable structural motif in many biologically active compounds, the vicinal amino alcohol unit can be obtained in optically active form by kinetic resolution of the racemate. A chiral organotin complex catalyzes this reaction, which is thought to proceed via a stannylene N,O‐aminal intermediate. Abstract A highly efficient kinetic resolution of racemic amino alcohols has been achieved for the first time with a chiral tin catalyst. A chir

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 05:02
• Detection of Exhaled Volatile Organic Compounds Improved by Hollow Nanocages of Layered Double Hydroxide on Ag Nanowries

  You're the VOC: A high‐quality microarray well SERS sensor is used for aldehyde volatile organic compound detection. The integrated gas species information was recorded in a barcode that can be read rapidly, conveniently and accurately by a third part. Abstract To detect biomarkers from human exhalation, air flow dynamics on the nanoparticle surface were explored by a surface‐enhanced Raman scattering (SERS) sensor. A hollow Co‐Ni layered d

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 04:59
• A Highly Warped Heptagon‐Containing sp2 Carbon Scaffold via Vinylnaphthyl π‐Extension

  Carbonaceous and curvaceous: A new strategy is described for the synthesis of heptagon‐containing all‐sp2‐hybridized carbon scaffolds from unfunctionalized alkene precursors. This direct approach is applied for the synthesis of a flexible, negatively‐curved polyaromatic hydrocarbon that exhibits excellent solubility, visible range absorption and fluorescence, and two reversible one‐electron oxidations at mild potentials. Abstract A new stra

  Angewandte Chemie International Edition

  Mon Sep 30, 2019 04:58
• Chiral Supramolecular Nano‐Architectures from Macroscopic Mechanical Rotations: Effects on Chiral Aggregation Behavior of Phthalocyanines

  Abstract: Fluid dynamics, resulting from the macroscopic mechanical rotation of a rotary evaporator or a magnetic stirrer, has been shown to selectively induce one of two enantiomers (mirror‐image structures) in certain nanoscale supramolecules. This has attracted considerable attention from the viewpoint of novel synthetic methods for chiral molecules and provides a clue to explain the biased distribution of L‐amino acids and D‐sugars in biologi

  Angewandte Chemie International Edition

  Sun Sep 29, 2019 06:55
• Thuricin Z, a narrow‐spectrum sactibiotic that targets cell membrane

  Sactionine‐containing antibiotics (sactibiotics) are a growing class of peptide antibiotics belonging to the ribosomally synthesized and post‐translationally modified peptide (RiPP) superfamily. Here we report characterization of a novel sactibiotic thuricin Z from Bacillus thuringiensis. Unusually, biosynthesis of thuricin Z involves two radical S‐adenosylmethionine (SAM) enzymes ThzC and ThzD. Although ThzC and ThzD are highly divergent from ea

  Angewandte Chemie International Edition

  Sun Sep 29, 2019 06:53
• Potential‐Responsive Surfaces for Manipulation of Cell Adhesion, Release, and Differentiation

  On the surface: Potential‐responsive surfaces are used to control cell adhesion and release, as well as stem cell differentiation. The cell adhesion can be modulated dynamically by applying a negative and positive potential to surfaces functionalized with specific molecular structures. This process alters cell morphology and ultimately defines the behavior and fate of the cells. Abstract In living systems, interfacial molecular interactions

  Angewandte Chemie International Edition

  Fri Sep 27, 2019 12:00
• Analytical Chemistry
• [ASAP] Pyrene-Based Chemosensor for Picric Acid—Fundamentals to Smartphone Device Design

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b03695

  Analytical Chemistry

  Sun Sep 29, 2019 21:00
• [ASAP] Magneto-Fluorescent Microbeads for Bacteria Detection Constructed from Superparamagnetic Fe₃O₄ Nanoparticles and AIS/ZnS Quantum Dots

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b01812

  Analytical Chemistry

  Sun Sep 29, 2019 21:00
• [ASAP] Covalent Cross-Linking as an Enabler for Structural Mass Spectrometry

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b02491

  Analytical Chemistry

  Sun Sep 29, 2019 21:00
• [ASAP] Bulk Organic Aerosol Analysis by Proton-Transfer-Reaction Mass Spectrometry: An Improved Methodology for the Determination of Total Organic Mass, O:C and H:C Elemental Ratios, and the Average Molecular Formula

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b02949

  Analytical Chemistry

  Sun Sep 29, 2019 21:00
• [ASAP] Integrated Probabilistic Annotation: A Bayesian-Based Annotation Method for Metabolomic Profiles Integrating Biochemical Connections, Isotope Patterns, and Adduct Relationships

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b02354

  Analytical Chemistry

  Sun Sep 29, 2019 21:00
• [ASAP] Development of an Extensive Linkage Library for Characterization of Carbohydrates

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b03101

  Analytical Chemistry

  Sun Sep 29, 2019 21:00
• [ASAP] Lysosome-Targeting Red-Emitting Aggregation-Induced Emission Probe with Large Stokes Shift for Light-Up <italic toggle="yes">in Situ</italic> Visualization of ß-<italic toggle="yes">N</italic>-Acetylhexosaminidase

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b03832

  Analytical Chemistry

  Sun Sep 29, 2019 21:00
• [ASAP] Chemiluminescence Immunoassays for Simultaneous Detection of Three Heart Disease Biomarkers Using Magnetic Carbon Composites and Three-Dimensional Microfluidic Paper-Based Device

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b03066

  Analytical Chemistry

  Sun Sep 29, 2019 21:00
• [ASAP] Self-Assembled Peptide Nanostructures for Photoelectrochemical Bioanalysis Application: A Proof-of-Concept Study

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b03741

  Analytical Chemistry

  Sun Sep 29, 2019 21:00
• [ASAP] Optimal Collision Energies and Bioinformatics Tools for Efficient Bottom-up Sequence Validation of Monoclonal Antibodies

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b03362

  Analytical Chemistry

  Sun Sep 29, 2019 21:00