Antibiotics, Vol. 8, Pages 210: Novel Small-molecule Antibacterials against Gram-positive Pathogens of Staphylococcus and Enterococcus Species Antibiotics doi: 10.3390/antibiotics8040210 Authors: Marius Seethaler Tobias Hertlein Björn Wecklein Alba Ymeraj Knut Ohlsen Michael Lalk Andreas Hilgeroth Defeat of the antibiotic resistance of pathogenic bacteria is one great challenge today and for the future. In the last century many classes of effective antibacterials have...
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Antibiotics, Vol. 8, Pages 209: Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients Antibiotics doi: 10.3390/antibiotics8040209 Authors: Rapone Converti Santacroce Cesarano Vecchiet Cacchio Scacco Grassi Grassi Gnoni Nardi Background: Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis...
Fri Nov 01, 2019 02:00
Atmosphere, Vol. 10, Pages 676: GNSS Ionosphere Sounding of Equatorial Plasma Bubbles Atmosphere doi: 10.3390/atmos10110676 Authors: Guanyi Ma Klemens Hocke Jinghua Li Qingtao Wan Weijun Lu Weizheng Fu Ground- and space-based Global Navigation Satellite System (GNSS) receivers can provide three-dimensional (3D) information about the occurrence of equatorial plasma bubbles (EPBs). For this study, we selected March 2014 data (during solar maximum of cycle 24) for the analysis....
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Atmosphere, Vol. 10, Pages 675: Climate Extremes over the Arabian Peninsula Using RegCM4 for Present Conditions Forced by Several CMIP5 Models Atmosphere doi: 10.3390/atmos10110675 Authors: Almazroui This paper investigates the temperature and precipitation extremes over the Arabian Peninsula using data from the regional climate model RegCM4 forced by three Coupled Model Intercomparison Project Phase 5 (CMIP5) models and ERA–Interim reanalysis data. Indices of extremes are...
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Atmosphere, Vol. 10, Pages 674: Electrochemical Evidence of non-Volatile Reduced Sulfur Species in Water-Soluble Fraction of Fine Marine Aerosols Atmosphere doi: 10.3390/atmos10110674 Authors: Ana Cvitešić Kušan Sanja Frka Irena Ciglenečki The traditional voltammetric method at the mercury electrode, and an acidification step developed for the determination of reduced sulfur species (RSS) in natural waters, was for the first time used for the quantification of RSS in the water-soluble...
Fri Nov 01, 2019 02:00
Atmosphere, Vol. 10, Pages 673: An Exceptional Case of Freezing Rain in Bucharest (Romania) Atmosphere doi: 10.3390/atmos10110673 Authors: Simona Andrei Bogdan Antonescu Mihai Boldeanu Luminiţa Mărmureanu Cristina Antonia Marin Jeni Vasilescu Dragoş Ene A high-impact freezing rain event affected parts of southeastern Romania on 24–26 January 2019. The freezing rain caused extensive damages in Bucharest, the capital city of Romania. The meteorological analysis...
Fri Nov 01, 2019 02:00
Atmosphere, Vol. 10, Pages 671: A Climatological Satellite Assessment of Absorbing Carbonaceous Aerosols on a Global Scale Atmosphere doi: 10.3390/atmos10110671 Authors: Hatzianastassiou Kalaitzi Gavrouzou Gkikas Korras-Carraca Mihalopoulos A global climatology of absorbing carbonaceous aerosols (ACA) for the period 2005–2015 is obtained by using satellite MODIS (Moderate Resolution Imaging Spectroradiometer)-Aqua and OMI (Ozone Monitoring Instrument)-Aura...
Fri Nov 01, 2019 02:00
Atmosphere, Vol. 10, Pages 672: Development and Evaluation of a Reynolds-Averaged Navier–Stokes Solver in WindNinja for Operational Wildland Fire Applications Atmosphere doi: 10.3390/atmos10110672 Authors: Wagenbrenner Forthofer Page Butler An open source computational fluid dynamics (CFD) solver has been incorporated into the WindNinja modeling framework. WindNinja is widely used by wildland fire managers, as well as researchers and practitioners in other fields, such as...
Fri Nov 01, 2019 02:00
Beverages, Vol. 5, Pages 63: Quality Green Tea (Camellia sinensis L.) Clones Marked through Novel Traits Beverages doi: 10.3390/beverages5040063 Authors: Pradeep Kumar Patel Dapeng Zhang Devajit Borthakur Monpi Hazarika Pulakesh Boruah Raj Barooah Santanu Sabhapondit Naba Jyoti Neog Romen Chandra Gogoi Tea clones and seed varieties released from Tocklai Tea Research Institutes are suitable primarily for manufacturing black tea (CTC/orthodox) while green tea manufactured...
Fri Nov 01, 2019 02:00
Bioengineering, Vol. 6, Pages 101: Determining Conditions for Successful Culture of Multi-Cellular 3D Tumour Spheroids to Investigate the Effect of Mesenchymal Stem Cells on Breast Cancer Cell Invasiveness Bioengineering doi: 10.3390/bioengineering6040101 Authors: Brown Bahsoun Morris Akam Mesenchymal stem cells have been widely implicated in tumour development and metastases. Moving from the use of two-dimensional (2D) models to three-dimensional (3D) to investigate this...
Fri Nov 01, 2019 02:00
Biomedicines, Vol. 7, Pages 86: Primary Membranous Glomerulonephritis: The Role of Serum and Urine Biomarkers in Patient Management Biomedicines doi: 10.3390/biomedicines7040086 Authors: Maifata Hod Zakaria Abd Ghani The detection of phospholipase A2 receptor (PLA2R) and thrombospondin domain containing 7A THSD7A among primary membranous glomerulonephritis (MGN) patients transformed the diagnosis, treatment monitoring, and prognosis. Anti-PLA2R can be detected in 70–90%...
Fri Nov 01, 2019 02:00
Biomimetics, Vol. 4, Pages 73: Findings of Case-Study Analysis: System-Level Biomimicry in Built-Environment Design Biomimetics doi: 10.3390/biomimetics4040073 Authors: Hayes Desha Gibbs Complex systems challenges like those facing 21st-century humanity, require system-level solutions that avoid siloed or unnecessarily narrow responses. System-level biomimicry aims to identify and adopt design approaches that have been developed and refined within ecosystems over 3.8 billion...
Fri Nov 01, 2019 02:00
Biomolecules, Vol. 9, Pages 685: An Insight into Storage Lipid Synthesis by Yarrowia lipolytica Yeast Relating to Lipid and Sugar Substrates Metabolism Biomolecules doi: 10.3390/biom9110685 Authors: Fabiszewska Misiukiewicz-Stępień Paplińska-Goryca Zieniuk Białecka-Florjańczyk Single cell oil (SCO) is the lipid accumulated in the cells of oleaginous microorganisms. Cellular lipids can be synthesized in two different pathways: de novo by metabolizing hydrophilic substrates...
Fri Nov 01, 2019 02:00
Biomolecules, Vol. 9, Pages 686: Synthesis of β-d-galactopyranoside-Presenting Glycoclusters, Investigation of Their Interactions with Pseudomonas aeruginosa Lectin A (PA-IL) and Evaluation of Their Anti-Adhesion Potential Biomolecules doi: 10.3390/biom9110686 Authors: Malinovská Thai Le Herczeg Vašková Houser Fujdiarová Komárek Hodek Borbás Wimmerová Csávás Pseudomonas aeruginosa is an opportunistic human pathogen associated with cystic fibrosis....
Fri Nov 01, 2019 02:00
Biomolecules, Vol. 9, Pages 684: Preparation of Chitosan/Poly(Vinyl Alcohol) Nanocomposite Films Incorporated with Oxidized Carbon Nano-Onions (Multi-Layer Fullerenes) for Tissue-Engineering Applications Biomolecules doi: 10.3390/biom9110684 Authors: Carlos David Grande Tovar Jorge Iván Castro Carlos Humberto Valencia Diana Paola Navia Porras José Herminsul Mina Hernandez Mayra Eliana Valencia José Daniel Velásquez Manuel N. Chaur Recently, tissue engineering became...
Fri Nov 01, 2019 02:00
Biomolecules, Vol. 9, Pages 679: Natural Products and Synthetic Analogs as a Source of Antitumor Drugs Biomolecules doi: 10.3390/biom9110679 Authors: Javad Sharifi-Rad Adem Ozleyen Tugba Boyunegmez Tumer Charles Oluwaseun Adetunji Nasreddine El Omari Abdelaali Balahbib Yasaman Taheri Abdelhakim Bouyahya Miquel Martorell Natália Martins William C. Cho Cancer is a heterogeneous disease and one of the major issues of health concern, especially for the public...
Fri Nov 01, 2019 02:00
Biomolecules, Vol. 9, Pages 683: Oleanolic Acid Exerts a Neuroprotective Effect Against Microglial Cell Activation by Modulating Cytokine Release and Antioxidant Defense Systems Biomolecules doi: 10.3390/biom9110683 Authors: José M. Castellano Silvia Garcia-Rodriguez Juan M. Espinosa María C. Millan-Linares Mirela Rada Javier S. Perona Microglia respond to adverse stimuli in order to restore brain homeostasis and, upon activation, they release a number of inflammatory...
Fri Nov 01, 2019 02:00
Biomolecules, Vol. 9, Pages 682: In Vivo Autophagy Up-Regulation of Small Intestine Enterocytes in Chinese Soft-Shelled Turtles during Hibernation Biomolecules doi: 10.3390/biom9110682 Authors: Waseem Ali Vistro Yue Zhang Xuebing Bai Ping Yang Yufei Huang Wenjia Qu Abdul Sattar Baloch Ruizhi Wu Imran Tarique Qiusheng Chen Many studies have focused on how autophagy plays an important role in intestinal homeostasis under pathological conditions. However, its...
Fri Nov 01, 2019 02:00
Biomolecules, Vol. 9, Pages 681: Antibody-Based Targeting of Cell Surface GRP94 Specifically Inhibits Cetuximab-Resistant Colorectal Cancer Growth Biomolecules doi: 10.3390/biom9110681 Authors: Mee Hyun Jeoung Taek-Keun Kim Ji Woong Kim Yea Bin Cho Hee Jun Na Byong Chul Yoo Hyunbo Shim Dong-Keun Song Kyun Heo Sukmook Lee Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Cetuximab, a human/mouse chimeric monoclonal antibody, is...
Fri Nov 01, 2019 02:00
Biomolecules, Vol. 9, Pages 680: Translation from the Ribosome to the Clinic: Implication in Neurological Disorders and New Perspectives from Recent Advances Biomolecules doi: 10.3390/biom9110680 Authors: Hui Chen Endo Tanaka De novo protein synthesis by the ribosome and its multitude of co-factors must occur in a tightly regulated manner to ensure that the correct proteins are produced accurately at the right time and, in some cases, also in the proper location. With novel...
Fri Nov 01, 2019 02:00
Biosensors, Vol. 9, Pages 130: Review of Electroanalytical-Based Approaches for the Determination of Benzodiazepines Biosensors doi: 10.3390/bios9040130 Authors: Honeychurch The benzodiazepine class of drugs are characterised by a readily electrochemically reducible azomethine group. A number are also substituted by other electrochemically active nitro, N-oxide, and carbonyl groups, making them readily accessible to electrochemical determination. Techniques such as polarography, voltammetry,...
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Brain Sciences, Vol. 9, Pages 305: Attention Modulates Electrophysiological Responses to Simultaneous Music and Language Syntax Processing Brain Sciences doi: 10.3390/brainsci9110305 Authors: Lee Jung Loui Music and language are hypothesized to engage the same neural resources, particularly at the level of syntax processing. Recent reports suggest that attention modulates the shared processing of music and language, but the time-course of the effects of attention on music and...
Fri Nov 01, 2019 02:00
Brain Sciences, Vol. 9, Pages 304: Electrical Stimulation in the Claustrum Area Induces a Deepening of Isoflurane Anesthesia in Rat Brain Sciences doi: 10.3390/brainsci9110304 Authors: Pavel Menardy Rotaru Paslaru Acatrinei Zagrean Popa Zagrean The role of the claustrum in consciousness and vigilance states was proposed more than two decades ago; however, its role in anesthesia is not yet understood, and this requires more investigation. The aim of our study...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1707: Development of a MEL Cell-Derived Allograft Mouse Model for Cancer Research Cancers doi: 10.3390/cancers11111707 Authors: Kim Choi Lee Kim Son Lim Kim Ryu Uversky Lee Kim Murine erythroleukemia (MEL) cells are often employed as a model to dissect mechanisms of erythropoiesis and erythroleukemia in vitro. Here, an allograft model using MEL cells resulting in splenomegaly was established to develop a diagnostic model...
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Cancers, Vol. 11, Pages 1708: Mutation Induction in Humans and Mice: Where Are We Now? Cancers doi: 10.3390/cancers11111708 Authors: Dubrova The analysis of mutation induction in human families exposed to mutagens provides the only source of reliable estimates of factors contributing to the genetic risk of human exposure to mutagens. In this paper, I briefly summarize the results of recent studies on the pattern of mutation induction in the human and mouse germline. The results of recent...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1706: Recreating Tumour Complexity in a Dish: Organoid Models to Study Liver Cancer Cells and their Extracellular Environment Cancers doi: 10.3390/cancers11111706 Authors: van Tienderen Groot Koerkamp IJzermans van der Laan Verstegen Primary liver cancer, consisting predominantly of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), remains one of the most lethal malignancies worldwide. This high malignancy is related to the complex...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1705: Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience Cancers doi: 10.3390/cancers11111705 Authors: Sati Akbaba Dina Ahmed Andreas Mock Thomas Held Suzan Bahadir Kristin Lang Mustafa Syed Juliane Hoerner-Rieber Tobias Forster Philippe Federspil Klaus Herfarth Peter Plinkert Juergen...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1704: Jak-Stat Signaling Induced by Interleukin-6 Family Cytokines in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11111704 Authors: Lokau Schoeder Haybaeck Garbers Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. It can be caused by chronic liver cell injury with resulting sustained inflammation, e.g., triggered by infections with hepatitis viruses B (HBV) and C (HCV). Death of hepatocytes leads to the...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1703: A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers11111703 Authors: Hui-Wen Chiu Ya-Ling Yeh Sheng-Yow Ho Yuan-Hua Wu Bour-Jr Wang Wei-Jan Huang Yuan-Soon Ho Ying-Jan Wang Li-Ching Chen Shih-Hsin Tu Radiation therapy (RT) is one of the main treatments for triple-negative breast cancer...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1699: Hyperprogressive Disease during Anti-PD-1 (PDCD1) / PD-L1 (CD274) Therapy: A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers11111699 Authors: Jong Yeob Kim Keum Hwa Lee Jeonghyun Kang Edith Borcoman Esma Saada-Bouzid Andreas Kronbichler Sung Hwi Hong Leandro Fórnias Machado de Rezende Shuji Ogino Nana Keum Mingyang Song Claudio Luchini Hans J. van der Vliet Jae Il Shin Gabriele Gamerith Hyperprogressive...
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Cancers, Vol. 11, Pages 1701: Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1 Cancers doi: 10.3390/cancers11111701 Authors: Nicholas P. D. Liau Artem Laktyushin Rhiannon Morris Jarrod J. Sandow Nicos A. Nicola Nadia J. Kershaw Jeffrey J. Babon Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cytokine exposure. Activating mutations of JAKs are causative for a number of leukemias,...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1700: Segmentation and Grade Prediction of Colon Cancer Digital Pathology Images Across Multiple Institutions Cancers doi: 10.3390/cancers11111700 Authors: Saima Rathore Muhammad Aksam Iftikhar Ahmad Chaddad Tamim Niazi Thomas Karasic Michel Bilello Distinguishing benign from malignant disease is a primary challenge for colon histopathologists. Current clinical methods rely on qualitative visual analysis of features such as glandular architecture...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1702: A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma Cancers doi: 10.3390/cancers11111702 Authors: White Jayasekara Picard Chen Watkins Cain Remke Gough Medulloblastoma is the most common malignant brain tumor in children and represents 20% of all pediatric central nervous system neoplasms. While advances in surgery, radiation and chemotherapy have improved overall survival, the lifelong sequelae of these treatments...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1698: Next-Generation Multimodality of Nanomedicine Therapy: Size and Structure Dependence of Folic Acid Conjugated Copolymers Actively Target Cancer Cells in Disabling Cell Division and Inducing Apoptosis Cancers doi: 10.3390/cancers11111698 Authors: Sambi DeCarlo Malardier-Jugroot Szewczuk Nanomedicine as a multimodality treatment of cancer utilizes the advantages of nanodelivery systems of drugs. They are superior to the clinical administration...
Fri Nov 01, 2019 02:00
Cells, Vol. 8, Pages 1378: Inhibition of GSK3β Reduces Ectopic Lipid Accumulation and Induces Autophagy by the AMPK Pathway in Goat Muscle Satellite Cells Cells doi: 10.3390/cells8111378 Authors: Wang Liu Zhan Guo Yang Zhong Li Zhang Wang Ectopic lipid accumulation in muscle is important not only for obesity and myopathy treatment, but also for meat quality improvement in farm animals. However, the molecular mechanisms involved in lipid metabolism in...
Fri Nov 01, 2019 02:00
Cells, Vol. 8, Pages 1377: Purine DNA Lesions at Different Oxygen Concentration in DNA Repair-Impaired Human Cells (EUE-siXPA) Cells doi: 10.3390/cells8111377 Authors: Krokidis Parlanti D’Errico Pascucci Pino Alimonti Pietraforte Masi Ferreri Chatgilialoglu Xeroderma Pigmentosum (XP) is a DNA repair disease characterized by nucleotide excision repair (NER) malfunction, leading to photosensitivity and increased incidence of skin malignancies. The role...
Fri Nov 01, 2019 02:00
Cells, Vol. 8, Pages 1376: TRPC6-Mediated ERK1/2 Activation Increases Dentate Granule Cell Resistance to Status Epilepticus Via Regulating Lon Protease-1 Expression and Mitochondrial Dynamics Cells doi: 10.3390/cells8111376 Authors: Kim Park Choi Kong Kang Transient receptor potential canonical channel-6 (TRPC6) is one of the Ca2+-permeable non-selective cation channels. TRPC6 is mainly expressed in dentate granule cell (DGC), which is one of the most resistant neuronal...
Fri Nov 01, 2019 02:00
Cells, Vol. 8, Pages 1374: Physical Activity Prevents Cartilage Degradation: A Metabolomics Study Pinpoints the Involvement of Vitamin B6 Cells doi: 10.3390/cells8111374 Authors: Deiana Malerba Dalle Carbonare Cheri Patuzzo Tsenov Moron Dalla Tor Mori Saviola Zipeto Schena Mottes Valenti Osteoarthritis (OA) is predominantly characterized by the progressive degradation of articular cartilage, the connective tissue produced by chondrocytes,...
Fri Nov 01, 2019 02:00
Cells, Vol. 8, Pages 1375: Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization Cells doi: 10.3390/cells8111375 Authors: Gajan Martin Kim Joshi Michelhaugh Sloma Mittal Firestine Shekhar Rad6B, a principal component of the translesion synthesis pathway, and activator of canonical Wnt signaling, plays an essential role in cutaneous melanoma development and progression. As Rad6...
Fri Nov 01, 2019 02:00
Cells, Vol. 8, Pages 1373: Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues Cells doi: 10.3390/cells8111373 Authors: Herring Elison Tessem The Nr4a family of nuclear hormone receptors is composed of three members—Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these transcription factors have been shown to regulate varied processes across a host of tissues. Of particular interest,...
Fri Nov 01, 2019 02:00
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