IJMS, Vol. 20, Pages 4794: Association with PD-L1 Expression and Clinicopathological Features in 1000 Lung Cancers: A Large Single-Institution Study of Surgically Resected Lung Cancers with a High Prevalence of EGFR Mutation International Journal of Molecular Sciences doi: 10.3390/ijms20194794 Authors: Lee Kim Sung Lee Han Kim Choi Programmed cell death ligand 1 (PD-L1) expression is an important biomarker for predicting response to immunotherapy in clinical...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4793: Mildew Resistance Locus O Genes CsMLO1 and CsMLO2 Are Negative Modulators of the Cucumis sativus Defense Response to Corynespora cassiicola International Journal of Molecular Sciences doi: 10.3390/ijms20194793 Authors: Guangchao Yu Qiumin Chen Xiangyu Wang Xiangnan Meng Yang Yu Haiyan Fan Na Cui Corynespora leaf spot caused by Corynespora cassiicola is one of the major diseases in cucumber (Cucumis sativus L.). However, the resistance mechanisms...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4792: Lysine Propionylation is a Widespread Post-Translational Modification Involved in Regulation of Photosynthesis and Metabolism in Cyanobacteria International Journal of Molecular Sciences doi: 10.3390/ijms20194792 Authors: Yang Huang Ge Lysine propionylation is a reversible and widely distributed post-translational modification that is known to play a regulatory role in both eukaryotes and prokaryotes. However, the extent and function of lysine propionylation...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4791: Expression Profile of Cell Cycle-Related Genes in Human Fibroblasts Exposed Simultaneously to Radiation and Simulated Microgravity International Journal of Molecular Sciences doi: 10.3390/ijms20194791 Authors: Hiroko Ikeda Masafumi Muratani Jun Hidema Megumi Hada Keigi Fujiwara Hikaru Souda Yukari Yoshida Akihisa Takahashi Multiple unique environmental factors such as space radiation and microgravity (μG) pose a serious threat to...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4790: Polyamine Catabolism in Acute Kidney Injury International Journal of Molecular Sciences doi: 10.3390/ijms20194790 Authors: Kamyar Zahedi Sharon Barone Manoocher Soleimani Acute kidney injury (AKI) refers to an abrupt decrease in kidney function. It affects approximately 7% of all hospitalized patients and almost 35% of intensive care patients. Mortality from acute kidney injury remains high, particularly in critically ill patients, where it can be more...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4788: Complete Sequence, Multichromosomal Architecture and Transcriptome Analysis of the Solanum tuberosum Mitochondrial Genome International Journal of Molecular Sciences doi: 10.3390/ijms20194788 Authors: Varré D’Agostino Touzet Gallina Tamburino Cantarella Ubrig Cardi Drouard Gualberto Scotti Mitochondrial genomes (mitogenomes) in higher plants can induce cytoplasmic male sterility and be somehow involved in nuclear-cytoplasmic...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4789: New Insights into Immunotherapy Strategies for Treating Autoimmune Diabetes International Journal of Molecular Sciences doi: 10.3390/ijms20194789 Authors: Miriam Cabello-Olmo Miriam Araña Ilian Radichev Paul Smith Eduardo Huarte Miguel Barajas Type 1 diabetes mellitus (T1D) is an autoimmune illness that affects millions of patients worldwide. The main characteristic of this disease is the destruction of pancreatic insulin-producing beta cells...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4787: Rhodococcus as A Versatile Biocatalyst in Organic Synthesis International Journal of Molecular Sciences doi: 10.3390/ijms20194787 Authors: Busch Hagedoorn Hanefeld The application of purified enzymes as well as whole-cell biocatalysts in synthetic organic chemistry is becoming more and more popular, and both academia and industry are keen on finding and developing novel enzymes capable of performing otherwise impossible or challenging reactions. The...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4786: Discovery of 3-Arylquinoxaline Derivatives as Potential Anti-Dengue Virus Agents International Journal of Molecular Sciences doi: 10.3390/ijms20194786 Authors: Chih-Hua Tseng Cheng-Ruei Han Kai-Wei Tang We designed and synthesized a series of novel 3-arylquinoxaline derivatives and evaluated their biological activities as potential dengue virus (DENV) replication inhibitors. Among them, [3-(4-methoxyphenyl)quinoxalin-2-yl](phenyl)methanol (19a), [6,7-dichloro-3-(4-methoxyphenyl)quinoxalin-2-yl](phenyl)methanol...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4785: The Organogermanium Compound THGP Suppresses Melanin Synthesis via Complex Formation with L-DOPA on Mushroom Tyrosinase and in B16 4A5 Melanoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms20194785 Authors: Junya Azumi Tomoya Takeda Yasuhiro Shimada Hisashi Aso Takashi Nakamura The organogermanium compound 3-(trihydroxygermyl)propanoic acid (THGP) has various biological activities. We previously reported that THGP forms a complex...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4783: New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20194783 Authors: Chiara Riganti Marialessandra Contino MultiDrug resistance (MDR) is a complex phenomenon responsible for multiple cross-resistance towards structurally unrelated drugs and it characterizes almost 70% of solid and haematological tumours at the diagnosis [...]
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4782: Strong Signs for a Weak Wall in Tricuspid Aortic Valve Associated Aneurysms and a Role for Osteopontin in Bicuspid Aortic Valve Associated Aneurysms International Journal of Molecular Sciences doi: 10.3390/ijms20194782 Authors: Christian Stern Bernhard Scharinger Adrian Tuerkcan Clemens Nebert Teresa Mimler Ulrike Baranyi Christian Doppler Thomas Aschacher Martin Andreas Marie-Elisabeth Stelzmueller Marek Ehrlich Alexandra Graf Guenther...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4784: Gene Expression of Haloferax volcanii on Intermediate and Abundant Sources of Fixed Nitrogen International Journal of Molecular Sciences doi: 10.3390/ijms20194784 Authors: Sungmin Hwang Nikita E. Chavarria Rylee K. Hackley Amy K. Schmid Julie A. Maupin-Furlow Haloferax volcanii, a well-developed model archaeon for genomic, transcriptomic, and proteomic analyses, can grow on a defined medium of abundant and intermediate levels of fixed nitrogen....
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4781: The Need for Multi-Omics Biomarker Signatures in Precision Medicine International Journal of Molecular Sciences doi: 10.3390/ijms20194781 Authors: Michael Olivier Reto Asmis Gregory A. Hawkins Timothy D. Howard Laura A. Cox Recent advances in omics technologies have led to unprecedented efforts characterizing the molecular changes that underlie the development and progression of a wide array of complex human diseases, including cancer. As a result,...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4779: JCPyV-Induced MAPK Signaling Activates Transcription Factors during Infection International Journal of Molecular Sciences doi: 10.3390/ijms20194779 Authors: Jeanne K. DuShane Colleen L. Mayberry Michael P. Wilczek Sarah L. Nichols Melissa S. Maginnis JC polyomavirus (JCPyV), a ubiquitous human pathogen, is the etiological agent of the fatal neurodegenerative disease progressive multifocal leukoencephalopathy (PML). Like most viruses, JCPyV infection...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4780: Optimal Isolation Method of Small Extracellular Vesicles from Rat Plasma International Journal of Molecular Sciences doi: 10.3390/ijms20194780 Authors: Kosuke Otani Yusei Fujioka Muneyoshi Okada Hideyuki Yamawaki Small extracellular vesicles (sEVs) mediate cell–to–cell communication. We recently reported that circulating sEVs regulate systolic blood pressure in an animal model of human systemic hypertension. However, the underlying...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4777: Low Energy Shock Wave Therapy Inhibits Inflammatory Molecules and Suppresses Prostatic Pain and Hypersensitivity in a Capsaicin Induced Prostatitis Model in Rats International Journal of Molecular Sciences doi: 10.3390/ijms20194777 Authors: Hung-Jen Wang Pradeep Tyagi Yu-Ming Chen Michael B. Chancellor Yao-Chi Chuang The effect of low energy shock wave (LESW) therapy on the changes of inflammatory molecules and pain reaction was studied in a capsaicin...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4778: More Than an Adipokine: The Complex Roles of Chemerin Signaling in Cancer
IJMS, Vol. 20, Pages 4778: More Than an Adipokine: The Complex Roles of Chemerin Signaling in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20194778 Authors: Kerry B. Goralski Ashley E. Jackson Brendan T. McKeown Christopher J. Sinal Chemerin is widely recognized as an adipokine, with diverse biological roles in cellular differentiation and metabolism, as well as a leukocyte chemoattractant. Research investigating the role of chemerin in the obesity–cancer...
Thu Sep 26, 2019 03:00
IJMS, Vol. 20, Pages 4771: Enhancing Breast Cancer Treatment Using a Combination of Cannabidiol and Gold Nanoparticles for Photodynamic Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20194771 Authors: Dimakatso R. Mokoena Blassan P. George Heidi Abrahamse Indisputably, cancer is a global crisis that requires immediate intervention. Despite the use of conventional treatments over the past decades, it is acceptable to admit that these are expensive, invasive,...
Thu Sep 26, 2019 03:00
JCM, Vol. 8, Pages 1552: Effectiveness of Leukocyte and Platelet-Rich Fibrin versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions: A Randomized Single Blinded Clinical Trial Journal of Clinical Medicine doi: 10.3390/jcm8101552 Authors: Xavier Garrido-Castells Ricardo Becerro-de-Bengoa-Vallejo César Calvo-Lobo Marta Elena Losa-Iglesias Patricia Palomo-López Emmanuel Navarro-Flores Daniel López-López Background: Leukocyte and platelet-rich...
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JCM, Vol. 8, Pages 1551: What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity Journal of Clinical Medicine doi: 10.3390/jcm8101551 Authors: Trevor Steward Asier Juaneda-Seguí Gemma Mestre-Bach Ignacio Martínez-Zalacaín Nuria Vilarrasa Susana Jiménez-Murcia Jose A Fernández-Formoso Misericordia Veciana de las Heras Nuria Custal Nuria Virgili Rafael Lopez-Urdiales Amador...
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JCM, Vol. 8, Pages 1550: Association between Bladder Outlet Obstruction and Bladder Cancer in Patients with Aging Male Journal of Clinical Medicine doi: 10.3390/jcm8101550 Authors: Yu-Hsiang Lin Chen-Pang Hou Horng-Heng Juang Phei-Lang Chang Tien-Hsing Chen Chien-Lun Chen Ke-Hung Tsui The associations between the treatment outcomes of benign prostatic hyperplasia/benign prostatic obstruction and lifelong health status, including urologic cancer incidence as well as...
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JCM, Vol. 8, Pages 1549: Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice Journal of Clinical Medicine doi: 10.3390/jcm8101549 Authors: Biagetti Herance Ferrer Aulinas Palomino-Schätzlein Mesa Castaño Luque Simó Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the disease and...
Thu Sep 26, 2019 03:00
JCM, Vol. 8, Pages 1548: Effectiveness, Tolerability, and Safety of Tofacitinib in Rheumatoid Arthritis: A Retrospective Analysis of Real-World Data from the St. Gallen and Aarau Cohorts Journal of Clinical Medicine doi: 10.3390/jcm8101548 Authors: Mueller Hasler Popp Mattow Durmisi Souza Hasler Rubbert-Roth Schulze-Koops Kempis : Introduction: Tofacitinib is an oral JAK inhibitor indicated for the treatment of rheumatoid arthritis (RA). The efficacy...
Thu Sep 26, 2019 03:00
JCM, Vol. 8, Pages 1546: A Dual Protective Effect of Intestinal Remote Ischemic Conditioning in a Rat Model of Total Hepatic Ischemia Journal of Clinical Medicine doi: 10.3390/jcm8101546 Authors: Zoltan Czigany Koichiro Hata Wei Lai Timo Schwandt Yuzo Yamamoto Shinji Uemoto Rene H. Tolba The present study aimed to investigate the effects of intestinal remote ischemic preconditioning (iRIC) on ischemia-reperfusion injury (IRI) and gut barrier integrity in a rat model...
Thu Sep 26, 2019 03:00
JCM, Vol. 8, Pages 1547: Immune Checkpoints as Promising Targets for the Treatment of Idiopathic Pulmonary Fibrosis? Journal of Clinical Medicine doi: 10.3390/jcm8101547 Authors: JanWillem Duitman Tom van den Ende C. Arnold Spek Idiopathic pulmonary fibrosis is a rare, progressive and fatal lung disease which affects approximately 5 million persons worldwide. Although pirfenidone and/or nintedanib treatment improves patients’ wellbeing, the prognosis of IPF remains poor...
Thu Sep 26, 2019 03:00
JCM, Vol. 8, Pages 1544: Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner Journal of Clinical Medicine doi: 10.3390/jcm8101544 Authors: Christelle Darrieutort-Laffite Paul Arnolfo Thomas Garraud Annie Adrait Yohann Couté Guy Louarn Valérie Trichet Pierre Layrolle Benoit Le Goff Frédéric Blanchard Calcific tendonitis is a frequent cause of chronic shoulder pain....
Thu Sep 26, 2019 03:00
JCM, Vol. 8, Pages 1545: Biomarkers of Hand Osteoarthritis Are Detectable after Mechanical Exercise Journal of Clinical Medicine doi: 10.3390/jcm8101545 Authors: Anna Bender Ulrich Kaesser Gerrit Eichner Georg Bachmann Juergen Steinmeyer Background: Hand osteoarthritis (OA) is one of the most common joint diseases, but studies on biomarkers are rare. The aim of this explorative study was (a) to evaluate potential biomarkers of hand OA, (b) to identify an optimal time point...
Thu Sep 26, 2019 03:00
Medical Sciences, Vol. 7, Pages 100: Targeted Therapies and Immunotherapies in the Treatment of Esophageal Cancers Medical Sciences doi: 10.3390/medsci7100100 Authors: Adam Barsouk Prashanth Rawla Andreas V. Hadjinicolaou John Sukumar Aluru Alexander Barsouk Esophageal cancer (EC) is among the most frequent and deadly cancers around the world. While esophageal adenocarcinoma (EAC) has one of the fastest-growing incidences amongst cancers in the US, it also has one of the...
Thu Sep 26, 2019 03:00
Medicina, Vol. 55, Pages 647: Pulmonary Embolism and Severe Asthma: Case Report and Literature Review Medicina doi: 10.3390/medicina55100647 Authors: Lee Fu Pulmonary embolism is a life-threatening disease. Its development is generally thought to be due to causes collectively known as the Virchow's triad. Chronic inflammations are associated with the activation of coagulation and increased risks of venous thromboembolic events. Asthma is one of the chronic inflammatory diseases...
Thu Sep 26, 2019 03:00
Medicina, Vol. 55, Pages 648: Effect of Balance Taping Using Kinesiology Tape and Cross Taping on Shoulder Impingement Syndrome: A Case Report Medicina doi: 10.3390/medicina55100648 Authors: Lee Choi Background and objectives: Shoulder impingement syndrome (SIS) is the most common disorder among people with shoulder pain. The purpose of this case report was to investigate the effect of the combined application of balance taping using kinesiology tape and cross taping on a part-time...
Thu Sep 26, 2019 03:00
Medicina, Vol. 55, Pages 646: Chronic Obstructive Pulmonary Disease and the Optimal Timing of Lung Transplantation Medicina doi: 10.3390/medicina55100646 Authors: Rodrigo Vazquez Guillamet Chronic obstructive pulmonary disease (COPD) accounts for the largest proportion of respiratory deaths worldwide and was historically the leading indication for lung transplantation. The success of lung transplantation procedures is measured as survival benefit, calculated as survival with transplantation...
Thu Sep 26, 2019 03:00
Medicina, Vol. 55, Pages 645: Helicobacter pylori Infection and Psoriasis: A Systematic Review and Meta-Analysis Medicina doi: 10.3390/medicina55100645 Authors: Mingyang Yu Rongguang Zhang Peng Ni Shuaiyin Chen Guangcai Duan Background and Objectives: To perform a systematic review and meta-analysis with the aim of determining the relationship between H. pylori infection and psoriasis. Methods: Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Web of Science...
Thu Sep 26, 2019 03:00
Medicina, Vol. 55, Pages 644: Effect of Quinolones Versus Cefixime on International Normalized Ratio Levels After Valve Replacement Surgery with Warfarin Therapy Medicina doi: 10.3390/medicina55100644 Authors: Liaqat Khan Asad Khalil Background and Objectives: A dispute over interaction of warfarin with two quinolones—i.e., moxifloxacin and levofloxacin—leading to significant increase in international normalized ratio (INR) levels and coagulopathies is...
Thu Sep 26, 2019 03:00
Medicina, Vol. 55, Pages 643: Lumboperitoneal Shunt: A New Modified Surgical Technique and a Comparison of the Complications with Ventriculoperitoneal Shunt in a Single Center Medicina doi: 10.3390/medicina55100643 Authors: Tsung-Hsi Yang Cheng-Siu Chang Wen-Wei Sung Jung-Tung Liu Background and objectives: Hydrocephalus remains a disease requiring surgical treatment even in the modern era. Ventriculoperitoneal (VP) shunt placement is the most common treatment, whereas lumboperitoneal...
Thu Sep 26, 2019 03:00
Medicines, Vol. 6, Pages 97: Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis Medicines doi: 10.3390/medicines6040097 Authors: Christina D. Kwon Raveena Khanna Kyle A. Williams Madan M. Kwatra Shawn G. Kwatra Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that...
Thu Sep 26, 2019 03:00
Microorganisms, Vol. 7, Pages 399: Characteristics of Gut Microbiota in Patients with Hypertension and/or Hyperlipidemia: A Cross-Sectional Study on Rural Residents in Xinxiang County, Henan Province Microorganisms doi: 10.3390/microorganisms7100399 Authors: Li Liu Song An Zeng Li Jiang Xie Wu Human gut microbiota can be affected by a variety of factors, including geography. This study aimed to clarify the regional specific characteristics of gut microbiota...
Thu Sep 26, 2019 03:00
Microorganisms, Vol. 7, Pages 400: Risk Factors for Long-Term Vancomycin-Resistant Enterococci Persistence—A Prospective Longitudinal Study Microorganisms doi: 10.3390/microorganisms7100400 Authors: Correa-Martinez Stollenwerk Kossow Schaumburg Mellmann Kampmeier Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens that require effective infection control measures, representing a challenge for healthcare systems. This study aimed at identifying...
Thu Sep 26, 2019 03:00
Microorganisms, Vol. 7, Pages 398: Whole Genome Sequencing for Tracing Geographical Origin of Imported Cases of Human Brucellosis in Sweden Microorganisms doi: 10.3390/microorganisms7100398 Authors: Sacchini Wahab Di Giannatale Zilli Abass Garofolo Janowicz Human infections with Brucella melitensis are occasionally reported in Sweden, despite the fact that the national flocks of sheep and goats are officially free from brucellosis. The aim of our study was to...
Thu Sep 26, 2019 03:00
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