• Critical Reviews in Oncology/Hematology (open access)
• Differential redox-regulation and mitochondrial dynamics in normal and leukemic hematopoietic stem cells: A potential window for leukemia therapy

  Publication date: Available online 25 September 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Katharina Mattes, Edo Vellenga, Hein SchepersAbstractThe prognosis for many patients with acute myeloid leukemia (AML) is poor, mainly due to disease relapse driven by leukemia stem cells (LSCs). Recent studies have highlighted the unique metabolic properties of LSCs, which might represent opportunities for LSC-selective targeting. LSCs c

  Critical Reviews in Oncology/Hematology (open access)

  Thu Sep 26, 2019 04:08
• TARGETED TREATMENT APPROACHES IN REFRACTORY GERM CELL TUMORS

  Publication date: Available online 25 September 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Laura Galvez-Carvajal, Alfonso Sanchez-Muñoz, Nuria Ribelles, Maribel Saez, Javier Baena, Sofia Ruiz, Catherine Ithurbisquy, Emilio AlbaABSTRACTGerm cell tumors (GCTs) are the most common type of solid tumor amongst patients between 15 and 35 years of age. They are also one of the types of tumor with the highest cure rate, due to their hi

  Critical Reviews in Oncology/Hematology (open access)

  Thu Sep 26, 2019 04:08
• International journal of basic and clinical endocrinology
• Decreased expression of microRNAs targeting type-2 diabetes susceptibility genes in peripheral blood of patients and predisposed individuals

  Abstract Aim Certain microRNA molecules (miRNAs) that target genes involved in beta-cell growth and insulin resistance are found deregulated in patients with type-2 diabetes mellitus (T2D) and correlate with its complications. However, the expression profile of miRNAs that regulate genes bearing T2D-related single-nucleotide polymorphisms has been hardly studied. We recently reported t

  International journal of basic and clinical endocrinology

  Wed Sep 25, 2019 17:00
• Strahlentherapie und Onkologie
• Recurrence pattern of stereotactic body radiotherapy in oligometastatic prostate cancer: a multi-institutional analysis

  Abstract Purpose For patients with oligometastatic/oligorecurrent/oligoprogressive lymph node metastases from PCa, metastases-directed therapy is an emerging strategy. The aim of this retrospective study was to evaluate the oncological outcome and pattern of recurrence in patients treated with stereotactic body radiation therapy (SBRT) to lymph node metastases.

  Strahlentherapie und Onkologie

  Wed Sep 25, 2019 17:00
• Tumor regression during radiotherapy for non-small cell lung cancer patients using cone-beam computed tomography images

  Abstract Purpose Previous literature has reported contradicting results regarding the relationship between tumor volume changes during radiotherapy treatment for non-small cell lung cancer (NSCLC) patients and locoregional recurrence-free rate or overall survival. The aim of this study is to validate the results from a previous study by using a different volume extraction procedure and

  Strahlentherapie und Onkologie

  Wed Sep 25, 2019 17:00
• HNO
• Innenohrschwerhörigkeit, Tinnitus

  HNO

  Thu Sep 26, 2019 09:51
• Festschrift für Roland Laszig

  HNO

  Thu Sep 26, 2019 09:51
• Onkoimmunologie im Alter

  Zusammenfassung Physiologische Alterungsprozesse des Immunsystems gehen mit einer erhöhten Anfälligkeit für Infektionskrankheiten, Autoimmun- und Tumorerkrankungen einher. Entsprechend der allgemeinen demographischen Entwicklung steigt auch die Anzahl der Tumorpatienten mit fortgeschrittenem Lebensalter zunehmend. Ein Ende dieser Entwicklung ist bislang nicht absehbar. Bei der Tumorbehandlung gewinnt die Immuntherapie mit Check

  HNO

  Wed Sep 25, 2019 17:00
• Oral Biology
• Comparative study of xeno-free induction protocols for neural differentiation of human dental pulp stem cells <em>in vitro</em>

  Publication date: Available online 25 September 2019Source: Archives of Oral BiologyAuthor(s): Thulasi Thiruvallur Madanagopal, Alfredo Franco-Obregón, Vinicius RosaAbstractOBJECTIVETo compare three different xeno-free protocols for neural differentiation of human dental pulp stem cells (DPSC).METHODSDPSC were treated with three different media to induce neural differentiation namely N1 (DMEM for 5 days), N2 (PSC neural induction media for 7 days

  Oral Biology

  Thu Sep 26, 2019 05:10
• British Journal of Oral and Maxillofacial Surgery
• Relations between mandible-only advancement surgery, the extent of the posterior airway space, and the position of the hyoid bone in Class II patients: a three-dimensional analysis

  Publication date: Available online 26 September 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): T. Rückschloß, O. Ristow, M. Berger, M. Engel, C. Freudlsperger, J. Hoffmann, R. SeebergerAbstractThe objective of the present study was to evaluate the relation between mandibular advancement, the three-dimensional extent of the posterior airway space (PAS), and the position of the hyoid bone, using cone-beam computed tomograph

  British Journal of Oral and Maxillofacial Surgery

  Thu Sep 26, 2019 09:22
• “FlapApp” – contemporary microvascular free flap surveillance

  Publication date: Available online 26 September 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): A.K. Bartella, M. Kamal, J. Steegmann, F. Hölzle, B. Lethaus

  British Journal of Oral and Maxillofacial Surgery

  Thu Sep 26, 2019 09:22
• Efficacy of buffered local anaesthetics in head and neck infections

  Publication date: Available online 26 September 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): G. Arora, S. Degala, S. DasukilAbstractLignocaine is one of the most commonly-used agents to anaesthetise an area preoperatively. It can, however, cause undesirable effects such as burning on injection, relatively slow onset, and unreliable, or lack of, numbness when injected into infected tissues as a result of the acidic pH of

  British Journal of Oral and Maxillofacial Surgery

  Thu Sep 26, 2019 09:22
• Secondary desmoplastic fibroma-like tissue changes in mandibular fibrous dysplasia: clinicopathological and molecular study of a case

  Publication date: Available online 26 September 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): A. Corsi, M.T. Fadda, V. Terenzi, V. Valentini, M. RiminucciAbstractFibrous dysplasia may show locally aggressive behaviour reflecting secondary intralesional changes, extension to soft tissue, or malignant transformation. We report the case of a patient with polyostotic fibrous dysplasia who had a giant mandibular lesion consis

  British Journal of Oral and Maxillofacial Surgery

  Thu Sep 26, 2019 09:22
• bioRxiv Subject Collection: Evolutionary Biology
• During environmental change, cooperation can promote rescue or lead to evolutionary suicide [NEW RESULTS]

  The adaptation of populations to changing conditions may be affected by interactions between individuals. For example, cooperative interactions may allow populations to maintain high densities, and thus keep track of moving environmental optima. At the same time, changes in population density alter the marginal benefits of cooperative investments, creating a feedback loop between population dynamics and the evolution of cooperation. Here we model

  bioRxiv Subject Collection: Evolutionary Biology

  Wed Sep 25, 2019 17:00
• Adaptive Tree Proposals for Bayesian Phylogenetic Inference [NEW RESULTS]

  Bayesian inference of phylogenies with MCMC is without a doubt a staple in the study of evolution. Yet, this method still suffers from a practical challenge identified more than two decades ago: designing tree topology proposals that efficiently sample the tree space. In this article, I introduce the concept of tree topology proposals that adapt to the posterior distribution as it is estimated. I use this concept to elaborate two adaptive variant

  bioRxiv Subject Collection: Evolutionary Biology

  Wed Sep 25, 2019 17:00
• No evidence for immune-gene specific signals of selection in termites [NEW RESULTS]

  It has been hypothesized that selection pressure from pathogens plays an important role in shaping social evolution. Social behaviour, in particular brood care, is associated with pathogen pressure in wood-dwelling lower termites. Yet, generally pathogen pressure is low in wood-dwelling termite species that never leave the nest except for the mating flight. In comparison, pathogen pressure is higher in species that leave the nest to forage, and t

  bioRxiv Subject Collection: Evolutionary Biology

  Wed Sep 25, 2019 17:00
• The genomic architecture of fitness drives population viability during rapid environmental change [NEW RESULTS]

  The rapid global loss of biodiversity calls for improved predictions of how population will evolve and respond demographically to ongoing environmental change. The heritability (h2) of selected traits has long been known to affect evolutionary and demographic responses to environmental change. Here, we show with novel deterministic models and stochastic simulations that the genetic architecture underlying h2 can dramatically affect population via

  bioRxiv Subject Collection: Evolutionary Biology

  Wed Sep 25, 2019 17:00
• Additional layer of regulation via convergent gene orientation in yeasts [NEW RESULTS]

  Convergent gene pairs can produce transcripts with complementary sequences. We had shown that mRNA duplexes form in vivo in Saccharomyces cerevisiae via interactions of mRNA overlapping 3'-ends and can lead to post-transcriptional regulatory events. Here we show that mRNA duplex formation is restricted to convergent genes separated by short intergenic distance, independently of their 3'-UTR length. We disclose an enrichment in genes involved in b

  bioRxiv Subject Collection: Evolutionary Biology

  Wed Sep 25, 2019 17:00
• Local adaptation to abiotic and biotic stresses and phenotypic selection on flowering time in annual Brachypodium spp. along an aridity gradient [NEW RESULTS]

  Plants have diverse strategies to cope with stress, including early flowering to "escape" abiotic stress and late flowering to mitigate biotic stress. Plants are usually exposed to multiple stresses simultaneously, but little is known about the impact of multiple co-occurring stresses on plant evolution. We tested for adaptation to both aridity and interspecific competition of the model plant Brachypodium spp., collected along the aridity gradien

  bioRxiv Subject Collection: Evolutionary Biology

  Wed Sep 25, 2019 17:00
• Enhancers facilitate the birth of de novo genes and their integration into regulatory networks [NEW RESULTS]

  Regulatory networks control the spatiotemporal gene expression patterns that give rise to and define the individual cell types of multicellular organisms. In eumetazoa, distal regulatory elements called enhancers play a key role in determining the structure of such networks, particularly the wiring diagram of "who regulates whom." Mutations that affect enhancer activity can therefore rewire regulatory networks, potentially causing changes in gene

  bioRxiv Subject Collection: Evolutionary Biology

  Wed Sep 25, 2019 17:00
• Bacterial genes outnumber archaeal genes in eukaryotic genomes [NEW RESULTS]

  The origin of eukaryotes is one of evolution's most important transitions, yet it is still poorly understood. Evidence for how it occurred should be preserved in eukaryotic genomes. Based on phylogenetic trees from ribosomal RNA and ribosomal proteins, eukaryotes are typically depicted as branching together with or within archaea. This ribosomal affiliation is widely interpreted as evidence for an archaeal origin of eukaryotes. However, the exten

  bioRxiv Subject Collection: Evolutionary Biology

  Wed Sep 25, 2019 17:00
• Seeing distinct groups where there are none: spurious patterns from between-group PCA [NEW RESULTS]

  Using sampling experiments, we found that, when there are fewer groups than variables, between-groups PCA (bgPCA) may suggest surprisingly distinct differences among groups for data in which none exist. While apparently not noticed before, the reasons for this problem are easy to understand. A bgPCA captures the g-1 dimensions of variation among the Sum(n_i) - g group means, but only a fraction of the dimensions of within-group variation (n_i are

  bioRxiv Subject Collection: Evolutionary Biology

  Wed Sep 25, 2019 17:00
• Primate hippocampus size and organisation are predicted by sociality but not diet [NEW RESULTS]

  The hippocampus is well known for its roles in spatial navigation and memory, but it is organized into regions that have different connections and functional specializations. Notably, the region CA2 has a role in social and not spatial cognition, as is the case for the regions CA1 and CA3 that surround it. Here we investigated the evolution of the hippocampus in terms of its size and organization in relation to the evolution of social and ecologi

  bioRxiv Subject Collection: Evolutionary Biology

  Wed Sep 25, 2019 17:00
• Biomedicine & Pharmacotherapy
• LINC00473 promotes hepatocellular carcinoma progression via acting as a ceRNA for microRNA-195 and increasing HMGA2 expression

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Jinggang Mo, Bo Li, Yong Zhou, Youwen Xu, Hao Jiang, Xingjing Cheng, Xiaoyu Wu, Yaqiong ZhangAbstractHepatocellular carcinoma (HCC) is a most aggressive malignant tumor. Nevertheless, the molecular mechanisms underlying HCC are still completely unclear. LINC00473 is identified as a tumor promoter in many cancers. In this investigation, the function of LINC0

  Biomedicine & Pharmacotherapy

  Thu Sep 26, 2019 03:53
• LncRNA-LINC00472 contributes to the pathogenesis of atrial fibrillation (Af) by reducing expression of JP2 and RyR2 via miR-24

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Liao-yuan Wang, Hua Shen, Qian Yang, Jie Min, Qing Wang, Wang Xi, Liang Yin, Shi-guan Le, Yu-feng Zhang, Jian Xiao, Zhi-nong Wang, Guang-yu JiAbstractBackgroundDysregulated methylation of the promoter of lncRNA LINC00472 reduces the expression of LINC00472 and subsequently up-regulates the expression of its competing endogenous RNA miR-24. In addition, JP2

  Biomedicine & Pharmacotherapy

  Thu Sep 26, 2019 03:53
• Therapy for myocardial infarction: <em>In vitro</em> and <em>in vivo</em> evaluation of puerarin-prodrug and tanshinone co-loaded lipid nanoparticulate system

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Jing Guo, Xiaowei Xing, Na Lv, Jingjie Zhao, Yusheng Liu, Huiping Gong, Yimeng Du, Qinghua Lu, Zhaoqiang DongAbstractMyocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. Nanoparticle systems carrying drugs have already been developed to treat MI. To improve the efficiency of tanshinone (TAN), and to achieve the synergistic e

  Biomedicine & Pharmacotherapy

  Thu Sep 26, 2019 03:53
• Dopamine delays articular cartilage degradation in osteoarthritis by negative regulation of the NF-κB and JAK2/STAT3 signaling pathways

  Publication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Wei Lu, Zhenfei Ding, Fuen Liu, Wenshan Shan, Chao Cheng, Jiegou Xu, Wei He, Wei Huang, Junting Ma, Zongsheng YinAbstractBackgroundThe progressive loss of cartilage matrix and the breakdown of articular cartilage induced by inflammation play an essential role in osteoarthritis (OA) pathogenesis. Dopamine (DA) is a critical neurotransmitter that is not only

  Biomedicine & Pharmacotherapy

  Thu Sep 26, 2019 03:53
• PeerJ Computer Science
• Perspectives on the utilization of resistance mechanisms from host and nonhost plants for durable protection of Brassica crops against Alternaria blight

  Background Alternaria brassicae, the causal organism of Alternaria blight, is a necrotroph infecting crops of the Brassicaceae family at all growth stages. To circumvent this problem, several disease management strategies are being used in the field, and disease-resistant varieties have also been developed. However, no strategy has proven completely successful, owing to the high variability in virulence among A. brassicae isolate

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00
• Exploring the expression and preliminary function of chicken Gimap5 gene

  GTPase immune-associated protein 5 (Gimap5) plays a key role in maintaining T cell homeostasis, immunological tolerance and inflammatory processes. However, there are no reports on the chicken Gimap5 gene. In this study, the Gimap5 gene was first cloned from chicken and characterized its tissue expression characteristics in different developmental stages. The transcriptional activities of the Gimap5 gene in immune response were identified. The re

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00
• Interspecific variation in the limb long bones among modern rhinoceroses—extent and drivers

  Among amniotes, numerous lineages are subject to an evolutionary trend toward body mass and size increases. Large terrestrial species may face important constraints linked to weight bearing, and the limb segments are particularly affected by such constraints due to their role in body support and locomotion. Such groups showing important limb modifications related to high body mass have been called “graviportal.” Often considered graviportal, rhin

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00
• Larval assemblages over the abyssal plain in the Pacific are highly diverse and spatially patchy

  Abyssal plains are among the most biodiverse yet least explored marine ecosystems on our planet, and they are increasingly threatened by human impacts, including future deep seafloor mining. Recovery of abyssal populations from the impacts of polymetallic nodule mining will be partially determined by the availability and dispersal of pelagic larvae leading to benthic recolonization of disturbed areas of the seafloor. Here we use a tree-of-life (T

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00
• Microbial communities associated with the black morel Morchella sextelata cultivated in greenhouses

  Morels (Morchella spp.) are iconic edible mushrooms with a long history of human consumption. Some microbial taxa are hypothesized to be important in triggering the formation of morel primordia and development of fruiting bodies, thus, there is interest in the microbial ecology of these fungi. To identify and compare fungal and prokaryotic communities in soils where Morchella sextelata is cultivated in outdoor greenhouses, ITS and 16S rDNA high t

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00
• Effect of orienteering experience on walking and running in the absence of vision and hearing

  Purpose This study aimed to examine differences between track and field (T&F) runners and foot-orienteers (Foot-O) in the walking and running tests in the absence of vision and hearing. We attempted to determine whether experienced foot orienteers show better ability to maintain the indicated direction compared to track and field runners. Methods This study examined

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00
• The relationships between bilingual learning, willingness to study abroad and convergent creativity

  Convergent creativity is a form of creative thinking that uses existing knowledge or traditional methods to analyze available information and generate an appropriate solution. The differences in the performance of participants in convergent creativity caused by bilingual learning is a popular research area in creativity. A final sample of 68 participants was asked to complete the remote associates test (RAT). The results indicate that a moderate

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00
• Physiological responses of hydroponically-grown Japanese mint under nutrient deficiency

  This research aims to determine growth and deficiency patterns as well as antioxidative potentials of Japanese mint (Mentha arvensis) hydroponically grown under limited macronutrients and micronutrients. The experiment was conducted for 60 days after transplanting in an evaporative greenhouse (avg temp = 28–30 °C, 60–65 %RH), using deep water culture technique. Plants were grown in nutrient solution consisting of complete Hoagland’s solution (CTR

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00
• Comprehensive evaluation of fluroxypyr herbicide on physiological parameters of spring hybrid millet

  Foxtail millet (Setaria italic L.) is an important food and fodder crop that is cultivated worldwide. Quantifying the effects of herbicides on foxtail millet is critical for safe herbicide application. In this study, we analyzed the effects of different fluroxypyr dosages on the growth parameters and physiological parametric of foxtail millet, that is, peroxidation characteristics, photosynthetic characteristics, and endogenous hormone production

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00
• Simulated manned Mars exploration: effects of dietary and diurnal cycle variations on the gut microbiome of crew members in a controlled ecological life support system

  Background Changes in gut microbiome are closely related to dietary and environment variations, and diurnal circle interventions impact on human metabolism and the microbiome. Changes in human gut microbiome and serum biochemical parameters during long-term isolation in a controlled ecological life support system (CELSS) are of great significance for maintaining the health of crewmembers. The Green Star 180 project performed an integrated study

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00
• Kinematics of male Eupalaestrus weijenberghi (Araneae, Theraphosidae) locomotion on different substrates and inclines

  Background The mechanics and energetics of spider locomotion have not been deeply investigated, despite their importance in the life of a spider. For example, the reproductive success of males of several species is dependent upon their ability to move from one area to another. The aim of this work was to describe gait patterns and analyze the gait parameters of Eupalaestrus weijenberghi (Araneae, Theraphosidae) in order to invest

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00
• Transcriptome association studies of neuropsychiatric traits in African Americans implicate PRMT7 in schizophrenia

  In the past 15 years, genome-wide association studies (GWAS) have provided novel insight into the genetic architecture of various complex traits; however, this insight has been primarily focused on populations of European descent. This emphasis on European populations has led to individuals of recent African descent being grossly underrepresented in the study of genetics. With African Americans making up less than 2% of participants in neuropsych

  PeerJ Computer Science

  Wed Sep 25, 2019 17:00