Intensive therapy to lower serum lipid levels with the use of statins is recommended after transient ischemic attack (TIA) or ischemic stroke of atherosclerotic origin. These recommendations are based on the results of the Stroke Prevention by Aggressive Reduction in Cholesterol Level (SPARCL)…
Mon Nov 18, 2019 02:00
Related ArticlesEffectiveness of adjunctive nebulized antibiotics in critically ill patients with respiratory tract infections. Eur J Clin Microbiol Infect Dis. 2019 Nov 16;: Authors: Leache L, Aquerreta I, Aldaz A, Monedero P, Idoate A, Ortega A Abstract The purpose of the study was to analyze the effectiveness of adding nebulized antibiotics to systemic antimicrobials in critically ill patients with respiratory tract infections (pneumonia or tracheobronchitis)...
Mon Nov 18, 2019 18:47
Related ArticlesFatality of Staphylococcus aureus infections in a Greek university hospital: role of inappropriate empiric treatment, methicillin resistance, and toxin genes' presence. Eur J Clin Microbiol Infect Dis. 2019 Nov 16;: Authors: Katsarou I, Paraskevopoulou NM, Papadimitriou-Olivgeris M, Giormezis N, Militsopoulou M, Kolonitsiou F, Marangos M, Anastassiou ED, Spiliopoulou I Abstract The aim of the present study was to identify predictors of...
Mon Nov 18, 2019 18:47
Related ArticlesEvaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study. Eur J Nutr. 2019 Nov 16;: Authors: Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N Abstract BACKGROUND: The combination of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2...
Mon Nov 18, 2019 18:47
Related ArticlesComplex rhinobronchial dystrophy and immunodeficiency: Chance association or exceptional congenital syndrome? Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Nov 13;: Authors: Migueres N, de Blay F, Braun JJ Abstract INTRODUCTION: We report a case of an exceptional syndromic association of apparently congenital rhinobronchial dystrophy associated with congenital anosmia and common variable immunodeficiency in a twelve-year-old girl. ...
Mon Nov 18, 2019 18:47
Related ArticlesProcalcitonin: Where Are We Now? Crit Care Clin. 2020 Jan;36(1):23-40 Authors: Hamade B, Huang DT Abstract Procalcitonin is a biomarker that is generally elevated in bacterial infections. This review describes a conceptual framework for biomarkers using lessons from the history of troponin, applies this framework to procalcitonin with a review of observational studies and randomized trials in and out of the intensive care unit, and concludes...
Mon Nov 18, 2019 18:47
Related ArticlesDynamics of interaction and effects of microplastics on planarian tissue regeneration and cellular homeostasis. Aquat Toxicol. 2019 Nov 09;218:105354 Authors: Gambino G, Falleni A, Nigro M, Salvetti A, Cecchettini A, Ippolito C, Guidi P, Rossi L Abstract Increasing microplastics pollution of marine and terrestrial water is a concerning issue for ecosystems and human health. Nevertheless, the interaction of microplastics with freshwater...
Mon Nov 18, 2019 18:44
Related ArticlesRepeated ethanol exposure influences key enzymes in cholesterol and lipid homeostasis via the AMPK pathway in the rat prefrontal cortex. Alcohol. 2019 Nov 14;: Authors: Xu S, Jeong SJ, Li G, Koo JW, Kang UG Abstract Cholesterol homeostasis has been proposed to be implicated in the development of addiction. However, the effects of ethanol on cholesterol homeostasis within the brain are not well understood. One of the most important regulators...
Mon Nov 18, 2019 18:44
Related ArticlesChanges of skin electrical potential in acupoints from Ren Mai and Du Mai conduits during Qigong practice: Documentation of a clinical phenomenon. J Bodyw Mov Ther. 2019 Oct;23(4):713-720 Authors: Matos LC, Machado J, Greten HJ, Monteiro FJ Abstract Qigong is a therapeutic method of traditional Chinese medicine (TCM) that combines slow, soft movements and postures with breath control and a special mental state of 'awareness'. TCM holds...
Mon Nov 18, 2019 18:44
Nature Chemistry, Published online: 18 November 2019; doi:10.1038/s41557-019-0375-xDespite the regular occurrence of high-profile accidents leading to serious injuries or deaths among lab personnel, the state of academic lab safety research has languished. Existing studies in this area are summarized and critiqued in this Review and suggestions are made for future research directions.
Mon Nov 18, 2019 02:00
Nature Chemistry, Published online: 18 November 2019; doi:10.1038/s41557-019-0361-3The Catellani reaction is a multi-component cascade sequence, catalysed by palladium and norbornene, which typically uses aromatic starting materials. Now, through the use of a modified norbornene co-catalyst, the scope of this reaction has been extended to alkenyl reagents, enabling the preparation of all-carbon tetrasubstituted olefins.
Mon Nov 18, 2019 02:00
Nature Chemistry, Published online: 18 November 2019; doi:10.1038/s41557-019-0358-yAll-carbon tetrasubstituted olefins are challenging to prepare in a regio- and stereocontrolled fashion. Now, using an amide-substituted norbornene as a co-catalyst, alkenyl halide- or triflate-mediated palladium/norbornene (Pd/NBE) catalysis has been demonstrated, providing an efficient strategy for modular and regioselective construction of all-carbon tetrasubstituted olefins.
Mon Nov 18, 2019 02:00
Nature Chemistry, Published online: 18 November 2019; doi:10.1038/s41557-019-0357-zReplacing rare elements in benchmark photosensitizers with iron would facilitate the large-scale implementation of solar energy conversion, but iron complexes generally do not exhibit sufficiently long-lived photoexcited states. Now, it has been shown that iron(ii) complexes with carefully designed ligands can absorb broadly across the visible light spectrum and have charge-transfer excited states with nanosecond lifetimes.
Mon Nov 18, 2019 02:00
Mature cystic teratomas are the most common ovarian germ cell tumour and account for 10–20% of all ovarian neoplasms. Malignant transformation of mature cystic teratomas is rare and has an incidence rate of less than 1%. The most common malignancy are squamous cell carcinomas. Here we present the case of an intestinal adenocarcinoma which is an exceedingly rare malignant entity arising within a mature cystic teratoma. Clinical presentation, imaging and histopathological diagnosis are discussed and...
Mon Nov 18, 2019 18:05
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Mon Nov 18, 2019 18:04
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Mon Nov 18, 2019 18:04
Publication date: Available online 17 November 2019Source: Journal of Neuroscience MethodsAuthor(s): Judith Bek, Ellen Poliakoff, Karen LanderAbstractBackgroundMotion is an important cue to emotion recognition, and it has been suggested that we recognize emotions via internal simulation of others’ expressions. There is a reduction of facial expression in Parkinson’s disease (PD), which may influence the ability to use motion to recognise emotions in others. However, the majority of previous work...
Mon Nov 18, 2019 17:49
Abstract It is currently unclear whether the acquisition of negative stimulus valence in evaluative and fear conditioning paradigms is interrelated or independent. The present study used a transfer paradigm to address this question. Three groups of participants were trained in a picture‐picture evaluative conditioning paradigm before completing acquisition of differential fear conditioning using graphical shapes as conditional stimuli (CSs). In group congruent, the shape used as CS+ (paired with...
Sun Nov 17, 2019 22:00
Abstract Trait mindfulness has been associated with well‐being. A key component of trait mindfulness is intentional attention and awareness which is most commonly measured by the Mindful Attention and Awareness Scale (MAAS). This study investigated the relationship between the MAAS and cardiovascular (HF‐HRV, heart rate) reactivity to two laboratory stressors that evoked different patterns of change in heart rate (HR). One stressor (viewing a video of a surgery) evoked HR deceleration while the...
Sun Nov 17, 2019 19:54
Abstract Convergent lines of evidence suggest that fluctuations in the size of the pupil may be associated with the trade‐off between the speed (adrenergic, sympathetic) and accuracy (cholinergic, parasympathetic) of behavior across a variety of task contexts. Here, we explored whether pupil size was related to this trade‐off during a visuospatial motor aiming task. Participants were shown visual targets at random locations on a screen and were instructed and incentivized to move a computer mouse‐controlled...
Sun Nov 17, 2019 19:48
האקדמיה ללשון העברית מחפשתסטודנט או סטודנטית לתמיכה באתר האקדמיה תיאור התפקיד תמיכה טכנית בהפעלת אתר האקדמיה, הזנת שוטפת של תכנים, סיוע לעורך התוכן, איתור תקלות ועבודה מול אנשי מערכות המידע. דרישות התפקיד היכרות בסיסית עם HTML, CSS, JavaScript ותוכנות Office. ידע וניסיון ב-wordpress – יתרון ידע ב-PHP – יתרון יכולת למידה גבוהה יוזמה ועצמאות שליטה בתוכנות עריכה של גרפיקה, שמע ווידאו – יתרון היקף העבודה עד 120 שעות בחודש מקום העבודה בקריית האוניברסיטה, גבעת רם, ירושלים שכר סטודנט לפי תנאי...
Mon Nov 18, 2019 15:59
Ο αιφνίδιος καρδιακός θάνατος πλήττει περίπου 220.000 ενήλικες στις ΗΠΑ ετησίως, οι περισσότεροι από τους οποίους δεν έχουν κανένα προηγούμενο καρδιακό σύμπτωμα. Εντοπίζοντας σπάνια γονίδια που αυξάνουν τον κίνδυνο αιφνίδιου καρδιακού θανάτου ερευνητές από το Γενικό Νοσοκομείο της Μασαχουσέτης, το Ινστιτούτο Broad του MIT και το Χάρβαρντ μπορούν πλέον να αποφανθούν για το ποια άτομα θα μπορούσαν να ωφεληθούν από στρατηγικές πρόληψης πριν την εμφάνιση συμπτωμάτων. Σύμφωνα με τα ευρήματα που παρουσιάστηκαν...
Mon Nov 18, 2019 14:08
Πολλοί ασθενείς με σοβαρή αλλά σταθερή καρδιοπάθεια που συνήθως υποβάλλονται σε αγγειοπλαστική με εμφύτευση stent για την αντιμετώπιση της αθηροσκλήρωσης, έχουν εξίσου καλή πορεία και με τη λήψη της σωστής φαρμακευτικής αγωγής και τις ανάλογες αλλαγές στον τρόπο ζωής, σύμφωνα με νέα μεγάλη μελέτη που παρουσιάστηκε στο ετήσιο συνέδριο της Αμερικανικής Καρδιολογικής Εταιρείας. Ουσιαστικά η μελέτη ISCHEMIA ανατρέπει τη μέχρι τώρα ιατρική πρακτική της τοποθέτησης stent σε καρδιοπαθείς που θεωρούνται...
Mon Nov 18, 2019 13:44
Αν και ο ύπνος είναι καθοριστικής σημασίας για τον οργανισμό όλων των έμβιων όντων, οι γενετικοί μηχανισμοί που τον ρυθμίζουν παραμένουν ακόμα ασαφείς. Επιστήμονες, όμως, από το Ινστιτούτο Τεχνολογίας της Καλιφόρνια (Caltech) εντόπισαν σε πειραματικό μοντέλο, στο ψάρι-ζέβρα (Danio rerio), ένα γενετικό μονοπάτι απαραίτητο για τον καλό ύπνο, το οποίο φαίνεται να ρυθμίζει και τον ύπνο στον ανθρώπινο οργανισμό. Το μονοπάτι αυτό ρυθμίζει τα επίπεδα ενός συγκεκριμένου νευρικού συστατικού που κάποια μέρα...
Mon Nov 18, 2019 13:31
Ένα νέο πρόγραμμα τεχνητής νοημοσύνης μπορεί να εξετάσει ηλεκτροκαρδιογραφήματα και να εντοπίσει τους ασθενείς με καρδιακή αρρυθμία (κολπική μαρμαρυγή) που κινδυνεύουν από πρόωρο θάνατο μέσα στο επόμενο έτος, κάνοντας προβλέψεις καλύτερα και από καρδιολόγους. Η κολπική μαρμαρυγή σχετίζεται με αυξημένο κίνδυνο εμφράγματος και εγκεφαλικού επεισοδίου. Οι ερευνητές του Ιατρικού Κέντρου Geisinger της Πενσιλβάνια, που έκαναν δύο σχετικές ανακοινώσεις στο ετήσιο συνέδριο της Αμερικανικής Καρδιολογικής...
Mon Nov 18, 2019 10:00
Αν είστε από αυτούς που ξεχνούν εύκολα ή κάνουν πολλά λάθη όταν βιάζονται, ο διαλογισμός ίσως να σας βοηθήσει να γίνετε λιγότερο… επιρρεπής στα κακώς κείμενα της καθημερινότητας, υποστηρίζει μία έρευνα του Πανεπιστημίου του Michigan που δημοσιεύθηκε στο Brain Sciences, η μεγαλύτερη του είδους της μέχρι σήμερα. Η έρευνα εξέτασε το πώς ο ανοιχτός, καθοδηγούμενος διαλογισμός που επικεντρώνεται στην αντίληψη των συναισθημάτων, των σκέψεων και των αισθήσεων καθώς αυτά απελευθερώνονται από το μυαλό και...
Mon Nov 18, 2019 09:30
Οι μοναχικοί ασθενείς με καρδιακά προβλήματα είναι πιο πιθανό να πεθάνουν εντός ενός χρόνου αφότου νοσηλευτούν. Σε αυτό το συμπέρασμα κατέληξε ερευνητική ομάδα του Πανεπιστημιακού Νοσοκομείου της Κοπεγχάγης σε δημοσίευση που έκανε στο Heart. Οι γυναίκες που ήταν μόνες είχαν τρεις φορές περισσότερες πιθανότητες να πεθάνουν 12 μήνες μετά τη νοσηλεία τους, ενώ ο κίνδυνος για τους άνδρες που ήταν μόνοι ήταν διπλάσιος. Η ερευνητική ομάδα εξέτασε τα αποτελέσματα που προέκυψαν εντός ενός έτους μετά από...
Mon Nov 18, 2019 09:20
Ερευνητές ανακάλυψαν ότι η δραστική ουσία ναλτρεξόνη αποκαθιστά σε μεγάλο βαθμό τη λειτουργία των ελαττωματικών υποδοχέων που σχετίζονται με την μυαλγική εγκεφαλομυελίτιδα, γνωστή ως Σύνδρομο Χρόνιας Κόπωσης, σύμφωνα με τη σχετική δημοσίευση στο Frontiers in Immunology. Οι επιστήμονες από το Εθνικό Κέντρο Νευροανοσολογίας και Αναδυόμενων Παθήσεων (NCNED) του Πανεπιστημίου Griffith είναι οι πρώτοι στον κόσμο που αναπτύσσουν το σύστημα gold standard (η καλύτερη υπάρχουσα μέθοδος), ευρύτερα γνωστό...
Mon Nov 18, 2019 08:50
Μια πρόδρομη μορφή δενδριτικών κυττάρων φαίνεται πως αποτελεί έναν αποδοτικό και αποτελεσματικό τρόπο ενεργοποίησης του ανοσοποιητικού συστήματος έτσι ώστε να καταπολεμήσει τους καρκινικούς όγκους, σύμφωνα με μια μελέτη που πραγματοποιήθηκε σε ζωικά και κυτταρικά μοντέλα από ερευνητές του Αντικαρκινικού Ινστιτούτου του Πανεπιστημίου Duke. Όπως περιγράφεται στη σχετική δημοσίευση στο Journal of Clinical Investigation, τα ευρήματα παρέχουν μια εναλλακτική έναντι του εμβολίου των δενδριτικών κυττάρων,...
Mon Nov 18, 2019 08:15
Οι άνθρωποι που δεν μπορούν να διαβάσουν ή να γράψουν λόγω αναλφαβητισμού, αντιμετωπίζουν σχεδόν τριπλάσιο κίνδυνο να εμφανίσουν άνοια κάποια στιγμή στη ζωή τους, σύμφωνα με μια νέα αμερικανική επιστημονική έρευνα. Οι ερευνητές, με επικεφαλής την Δρ. Jennifer Manly του Ιατρικού Κολεγίου του Πανεπιστημίου Κολούμπια της Νέας Υόρκης, που έκαναν τη σχετική δημοσίευση στο Neurology της Αμερικανικής Ακαδημίας Νευρολογίας, μελέτησαν 983 ανθρώπους άνω των 65 ετών, από τους οποίους οι 237 ήταν αναλφάβητοι...
Mon Nov 18, 2019 08:02
Abstract In recent years, an understanding has developed that sports injuries are the emergent outcomes of complex, dynamic systems. Thus, the influence of local contextual factors on injury outcomes is increasingly being acknowledged. These realisations place injury prevention research at a crossroads. Currently, injury prevention researchers develop universally applicable injury prevention solutions, but the adoption of these solutions in practice is low. This occurs because...
Mon Nov 18, 2019 02:00
Background and Aims. Ubiquitin-specific protease 18 (USP18) is involved in immunoregulation and response to interferon- (IFN-) based treatment in patients chronically infected with hepatitis C virus (HCV). We investigated whether and how its upregulation alters HCV infection. Methods. Overexpression of wild-type (USP18 WT) or catalytically inactive mutant (USP18 C64S) USP18 was examined for effects on HCV replication in the absence and presence of IFNα or IFNλ using both the HCV-infective model and...
Mon Nov 18, 2019 17:05
Chronic wounds exhibit persistent inflammation with markedly delayed healing. The significant burden of chronic wounds, which are often resistant to standard therapy, prompts further research on novel therapies. Since the interleukin-17 family has been implicated as a group of proinflammatory cytokines in immune-mediated diseases in the gut and connective tissue, as well as inflammatory skin conditions, we consider here if it may contribute to the pathogenesis of chronic wounds. In this review, we...
Mon Nov 18, 2019 16:05
Dendritic cells (DCs) are the most efficient antigen-presenting cells and link the innate immune sensing of the environment to the initiation of adaptive immune responses, which may be directed to either acceptance or elimination of the recognized antigen. In cancer patients, though DCs would be expected to present tumor antigens to T lymphocytes and induce tumor-eliminating responses, this is frequently not the case. The complex tumor microenvironment subverts the immune response, blocks some effector...
Mon Nov 18, 2019 13:05
New Findings What is the central question of this study? Impaired autophagy has been reported to be involved in type 2 diabetes. However, role of autophagy in vascular dysfunction in type 2 diabetes remains unanswered. What is the main finding and its importance? The main findings of this study are autophagy is decreased in the mesenteric arteries of type 2 diabetic mice and stimulation of autophagy using rapamycin and trehalose improves vascular function, which is associated with normalization...
Sun Nov 17, 2019 15:13
Publication date: Available online 17 November 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Gilda Cennamo, Chiara Comune, Federica Mirra, Pasquale Napolitano, Daniela Montorio, Giuseppe de CrecchioABSTRACTBackgroundTo evaluate choriocapillary vascular density (CVD) in eyes with central serous chorioretinopathy (CSC) complicated by choroidal neovascularization (CNV), at baseline and after intravitreal injections (IVR) of Ranibizumab, using optical coherence tomography angiography...
Mon Nov 18, 2019 17:00
Publication date: Available online 18 November 2019Source: Magnetic Resonance ImagingAuthor(s): SK. HashemizadehKolowri, Rong-Rong Chen, Ganesh Adluru, Leslie Ying, Edward VR. DiBellaAbstractObjective: To develop a kernel optimization method called coil-combined split slice-GRAPPA (CC-SSG) to improve the accuracy of the reconstructed coil-combined images for simultaneous multi-slice (SMS) diffusion weighted imaging (DWI) data.Methods: The CC-SSG method optimizes the tuning parameters in the k-space...
Mon Nov 18, 2019 16:42
Publication date: Available online 18 November 2019Source: Magnetic Resonance ImagingAuthor(s): Amaresha Shridhar Konar, Nithin N. Vajuvalli, Rashmi Rao, Divya Jain, D.R. Ramesh Babu, Sairam GeethanathAbstractMagnetic Resonance Imaging (MRI) provides excellent soft tissue contrast with one significant limitation of slow data acquisition. Dynamic Contrast Enhanced MRI (DCE-MRI) is one of the widely employed techniques to estimate tumor tissue physiological parameters using contrast agents. DCE-MRI...
Mon Nov 18, 2019 16:42
Publication date: Available online 18 November 2019Source: American Journal of OtolaryngologyAuthor(s): Vivian Narana Ribeiro El Achkar, Andressa Duarte, Román Carlos, Jorge Esquiche León, Alfredo Ribeiro-Silva, Shirley Shizue Nagata Pignatari, Estela KaminagakuraAbstractObjectiveTo characterize inflammatory cells in Recurrent Respiratory Papillomatosis (RRP) and to correlate it with severity using the Derkay laryngoscopic scale.Materials and methodsThe data and biopsies from 36 patients with Juvenile...
Mon Nov 18, 2019 16:19
A 40-year-old gentleman presented with a history of multiple swellings involving his face, scalp, left axilla, back, and right thigh for the past 8 years. For the last 6 months, he developed intermittent low-grade fever, anorexia, weight loss, and gradually worsening breathlessness. On evaluation, the patient was found to have abnormally elevated absolute eosinophil count. Workup for the etiology of eosinophilia was unrewarding. All investigations related to an underlying myeloproliferative disorder...
Mon Nov 18, 2019 13:05
Abstract Alternating between different tasks represents an executive function essential to activities of daily living. In the oculomotor literature, reaction times (RT) for a ‘standard’ and stimulus-driven (SD) prosaccade (i.e., saccade to target at target onset) are increased when preceded by a ‘non-standard’ antisaccade (i.e., saccade mirror-symmetrical to target at target onset), whereas the converse switch does not elicit an RT cost. The prosaccade switch-cost has been attributed...
Mon Nov 18, 2019 02:00
Abstract Muscle synergy is important for simplifying functional movement, which constitutes spatiotemporal patterns of activity across muscles. To execute selective finger movements that are independent of synergistic movement patterns, we hypothesized that inhibitory neural activity is necessary to suppress enslaved finger movement caused by synergist muscles. To test this hypothesis, we focused on a pair of synergist muscles used in the hand opening movement, namely the index...
Mon Nov 18, 2019 02:00
33 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/11/18PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Nov 18, 2019 15:53
33 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/11/18PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Nov 18, 2019 13:52
Abstract Depressive disorders are complex, multifactorial disorders that have been traditionally attributed exclusively to neuronal abnormalities. However, recent studies have increased our understanding of the contribution of glial cells – and particularly of oligodendroglia – to the pathogenesis and treatment outcome of depression and stress‐related disorders. This review scrutinizes recent studies focusing on the neurosupportive functions exerted by myelin and oligodendrocyte lineage cells and...
Sun Nov 17, 2019 20:19
Publication date: Available online 18 November 2019Source: NeuroImageAuthor(s): Rongtao Jiang, Nianming Zuo, Judith M. Ford, Shile Qi, Dongmei Zhi, Chuanjun Zhuo, Yong Xu, Zening Fu, Juan Bustillo, Jessica A. Turner, Vince D. Calhoun, Jing SuiAbstractAlthough both resting and task-induced functional connectivity (FC) have been used to characterize the human brain and cognitive abilities, the potential of task-induced FCs in individualized prediction for out-of-scanner cognitive traits remains largely...
Mon Nov 18, 2019 15:42
Publication date: Available online 17 November 2019Source: NeuroImageAuthor(s): Frederik Van de Steen, Ruth M. Krebs, Nigel Colenbier, Hannes Almgren, Daniele MarinazzoAbstractPrevious studies have characterized the brain regions involved in encoding monetary reward and punishment outcomes. The question of how this information is integrated across brain regions has received less attention. Here, we investigated changes in effective connectivity related to the processing of positive and negative monetary...
Mon Nov 18, 2019 15:42
Condition: Hip OsteoarthritisInterventions: Procedure: Hip Arthroscopy; Procedure: Total Hip ArthroplastySponsor: Western University, CanadaNot yet recruiting
Mon Nov 18, 2019 15:24
Conditions: Head Neck Tumors; Neuroendocrine Tumors; Soft Tissue Sarcoma; Rare Cancer; VaccinationInterventions: Biological: Autologous DC vaccine; Drug: Interleukin-2Sponsor: Istituto Scientifico Romagnolo per lo Studio e la cura dei TumoriNot yet recruiting
Mon Nov 18, 2019 15:24
Condition: Fungal InfectionInterventions: Drug: APX001; Drug: Itraconazole; Drug: RifampinSponsor: Amplyx PharmaceuticalsRecruiting
Mon Nov 18, 2019 15:24
Condition: Oral CancerIntervention: Device: intraoral camerasSponsor: NYU Langone HealthNot yet recruiting
Mon Nov 18, 2019 15:24
Abstract Purpose To present the impact of treatment on health-related quality-of-life (HRQOL) and health utility measures from the randomized controlled trial (ClinicalTrials.gov Identifier: NCT02398721) that investigated the FNAC versus watchful surveillance in patients with incidental benign thyroid nodules. Methods Health utility and HRQOL were evaluated...
Mon Nov 18, 2019 02:00
Abstract Purpose To investigate the interobserver agreement (IA) and the impact of consensus reading using four risk stratification systems for thyroid nodules (TN). Methods Four experienced specialists independently rated US images of 80 TN according to the Kwak-TIRADS, EU-TIRADS, ACR TI-RADS, and ATA Guidelines. The cases were randomly extracted from a...
Mon Nov 18, 2019 02:00
Publication date: Available online 18 November 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Bella Shadur, Andrew Fong, Betina Altavilla, Rebecca Anne Saad, Brynn Kevin Wainstein
Mon Nov 18, 2019 15:13
Publication date: Available online 18 November 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Susan Waserman, Ernie Avilla, Laurie Harada, Joni Huang, Monika Kastner
Mon Nov 18, 2019 15:13
Abstract Seminal work by Oettgen et al.1 in the early 90's revealed the existence of alternative pathways of anaphylaxis (non IgE‐mediated) in IgE‐deficient mice. These are mediated by IgG‐immune complexes which, depending on their nature, signal on a number of myeloid cells including macrophages/monocytes, basophils, mast cells and neutrophils. While extensively characterized in mice, conclusive evidence of the existence of alternative pathways of anaphylaxis in humans have remained elusive.
Sun Nov 17, 2019 20:04
Related ArticlesA nodule in the palatal mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 May 30;: Authors: Pontes HAR, de Souza LL, Rodrigues-Fernandes CI, Fernandes LA, Santos VL, de Souza ABC, de Carvalho VL, Khan W, de Almeida OP, Fonseca FP, Pontes FSC PMID: 31734141 [PubMed - as supplied by publisher]
Mon Nov 18, 2019 15:12
Publication date: Available online 18 November 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Lucia Conti, Manuela Del Cornò, Sandra GessaniAbstractColorectal cancer (CRC) is a leading cause of cancer-related mortality in the world. Patterns and trends in CRC incidence and mortality correlate with increasing adoption of Western lifestyles and with the overweight/obesity epidemic. Both genetic background and a range of modifiable environmental/lifestyle factors play a role in CRC etiology....
Mon Nov 18, 2019 15:11
Abstract Introduction The nuclear pore complex is comprised of approximately 30 proteins named nucleoporins (Nups) and tightly regulates nucleocytoplasmic transport of macromolecules across the nuclear membrane. Genetic alterations in many NUP genes are associated with many human maladies, such as neurological disease, autoimmune disorders and cancer. Methods ...
Mon Nov 18, 2019 15:08
Abstract Background The combination of dexamethasone, high-dose cytarabine, and cisplatin (DHAP) is an established salvage regimen for lymphoma patients. We hypothesized that a modified administration schedule for cisplatin and cytarabine results in lower toxicity and improved efficacy. Methods We retrospectively analysed 119 patients with relapsed...
Mon Nov 18, 2019 15:08
Abstract Introduction Because spermatocytic tumors of the testis are rare, only limited evidence exists regarding the malignant potential and the optimal management of localized and metastatic disease. Materials and methods We performed a systematic review through MEDLINE, EMBASE, Scopus, Cochrane Database of Systematic Reviews and Web of Science...
Mon Nov 18, 2019 15:08
Abstract Objective To investigate the presence of vimentin expression in CTCs and its clinical relevance in patients with advanced lung cancer. Methods Peripheral blood was obtained from 61 treatment-naive patients with advanced lung cancer. Subtraction enrichment and immunostaining-fluorescence in situ hybridization (SE-iFISH) platform was...
Mon Nov 18, 2019 15:08
Abstract Background The American Society of Clinical Oncology and Friends of Cancer Research submitted recommendations to the FDA to reduce barriers in clinical trial participation. They proposed the removal of several specific exclusion criteria, including brain metastasis. Clinical trials involving small cell lung cancer (SCLC) have varying exclusion criteria regarding brain metastasis. ...
Mon Nov 18, 2019 15:08
Abstract Purpose Myelodysplastic syndromes (MDSs) refractory or relapsed after hypomethylating agents (HMAs) remain a therapeutic challenge. The CHG regimen has been demonstrated to be effective in initially treating higher risk MDS. The current study evaluated the efficacy and toxicity of the CHG regimen in patients who were resistant to decitabine. Methods ...
Mon Nov 18, 2019 15:08
Abstract Background The role of tumour-associated macrophages (TAMs) in predicting the prognosis of colorectal cancer (CRC) remains controversial. This is especially so because the prognostic significance and clinicopathological relevance of different subtypes of TAMs in the immune microenvironment of CRC have not yet been established. Objective ...
Mon Nov 18, 2019 15:08
Abstract Purpose Tumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation. Methods TNBC patients (n = 179) with complete clinical data and up to 18-year follow-up were obtained...
Mon Nov 18, 2019 15:08
Abstract Purpose To describe the clinical characteristics and outcomes of patients with dual-phenotype hepatocellular carcinoma (DPHCC) and investigate the use of radiomics to establish an image-based signature for preoperative differential diagnosis. Methods This study included 50 patients with a postoperative pathological diagnosis of DPHCC...
Mon Nov 18, 2019 15:08
Abstract Purpose Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide and new improvements are urgently needed. Several miRNA-targeted therapeutics have reached clinical development. MicroRNA-143 (miR-143) was found to significantly suppress the migration and invasion of NSCLC. It might be of great potential for NSCLC treatment. However, the therapeutic effect of miR-143 against NSCLC in...
Mon Nov 18, 2019 15:08
Related ArticlesAnatomy and white matter connections of the lateral occipital cortex. Surg Radiol Anat. 2019 Nov 16;: Authors: Palejwala AH, O'Connor KP, Pelargos P, Briggs RG, Milton CK, Conner AK, Milligan TM, O'Donoghue DL, Glenn CA, Sughrue ME Abstract PURPOSE: White matter tracts link different regions of the brain, and the known functions of those interconnected regions may offer clues about the roles that white matter tracts play in information...
Mon Nov 18, 2019 14:50
Abstract Introduction The tendon of the palmaris longus is commonly used as a tendon graft in many reconstructive surgeries. Easy to access and at proximity to the hand, the palmaris longus tendon is considered as the optimal tendon source for hand reconstructive surgery. However, and besides its inconsistency, the size of the palmaris longus tendon is reported to show variability. The aim of this study is to look for the surgical adequacy...
Mon Nov 18, 2019 02:00
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s):
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): Jérôme Doyen, Danny Jazmati, Dirk Geismar, Sabine Frisch, Stefanie Schulze Schleithoff, Xavier Vermeren, Monika Scheer, Christoph Blasé, Stephan Tippelt, Beate Timmermann
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): Melis Gultekin, Ferah Yildiz
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): Samantha M. Buszek, Simona F. Shaitelman
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): Lior Z. Braunstein
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): Youlia M. Kirova, Geoffroy Boulle, Brigitte De La Lande, Alain Fourquet
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): Divya Khosla, Rakesh Kapoor, Ritesh Kumar
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s):
Mon Nov 18, 2019 14:43
Don't Get Stuck on the Shoulder: Radiation Oncologists Should Get Into the CAR With T-Cell Therapies
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): John P. Plastaras, Elise A. Chong, Stephen J. Schuster
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): Jonathan P.S. Knisely
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): John P. Kirkpatrick, Peter E. FecciThis article is a Gray Zone opinion that will be published at a later dateThe full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): Matthew J. Shepard, Jason P. Sheehan
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): Richard Li, Nayana Vora
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): C. Norman Coleman, Mansoor M. Ahmed
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s): Ann Henry
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s):
Mon Nov 18, 2019 14:43
Publication date: 1 December 2019Source: International Journal of Radiation Oncology*Biology*Physics, Volume 105, Issue 5Author(s):
Mon Nov 18, 2019 14:43
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