Abstract Perforating pilomatricoma (PP) is a rare clinical variant of pilomatricoma presenting as a crusted or ulcerated nodule. Previous reports have suggested that the tumor cells perforate the epidermis through a process of transepithelial elimination. Here, we report six cases of PP and examine the mechanism of transepithelial elimination in PP. Histologically, the dermis above or around the tumor nest exhibited edema, dilated vascular spaces, sparse collagen bundles and absence of elastic fibers,...
Fri Nov 01, 2019 19:13
Abstract To the best of our knowledge, 11 reports have described the efficacy of the bivalent human papillomavirus vaccine (BHPV) and quadrivalent human papillomavirus vaccine (QHPV) in the treatment of cutaneous warts1–3. Nine reports described the complete regression of cutaneous warts in all patients treated with BHPV or QHPV (total of 16 cases). On the other hand, Abeck and Fölster‐Holst2 reported that 10 of 16 patients were cured, with younger patients having better cure rates.
Fri Nov 01, 2019 20:53
Clinical significance of BRAF/NRAS concurrent mutations in a clinic‐based metastatic melanoma cohort
Abstract Innovative therapeutic strategies in metastatic melanoma depend on molecular features and the combination of BRAF and MEK inhibitors (BRAFi+MEKi) which has recently shown an improved clinical efficacy in BRAF V600MUT metastatic melanoma patients, is now the standard of care. BRAF and NRAS activating mutations lead to the MAPK pathway deregulation1 and may coexist despite their earlier description as mutually exclusive2. This event is probably related to the existence of several mutually‐exclusive...
Fri Nov 01, 2019 20:49
Abstract Dystrophic epidermolysis bullosa (DEB) is a skin blistering disease caused by mutations in the COL7A1 gene encoding the anchoring fibril‐constituent collagen VII.1 Secondary to skin fragility, DEB manifests as chronic wounds and progressive soft tissue fibrosis. As a consequence of a chronically injured and stiffened dermal microenvironment people with severe DEB are prone to develop early‐onset metastatic cutaneous squamous cell carcinomas (cSCCs).1,2 Dermal fibrosis in DEB is paradigmatic...
Fri Nov 01, 2019 20:43
Abstract Background Selecting a topical treatment from among the numerous topical agents for external genital warts remains challenging without clear evidence. Objectives To comparatively evaluate the efficacy and safety of topical agents for external genital warts via a network meta‐analysis Methods We included all randomised, controlled trials that evaluated any topically applied treatment for external genital warts. Using the R package netmeta, network meta‐analyses were performed...
Fri Nov 01, 2019 20:11
Abstract Background A Venous Leg Ulcer (VLU) has a significant negative impact on quality of life. Prevention for a VLU is not yet imbedded in clinical practice because risk factors for developing a first VLU are not well‐known. Objectives The objective was to further explore the progression of Chronic Venous Disease (CVD) into a first VLU from a patients' perspective. Methods A qualitative study using semi‐structured interviews was conducted amongst male and female patients with...
Fri Nov 01, 2019 19:39
Abstract Patients with atopic dermatitis (AD) have an increased risk of bacterial skin infections that cause significant morbidity and, if untreated, may become systemic. Staphylococcus aureus (S. aureus) colonizes the skin of most AD subjects and is the most common organism to cause infections. Overt bacterial infection is easily recognised by the appearance of weeping lesions, honey‐coloured crusts, and pustules. However, the wide variability in clinical presentation of bacterial infection in...
Fri Nov 01, 2019 19:35
Fri Nov 01, 2019 13:31
Summary This study which was carried out in four university hospitals in France was designed to assess the usefulness of the technique, trichoscopy, in the diagnosis of tinea capitis, also known as scalp ringworm. Tinea capitis is an infection of the scalp hair and the surrounding skin with a fungus. Fungi are microscopic organisms that can live on the hair, nails, and outer skin layer. It is common in children and the main treatment is a course of antifungal drugs taken by mouth. Currently tinea...
Fri Nov 01, 2019 13:31
Summary Recessive dystrophic epidermolysis bullosa (RDEB) is a rare and highly disabling genetic disease. RDEB hallmarks are skin fragility, constant blistering, and defective wound healing leading to inflammation and fibrosis, which means tissue hardening. Fibrosis underlies major RDEB complications, including limb deformities and cancer, and preventing it is a strategy to improve the disease course. Despite the identification of several molecules that are deregulated in RDEB fibrosis, the disease...
Fri Nov 01, 2019 13:31
Summary 黑色素瘤是皮肤癌的最危险形式:全世界约 15% 的病例致死,但通过早期发现,其生存率可优于 95%。多痣或红色毛发会增加患黑色素瘤的风险;拥有某些特定类型的MC1R基因(称为R等位基因)是红色毛发的主要原因,也使黑色素瘤风险增加。这项来自澳大利亚的研究旨在发现这两个危险因素共同增加的黑色素瘤风险是否比简单地将这两个风险水平相加得到的风险更大。611 名黑色素瘤患者和 656 名未患黑色素瘤的患者捐赠 DNA 样本,研究人员记录他们在 21 岁时大痣的数目、皮肤和眼睛颜色以及毛发颜色。作者发现,红色毛发和超过 20 颗大痣的人患黑色素瘤的可能性是0‐4颗痣和黑褐色毛发的人的 10 倍。特别是从人们携带的 MC1R 基因的类型来看,有超过 20 颗痣和 MC1R R/R 基因型的人患黑色素瘤的可能性是 0‐4 颗痣和有 MC1R 野生型/野生型(一致)基因型的人的 25 倍。R/R 基因型(有或没有红色毛发表型)和高痣数本身都是很强的黑色素瘤危险因素,但将它们组合在一起会导致黑色素瘤的极高风险。在澳大利亚,年龄 75 岁以下的男性发生黑色素瘤的终生绝对风险是,有超过 20...
Fri Nov 01, 2019 13:31
Summary Vitamin D is essential for bone health and is produced by the skin in response to ultraviolet radiation (UVR) from sunlight. UVR is also the main cause of skin cancer, the UK's most common type of cancer. Therefore, there have been several concerns that sun protection methods such as using sunscreen can affect vitamin D production. Researchers from the QIMR Berghofer Medical Research Institute in Australia, and the Australian National University, systematically reviewed for the first time...
Fri Nov 01, 2019 13:31
Summary This study from the USA, Denmark and Germany looked at how often plaque psoriasis and palmoplantar pustulosis (PPP) occur together. Plaque psoriasis is the commonest form of psoriasis. PPP is a condition where pus‐filled spots are seen on the palms and soles, often on skin that is red and scaly like psoriasis. It is not known how PPP is related to psoriasis, if at all. From insurance records in the USA and Germany, and from the Danish National Patient Register, the researchers found approximately...
Fri Nov 01, 2019 13:31
Summary Melanoma is the most dangerous form of skin cancer: around 15% of cases worldwide are fatal, but with early detection, survival rates are better than 95%. Having many large moles or having red hair increases a person's risk of developing melanoma; having certain versions of the MC1R gene, called R alleles, the main cause of red hair, also increases melanoma risk. This study, from Australia, aimed to find out if having both those risk factors increased melanoma risk more than the two risk...
Fri Nov 01, 2019 13:31
Summary 隐性营养不良性大疱性表皮松解症(RDEB)是一种罕见且致残性极高的遗传疾病。RDEB 的标志是皮肤脆弱、持续起疱以及伤口愈合不良,从而导致炎症和纤维化,这意味着组织变硬。纤维化是 RDEB 的主要并发症(包括肢体畸形和癌症)的潜在机制,而预防它是改善疾病进程的策略。尽管已鉴定出在 RDEB 纤维化过程中失控的几种分子,但其发病机理尚未完全明确。我们的遗传密码包含产生 RNA 分子(称为信使 RNA)的信息,这些 RNA 分子可用于构建形成人体的蛋白质。但是,一大类 RNA 分子(称为 microRNA)不会转化为蛋白质,而是调节所产生的蛋白质数量。microRNA 的功能改变导致许多疾病的发展。本研究在意大利 Bambino Gesù 儿童医院进行,旨在识别和鉴定 RDEB 患者中改变并导致其皮肤纤维化的 microRNA 的作用。这项实验室研究使用了一种细胞类型,即成纤维细胞,该细胞遍布皮肤,并且是纤维化的主要参与者。作者观察到,与健康个体的细胞相比,从 RDEB 患者获得的成纤维细胞中某些 microRNA 含量更高,并证明其中之一,miR‐145‐5p 促进了纤维化。研究人员关闭了...
Fri Nov 01, 2019 13:31
Summary Vitamin D is produced by the skin in response to ultraviolet radiation (UVR) from sunlight. A lack of vitamin D, known as vitamin D deficiency, can cause bones to become soft and weak, which can lead to bone deformities. Whilst UVR exposure is a main source of vitamin D, it is also a primary cause of skin cancer, leading to debates on how to get the balance between ideal (sufficient) vitamin D levels and sun protection. This review aimed to offer practical recommendations on the impact...
Fri Nov 01, 2019 13:31
Summary Chronic itch (pruritus) can severely affect quality of life; it can be associated with several different skin diseases or systemic disease (affecting the whole body rather than just the skin). Current treatments are not always successful, and a fuller understanding of the mechanisms of itch should lead to better treatment. Substance P, which is secreted by nerve fibres, plays an important role in itch; this binds to a receptor, neurokinin 1, on several cell types in the central and peripheral...
Fri Nov 01, 2019 13:31
Summary Patients and their family members can find it helpful to share their stories with fellow sufferers. Online groups are particularly useful for those who are shy or self‐conscious about how they look. Alopecia UK is a support group for people experiencing hair loss. Their website links to a monitored Facebook group restricted to members. There is not much research into the benefits of online support for skin conditions, so these psychologists from Sheffield in the UK interviewed 12 people...
Fri Nov 01, 2019 13:31
Summary Psoriasis is an incurable skin condition that affects between two and four in every 100 people in the Western world. It causes uncomfortable, red scaly patches on the skin, and is also linked with joint disease, high body weight (‘obesity’), heart attacks and low mood. Previous studies have shown that being obese can worsen psoriasis and it is thought that losing weight may improve it. Inspired by the difficulties faced by a patient with severe psoriasis and obesity, the authors of this...
Fri Nov 01, 2019 13:31
Summary 患者及其家人会发现,与其他患者分享他们的故事会很有帮助。在线群组对于那些对自己的模样害羞或不自然的人特别有用。Alopecia UK 是一个为脱发患者提供支持的群组。他们的网站链接到仅限成员进入的受监控的 Facebook 群组。 关于皮肤病在线支持的获益的研究还很少,因此,这些来自英国谢菲尔德的心理学家采访了 12 位受 Alopecia UK Facebook 群组帮助的患者。 这类研究的常用方法是“内容分析”,即对患者访谈进行分析以识别主题。 这些研究人员使用了“解释性现象学分析”。首先,他们要求参与者提供他们认为特别有用的帖子的屏幕截图。然后,他们询问有关患者对网站和屏幕截图的体验的一系列问题。最终,他们分析了访谈内容以寻找个人和群组表达的主题。 参与者(均为女性)描述了在线论坛如何使其摆脱痛苦感和缺乏吸引力的感受,分享如何处理外表的实用技巧,减少孤独感和增加正常感受,并使其更能接受自己的外表和对社交更有信心。一些人报告了无帮助的评论和不准确的建议。 该研究表明,在线同伴支持可以通过将患者与一个安全私密的社区联系起来,从而鼓励他们适应慢性(长期)疾病。这样的平台可以与其他疗法结合使用。
Fri Nov 01, 2019 13:31
Summary Skin cancer commonly affects people who have received a solid organ transplant (heart, lung, liver and kidney). Transplant patients can get multiple skin cancers, some of which can grow very quickly. The commonest types of skin cancer are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Immunosuppressant medication is used to prevent rejection of the transplanted organ. This alters the body's immune system, which in turn means that transplant patients are more prone to skin...
Fri Nov 01, 2019 13:31
Summary Eczema (also known as atopic dermatitis or AD) is a complex skin condition that generally develops in early childhood, affecting 15 to 20% of children worldwide. Although it clears by itself in some children, it persists into adulthood in many children, contrary to popular belief. Many children develop related allergic diseases such as asthma, allergic rhinitis and eosinophilic oesophagitis (allergic inflammation of the oesophagus), a pathway known as the “atopic march”. The authors, based...
Fri Nov 01, 2019 13:31
Summary Vitamin D, vital for bone health, is produced by the skin in response to ultraviolet radiation (UVR) from sunlight. However, as well as being the main source of vitamin D, UVR is a major cause of skin cancer. This has led to questions about how to prevent low levels of vitamin D whilst limiting the risk of skin cancer. This study, led by researchers from King's College London, found that use of sunscreen did not prevent most people from getting enough vitamin D whilst on a week‐long holiday...
Fri Nov 01, 2019 13:31
Summary 湿疹(也称为特应性皮炎或 AD)是一种复杂的皮肤病,通常在儿童早期发病,全世界 15% 至 20% 的儿童患此病。尽管它在某些儿童中会自行消退,但在许多儿童中,它会持续到成年期,这与普遍的看法相反。许多儿童患相关的过敏性疾病,例如哮喘、过敏性鼻炎和嗜酸性食管炎(食管的过敏性炎症),这是一种称为“特应性进程”的患病途径。爱尔兰和美国的作者旨在通过对大型患者队列(研究组)中开展的几项近期研究进行调查,从而找到可再现的模式(即临床相关特征),以帮助医生预测儿童期 AD 是否会消退或是进展。这些研究表明,实际上大多数特应性疾病的儿童患者并不遵循经典的“特应性进程”模式,而是遵循各种疾病过程。尽管数据来自不同来源或以不同的方式描述,但作者确定了儿童早期 AD 的共同特征,可以帮助估计持续性疾病(即进展至成年期)和相关过敏性疾病的风险。他们发现,在幼年时患重度 AD 的儿童以及父母有相关病史的儿童中,疾病进展的风险更高。遗传因素、过敏和居住在城市环境中也增加这种风险。作者提供了执业医师指南,可以帮助医生确定疾病进展风险较高的 AD 儿童患者,并确定最佳治疗方法,例如定期检查或将其转诊给专科医师进行进一步检查或治疗。
Fri Nov 01, 2019 13:31
Summary 银屑病是一种无法治愈的皮肤病,在西方世界每 100 人中有 2 到 4 人患此病。它会在皮肤上造成令人不舒服的红色鳞屑状斑块,并且还与关节疾病、高体重(“肥胖”)、心脏病发作和情绪低落有关。既往研究表明,肥胖会使银屑病恶化,据认为减轻体重可以改善银屑病。受到重度银屑病和肥胖患者所面临的困难的启发,这项基于英国的研究的作者旨在确定减轻体重对银屑病的影响以及减轻体重是否可以预防银屑病的发展。作者系统性检索了科学文献数据库,并确定了 14 项相关研究,其中探讨了三种主要的减肥方法:生活方式改变(饮食和运动)、减肥药物和减肥手术(例如胃旁路术)。这些研究表明,生活方式改变后的体重减轻可以使肥胖患者中的银屑病持续改善。研究人员发现,探讨减肥药物和减肥手术对银屑病患者的作用的研究很少,并且这些研究没有明确或一致的结果。两项研究表明,减肥手术可以预防银屑病发作。作者向他们的患者解释了这些信息,这些患者被鼓励接受针对银屑病的其他治疗的同时减肥。他们还在银屑病诊所内建立了一套护理流程,以帮助所有患银屑病和肥胖症的患者减轻体重。
Fri Nov 01, 2019 13:31
Summary 慢性瘙痒症(瘙痒)会严重影响生活质量;它可能与几种不同的皮肤病或全身性疾病(不仅影响皮肤,而且影响整个身体)有关。当前治疗方法并不总是能取得成功,对瘙痒机理的更全面理解应该可以得出更好的治疗方法。 神经纤维分泌的 P 物质在瘙痒中起重要作用。它与中枢神经系统和周围神经系统的几种细胞类型的受体神经激肽 1 结合。 来自德国的作者回顾了有关这些物质在慢性瘙痒中作用的已知信息。 他们发现,P 物质和神经激肽 1 受体在与瘙痒相关的几种疾病中过表达(产生过多)。 他们还回顾了拮抗神经激肽 1 受体结合的药物的临床研究。这些药物包括阿瑞匹坦,这是一种口服药物(经口服用),已用于治疗化疗引起的恶心和呕吐。 但是,专门为减轻瘙痒而开发的 serlopitant 和 tradipant 在某些疾病,如结节性瘙痒和特应性湿疹的安慰剂对照试验(意味着某些人服用药物,而另一些人服用一种模拟药或安慰剂,并比较其结果)中显示出更大的前景。 作者指出,需要进一步试验来评估这些药物在慢性瘙痒中的安全性和有效性。
Fri Nov 01, 2019 13:31
Summary 接受实体器官移植的人(心脏、肺、肝脏和肾脏)通常会患上皮肤癌。移植患者可能会患上多种皮肤癌,其中一些可能会迅速发展。皮肤癌中最常见的类型是基底细胞癌(BCC)和鳞状细胞癌(SCC)。免疫抑制药物用于防止移植器官排斥。这改变了人体免疫系统,反过来又意味着移植患者更容易患上可迅速生长的皮肤癌。在过去20年中,已经引入了新的免疫抑制剂,它们被认为可以降低皮肤癌的风险。既往研究表明,使用新药可降低 SCC 风险,但迄今为止,尚无研究关注 BCC 的发病率。这项来自爱尔兰的研究旨在发现在过去 20 年中(期间有较新的免疫抑制药物上市),移植患者皮肤癌的发病率是否有所降低。爱尔兰国家癌症登记处登记爱尔兰共和国的所有皮肤癌。作者研究了接受实体器官移植的患者中皮肤癌的发病率,并将其与普通人群中皮肤癌的发病率进行了比较。他们发现,在过去二十年中,接受器官移植的患者中 SCC 和 BCC 的发病率已显著降低。皮肤癌风险的这种变化与免疫抑制剂的变化以及针对移植受者的重点教育和常规皮肤癌筛查相吻合。
Fri Nov 01, 2019 13:31
Summary 维生素 D 对骨骼健康至关重要,它是皮肤受阳光中紫外线(UVR)的照射后产生的。但是,UVR 不仅是维生素 D 的主要来源,也是皮肤癌的主要原因。这引发了有关如何预防维生素 D 含量过低,同时又限制皮肤癌风险的疑问。 这项由伦敦国王学院的研究人员主导的研究发现,防晒霜并不会影响大多数人在紫外线指数很高地区的为期一周度假中摄入足够的维生素 D。 在度假期间,有 20 人使用广谱防晒霜,其防晒系数(SPF)为 15,可提供 UVB 防护和高 UVA 防护效果。另 20 人使用非广谱防晒霜,SPF 15,但 UVA 防护效果较低。告诉这两组人如何正确使用防晒霜以达到标签所示的 SPF。 相反,22 人使用了自己的防晒霜,无使用说明,17 人组成对照组,他们留在波兰。在度假前 24 小时和度假后 24 至 48 小时,从参与者中采集血液样本,以检查维生素 D 水平。 前两组的维生素 D 水平显著改善。使用自己的防晒霜的组中,也有大量维生素 D 合成,但所有人都出现晒伤。同一时期,对照组的维生素 D 略有下降。
Fri Nov 01, 2019 13:31
Fri Nov 01, 2019 13:31
Summary 维生素 D 对骨骼健康至关重要,它是皮肤受阳光中紫外线(UVR)的照射后产生的。UVR 也是皮肤癌(英国最常见的癌症类型)的主要原因。因此,人们一直担心防晒方法(例如使用防晒霜)会影响维生素 D 的产生。 来自澳大利亚的 QIMR Berghofer 医学研究所和澳大利亚国立大学的研究人员首次系统性回顾了 1970 年至 2017 年期间发表的所有实验性研究、现场试验和观察性研究,共计 75 项研究,以了解防晒霜使用对维生素 D 水平的影响。 研究人员发现,尽管实验研究(在实验室环境中使用人造光源)支持使用防晒霜可能影响维生素D的理论风险,但现场试验和观察性研究的大量证据(发生在涉及自然阳光的现实生活场景中)表明其风险较低。 研究人员解释,实验研究中的条件并不能反映现实世界条件,因此该结果不能用于向公众提供实用建议。 该综述的作者得出结论,几乎没有证据表明使用防晒霜在现实生活中会降低维生素 D 水平,在某些情况下,使用防晒霜和维生素 D 水平升高相关。因此,对维生素 D 水平的顾虑不应干扰皮肤癌的预防建议。未来的预防路径应考虑目前已广泛推荐的高防晒系数的防晒霜。
Fri Nov 01, 2019 13:31
Summary 美国、丹麦和德国开展的这项研究探讨了斑片状银屑病和掌跖脓疱病(PPP)共同发生的频率。斑片状银屑病是银屑病的最常见形式。PPP 是一种手掌和脚底上可看到充满脓液的斑点的疾病,通常在发红和鳞屑状皮肤上可见,如银屑病。PPP 与银屑病之间的关系(如果有)尚不明确。 从美国和德国保险记录以及丹麦国家患者登记处中,研究人员发现大约4000名被诊断患 PPP 的患者。 如本研究的评论所述,他们中的许多结果因不同国家而异。 例如,PPP 患病率从丹麦的 0.005% 到德国的 0.08% 不等。 PPP 患者中斑片状银屑病的患病率范围从丹麦患者的 14.2% 到德国的 36.4% 和美国的 61.3% 不等。 治疗方面,PPP 和斑片状银屑病患者更有可能被推荐使用强效类固醇药膏、软膏或凝胶,尤其是在美国和丹麦。在美国和丹麦,更多的同时患有这两种疾病的患者接受阿维 A 酸、甲氨蝶呤和生物制剂治疗,接受生物制剂治疗的比例差异很大:美国患者为 18.4%,而丹麦为 8.5%,德国为 2.5%。 与仅患 PPP 的患者相比,同时患 PPP 和斑片状银屑病的患者更有可能患与银屑病相关的关节疾病,这在所有三个国家中大致相同。
Fri Nov 01, 2019 13:31
Summary 维生素 D 是皮肤受阳光中紫外线(UVR)的照射后产生的。缺乏维生素 D (称为维生素 D 缺乏症)会导致骨骼变软变弱,从而导致骨骼畸形。尽管紫外线辐射是维生素 D 的主要来源,但它也是皮肤癌的主要原因,这引发了关于如何在理想(足够)的维生素 D 水平和防晒之间取得平衡的争论。 这篇综述旨在就防晒霜对维生素 D 状态的影响提供实用建议。由内分泌学、皮肤病学、光生物学、流行病学和生物人类学领域的 13 名专家组成的国际专家组在 2017 年 6 月的一天会议前回顾了有关维生素 D 水平和防晒霜使用的文献。他们检验了评估和确定维生素 D 充足性的最新方法、当前的公共卫生建议、日晒对维生素 D 的影响以及防晒霜使用的影响。 对理想的维生素 D 水平,尚无国际共识,建议之间也相差很大。在本次回顾中, ≥50 nmol/L 25(OH)D 的血液水平是最广泛认可的目标水平。结论是,每天使用广谱防晒霜(同时提供 UVA 和 UVB 防护效果)不会影响健康人的维生素 D 产生。但是,光敏性疾病患者是例外,因此,他们可以从维生素 D 筛查和补充中受益。
Fri Nov 01, 2019 13:31
Summary 这项研究是在法国的四所大学医院进行,旨在评估该技术(毛发镜检)在诊断头癣,也称为头皮癣方面的有用性。 头癣是真菌感染头皮毛发和周围皮肤的一种疾病。真菌是可以生活在头发、指甲和皮肤表层的显微镜下微生物。它在儿童中常见,主要治疗方法是口服抗真菌药。 目前,头癣可通过头发培养(采集样本并在实验室中生长真菌)或遗传分析诊断。 毛发镜检是使用称为皮肤镜的手持式放大镜进行显微镜检查的一种形式,使用放大镜可以让受过培训的人员看到头发生长和形状的细微差别。 本研究是由皮肤病学实习生与一位专家评估人员一起进行的,他们还对患者进行了检查。结果发现,毛发镜检显示受感染头发中有许多可见的变化,且各自可根据特定的可识别特征来命名,例如,开瓶器头发或莫尔斯电码头发。发现这些变化中仅有一种是感染的准确预测指标,后续得到实验室证实。 这些结果表明,这种简单的观察技术可用于准确诊断头癣。此外,一些可见的变化是特定真菌所特有的。这有助于皮肤科医生选择正确的抗真菌药物治疗方法,这些治疗方法对于不同微生物而言各不相同。
Fri Nov 01, 2019 13:31
Fri Nov 01, 2019 13:31
Abstract Linear IgA bullous dermatosis (LABD) is an autoimmune blistering skin disorder associated with IgA‐class autoantibodies directing autoantigens in the basement membrane zone (BMZ). LABD autoantibodies mainly target either the 120‐kDa (LAD1) and 97‐kDa (LABD97) processed extracellular polypeptides of BP180 (also known as collagen XVII) or collagen VII, and these LABD types are respectively known as lamina‐densa type‐ and sublamina‐densa type‐LABD.1,2 In LABD, the linear deposition of IgG‐class...
Fri Nov 01, 2019 10:13
Abstract Background Both atopic dermatitis and celiac disease are often accompanied by other immune-mediated disorders. Objective The objective of this study was to evaluate the potential association between atopic dermatitis and celiac disease in a broad community-based population. Methods ...
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Amrita Sil, Jayadev Betkerur, Nilay Kanti DasIndian Dermatology Online Journal 2019 10(6):745-750 Biomedical research relies on proving (or disproving) a research hypothesis, and P value becomes a cornerstone of “null hypothesis significance testing.” P value is the maximum probability of getting the observed outcome by chance. For a statistical test to achieve significance, the error by chance must be less than 5%. The pros are the P value that gives the strength of evidence against the null...
Fri Nov 01, 2019 00:00
Pooja Goswami, BC Ghiya, Vineet Kumar, S Rekha, RD MehtaIndian Dermatology Online Journal 2019 10(6):627-631 Introduction: Cutaneous leishmaniasis is a vector borne disease caused by Leishmania major and Leishmania tropica. Bikaner is an endemic pocket for cutaneous leishmaniasis caused by Leishmania tropica. Materials and Methods: A prospective study was done to evaluate the efficacy of different concentrations of intralesional amphotericin B as a treatment modality for cutaneous leishmaniasis...
Fri Nov 01, 2019 00:00
Taru Garg, Anuja Yadav, Ram Chander, Anita NangiaIndian Dermatology Online Journal 2019 10(6):727-729
Fri Nov 01, 2019 00:00
Shailja Chauhan, Vikram K Mahajan, Karaninder S Mehta, Rajinder S Yadav, Pushpinder S Chauhan, Satya Bhushan, Vikas Sharma, Anuj Sharma, Dhaarna Wadhwa, Aditi SharmaIndian Dermatology Online Journal 2019 10(6):632-638 Background: Activated coagulation cascade is implicated in urticaria pathogenesis marked by high plasma D-dimer, a marker of fibrinolysis, levels correlating with high urticaria activity score (UAS) and poor therapeutic outcome. Methods: Quantitative plasma D-dimer levels and coagulation...
Fri Nov 01, 2019 00:00
Anuja Yadav, Pravesh Yadav, Ram ChanderIndian Dermatology Online Journal 2019 10(6):717-718
Fri Nov 01, 2019 00:00
Ömer Faruk Elmas, Emine Müge Acar, Asuman KilitçiIndian Dermatology Online Journal 2019 10(6):639-643 Aim: Ashy dermatosis (AD) is a cutaneous pigmentation disorder with unknown etiology characterized by ash-colored hyperpigmented macules. The diagnosis of Ashy dermatosis is primarily based on the clinical and histopathological findings. In this study, we aimed to identify the dermoscopic features of AD, which may facilitate the diagnosis by reducing the need for invasive procedures. Material and...
Fri Nov 01, 2019 00:00
Ananta Khurana, Kabir Sardana, Anuradha Chowdhary, Khushboo SethiaIndian Dermatology Online Journal 2019 10(6):737-738
Fri Nov 01, 2019 00:00
Delanthimar Joshika Bhandary, Banavasi Shanmukha Girisha, Basanna Nagargund MahadevappaIndian Dermatology Online Journal 2019 10(6):644-649 Background: Alopecia areata (AA) is an autoimmune condition affecting hair-bearing regions of the body. Few studies worldwide have focused exclusively on beard alopecia areata (BAA). Aims: To describe the clinical associations, comorbidities, and dermoscopy of BAA. Materials and Methods: Forty-six patients with BAA were recruited for this hospital-based cross-sectional...
Fri Nov 01, 2019 00:00
Shital Poojary, Kavya BaddireddyIndian Dermatology Online Journal 2019 10(6):757-758
Fri Nov 01, 2019 00:00
Dharshini Sathishkumar, Parthiban Udhayakumar, Debasis Das Adhikari, Renu GeorgeIndian Dermatology Online Journal 2019 10(6):650-656 Background: Skin problems are commonly encountered in the pediatric emergency department (PED). Although there are a few studies on the prevalence and spectrum of skin conditions in children attending the PED, only limited information is available on the outcome of the children with skin-related ailments requiring hospitalization. Aim: To study the clinical profile...
Fri Nov 01, 2019 00:00
Shivani B Kaushik, Animesh A Upadhyay, Ethan Routt, Robert PhelpsIndian Dermatology Online Journal 2019 10(6):721-723
Fri Nov 01, 2019 00:00
Mohan Kumar Periyasamy, Shanmuga C Sekar, Reena RaiIndian Dermatology Online Journal 2019 10(6):657-662 Introduction: Allergic contact dermatitis (ACD) is an inflammatory disorder, which occurs as a result of repeated contact with an allergen. Fragrances are the products obtained naturally or produced synthetically. The purpose of this study is to detect the fragrance allergens producing ACD. Materials and Methods: This is an open-label prospective observational study. Patients of age above 18...
Fri Nov 01, 2019 00:00
Neel Prabha, Namrata Chhabra, Ankur Kumar Shrivastava, Ripu Daman Arora, VR Roja, Shrikant Kaushik, Nitin M NagarkarIndian Dermatology Online Journal 2019 10(6):731-734
Fri Nov 01, 2019 00:00
Ajay Chopra, Debdeep Mitra, Reetu Agarwal, Neerja Saraswat, Krishna Talukdar, Abhay SolankiIndian Dermatology Online Journal 2019 10(6):663-668 Background: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. It is diagnosed based on clinical features and confirmed on the histological findings and peripheral slit-skin smear staining. Dermoscopy is a handy, easily accessible tool to diagnose this granulomatous disease and classify patients based on the immunological and clinical...
Fri Nov 01, 2019 00:00
Chander Grover, Deepak JakharIndian Dermatology Online Journal 2019 10(6):741-742
Fri Nov 01, 2019 00:00
Iffat Hassan, Saniya Akhtar, Sumaya Zeerak, Farhan Rasool, Parvaiz Anwar Rather, Yasmeen J Bhat, Insha Latif, Shagufta Rather, Syed Mubashir, Shazia Jeelani, Reeta Devi, Yakzata Bashir, Nahida Nabi, Samina Batool, Samia AleemIndian Dermatology Online Journal 2019 10(6):669-675 Introduction: Allergic contact dermatitis (ACD) is a growing concern due to increased use of cosmetics and topical medications routinely and exposure to a large number of allergens on day-to-day basis. Patch testing is a...
Fri Nov 01, 2019 00:00
Chitaranjan Mishra, Naresh Babu Kannan, Kim Ramasamy, Dhipak Arthur BalasubramanianIndian Dermatology Online Journal 2019 10(6):753-754
Fri Nov 01, 2019 00:00
Surajsingh Wadhawa, Sudha Agrawal, Manoj Chaudhary, Sanjib SharmaIndian Dermatology Online Journal 2019 10(6):676-681 Background: Hyperhidrosis (HH) is a disorder characterized by excessive sweating beyond required for normal thermoregulation, as a result of the excessive functioning of the sudomotor sweat control system. HH is broadly classified into 2 categories: primary HH and secondary. Our aim was to study the prevalence of HH in patients attending dermatological outpatients. Methods: Randomly...
Fri Nov 01, 2019 00:00
Prabhakar M Sangolli, Dammaningala Venkataramaiah LakshmiIndian Dermatology Online Journal 2019 10(6):617-626 Vasculitis poses a great diagnostic, investigative and therapeutic challenge to the treating physician. The classification of vasculitides itself still eludes universal acceptance. Comprehensive management comprises establishing the diagnosis of true vasculitis after ruling out vasculitis mimics, finding the etiology if feasible, assessing the caliber of the vessels involved, deciphering...
Fri Nov 01, 2019 00:00
Ishmeet Kaur, Deepak Jakhar, Archana SingalIndian Dermatology Online Journal 2019 10(6):682-685 Background: Pityriasis versicolor (PV) is a superficial mycosis caused by Malassezia yeast; a lipophilic fungus. Dermoscopy may be a value addition in the diagnosis of PV in some cases, where results of KOH (potassium hydroxide) examination are ambiguous. There is paucity of Indian data on dermoscopy of PV. Materials and Methods: Thirty consecutive patients diagnosed clinically with pityriasis versicolor...
Fri Nov 01, 2019 00:00
Ramesh Kumar Kushwaha, Arti Singh, Alpana Mohta, Suresh Kumar JainIndian Dermatology Online Journal 2019 10(6):719-720
Fri Nov 01, 2019 00:00
Anupama Bains, Deepak Vedant, Anurag Verma, Abhishek Bhardwaj, Aasma NalwaIndian Dermatology Online Journal 2019 10(6):686-691 Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome is characterized by the triad of follicular keratotic papules, total to subtotal alopecia, and photophobia. We hereby report a case of IFAP syndrome in a 1-year-old boy who presented with all these classical features along with hyperkeratotic plaques over knees, plantar keratoderma, and umbilical hernia....
Fri Nov 01, 2019 00:00
Liza Mohapatra, Kallolinee Samal, Prasenjeet Mohanty, Siddhartha DashIndian Dermatology Online Journal 2019 10(6):724-726
Fri Nov 01, 2019 00:00
Liza Mohapatra, Kallolinee Samal, Prasenjeet Mohanty, Siddhartha DashIndian Dermatology Online Journal 2019 10(6):692-694 Reverse Koebner response is the nonappearance or disappearance of the lesions of particular dermatoses at the site of injury. Herein we report a case of the reverse Koebner phenomenon in bullous pemphigoid in a 35-year-old male patient with sparing of the waist area which could probably be because of the phenomenon of locus majoris resistentiae. The histopathology of the lesion...
Fri Nov 01, 2019 00:00
Mary Zothanpuii Chhangte, Binod Kumar Thakur, Shikha Verma, Biswajit DeyIndian Dermatology Online Journal 2019 10(6):729-731
Fri Nov 01, 2019 00:00
Anju George, Renu George, Sunitha S Varghese, Ramesh B TeluguIndian Dermatology Online Journal 2019 10(6):695-697 Hypertrophic lichen planus (HLP) is a chronic variant of lichen planus with an estimated risk of 0.4% developing squamous cell carcinoma (SCC) in later years. We report the case of a 12-year- old boy with history of hypertrophic lichen planus since 4 years of age, with malignant transformation into squamous cell carcinoma along with lymph node metastasis.
Fri Nov 01, 2019 00:00
Rajeshwari Dabas, Navya Donaparthi, Radhakrishnan Subramaniyan, Manasa Shettisara JanneyIndian Dermatology Online Journal 2019 10(6):735-737
Fri Nov 01, 2019 00:00
Rohini Soni, Archana J Lokhande, Paschal D'souzaIndian Dermatology Online Journal 2019 10(6):698-703 Sweat dermatitis is a peculiar kind of irritant inflammatory dermatoses occurring due to prolonged exposure of retained sweat over the skin. It is commonly seen in hot and dry climates like tropics during summer months due to thermal stress. Typically, parchment paper or cellophane paper like scaling is seen over occluded areas of back, shoulder, and other areas. Here we have reported a varied presentation...
Fri Nov 01, 2019 00:00
Shyam B VermaIndian Dermatology Online Journal 2019 10(6):739-740
Fri Nov 01, 2019 00:00
Adrián De Quintana Sancho, Leandra Reguero Del Cura, Susana Armesto Alonso, Marcos Antonio González LópezIndian Dermatology Online Journal 2019 10(6):704-706 Elephantiasis nostras verrucosa (ENV) is the most severe form of chronic non-filarial lymphedema that leads to disfiguration of body parts. Multiple topical and surgical treatments have been typically used with high relapse rates and local complications. In this context, CO2 laser emerges as a new well-tolerated and effective treatment option....
Fri Nov 01, 2019 00:00
Divya Sachdev, Satyaki Ganguly, Namrata ChhabraIndian Dermatology Online Journal 2019 10(6):743-744
Fri Nov 01, 2019 00:00
Pravesh Yadav, Anuja Yadav, Keemi Dalal, Ram ChanderIndian Dermatology Online Journal 2019 10(6):707-709 Systemic lupus erythematosus (SLE) is a connective tissue disorder with a high prevalence in certain races like Africans. It also has a female predilection. The pathogenesis of SLE is a complex interplay of genetic and environmental factors. Familial presentation of SLE has been well documented. We herein illustrate a scenario of SLE presenting in related females (mother and daughter) concurrently...
Fri Nov 01, 2019 00:00
Amiya K MukhopadhyayIndian Dermatology Online Journal 2019 10(6):751-752
Fri Nov 01, 2019 00:00
Naziya Muhammed, Atul M Dongre, Uday S KhopkarIndian Dermatology Online Journal 2019 10(6):710-713 Linear and unilateral basaloid follicular hamartoma (BFH) is a rare disease that manifests with papules and plaques with distribution along lines of Blaschko. It runs a benign course but with the risk of basal cell carcinoma (BCC) in long term course. BCC can be differentiated from BFH with histopathology and immunohistochemistry. Dermoscopic features of BCC are well studied. Dermoscopic features...
Fri Nov 01, 2019 00:00
Murat Ozturk, Rojda Aktar, Remzi ErtenIndian Dermatology Online Journal 2019 10(6):755-756
Fri Nov 01, 2019 00:00
Rashmi Sriram, Rajendra Okade, TA SushmaIndian Dermatology Online Journal 2019 10(6):714-716 Adult Onset Xanthogranulomatous Disease represents an umbrella term encompassing 4 distinct entities with partially overlapping clinicopathological features: adult-onset xanthogranuloma, adult-onset asthma with periocular xanthogranuloma, Erdheim-Chester disease, and necrobiotic xanthogranuloma. They are characterized by a predilection to affect the orbit and ocular adnexa and special histopathological...
Fri Nov 01, 2019 00:00
Payal Chauhan, Rashmi Jindal, Nadia ShiraziIndian Dermatology Online Journal 2019 10(6):759-760
Fri Nov 01, 2019 00:00
Abstract At least 20 clinically relevant factors affect percutaneous absorption of drugs and chemicals: relevant physico-chemical properties, vehicle/formulation, drug exposure conditions (dose, duration, surface area, exposure frequency), skin appendages (hair follicles, glands) as sub-anatomical pathways, skin application sites (regional variation in penetration), population variability (premature, infants, and aged), skin surface conditions (hydration, temperature, pH), skin...
Fri Nov 01, 2019 02:00
Abstract Female androgenetic alopecia (FAGA) is a common cause of non-scarring alopecia in women. The onset may be at any age following puberty and the frequency increases with age. Clinically, it shows a diffuse hair thinning over the central scalp, while the frontal hairline is usually retained. FAGA can have a significant psychological impact, leading to anxiety and depression. For this reason, early diagnosis is very important to stop the progression of the disease. The sex...
Fri Nov 01, 2019 02:00
Abstract Even after complete removal with Mohs micrographic surgery (MMS), cutaneous squamous cell carcinoma (cSCC) may recur; however, information about risk factors for recurrence in Asian patients is limited. This retrospective study reviewed cSCC patients treated with MMS at a single tertiary referral center from 2000 to 2017. Two hundred and thirty‐seven patients were included and 36 showed recurrence (20 with local recurrence, 16 with distant metastasis). History of organ transplantation,...
Thu Oct 31, 2019 18:43
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