Abstract Background OSCC is most commonly associated with positive surgical margins. The important cause of loco regional recurrence is histologically positive or closed margins. Clear surgical margins might favor the patient with a better prognosis and prevent repetitive surgeries. The present study was designed to the diagnostic utility of touch imprint (TI) smears using H and E, Pap, Giemsa and Feulgen stains, so that they can be used on a routine basis. Materials and methods A total...
Fri Nov 01, 2019 15:15
Abstract Carcinoma ex pleomorphic adenoma (CXPA) of the salivary glands is a relatively rare carcinoma. The detection rate of the carcinoma component in the cytological specimens is not high and may be challenging in cytological examination. The purpose of the present study was to analyze the cytological specimens of CXPA with emphasis on the detection of the carcinoma component. We reviewed the cytological characteristics of patients histopathologically diagnosed with CXPA who underwent preoperative...
Fri Nov 01, 2019 15:01
Abstract INTRODUCTION Focused and expanded mutation panels were assessed for the incremental utility of using an expanded panel in combination with microRNA risk classification. METHODS Molecular results were reviewed for patients who underwent either a focused mutation panel (ThyGenX®) or an expanded mutation panel (ThyGeNEXT®) for strong and weak oncogenic driver mutations and fusions. microRNA results (ThyraMIR®) predictive of malignancy, including strong positive results highly specific...
Fri Nov 01, 2019 15:00
Publication date: Available online 31 October 2019Source: Human PathologyAuthor(s): Calixto-Hope G. Lucas, David A. Solomon, Arie PerrySummaryAdvances in molecular profiling of central nervous system tumors have enabled the development of classification schemes with improved diagnostic and prognostic accuracy. As such, the 2016 World Health Organization Classification of Tumors of the Central Nervous System (WHO 2016) introduced a paradigm shift in the diagnosis of brain tumors. For instance, integrated...
Fri Nov 01, 2019 20:34
Publication date: Available online 1 November 2019Source: Pathology - Research and PracticeAuthor(s): Pollyanna Domeny-Duarte, Ligia Niero, Maria Ap. Custodio DominguesABSTRACTTime optimization and cost reduction without quality loss is fundamental for scientific production. The TMA technique allows large-scale analysis of paraffin-embedded and fixed tissues using non-decalcified bone marrow specimens. Cytoinclusion samples (n = 264) were selected from patients diagnosed with monoclonal gammopathy...
Fri Nov 01, 2019 18:08
Publication date: Available online 1 November 2019Source: Pathology - Research and PracticeAuthor(s): Fang Li, Zihao Chen, Bibo Tan, Yueping Liu, Qun Zhao, Liqiao Fan, Huiyan Deng, Yanqi Ma, Yong LiAbstractThe purpose of this study was to analyze the influencing factors of BVI in advanced gastric cancer and explore the factors affecting the prognosis of advanced gastric cancer, so as to accurately evaluate the disease status and enable patients to receive effective treatment. We retrospectively analyzed...
Fri Nov 01, 2019 18:08
Publication date: Available online 31 October 2019Source: Pathology - Research and PracticeAuthor(s): Stefano Fratoni, Pasquale Niscola, Xiangfeng Frank Zhao, Luigi Maria Larocca, Anna Capalbo, Maria Fabbretti, Laura Bernardini, Elisabetta Abruzzese
Fri Nov 01, 2019 18:08
Publication date: Available online 31 October 2019Source: Pathology - Research and PracticeAuthor(s): Xiaobo He, Ying ShuAbstractGastric cancer is the most common malignant tumor of the digestive system and it is beneficial to find a safer and more effective therapeutic target if we have a deep understanding of the molecular function mechanism during the development of gastric cancer. In recent years, through many researches, we found that miRNA functions as oncogene or cancer suppressor gene, and...
Fri Nov 01, 2019 18:08
Publication date: Available online 31 October 2019Source: Pathology - Research and PracticeAuthor(s): Yan Xu, Chaochao Ren, Xiang Zhao, Wei Wang, Ning ZhangAbstractBackgroundPeriodontal ligament stem cells (PDLSCs) could differentiate into osteoblasts and have a great prospect in treating bone diseases. microRNAs (miRs) and nuclear factor kappa-B (NF-κB) signaling pathway have proved pivotal in regulating osteogenic differentiation. This study intended to discuss the mechanism of miR-132 and NF-κB...
Fri Nov 01, 2019 18:08
Publication date: Available online 31 October 2019Source: Pathology - Research and PracticeAuthor(s): Xinyi Chen, Yanhua Yang, Wei Wang, Bo Han, Mei Qi, Shaoqing Geng, Jing Xu, Qian Zhang, Xueli Wang, Shouzhen Chen, Kai Shi, Xuexuan Ke, Jing ZhangAbstractIntraductal carcinoma of the prostate (IDC-P) and bone metastasis have been both identified to associate with unfavorable clinical outcome of the prostate carcinoma (PCa). Our objective is to examine whether IDC-P or bone metastasis at diagnostic...
Fri Nov 01, 2019 18:08
Publication date: Available online 31 October 2019Source: Pathology - Research and PracticeAuthor(s): Shengli Wang, Zhigang Cui, Hang Li, Juan Li, Xiaoting Lv, Zitai Yang, Min Gao, Yanhong Bi, Ziwei Zhang, Baosen Zhou, Zhihua YinAbstractBackgroundLong non-coding RNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) is a novel lncRNA localized specifically to nuclear paraspeckles. The study analyses the association between NEAT1 genetic polymorphisms and the susceptibility of lung cancer in a Chinese...
Fri Nov 01, 2019 18:08
Abstract Background In this study, we aimed to evaluate ultrasonographical and cytological features of thyroid nodules in patients who were treated with radioactive iodine (RAI) for hyperthyroidism years ago. Methods Patients who had a history of RAI treatment for hyperthyroidism and had thyroid nodules that were evaluated with fine‐needle aspiration biopsy (FNAB) were included in the study. Results There were 27 patients (22 female and 5 male) with a mean age of 59.3 ± 13.5. The...
Thu Oct 31, 2019 20:43
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