- Microbiomes as sources of emergent host phenotypesMicrobial communities associated with animals exert powerful influences on host physiology, regulating metabolism and immune function, as well as complex host behaviors. The importance of host–microbiome interactions for maintaining homeostasis and promoting health raises evolutionarily complicated questions about how animals and their microbiomes have coevolved, and how these relationships affect the ways that animals interact with their environ
- Superconductivity in the doped Hubbard model and its interplay with next-nearest hopping t'The Hubbard model is widely believed to contain the essential ingredients of high-temperature superconductivity. However, proving definitively that the model supports superconductivity is challenging. Here, we report a large-scale density matrix renormalization group study of the lightly doped Hubbard model on four-leg cylinders at hole doping concentration = 12.5%. We reveal a delicate interplay between superconductivity and charge density wave
- Translational genomics and precision medicine: Moving from the lab to the clinicTranslational genomics aims to improve human health by building on discoveries made through genetics research and applying them in the clinical setting. This progress has been made possible by technological advances in genomics and analytics and by the digital revolution. Such advances should enable the development of prognostic markers, tailored interventions, and the design of prophylactic preventive approaches. We are at the cusp of predicting
- Structural insights into TRPM8 inhibition and desensitizationThe transient receptor potential melastatin 8 (TRPM8) ion channel is the primary detector of environmental cold and an important target for treating pathological cold hypersensitivity. Here, we present cryo–electron microscopy structures of TRPM8 in ligand-free, antagonist-bound, or calcium-bound forms, revealing how robust conformational changes give rise to two nonconducting states, closed and desensitized. We describe a malleable ligand-bindin
- Probing Majorana neutrinos with double-{beta} decayA discovery that neutrinos are Majorana fermions would have profound implications for particle physics and cosmology. The Majorana character of neutrinos would make possible the neutrinoless double-β (0ββ) decay, a matter-creating process without the balancing emission of antimatter. The GERDA Collaboration searches for the 0ββ decay of 76Ge by operating bare germanium detectors in an active liquid argon shield. With a total exposure of 82.4 kg⋅y
- A polarization-induced 2D hole gas in undoped gallium nitride quantum wellsA high-conductivity two-dimensional (2D) hole gas, analogous to the ubiquitous 2D electron gas, is desirable in nitride semiconductors for wide-bandgap p-channel transistors. We report the observation of a polarization-induced high-density 2D hole gas in epitaxially grown gallium nitride on aluminium nitride and show that such hole gases can form without acceptor dopants. The measured high 2D hole gas densities of about 5 x 1013 per square centim
- Spatiotemporal immune zonation of the human kidneyTissue-resident immune cells are important for organ homeostasis and defense. The epithelium may contribute to these functions directly or by cross-talk with immune cells. We used single-cell RNA sequencing to resolve the spatiotemporal immune topology of the human kidney. We reveal anatomically defined expression patterns of immune genes within the epithelial compartment, with antimicrobial peptide transcripts evident in pelvic epithelium in the
- Ultrasound imaging of gene expression in mammalian cellsThe study of cellular processes occurring inside intact organisms requires methods to visualize cellular functions such as gene expression in deep tissues. Ultrasound is a widely used biomedical technology enabling noninvasive imaging with high spatial and temporal resolution. However, no genetically encoded molecular reporters are available to connect ultrasound contrast to gene expression in mammalian cells. To address this limitation, we intro
- Ongoing accumulation of plant diversity through habitat connectivity in an 18-year experimentDeleterious effects of habitat fragmentation and benefits of connecting fragments could be significantly underestimated because changes in colonization and extinction rates that drive changes in biodiversity can take decades to accrue. In a large and well-replicated habitat fragmentation experiment, we find that annual colonization rates for 239 plant species in connected fragments are 5% higher and annual extinction rates 2% lower than in unconn
Nature Communications - current - nature.com science feeds
- Argonaute bypasses cellular obstacles without hindrance during target searchNature Communications, Published online: 26 September 2019; doi:10.1038/s41467-019-12415-yArgonaute protein is loaded with small RNA and scans long stretch of sequences to find complementary target sites. Here, using single-molecule FRET and kinetic modelling, the authors showed that prokaryotic Argonaute protein binds target DNA loosely and slides along the DNA during target search.
- Distinct transcriptional roles for Histone H3-K56 acetylation during the cell cycle in YeastNature Communications, Published online: 26 September 2019; doi:10.1038/s41467-019-12400-5H3K56Ac promotes nucleosome turnover at promoter-proximal locations and assembly of new nucleosomes during S phase. Here the authors find that H3K56Ac is both a genome-wide activator of transcription in yeast while also repressing promiscuous transcription that occurs after replication fork passage.
- The risks of long-term re-injection in supercritical geothermal systemsNature Communications, Published online: 26 September 2019; doi:10.1038/s41467-019-12146-0Can we pump water into deep active volcanic areas? Here, the authors model the effect of water circulation into supercritical geothermal systems and show that the effect of rock cooling dominates the seismicity increase over the pore pressure changes.
- Piezophototronic gated optofluidic logic computations empowering intrinsic reconfigurable switchesNature Communications, Published online: 26 September 2019; doi:10.1038/s41467-019-12148-yDesigning optofluidic nano/microsystems to realize large-scale Boolean circuits remains a challenge. Here, the authors propose a flexible optofluidic framework to perform binary computations with an integrated piezophototronic mechanism controlling the optofluidic switching of logic gates (PPOF).
- First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasoundNature Communications, Published online: 26 September 2019; doi:10.1038/s41467-019-12426-9MR-focused ultrasound can be used to transiently open the blood-brain barrier (BBB). Here, the authors report the results of a first-in-human trial on four patients with amyotrophic lateral sclerosis (ALS), showing that the procedure reversibly permeabilised the BBB in the motor cortex without complications, and suggest that the procedure could in the future
- Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probesNature Communications, Published online: 26 September 2019; doi:10.1038/s41467-019-12372-6Multiplexed imaging of synaptic proteins can provide useful information on the heterogeneity of synaptic architecture and plasticity. Here the authors use high affinity locked nucleic acid probes and low affinity DNA imaging probes to achieve multiplexed confocal and super-resolution imaging of synaptic and cytoskeletal proteins.
- Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silkNature Communications, Published online: 26 September 2019; doi:10.1038/s41467-019-12365-5Spider silk is of interest in material science research. Here the authors show that the tight binding of a spider silk protein domain relies on the amino acid methionine, which is abundant in the domain core where it facilitates dynamic shape adaption of the binding interface.
- Ideological differences in the expanse of the moral circleNature Communications, Published online: 26 September 2019; doi:10.1038/s41467-019-12227-0How do liberals and conservatives differ in their expression of compassion and moral concern? The authors show that conservatives tend to express concern toward smaller, more well-defined, and less permeable social circles, while liberals express concern toward larger, less well-defined, and more permeable social circles.
JoVE: Journal of Visualized Experiments
- Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric ApproachHere, we present a protocol for collection of confocal Raman spectra from human subjects in clinical studies combined with chemometric approaches for spectral outlier removal and the subsequent extraction of key features.
- Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye TrackingHere, we present a protocol to study the relationship between the eye movement parameters and cognitive functions in non-demented Parkinson's disease patients. The experiment used an eye tracker to measure the saccadic amplitude and fixation duration in a visual search task. The correlation with performance in multi-domain cognitive tasks was subsequently measured.
- A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects (TEdeff) in CancersThe protocol details an in vitro murine carcinoma model of non-genetic defective transcription elongation. Here, chronic inhibition of CDK9 is used to repress productive elongation of RNA Pol II along pro-inflammatory response genes to mimic and study the clinically overserved TEdeff phenomenon, present in about 20% of all cancer types.
- Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase EThe goal of this protocol is to isolate mononuclear cells that reside in the lamina propria of the colon by enzymatic digestion of the tissue using collagenase. This protocol allows for the efficient isolation of mononuclear cells resulting in a single cell suspension which in turn can be used for robust immunophenotyping.
- Scratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound HealingHere, we present a protocol for an in vitro scratch assay using primary fibroblasts and for an in vivo skin wound healing assay in mice. Both assays are straightforward methods to assess in vitro and in vivo wound healing.
- Lung Fixation under Constant Pressure for Evaluation of Emphysema in MicePresented here is a useful protocol for lung fixation that creates a stable condition for histological evaluate of lung specimens from a mouse model of emphysema. The main advantage of this model is that it can fix many lungs with the same constant pressure without lung collapse or deflation.
Journal of the American Chemical Society: Latest Articles (ACS Publications)
- [ASAP] Single Site Cobalt Substitution in 2D Molybdenum Carbide (MXene) Enhances Catalytic Activity in the Hydrogen Evolution ReactionJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b08897
- [ASAP] Nicking-Assisted Reactant Recycle To Implement Entropy-Driven DNA CircuitJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b07521
- [ASAP] Measuring DNA Hybridization Kinetics in Live Cells Using a Time-Resolved 3D Single-Molecule Tracking MethodJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b08036
- [ASAP] Rational Design of an Organocatalyst for Peptide Bond FormationJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b07742
- [ASAP] Ferroelectricity and Rashba Effect in a Two-Dimensional Dion-Jacobson Hybrid Organic–Inorganic PerovskiteJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b07776
- [ASAP] Acid p<italic toggle="yes">K</italic><sub>a</sub> Dependence in O–O Bond Heterolysis of a Nonheme Fe<sup>III</sup>–OOH Intermediate To Form a Potent Fe<sup>V</sup>-O Oxidant with Heme Compound I-Like ReactivityJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b08442
- [ASAP] High Figure of Merit in Gallium-Doped Nanostructured n-Type PbTe-<italic toggle="yes">x</italic>GeTe with Midgap StatesJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b09249
- [ASAP] Lewis Pairs as Highly Tunable Dynamic Cross-Links in Transient Polymer NetworksJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b07452
- [ASAP] Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an <italic toggle="yes">S</italic>-Adenosylmethionine Derived Methyl RadicalJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b08541
- [ASAP] Water Networks Can Determine the Affinity of Ligand Binding to ProteinsJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b06275
- [ASAP] Versatile Peptide Macrocyclization with Diels–Alder CycloadditionsJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b07578
- [ASAP] Controlling the Circadian Clock with High Temporal Resolution through PhotodosingJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b05445
- [ASAP] Photochemistry of 2-Nitroarenes: 2-Nitrophenyl-a-trifluoromethyl Carbinols as Synthons for FluoroorganicsJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b07241
- [ASAP] Sequence-Defined Dendrons Dictate Supramolecular Cogwheel Assembly of Dendronized Perylene BisimidesJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b08714
- [ASAP] Ruthenium-Catalyzed Enantioselective C–H Functionalization: A Practical Access to Optically Active Indoline DerivativesJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b07251
- [ASAP] Metal–Organic Layers as Multifunctional Two-Dimensional Nanomaterials for Enhanced Photoredox CatalysisJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b08956
- [ASAP] Mechanism-Enabled Population Balance Modeling of Particle Formation en Route to Particle Average Size and Size Distribution Understanding and ControlJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b06364
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Πέμπτη 26 Σεπτεμβρίου 2019
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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