Pediatric diffuse intrinsic pontine gliomas Huber Said Padilla-Zambrano, Ezequiel Garcia-Ballestas, Amit Agrawal, Maximiliano Paez-Nova, Alfonso I Pacheco-Hernandez, Luis Rafael Moscote-Salazar Glioma 2019 2(3):127-132 Historically, brainstem gliomas have been one of the most difficult types of neoplasms to treat. They comprise 10%–20% of pediatric tumors of the central nervous system. The average age of diagnosis is 7–9 years, without a predilection for gender. The advent of magnetic resonance imaging and radiotherapy has significantly aided in the diagnosis and treatment of brainstem gliomas.

Role of natural killer cells in isocitrate dehydrogenase 1/2 mutant glioma pathogenesis and emerging therapies Xiaoran Zhang, Aleksandra Safonova, Aparna Rao, Nduka Amankulor Glioma 2019 2(3):133-138 Gliomas are the most common primary central nervous system malignancy and have an overall poor prognosis, despite aggressive treatment. Understanding the immune microenvironment of these fatal tumors will advance discovery of immune-related therapeutic targets. Natural killer (NK) cells are innate lymphoid cells that constitute the first line of host-tumor immune responses since these cells do not require prior sensitization or tumor antigen recognition to kill. NK cells kill tumor cells by recognizing stress-induced ligands expressed on tumor cells, thereby providing an efficient path to early tumor cytolysis. Dysregulation of NK-mediated immunity plays a prominent role in immune escape for glioblastoma (World Health Organization Grade IV gliomas) and for various low-grade diffuse gliomas. Thus, the biology of NK cells is fertile ground for identifying novel immunotherapeutic targets in glioma. This review discusses the biology of NK cells as well as the potential applications for immunotherapy in the treatment of gliomas.

Current management of glioma in Pakistan Umm E Hani Abdullah, Altaf Ali Laghari, Muhammad Usman Khalid, Huzaifa Bin Rashid, Adnan Abdul Jabbar, Fatima Mubarak, Asim Hafiz, Shahzad Shamim, Syed Ather Enam Glioma 2019 2(3):139-144 To date, information on the management of specific neurosurgical tumors, such as glioma, in Pakistan remains scattered and scarce. Our review synthesizes the predicaments of glioma management routinely presented to the neurosurgery, medical oncology, radiation oncology, and radiology departments in Pakistan. Expert opinions were integrated from each of the relevant fields in the form of personal citations. The data presented in our review were collected from various PubMed and non-PubMed indexed articles, coupled with various health reports from the Government of Pakistan along with the World Health Organization. Through these data, it was postulated that the utilization of innovative and instrumental technologies is a constant struggle for neurosurgeons in Pakistan, considering the cost-effectiveness. Hence, this results in significant limitations for surgeons to provide the best outcome for their patients. As most Pakistanis (74%) pay out of pocket, measuring cost-effectiveness is extremely crucial. It was found that significant differences in intra-operative and postoperative care existed among various centers. Public sector institutions fared much worse. The role of diagnostics in glioma surgery is severely limited across centers in Pakistan and as such, research and training need to be addressed promptly. In order to achieve success in glioma management, the data in our article demonstrate various facets of health care that need to be addressed simultaneously and swiftly. Surgical access needs to be improved; only then, optimal management of glioma can be accomplished in Pakistan.

Impact of stereotactic radiosurgery on first recurrence of glioblastoma Maciej Harat, Sebastian Dzierzecki, Katarzyna Dyttus-Cebulok, Miroslaw Zabek, Roman Makarewicz Glioma 2019 2(3):145-152 Background and Aim: The benefit of stereotactic radiosurgery (SRS) in recurrent glioblastoma multiforme (GBM) remains unclear, partly due to disease heterogeneity. Subventricular zone (SVZ) invasion is a prognostic factor for primary GBM, but whether SVZ involvement is also prognostic in recurrent GBM treated with SRS is unknown. Here, we aimed to determine prognostic factors after first GBM recurrence. Materials and Methods: Thirty-nine consecutive patients with a first recurrence of glioblastoma treated at the Gamma Knife Center, Warsaw, Poland and the Franciszek Lukaszczyk Oncology Center, Bydgoszcz, Poland, between 2012 and 2016 were retrospectively reviewed. Magnetic resonance images were reviewed according to SVZ invasion by primary tumors and at the time of recurrence. Outcomes were evaluated using univariable and multivariable analyses. The study protocol was approved by the Ludwik Rydygier Collegium Medicum of Nicolas Copernicus University Institutional Review Board (approved No. KB 494/2018) on June 19, 2018. Results: SRS was the only prognostic factor for overall survival after recurrence in multivariable analysis. The median overall survival after the first recurrence was 18 months in the SRS group versus 6.5 months in the non-SRS group (P = 0.02). Survival after the first recurrence treated with SRS was shorter when recurrences were localized to the SVZ. Conclusion: SRS appears to be an effective salvage modality for small recurrent GBMs. Although SVZ-positive tumors have a worse prognosis, these tumors may benefit from SRS.

Patterns of computed tomographic findings in patients from Maiduguri, Nigeria, diagnosed with a brain tumor Alhaji Modu Ali, Maryam Abdullahi Buji, Ahmed Abubakar Glioma 2019 2(3):153-156 Background and Aim: Brain tumors are a fairly common neurological problem in Nigeria and associated with a relatively low morbidity and mortality rate. Magnetic resonance imaging is the best imaging modality revealing precisely the tumor's location, patterns, and to some extent, the tumor characterization; however, only computed tomography (CT) is readily available in the study locality. In this study, we assessed the patterns of CT findings among patients diagnosed with a brain tumor using CT. Materials and Methods: This was a retrospective study, in which brain CT records of 40 cases of brain tumor diagnosed between January 2016 and August 2018 were reviewed, irrespective of patient age, sex, or clinical information. This study was approved by the Human Research Ethical Committee of the Federal Neuro-Psychiatric Hospital, Maiduguri (approval No. FNPH/GEN/092/VOLII) on December 22, 2015. Results: Of the 40 brain tumors diagnosed during the study, 17 (42%) cases were male and 23 (58%) were female. Their age range was 2–70 years (28.4 ± 20.2 years). About 22% of cases were extra-axial, whereas 31 (78%) were intra-axial. Twenty-seven (68%) patients had definitive diagnosis, with eight (20%) cases being meningioma, whereas 13 (32%) had nonspecific findings (a longer differential diagnosis). Conclusion: Meningioma was the most common type of brain tumor in this study despite the limitation of histopathology facility within the immediate locality. The low rate of glioma was probably due to few old adults included in the study.

Isolated fungal granuloma mimicking a high-grade glioma Kriti Chauhan, Hitesh Chaudhari, Vineet Saggar, Ritu Bisht Glioma 2019 2(3):157-158