Bempedoic Acid For LDL-Lowering, Heart Transplant Center and Survival, Users' Guide to Reading Machine Learning Articles, House of God Sequel, and more ORIGINAL INVESTIGATION Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease: The CLEAR Wisdom Randomized Clinical Trial Anne C. Goldberg, MD; Lawrence A. Leiter, MD; Erik S. G. Stroes, MD, PhD; et al. Editorial: Bempedoic Acid for Lowering LDL Cholesterol; Michael C. Honigberg, MD, MPP; Pradeep Natarajan, MD, MMSc Association of Transplant Center With Survival Benefit Among Adults Undergoing Heart Transplant in the United States William F. Parker, MD, MS; Allen S. Anderson, MD; Robert D. Gibbons, PhD; et al. Earn CME credit Editorial: Optimizing the Use of Heart Transplant in the United States; Alexander T. Sandhu, MD, MS; Y. Joseph Woo, MD; Kiran K. Khush, MD, MAS PRELIMINARY COMMUNICATION Association of Cardiac Resynchronization Therapy With Change in Left Ventricular Ejection Fraction in Patients With Chemotherapy-Induced Cardiomyopathy Jagmeet P. Singh, MD, DPhil; Scott D. Solomon, MD; Michael G. Fradley, MD; et al. Editorial: Need for Multidisciplinary Research and Data-Driven Guidelines for the Cardiovascular Care of Patients With Cancer; Wouter C. Meijers, MD, PhD; Javid J. Moslehi, MD RESEARCH LETTER Immunization Status at the Time of Liver Transplant in Children and Adolescents Amy G. Feldman, MD, MSCS; Shikha S. Sundaram, MD, MSCI; Brenda L. Beaty, MSPH; et al. Prevalence of e-Cigarette Use Among Adults in the United States, 2014-2018 Hongying Dai, PhD; Adam M. Leventhal, PhD VIEWPOINT The Risk and Cost of Limited Clinician and Patient Accountability in Health Care S. Claiborne Johnston, MD, PhD Audio Interview: The Risk and Cost of Limited Clinician and Patient Accountability in Health Care Redefining Heart Failure With a Reduced Ejection Fraction Javed Butler, MD, MPH, MBA; Stefan D. Anker, MD; Milton Packer, MD Integrating Social Care Into the Delivery of Health Care Kirsten Bibbins-Domingo, PhD, MD, MAS Potential Liability for Physicians Using Artificial Intelligence W. Nicholson Price II, JD, PhD; Sara Gerke, Dipl-Jur Univ; I. Glenn Cohen, JD A PIECE OF MY MIND These Things Happen Ajay Soni, MD EDITORIAL Bempedoic Acid for Lowering LDL Cholesterol Michael C. Honigberg, MD, MPP; Pradeep Natarajan, MD, MMSc Optimizing the Use of Heart Transplant in the United States Alexander T. Sandhu, MD, MS; Y. Joseph Woo, MD; Kiran K. Khush, MD, MAS Need for Multidisciplinary Research and Data-Driven Guidelines for the Cardiovascular Care of Patients With Cancer Wouter C. Meijers, MD, PhD; Javid J. Moslehi, MD Evaluating Machine Learning Articles Finale Doshi-Velez, PhD; Roy H. Perlis, MD, MSc USERS' GUIDES TO THE MEDICAL LITERATURE How to Read Articles That Use Machine Learning: Users’ Guides to the Medical Literature Yun Liu, PhD; Po-Hsuan Cameron Chen, PhD; Jonathan Krause, PhD; et al. Earn CME credit Editorial: Evaluating Machine Learning Articles; Finale Doshi-Velez, PhD; Roy H. Perlis, MD, MSc Video: Understanding How Machine Learning Works JAMA CLINICAL GUIDELINES SYNOPSIS Primary Prevention of Cardiovascular Disease Atul Jain, MD, MS; Andrew M. Davis, MD, MPH FROM THE MEDICAL LETTER ON DRUGS AND THERAPEUTICS Drugs for Atrial Fibrillation Clinical Review Audio: Review of Atrial Fibrillation Treatment MEDICAL NEWS & PERSPECTIVES Older Patients (Still) Left Out of Cancer Clinical Trials Jennifer Abbasi How Certain Foods Affect Cognition, Seizures, and Cardiometabolic Disease: Food for Thought Rebecca Voelker, MSJ THE JAMA FORUM Heritable Genome Editing—Edited Eggs and Sperm to the Rescue? Eli Adashi, MD, MS; I. Glenn Cohen, JD NEWS FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION PFAS Water Contamination Examined Bridget Kuehn, MSJ Tuberculosis in Deer Hunters Bridget Kuehn, MSJ BIOTECH INNOVATIONS “Electronic Nose” Predicts Immunotherapy Response Jennifer Abbasi Supercooling Triples Liver Preservation Time Jennifer Abbasi Microneedle Sensor Monitors Antibiotics Jennifer Abbasi THE ARTS AND MEDICINE Man’s 4th Best Hospital, Sequel to The House of God Samuel Shem POETRY AND MEDICINE The Dying Psychiatrist Jack Coulehan, MD JAMA REVISITED Physicians and Statistics JAMA PATIENT PAGE Testing for Nonalcoholic Fatty Liver Disease Yen-Yi Juo, MD, MPH; Edward H. Livingston, MD AUDIO Audio Summary Bempedoic Acid For LDL-Lowering, Heart Transplant Center and Survival, Users' Guide to Reading Machine Learning Articles, House of God Sequel, and more Audio Interview The Risk and Cost of Limited Clinician and Patient Accountability in Health Care Clinical Review Audio Review of Atrial Fibrillation Treatment COMMENT & RESPONSE Historical Practice of Separating Twins at Birth Adam M. Kelmenson, MS; Ilene Wilets, PhD Historical Practice of Separating Twins at Birth—Reply Leon Hoffman, MD; Lois Oppenheim, PhD Intraoperative Ventilation Strategies to Reduce Pulmonary Complications in Obese Patients Carlos Ferrando, MD, PhD; Gerardo Tusman, MD; Fernando Suarez-Sipmann, MD, PhD Intraoperative Ventilation Strategies to Reduce Pulmonary Complications in Obese Patients—Reply Marcelo Gama de Abreu, MD, MSc, PhD, DESA; Marcus Schultz, MD, PhD; Paolo Pelosi, MD, FERS; et al. CORRECTION Incorrect and Omitted Names for Collaborators Clarification of Reporting of Conflicts of Interest Incorrect Word Affecting Meaning of Sentence JAMA MASTHEAD JAMA

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