Related ArticlesDiagnostic Value of Acoustic and Aerodynamic Measurements in Vocal Fold Movement Disorders and their Correlation with Laryngeal Electromyography and Voice Handicap Index. J Voice. 2019 Nov 19;: Authors: Valentino WL, Park J, Alnouri G, Gracely EJ, Tami A, Vance D, Palmer J, Sataloff RT Abstract OBJECTIVES: Investigate the relationships between the Voice Handicap Index, laryngeal electromyography, and objective acoustic voice testing in...
Sun Nov 24, 2019 13:10
Related ArticlesDirect oral anticoagulants in patients with antiphospholipid syndrome: a cohort study. Lupus. 2019 Nov 22;:961203319889156 Authors: Malec K, Broniatowska E, Undas A Abstract OBJECTIVES: Despite controversies, direct oral anticoagulants (DOACs) are increasingly used in antiphospholipid syndrome (APS). We investigated the safety and efficacy of DOACs versus vitamin K antagonists (VKAs) in real-life consecutive APS patients. PATIENTS...
Sun Nov 24, 2019 13:10
Related ArticlesMolecular Targeting Therapy against EGFR Family in Breast Cancer: Progress and Future Potentials. Cancers (Basel). 2019 Nov 20;11(12): Authors: Maennling AE, Tur MK, Niebert M, Klockenbring T, Zeppernick F, Gattenlöhner S, Meinhold-Heerlein I, Hussain AF Abstract ：The epidermal growth factor receptor (EGFR) family contains four transmembrane tyrosine kinases (EGFR1/ErbB1, Her2/ErbB2, Her3/ErbB3 and Her4/ErbB4) and 13 secreted polypeptide...
Sun Nov 24, 2019 13:10
Related ArticlesAssessing the Role of Virtual Surgical Planning in Mandibular Reconstruction With Free Fibula Osteocutaneous Graft. J Craniofac Surg. 2019 Sep;30(6):e563-e566 Authors: Saini V, Gaba S, Sharma S, Kalra P, Sharma RK Abstract BACKGROUND: The role of virtual surgical planning and three-dimensional printing in improving the accuracy, precision, functional and aesthetic outcomes have been demonstrated in the literature; however, there is a...
Sun Nov 24, 2019 13:10
Related ArticlesEstablishing Orbital Floor Symmetry to Support Mirror Imaging in Computer-Aided Reconstruction of the Orbital Floor. J Craniofac Surg. 2019 Sep;30(6):1888-1890 Authors: Jozaghi Y, Chan HHL, Davies JC, Irish JC Abstract BACKGROUND: Surgical precision in the reconstruction of the orbital floor is crucial to functional visual and aesthetic outcomes. Increasingly, computer-aided design is being utilized to aid in precise preoperative planning...
Sun Nov 24, 2019 13:10
Related ArticlesMycobacterium tuberculosis enters macrophages with aid from a bacterial lipid. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Gawrisch K PMID: 31757857 [PubMed - as supplied by publisher]
Sun Nov 24, 2019 13:07
Related ArticlesQuelling germ cell pluripotency on the genital ridge. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Updike DL PMID: 31757856 [PubMed - as supplied by publisher]
Sun Nov 24, 2019 13:07
Related ArticlesThe conical shape of DIM lipids promotes Mycobacterium tuberculosis infection of macrophages. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Augenstreich J, Haanappel E, Ferré G, Czaplicki G, Jolibois F, Destainville N, Guilhot C, Milon A, Astarie-Dequeker C, Chavent M Abstract Phthiocerol dimycocerosate (DIM) is a major virulence factor of the pathogen Mycobacterium tuberculosis (Mtb). While this lipid promotes the entry of Mtb into...
Sun Nov 24, 2019 13:07
Related ArticlesSingle-molecule imaging of HIV-1 envelope glycoprotein dynamics and Gag lattice association exposes determinants responsible for virus incorporation. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Pezeshkian N, Groves NS, van Engelenburg SB Abstract The HIV-1 envelope glycoprotein (Env) is sparsely incorporated onto assembling virus particles on the host cell plasma membrane in order for the virus to balance infectivity and evade the...
Sun Nov 24, 2019 13:07
Related ArticlesSocial behavior for autonomous vehicles. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Schwarting W, Pierson A, Alonso-Mora J, Karaman S, Rus D Abstract Deployment of autonomous vehicles on public roads promises increased efficiency and safety. It requires understanding the intent of human drivers and adapting to their driving styles. Autonomous vehicles must also behave in safe and predictable ways without requiring explicit communication....
Sun Nov 24, 2019 13:07
Related ArticlesArousal regulates frequency tuning in primary auditory cortex. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Lin PA, Asinof SK, Edwards NJ, Isaacson JS Abstract Changes in arousal influence cortical sensory representations, but the synaptic mechanisms underlying arousal-dependent modulation of cortical processing are unclear. Here, we use 2-photon Ca2+ imaging in the auditory cortex of awake mice to show that heightened arousal, as...
Sun Nov 24, 2019 13:07
Related ArticlesDistinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Gaucher J, Kinouchi K, Ceglia N, Montellier E, Peleg S, Greco CM, Schmidt A, Forne I, Masri S, Baldi P, Imhof A, Sassone-Corsi P Abstract Binge drinking and chronic exposure to ethanol contribute to alcoholic liver diseases (ALDs). A potential link between ALDs and circadian disruption...
Sun Nov 24, 2019 13:07
Related ArticlesChromosome disentanglement driven via optimal compaction of loop-extruded brush structures. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Brahmachari S, Marko JF Abstract Eukaryote cell division features a chromosome compaction-decompaction cycle that is synchronized with their physical and topological segregation. It has been proposed that lengthwise compaction of chromatin into mitotic chromosomes via loop extrusion underlies the...
Sun Nov 24, 2019 13:07
Related ArticlesResolving titin's lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Rudolph F, Hüttemeister J, da Silva Lopes K, Jüttner R, Yu L, Bergmann N, Friedrich D, Preibisch S, Wagner E, Lehnart SE, Gregorio CC, Gotthardt M Abstract Cardiac protein homeostasis, sarcomere assembly, and integration of titin as the sarcomeric backbone are tightly regulated to facilitate...
Sun Nov 24, 2019 13:07
Related ArticlesBottleneck and selection in the germline and maternal age influence transmission of mitochondrial DNA in human pedigrees. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Zaidi AA, Wilton PR, Su MS, Paul IM, Arbeithuber B, Anthony K, Nekrutenko A, Nielsen R, Makova KD Abstract Heteroplasmy-the presence of multiple mitochondrial DNA (mtDNA) haplotypes in an individual-can lead to numerous mitochondrial diseases. The presentation of such...
Sun Nov 24, 2019 13:07
Related ArticlesGrowth dynamics of the Arabidopsis fruit is mediated by cell expansion. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Ripoll JJ, Zhu M, Brocke S, Hon CT, Yanofsky MF, Boudaoud A, Roeder AHK Abstract Fruit have evolved a sophisticated tissue and cellular architecture to secure plant reproductive success. Postfertilization growth is perhaps the most dramatic event during fruit morphogenesis. Several studies have proposed that fertilized...
Sun Nov 24, 2019 13:07
Related ArticlesExtensive free-energy simulations identify water as the base in nucleotide addition by DNA polymerase. Proc Natl Acad Sci U S A. 2019 Nov 22;: Authors: Roston D, Demapan D, Cui Q Abstract Transphosphorylation of nucleotide triphosphates is the central reaction in DNA replication by DNA polymerase as well as many other biological processes. Despite its importance, the microscopic chemical mechanism of transphosphorylation of nucleotide...
Sun Nov 24, 2019 13:07
Related ArticlesFeasibility and safety of endoscopic procedure in burr hole surgery for chronic subdural hematoma in patients of very advanced age. World Neurosurg. 2019 Nov 20;: Authors: Wakuta N, Abe H, Fukuda K, Nonaka M, Morishita T, Arima H, Inoue T Abstract OBJECTIVE: The usefulness of endoscopic procedures for chronic subdural hematoma (CSDH) has been described, but the indications in patients of very advanced age have not been analyzed. The aim...
Sun Nov 24, 2019 14:43
Related ArticlesOff-Label Use of The WEB Device. World Neurosurg. 2019 Nov 20;: Authors: Zanaty M, Roa JA, Tjoumakaris SI, Jabbour P, Mouchtouris N, Sweid A, Ortega-Gutierrez S, Ishii D, Limaye K, Asi K, Samaniego EA, Hasan DM Abstract INTRODUCTION: We present our initial experience with the off-label use of the WEB device. METHODS: We performed a retrospective study from 2 institutions of patients with intracranial aneurysms who underwent treatment...
Sun Nov 24, 2019 14:43
Related ArticlesAdult atypical teratoid/rhabdoid tumor in the pineal region Case report and literature review. World Neurosurg. 2019 Nov 20;: Authors: Monteiro J, Santiago B, Manilha R, Viegas C, Oliveira A, Cunha E Sá M PMID: 31759153 [PubMed - as supplied by publisher]
Sun Nov 24, 2019 14:43
Related ArticlesMotion preservation at all cost? Multilevel hinge non-union, plate breakage, and intra-dural plate migration following cervical laminoplasty: a case report and literature review. World Neurosurg. 2019 Nov 20;: Authors: Rosinski A, Odeh K, Leasure J, Kondrashov D Abstract Cervical laminoplasty is a motion-preserving procedure that addresses spinal cord compression and avoids post-laminectomy kyphosis associated with cervical laminectomy....
Sun Nov 24, 2019 14:43
Related ArticlesThe coexistence of gliosarcoma and arteriovenous malformation with the BRAF V600E mutation: case report. World Neurosurg. 2019 Nov 20;: Authors: Zeng X, Zhan Q, Gao Y, Cui N, Dong M, Feng L, Chu L, Liu J Abstract The authors reported a case of a 33-year-old female sufferred from the combination of primary gliosarcoma and arteriovenous malformation (AVM) as the first clinical presentation of intracranial hemorrhage. Subsequently, gene...
Sun Nov 24, 2019 14:43
Related ArticlesTranscirculation Approach for Endovascular Embolization of Intracranial Aneurysms, Arteriovenous Malformations and Dural Fistulas: A Multicenter Study. World Neurosurg. 2019 Nov 20;: Authors: Roa JA, Ortega-Gutierrez S, Martinez-Galdamez M, Maud A, Dabus G, Pazour A, Dandapat S, Arteaga MS, Fernandez JG, Paez-Granda D, Kalousek V, Pons RB, Mowla A, Duckwiler G, Szeder V, Jabbour P, Hasan DM, Samaniego EA Abstract BACKGROUND: Unfavorable...
Sun Nov 24, 2019 14:43
Related ArticlesCerebral Hyperperfusion Syndrome after Revascularization Surgery in Patients with Moyamoya Disease: Systematic Review and Meta-analysis. World Neurosurg. 2019 Nov 20;: Authors: Yu J, Zhang J, Li J, Zhang J, Chen J Abstract BACKGROUND: Cerebral hyperperfusion syndrome (CHS) following bypass surgery is known as a complication of moyamoya disease (MMD). However, the incidence of CHS has not been accurately reported, and there is no consensus...
Sun Nov 24, 2019 14:43
Related ArticlesSpinal Intradural, Extramedullary Dermoid Cyst: a Case Report. World Neurosurg. 2019 Nov 20;: Authors: Khalighinejad F, Majizadeh M, Moktari A, Rakhshan R, Hajizadeh M, Rezvani M Abstract INTRODUCTION: Dermoid cysts are benign congenital tumors that develop early in life. These tumors are classified by the presence of all three germ layers. Spinal intradural extramedullary teratoma is a rare disease, which is more common in children under...
Sun Nov 24, 2019 14:43
Related ArticlesPredictive Effect of Cervical Sagittal Parameters on Conservative Treatment of Single-segment Cervical Spondylotic Radiculopathy. World Neurosurg. 2019 Nov 20;: Authors: Lin T, Wang Z, Chen G, Liu W Abstract STUDY DESIGN: A retrospective study. OBJECTIVE: To explore (1)whether the cervical sagittal parameters affect the conservative treatment of single-segment cervical spondylotic radiculopathy and (2)whether the conservative...
Sun Nov 24, 2019 14:43
Related ArticlesCauda Equina Syndrome Secondary to Diffuse Infiltration of the Cauda Equina by Acute Myeloid Leukemia: A Case Report and Literature Review. World Neurosurg. 2019 Nov 20;: Authors: Walton A, Mecklosky J, Carr C, Scullen T, Mathkour M, Werner C, Amenta PS Abstract BACKGROUND: Cauda equina syndrome (CES) results from the dysfunction of the lumbar, sacral, and coccygeal rootlets composing the cauda equina. The underlying etiology is most...
Sun Nov 24, 2019 14:43
Related ArticlesPrognostic efficacy of extensive invasion of primary tumor volume for T3-4 nasopharyngeal carcinoma receiving intensity-modulated radiotherapy. Oral Oncol. 2019 Nov 20;100:104478 Authors: Xue F, Ou D, Ou X, Zhou X, Hu C, He X Abstract OBJECTIVES: This study aimed to explore the prognostic value of extensive invasion of primary tumor volume for local control in patients with T3-4 NPC receiving intensity-modulated radiotherapy (IMRT). ...
Sun Nov 24, 2019 15:08
Related ArticlesImage quality of flat-panel computed tomography using 2 different acquisition times versus multidetector computed tomography in whole-head temporal bone specimen. Eur Arch Otorhinolaryngol. 2019 Nov 22;: Authors: Reimann K, Hirt B, Schulze M Abstract PURPOSE: Imaging of temporal bone and skull base acquire high resolution due to the small anatomic structures with high clinical relevance. The purpose of this study was to compare image...
Sun Nov 24, 2019 13:06
Related Articles3D exoscopic surgery of lateral skull base. Eur Arch Otorhinolaryngol. 2019 Nov 22;: Authors: Rubini A, Di Gioia S, Marchioni D Abstract PURPOSE: The aim of the study is to assess whether the 3D exoscopic surgery technique could be used in lateral skull base surgery and if it could ultimately replace the microscope in the future. METHODS: This is a retrospective study in which were included 24 patients affected by lateral skull...
Sun Nov 24, 2019 13:06
Related ArticlesRadiation induced optic neuropathy: Does treatment modality influence the risk? Bull Cancer. 2019 Nov 19;: Authors: Mohamed Ali A, Mathis T, Bensadoun RJ, Thariat J Abstract Radiation induced optic neuropathy (RION) is a rare but disastrous complication of radiation therapy in treatment of periorbital tumors. The objective of this study is to investigate the incidence of RION in series of patients treated from peri orbital tumors by recent...
Sun Nov 24, 2019 13:06
Related ArticlesMagnetic Resonance Imaging Features of Collet-Sicard Syndrome Associated With Glomus Jugulare Paraganglioma. J Craniofac Surg. 2019 Sep;30(6):e574-e576 Authors: Mutlu V, Ogul H Abstract Collet-Sicard syndrome is an unusual disorder. The authors here demonstrated the Magnetic resonance (MR) imaging findings of the Collet-Sicard syndrome associated with glomus jugulare tumor. Neoplastic or non-neoplastic lesion of skull base can cause Collet-Sicard...
Sun Nov 24, 2019 13:06
Abstract MEK inhibitors (MEKi) demonstrate anti‐proliferative activity in patients with metastatic uveal melanoma, but responses are short‐lived. In the present study, we evaluated the MEKi trametinib alone and in combination with drugs targeting epigenetic regulators, including DOT1L, EZH2, LSD1, DNA methyltransferases and histone acetyltransferases. The DNA methyltransferase inhibitor (DNMTi) decitabine effectively enhanced the anti‐proliferative activity of trametinib in cell viability, colony...
Sat Nov 23, 2019 18:58
Related ArticlesLoss of Domain: Going Beyond the Stewart Test. World J Surg. 2019 Nov 22;: Authors: Ramana B, Arora E PMID: 31758255 [PubMed - as supplied by publisher]
Sun Nov 24, 2019 13:00
Despite existing best practice care recommendations for addressing tobacco smoking, alcohol consumption and weight management in preconception and antenatal care, such recommendations are often not implemented...
Sat Nov 23, 2019 02:00
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