Effect of clomiphene citrate treatment on the Sertoli cellsof dysmetabolic obese men with low testosterone levels

Abstract Background Clomiphene citrate (CC) has been shown to restore the hypothalamic pituitary‐gonadal (HPG) axis by increasing testosterone (T) levels to physiological levels in patients with dysmetabolic conditions such as obesity, metabolic syndrome and type 2 diabetes mellitus (T2DM). However, the data are unclear regarding the effects on Sertoli cell (SC) function. Aim To study SC function by assessing Inhibin B (IB) and Anti‐Mullerian Hormone (AMH) levels at baseline and after 3...

Clinical Endocrinology

Fri Nov 01, 2019 17:43

Gender differences and temporal trends over two decades in acromegaly: a single center study in 112 patients

Abstract Purpose To evaluate the impact of gender and year at surgery on clinical presentation and postoperative outcomes in acromegaly. Methods Retrospective review of patients operated between 1994 and 2016 to compare presentation and outcomes in groups defined by gender and year of surgery. Kaplan–Meier survival analyses with a composite endpoint (recurrence,...

International journal of basic and clinical endocrinology

Fri Nov 01, 2019 02:00

Comparing directly measured versus mathematically calculated free serum 25-hydroxy vitamin D level in children

Abstract Introduction 25-Hydroxy vitamin D (25(OH)D) is essential for calcium homeostasis and bone metabolism. The majority of serum 25(OH)D is bound to vitamin D-binding protein (VDBP) (~ 85%) and to albumin (~ 15%), with only a miniscule amount circulating as free 25(OH)D. Free 25(OH)D can be calculated mathematically by Bikle method from the concentrations of total 25(OH)D, VDBP, and albumin or measured directly by ELISA. A direct head-to-head...

Journal of Bone and Mineral Metabolism

Fri Nov 01, 2019 02:00