Related ArticlesInduction of growth cessation by acacetin via β-catenin pathway and apoptosis by apoptosis inducing factor activation in colorectal carcinoma cells. Mol Biol Rep. 2019 Nov 16;: Authors: Prasad N, Sharma JR, Yadav UCS Abstract Acacetin, a bioflavanoid, contains anti-inflammatory and anti-cancer activities as shown in different experimental models. However, its anticancer potential and mechanism of action against colorectal cancer cells...
Mon Nov 18, 2019 15:12
Related ArticlesAssociation and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation. Med Oncol. 2019 Nov 16;37(1):6 Authors: Liu K, Lu R, Zhao Q, Du J, Li Y, Zheng M, Zhang S Abstract BACKGROUND: We previously showed that cobalt chloride (CoCl2) induction of polyploid giant cancer cells (PGCCs) was characterized by abnormal cell cycle-related protein expression and G2/M arrest. The role of the p38MAPK-ERK-JNK...
Mon Nov 18, 2019 15:12
Related ArticlesLong non-coding RNA NEAT1 promotes bladder progression through regulating miR-410 mediated HMGB1. Biomed Pharmacother. 2019 Nov 14;121:109248 Authors: Shan G, Tang T, Xia Y, Qian HJ Abstract LncRNA NEAT1 is reported as a crucial oncogene in multiple cancers. But, its biological role in bladder cancer is barely understood. Therefore, we concentrated on the function and role of NEAT1 in bladder cancer. Firstly, NEAT1 expression in bladder...
Mon Nov 18, 2019 15:12
Related ArticlesSynthesis and characterization of zinc oxide nanoparticles from Morus nigra and its anticancer activity of AGS gastric cancer cells. J Photochem Photobiol B. 2019 Nov 09;202:111698 Authors: Tang Q, Xia H, Liang W, Huo X, Wei X Abstract Gastric cancer was a foremost one among the majority of regular carcinoma cases globally. Even the achievements on enhanced treatment approaches and early findings cannot decrease the mortality and morbidity...
Mon Nov 18, 2019 15:12
Related ArticlesPrevalence and correlates of non-tissue prostate cancer diagnosis in the United States. J Geriatr Oncol. 2019 Nov 13;: Authors: Aksenov L, Gansler T, Sineshaw HM, Fedewa S, Yabroff KR, Jemal A, Moul J Abstract BACKGROUND: Given the potential complications of prostate biopsies, it is sometimes reasonable in selected patients to make a non-tissue diagnosis of prostate cancer. Little is known about prevalence and factors associated with...
Mon Nov 18, 2019 14:46
Related ArticlesCorrigendum to "The local thermal effect of using monopolar electrosurgery in the presence of a deep brain stimulator: Cadaveric studies on a lamb brain" [J. Clin. Neurosci. (2019) 134-139]. J Clin Neurosci. 2019 Nov 13;: Authors: Tipper G, Taqvi AA, Singh A, Pohl U, Low H PMID: 31734161 [PubMed - as supplied by publisher]
Mon Nov 18, 2019 15:12
Related ArticlesRisk factors associated with drug resistant focal epilepsy in adults: A case control study. Seizure. 2019 Nov 05;73:46-50 Authors: Roy PL, Ronquillo LH, Ladino LD, Tellez-Zenteno JF Abstract PURPOSE: Using an adult cohort of patients with focal epilepsy, we aimed to identify risk factors for development of drug-resistant epilepsy, which if identifiable would allow patients to receive appropriate counsel and earlier surgical treatment....
Mon Nov 18, 2019 15:02
Related ArticlesGinsenoside compound K alleviates sodium valproate-induced hepatotoxicity in rats via antioxidant effect, regulation of peroxisome pathway and iron homeostasis. Toxicol Appl Pharmacol. 2019 Nov 14;:114829 Authors: Zhou L, Chen L, Zeng X, Liao J, Ouyang D Abstract Sodium valproate (SVP) is a first-line treatment for various forms of epilepsy; however, it can cause severe liver injury. Ginsenoside compound K (G-CK) is the main active ingredient...
Mon Nov 18, 2019 15:02
Related ArticlesPerampanel attenuates epileptiform phenotype in C6 glioma. Neurosci Lett. 2019 Nov 14;:134629 Authors: Mayer J, Kirschstein T, Resch T, Porath K, Krause BJ, Köhling R, Lange F Abstract Epileptic seizures are frequent in patients with glioma, and anticonvulsive treatment is often indicated. Glioma cells release glutamate via the Xc- antiporter system, which appears to be a major pathomechanism of glioma-associated seizures and excitotoxicity....
Mon Nov 18, 2019 15:02
Related ArticlesCenobamate: new hope for treatment-resistant epilepsy. Lancet Neurol. 2019 Nov 13;: Authors: Arnold S PMID: 31734104 [PubMed - as supplied by publisher]
Mon Nov 18, 2019 15:02
Related ArticlesSafety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial. Lancet Neurol. 2019 Nov 13;: Authors: Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M Abstract BACKGROUND: More than a third of patients with epilepsy are treatment resistant, and thus new, more effective therapies to...
Mon Nov 18, 2019 15:02
Related ArticlesAssessment of Oral Mucositis among Patients Undergoing Radiotherapy for Head and Neck Cancer: An Audit. Kathmandu Univ Med J (KUMJ). 2019 Jan.-Mar;17(65):61-65 Authors: Luitel A, Rimal J, Maharjan IK, Regmee P Abstract Background Radiation-induced oral mucositis is one of the major ionizing radiation toxicities and normal tissue injuries resulting from radiotherapy. It occurs in up to 80% of head and neck cancer irradiated patients, reaching...
Mon Nov 18, 2019 14:39
Related ArticlesValidation of the French Versions of the Speech Handicap Index and the Phonation Handicap Index in Patients Treated for Cancer of the Oral Cavity or Oropharynx. Folia Phoniatr Logop. 2019 Nov 15;:1-14 Authors: Balaguer M, Farinas J, Fichaux-Bourin P, Puech M, Pinquier J, Woisard V Abstract CONTEXT: Nowadays, clinical tools are available to evaluate the functional impact of speech disorders in neurological conditions, but few are validated...
Mon Nov 18, 2019 14:39
Related ArticlesGenome-Wide Profiling of Acquired Uniparental Disomy Reveals Prognostic Factors in Head and Neck Squamous Cell Carcinoma. Neoplasia. 2019 Nov 14;21(11):1102-1109 Authors: Tuna M, Liu W, Amos CI, Mills GB Abstract Acquired uniparental disomy (aUPD) leads to homozygosity facilitating identification of monoallelically expressed genes. We analyzed single-nucleotide polymorphism array-based genotyping data of 448 head and neck squamous cell...
Mon Nov 18, 2019 14:39
Related ArticlesAllergic rhinitis and asthma assessment of risk factors in pediatric patients: A systematic review. Int J Pediatr Otorhinolaryngol. 2019 Oct 31;129:109759 Authors: Testa D, DI Bari M, Nunziata M, Cristofaro G, Massaro G, Marcuccio G, Motta G Abstract Allergic rhinitis (AR) is the most prevalent allergic disease in children and can be associated with asthma (A); this association can have significant effect on child's quality of life. The...
Mon Nov 18, 2019 14:39
Related ArticlesA retrospective study of patients with Robin sequence: Patient characteristics and their impact on clinical outcomes. Int J Pediatr Otorhinolaryngol. 2019 Nov 07;129:109769 Authors: Hamilton S, Dzioba A, Husein M Abstract INTRODUCTION: Robin sequence (RS) is a congenital set of abnormalities of the head and neck, consisting of a hypoplastic mandible (micrognathia), a tongue that is displaced posteriorly (glossoptosis), and obstruction...
Mon Nov 18, 2019 14:39
Related ArticlesRemote leptomeningeal dissemination in olfactory neuroblastoma mimicking multiple parasagittal meningiomas: a diagnostic and therapeutic challenge. World Neurosurg. 2019 Nov 14;: Authors: Martinez-Perez R, Hardesty D, Palmer J, Zachariah M, Otto B, Carrau R, Prevedello D Abstract BACKGROUND: Olfactory neuroblastoma (ON) is a highly aggressive and locally recurrent neoplasm. Distant systemic metastases are not uncommon, but remote leptomeningeal...
Mon Nov 18, 2019 14:39
Related ArticlesEffect of obturators on facial form following surgery for head and neck cancer and impact on the perception of appearance. J Dent. 2019 Nov 14;:103230 Authors: Coward TJ, Richards R, Fenlon MR, Scott BJJ Abstract OBJECTIVES: To describe the correlation between changes in the surface area and depth of the face in individuals wearing an obturator compared with it not being in place, and self-reported Quality of Life in relation to appearance....
Mon Nov 18, 2019 14:39
Related ArticlesCorrigendum to "Subtle Eyelid Retraction after Lower Blepharoplasty" [Journal of Plastic, Reconstructive & Aesthetic Surgery, 72 (10), 2019, 1682-1687]. J Plast Reconstr Aesthet Surg. 2019 Nov 13;: Authors: Harounian J, Wulc AE, Brackup AB, Ramesh S PMID: 31734234 [PubMed - as supplied by publisher]
Mon Nov 18, 2019 14:39
Related ArticlesSclerotherapy for lymphatic malformations of head and neck: Systematic review and meta-analysis. J Vasc Surg Venous Lymphat Disord. 2019 Nov 13;: Authors: De Maria L, De Sanctis P, Balakrishnan K, Tollefson M, Brinjikji W Abstract BACKGROUND: Percutaneous sclerotherapy is a commonly used modality for treatment of lymphatic malformations (LMs) of the head, face, and neck. The safety and efficacy of sclerotherapy with various agents for...
Mon Nov 18, 2019 14:39
Related ArticlesImage-guided surgery of head and neck carcinoma in rabbit models by intra-operatively defining tumour-infiltrated margins and metastatic lymph nodes. EBioMedicine. 2019 Nov 13;: Authors: Sun P, Zhang Y, Li K, Wang C, Zeng F, Zhu J, Wu Y, Tao X Abstract BACKGROUND: The infiltrative nature and lymphatic metastasis of head and neck squamous cell carcinoma (HNSCC) are the main reasons leading to its poor prognosis. METHODS: A multimodal...
Mon Nov 18, 2019 14:39
Related ArticlesTreatment Outcomes of Arytenoid Dislocation by Closed Reduction: A Multidimensional Evaluation. J Voice. 2019 Nov 13;: Authors: Wu X, Mao W, Zhang J, Wei C Abstract OBJECTIVE: This study aimed to investigate the treatment outcomes of arytenoid dislocation by a multidimensional evaluation. METHODS: From April 2010 to May 2018, the records of 57 patients with a history of arytenoid dislocation were reviewed. All the patients were...
Mon Nov 18, 2019 14:39
Related ArticlesThe clinical characteristics of patients with an isolate epiglottic collapse. Auris Nasus Larynx. 2019 Nov 13;: Authors: Sung CM, Kim HC, Yang HC Abstract OBJECTIVE: We analyzed the clinical characteristics of patients with isolated epiglottic collapse (IEC) who had an epiglottic anteroposterior (AP) collapse as the only cause of snoring during drug-induced sleep endoscopy (DISE). METHODS: A retrospective analysis of 334 consecutive...
Mon Nov 18, 2019 14:39
Related ArticlesAn update on autoimmune inner ear disease: A systematic review of pharmacotherapy. Am J Otolaryngol. 2019 Oct 28;:102310 Authors: Strum D, Kim S, Shim T, Monfared A PMID: 31733712 [PubMed - as supplied by publisher]
Mon Nov 18, 2019 14:39
Related ArticlesThe impact of thyroid diseases starting from birth on reproductive function. Hormones (Athens). 2019 Nov 16;: Authors: Krassas GE, Markou KB Abstract The aim of this review is to provide relevant information regarding the impact of thyroid disease, starting from birth and mainly concerning hyperthyroidism and hypothyroidism, on reproduction. Hyperthyroidism occurs much less commonly in children than hypothyroidism, with Graves' disease...
Mon Nov 18, 2019 15:11
Abstract NAD kinase is a crucial enzyme for production of NADP+. Myxococcus xanthus is a gram-negative soil bacterium that forms fruiting bodies and spores under starvation, and it accumulates polyphosphate (poly(P)) during early development. We found that M. xanthus NAD kinase (PanK) utilized both ATP and poly(P) as phosphoryl donors; therefore, PanK was designated as a poly(P)/ATP-NAD kinase. Unlike other poly(P)/ATP-NAD kinases, PanK hardly exhibited NADH kinase activity. The...
Mon Nov 18, 2019 02:00
Related ArticlesGenetic factors in isolated and syndromic laryngeal cleft. Paediatr Respir Rev. 2019 Oct 08;: Authors: Li Y, Rui X, Li N Abstract A laryngotracheoesophageal cleft (LC) is a rare congenital anomaly of the upper aerodigestive tract resulting from the absence of fusion of the posterior cricoid lamina, which affects an abnormal communication between the larynx, trachea and esophagus. The genetic etiology of LC remains elusive. The involvement...
Mon Nov 18, 2019 18:53
Abstract Purpose Practice patterns vary for adjuvant treatment of 1p/19q-codeleted oligodendroglioma patients. This study evaluates the outcomes of adjuvant (aRT) versus salvage radiation therapy (sRT) in a multi-institutional cohort. Methods Oligodendroglioma patients with confirmed 1p/19q codeletion who were treated with RT with or without chemotherapy...
Mon Nov 18, 2019 02:00
Namrata S Rao, Abhilash Chandra, Kiran Preet MalhotraThyroid Research and Practice 2019 16(3):121-127 Background: Several cases of complete or partially reversible renal failure have been reported in association with severe hypothyroidism, which have responded to thyroxine replacement. However, its risk factors, pathology, pathophysiology, and time of recovery remain unclear. Aim: We report our experience with 31 cases of renal failure in association with severe hypothyroidism, from a goiter-endemic...
Mon Nov 18, 2019 00:00
Mahmood Dhahir Al-MendalawiThyroid Research and Practice 2019 16(3):144-144
Mon Nov 18, 2019 00:00
Nermin Ahmed Sheriba, Maram Mohamed Mahdy, Rana Hashem Ibrahim Elattary, Maha Mohamed El-NabarawyThyroid Research and Practice 2019 16(3):95-99 Background: Thyroid nodules are a common clinical problem. The prevalence of malignancy in thyroid nodules is currently about 5%–15%. Fine-needle aspiration biopsy (FNAB) has improved the preoperative prediction of malignancy, but still has disadvantages including operator variability and nondiagnostic reports. Midkine (MK) is a novel heparin-binding...
Mon Nov 18, 2019 00:00
Subhash Yadav, Rajiv Kumar, Munita Bal, Asawari PatilThyroid Research and Practice 2019 16(3):137-139 It is a rare event to find squamous cells in the thyroid gland. Squamous metaplasia (SM) of the thyroid follicular epithelium is one of such conditions. SM can occur in association with nonneoplastic as well as neoplastic thyroid lesions. Here, we report a case of papillary carcinoma of the thyroid in a 26-year-old female showing extensive SM. On immunohistochemistry, squamous as well as papillary...
Mon Nov 18, 2019 00:00
Honnegowda Thittamaranahalli Muguregowda, G Krishna, KG PrakashThyroid Research and Practice 2019 16(3):100-104 Background: The thyroid gland, a highly vascular endocrine gland, is composed of two lateral lobes connected by isthmus. A wide range of morphological alterations of the thyroid gland such as hypoplasia, ectopy to hemiagenesis, and genesis are common because of disturbed embryogenesis. The significance of diagnosing such extensions of the thyroid gland is crucial. It may alter the normal...
Mon Nov 18, 2019 00:00
Sanjay KalraThyroid Research and Practice 2019 16(3):93-94
Mon Nov 18, 2019 00:00
Archana S Bhat, Lisa Varma, Hilda Fernandes, CS JayaprakashThyroid Research and Practice 2019 16(3):105-107 Introduction: It is well known that nuclear grooves play a major role in the diagnosis of papillary carcinoma thyroid (PCT). Furthermore, grooves are found in many nonneoplastic lesions of thyroid. Aims: The aim of this study is to calculate the percentage of nuclear grooves in histopathologically proven cases of papillary carcinoma and nonneoplastic lesions (Hashimoto's thyroiditis...
Mon Nov 18, 2019 00:00
Joseph Antoine Flordelis Chatto, Annette Laurente SalillasThyroid Research and Practice 2019 16(3):128-136 Papillary thyroid caarcinoma (PTC) is the most common thyroid and endocrine malignancy. Although considered to be indolent, aggressive variants have been identified, including the Tall Cell (TCV), Columnar Cell (CCV), Hobnail (HPTC) and Solid Variants (SVPTC). The objective of this study is to pre-operatively recognize the cytologic features of these variants. Four cases with final diagnoses...
Mon Nov 18, 2019 00:00
Md Abu Jar Gaffar, A B. M. Kamrul-Hasan, Afsar Ahammed, Muhammad Abul Hasanat, Md FariduddinThyroid Research and Practice 2019 16(3):108-112 Context: An increase in occurrence of Graves' disease (GD) has been reported in many countries after the introduction of the salt iodization program. Aims: To observe iodine nutrition status in GD. Settings and Design: Cross-sectional observational study conducted in the Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka,...
Mon Nov 18, 2019 00:00
Veer Karuna, Priya Gupta, Mamta Gupta, Kriti GroverThyroid Research and Practice 2019 16(3):140-143 Few benign and malignant tumors of thyroid lesion share many histological features, including papillary and trabecular pattern, hyalinized stroma, calcification, nuclear grooving, and nuclear inclusion. The lesions those have these common features are hyalinizing trabecular tumor, papillary thyroid carcinoma, medullary carcinoma, paraganglioma, trabecular follicular adenoma (TFA), and poorly differentiated...
Mon Nov 18, 2019 00:00
Arvind Mishra, Rohin Saini, Madhukar Mittal, Dandu Himanshu, Kamlesh Kumar Gupta, Abbas Ali MahdiThyroid Research and Practice 2019 16(3):113-120 Introduction and Objectives: Thyroid hormone changes in critically ill patients are commonly observed phenomenon. This is known as sick euthyroid syndrome. Sequential organ faillure assessment (SOFA) score is used to track and determine the extent of a person's organ function or its rate of failure. We performed a prospective observation study to analyze...
Mon Nov 18, 2019 00:00
Aparajita Roy, Rahul Gupta, Anshita Aggarwal, Bindu KulshreshthaThyroid Research and Practice 2019 16(3):145-146
Mon Nov 18, 2019 00:00
Northern and southern muriquis group into two different genetic clusters separated by roughly 2.0 million years ago. Abstract The taxonomy of muriquis, the largest extant primates in the New World, is controversial. While some specialists argue for a monotypic genus (Brachyteles arachnoides), others favor a two‐species classification, splitting northern muriquis (Brachyteles hypoxanthus) from southern muriquis (B. arachnoides). This uncertainty affects how we study the differences between these...
Sun Nov 17, 2019 18:49
Opinion statement The optimal management of advanced stage BRAF-mutated melanoma is widely debated and complicated by the availability of several different regimens that significantly improve outcomes but have not been directly compared. While there are many unanswered questions relevant to this patient population, the major uncertainty in current practice is the choice between BRAF/MEK inhibitors or immunotherapy for those with previously untreated metastatic or high-risk disease....
Mon Nov 18, 2019 02:00
Background and Objectives Actinic keratoses (AK) are common pre‐cancerous lesions, which are associated with ultraviolet light exposure and aging. Wounding therapies such as fractionated laser resurfacing (FLR) have been previously demonstrated to effectively treat facial AK. However, the effectiveness of FLR on other sites commonly afflicted with AK has not been studied in detail. Previously, our group has reported that treatment of aged skin with wounding therapies including dermabrasion and ablative...
Sun Nov 17, 2019 18:33
Background and Objectives To investigate the effects of percutaneous interstitial Nd:YAG laser irradiation on the apocrine glands and molecules involved in odor production (apolipoprotein [ApoD], androgen receptor [AR]) in the subcutaneous tissue of a pig. Study Design/Materials and Methods Skin on the back of healthy adult miniature pigs was exposed to pulsed Nd:YAG laser irradiation at 5 or 10 W, or continuous Nd:YAG laser irradiation at 10 W. Samples were taken 1 hour, 1 week, and 1 month...
Sun Nov 17, 2019 18:29
A new species of the genus Mesacanthion Filipjev, 1927 was discovered during a survey of natural beaches of Jeju Island in South Korea. The new species Mesacanthion jejuensis sp. nov. shares general morphology of the genus such as the outer labial and cephalic setae being situated at the middle of cephalic capsule, well-developed mandibles with two columns united by a curved bar, and three equally sized and shaped teeth shorter than the mandibles. The new species belongs to a group of Mesacanthion...
Mon Nov 18, 2019 02:00
Despite continuous improvements, our knowledge of the palaeoneurology of sauropod dinosaurs is still deficient. This holds true even for Titanosauria, which is a particularly speciose clade of sauropods with representatives known from numerous Cretaceous sites in many countries on all continents. The data currently available regarding the palaeoneurology of titanosaurs is strongly biased towards Gondwanan forms (Argentina above all, but also India, Malawi and Australia). In contrast, the palaeoneurology...
Mon Nov 18, 2019 02:00
Microbial symbionts can play critical roles when their host attempts to colonize a new habitat. The lack of symbiont adaptation can in fact hinder the invasion process of their host. This scenario could change if the exotic species are able to acquire microorganisms from the invaded environment. Understanding the ecological factors that influence the take-up of new microorganisms is thus essential to clarify the mechanisms behind biological invasions. In this study, we tested whether different forest...
Mon Nov 18, 2019 02:00
Phytophthora hibernalis, the causal agent of brown rot of citrus fruit, is an important worldwide pathogen and a quarantine pest in China. Current diagnosis of the disease relies on disease symptoms, pathogen isolation and identification by DNA sequencing. However, symptoms caused by P. hibernalis can be confused with those by other Phytophthora and fungal species. Moreover, pathogen isolation, PCR amplification and sequencing are time-consuming. In this study, a rapid assay including 20-min recombinase...
Mon Nov 18, 2019 02:00
To conserve energy in times of limited resource availability, particularly during cold winters, hibernators suppress even the most basic of physiologic processes. Breathing rates decrease from 40 breaths/minute to less than 1 breath/min as they decrease body temperature from 37 °C to ambient. Nevertheless, after months of hibernation, these incredible mammals emerge from torpor unscathed. This study was conducted to better understand the protective and possibly anti-inflammatory adaptations that...
Mon Nov 18, 2019 02:00
Host dietary specialization and neutral assembly shape gut bacterial communities of wild dragonflies
Host-associated gut microbiota can have significant impacts on host ecology and evolution and are often host-specific. Multiple factors can contribute to such host-specificity: (1) host dietary specialization passively determining microbial colonization, (2) hosts selecting for specific diet-acquired microbiota, or (3) a combination of both. The latter possibilities indicate a functional association and should produce stable microbiota. We tested these alternatives by analyzing the gut bacterial...
Mon Nov 18, 2019 02:00
Abstract Purpose of Review Hematopoietic cell transplantation (HCT) is an established curative treatment for children with primary immunodeficiencies. This article reviews the latest developments in conditioning regimens for primary immunodeficiency (PID). It focuses on data regarding transplant outcomes according to newer reduced toxicity conditioning regimens used in HCT for PID. ...
Mon Nov 18, 2019 02:00
Epithelial ovarian cancer is the most common and leading cause of death for gynaecologic cancer in the western world. Current standard treatments with limited selection of chemotherapies cannot meet patients’ urgent needs. Novel targeted therapies may improve patients’ survival rate with less side effects that have been demonstrated by using approved medicines such as poly ADP-ribose polymerase and angiogenesis inhibitors. Many classes of targeted therapies impacting cell signalling pathways related...
Fri Nov 15, 2019 02:00
Although giant cell tumor of bone has been considered as a disease with benign course, it can lead to bone destruction and serious morbidity. A 19-year-old case was presented with hip pain. There was a recurrence after 9 months of curative surgical resection and zoledronic acid use, and as surgical morbidity would be high, antiosteoclastic receptor activator of nuclear factor kappa B ligand inhibitor denosumab treatment was administered. She had a complete remission after 18 months of denosumab treatment....
Fri Nov 15, 2019 02:00
Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78
Objective Human colorectal cancer (CRC), a highly malignant and metastatic carcinoma, is resistant to many present anticancer therapies. The inhibition of tumor survival and growth through receptor suppression is a promising way to treat CRC. The study aimed to investigate the effect of a natural plant triterpenoid, berberine (BBR), on SW480 cells and whether its role is mediated by Glucose-regulated protein 78 (GRP78). Methods MTT assay, wound healing assay, and Annexin V-FITC assay were...
Fri Nov 15, 2019 02:00
Esophageal cancer has recent shown a higher incidence but lower 5-year survival rate after normal clinical treatment in China. The aim of this study was to observe whether the inhibition of miR-196a affects esophageal cancer cell growth by modulating the nuclear factor-κB target gene and to detect the possible cooperative therapeutic effects on esophageal cancer by knocking down miR-196a expression combined with the specific inhibitor of nuclear factor-κB target genes. Thus, anti-miR-196a or sotrastaurin,...
Fri Nov 15, 2019 02:00
Trauma requiring neurosurgical intervention in the obstetric population is rare. Provision of care must include consideration for both maternal and fetal well-being, and conflicts may arise. Management strategies to reduce elevated maternal intracranial pressure (ICP) and provide adequate surgical exposure, for example, may compromise uteroplacental perfusion. There is scarce literature to guide anesthetic care and few resources summarizing management of these uncommon cases. We conducted a systematic...
Thu Nov 14, 2019 02:00
We studied effectiveness of the AS04‐adjuvanted HPV‐16/18 (AS04‐HPV‐16/18) vaccine against human papillomavirus (HPV) oropharyngeal infections associated with the increase of head/neck cancers in western countries. All 38631 resident adolescents from 1994‐95 birth cohorts of 33 Finnish communities were invited in this community‐randomized trial (NCT00534638). During 2008‐2009, 11275 girls and 6129 boys were enrolled in 3 arms of 11 communities each. In Arm A, 90% of vaccinated girls/boys, and in...
Sun Nov 17, 2019 16:24
Objective: Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type of the thyroid gland is a rare indolent malignant disease encountered in approximately 0.5% of patients with Hashimoto thyroiditis (HT). The purpose of the present systematic review was to accumulate the current evidence in the field. Study Design: We searched the Medline, Scopus, EMBASE, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials CENTRAL databases from inception to May...
Mon Nov 18, 2019 09:48
This systematic review was conducted to inform the Canadian Task Force on Preventive Health Care recommendations on screening for thyroid dysfunction (TD). The review sought to answer key questions on the bene...
Mon Nov 18, 2019 02:00
Background: The aim of this study was to evaluate endolymphatic hydrops using the 3T temporal bone magnetic resonance imaging (MRI), performed according to the chosen protocol, and determine whether it could be applied as an objective diagnostic tool for Menière's disease. Methods: 105 participants diagnosed with probable (n = 50) and definite (n = 55) Menière's disease were included in this prospective study at Vilnius University Hospital, Santaros Clinics. Audiometry, vestibular function...
Fri Nov 15, 2019 02:00
Hypothesis/Objective: Determine variables associated with electrode impedance fluctuations and loss of residual hearing in cochlear implant (CI) recipients. Background: CI recipients with postoperative hearing preservation demonstrate superior speech perception with an electric-acoustic stimulation (EAS) device as compared with a CI-alone device. Maintaining superior speech perception over time relies on long-term hearing preservation; therefore, understanding variables that may contribute...
Fri Nov 15, 2019 02:00
Objectives: To compare patients surgically managed for spontaneous cerebrospinal fluid (CSF) leaks of the temporal bone arising from the middle cranial fossa (MCF) and posterior cranial fossa (PCF) and to describe the surgical management of posterior fossa CSF leaks. Study Design: Retrospective case review. Setting: Academic tertiary center. Patients: Adult patients presenting with spontaneous temporal bone CSF leaks undergoing operative repair between January 2010 and August 2018....
Fri Nov 15, 2019 02:00
Objective: Evaluate the incidence of and potential contributory factors to facial nerve paresis and other cranial neuropathies (CN) following stereotactic radiosurgery with Gamma Knife (GK) for primary treatment of vestibular schwannoma (VS). Study Design: Retrospective chart review. Setting: Tertiary referral center. Patients: Charts were reviewed for all adult patients receiving primary GK treatment for unilateral VS between 2005 and 2013. Patients with NF2 or previous surgery...
Fri Nov 15, 2019 02:00
Objective: To evaluate the efficacy of cognitive and/or behavioral therapies in improving health-related quality of life (HRQOL), depression, and anxiety associated with tinnitus. Data Sources: EMBASE, MEDLINE, PubMed, PsycINFO, and the Cochrane Registry were used to identify English studies from database inception until February 2018. Study Selection: Randomized controlled trials (RCTs) comparing cognitive and/or behavioral therapies to one another or to waitlist controls for the treatment...
Fri Nov 15, 2019 02:00
Objective: To determine the association between geriatric age and postoperative healthcare utilization after cochlear implantation. Study Design: Retrospective chart review. Setting: Tertiary referral center. Patients: : Older adults (>59 yr) who underwent unilateral cochlear implantation from 2009 until 2016. Intervention(s): : Standard electrode length cochlear implantation. Main Outcome Measure(s): : Postoperative surgical and audiological visit rate after cochlear...
Fri Nov 15, 2019 02:00
Hypothesis: Surgical manipulations during laser stapedotomy can produce intracochlear pressure changes comparable to pressures created by high-intensity acoustic stimuli. Background: New-onset sensorineural hearing loss is a known risk of stapes surgery and may result from pressure changes from laser use or other surgical manipulations. Here, we test the hypothesis that high sound pressure levels are generated in the cochlea during laser stapedotomy. Methods: Human cadaveric heads underwent...
Fri Nov 15, 2019 02:00
The relationship between Menière's disease and endolymphatic hydrops is ambiguous. On the one hand, the existence of cases of endolymphatic hydrops lacking the classic symptoms of Menière's disease has prompted the assertion that endolymphatic hydrops alone is insufficient to cause symptoms and drives the hypothesis that endolymphatic hydrops is a mere epiphenomenon. Yet, on the other hand, there is considerable evidence suggesting a relationship between the mechanical pressure effects of endolymphatic...
Fri Nov 15, 2019 02:00
Objectives: Indication and implantation of active middle ear implants (AMEI) are well established. Choice of the coupling site depends from the individual anatomical situation. Long-term stability of different coupling sites in terms of functional outcome and complications are rare and were investigated in this study. Design: Retrospective analysis of 41 consecutive patients (45 ears) with coupling of the AMEI at the incus, stapes, and round window. Analysis of preoperative, postoperative,...
Fri Nov 15, 2019 02:00
Hypothesis: Three-dimensional (3D)-printed microneedles can create precise holes on the scale of micrometers in the human round window membrane (HRWM). Background: An intact round window membrane is a barrier to delivery of therapeutic and diagnostic agents into the inner ear. Microperforation of the guinea pig round window membrane has been shown to overcome this barrier by enhancing diffusion 35-fold. In humans, the challenge is to design a microneedle that can precisely perforate the thicker...
Fri Nov 15, 2019 02:00
Hypothesis: Local administration of the calcium-channel blocker (CCB), diltiazem, via intratympanic (IT) chitosan-glycerophosphate (CGP) hydrogel will protect against cisplatin-induced ototoxicity. Background: Cisplatin induces calcium-mediated apoptosis of cochlear outer hair cells (OHCs). Previous work demonstrated otoprotection and reduced auditory brainstem response (ABR) threshold shifts in a cisplatin-induced ototoxicity mouse model treated with multiple doses of IT diltiazem given...
Fri Nov 15, 2019 02:00
Objective: Balloon Eustachian tuboplasty (BET) appears to be a promising therapeutic option for Eustachian tube dysfunction. However, data are lacking on its effect in adults with chronic otitis media with effusion (COME) and whether it should be combined with tympanocentesis. The aim of our study was to determine if there is a beneficial effect of BET combined with tympanocentesis compared with BET only and provide data on the effect of BET in adults with COME. Study Design: Randomized clinical...
Fri Nov 15, 2019 02:00
Objective: To describe the possible diagnostic role of video-head impulse test (vHIT) in patients presenting with positional downbeat nystagmus (PDN) due to benign paroxysmal positional vertigo (BPPV) involving the anterior canal (AC) or the non-ampullary arm of the posterior canal (PC). Patients: Three patients presenting with positional vertigo, PDN, symmetrical cervical and ocular vestibular-evoked myogenic potentials, and selective deficit of the vestibulo-ocular reflex (VOR) gain for...
Fri Nov 15, 2019 02:00
Objective: Describe the first case of cochlear implantation (CI) for auditory rehabilitation of a patient with craniometaphyseal dysplasia (CMD) and progressive mixed hearing loss. Patients: A 65-year-old woman with known autosomal dominant CMD presented with progressive mixed hearing loss and declining benefit from conventional hearing aids. Computed tomography and magnetic resonance imaging revealed hyperostosis of the entire craniofacial skeleton. Hearing evaluation demonstrated pure-tone...
Fri Nov 15, 2019 02:00
Objectives: Describe audiologic outcomes in hearing preservation cochlear implantation (CI) using a precurved electrode array inserted using an external sheath and evaluate association of electrode positioning and preservation of residual hearing. Study Design: Retrospective review. Setting: Tertiary otologic center. Patients: Twenty-four adult patients who underwent hearing preservation CI with precurved electrode array. Interventions: CI, intraoperative computed tomography...
Fri Nov 15, 2019 02:00
The presence of increased tumor-infiltrating lymphocytes (TILs) is established as a positive prognostic factor in many malignancies including colorectal carcinoma (CRC). However, multiple different approaches have been used to assess TILs. In 2014, the International TILs Working Group (ITWG) proposed a standardized methodology for evaluating TILs, initially in the context of breast cancer, but subsequently expanded to other malignancies. To date, the efficacy of the ITWG system has not been investigated...
Thu Nov 14, 2019 02:00
The prevalence and prognostic value of human papillomavirus (HPV) infection and epidermal growth factor receptor (EGFR) alteration in sinonasal squamous cell carcinoma (SNSCC) are not known. The reliability of p16 overexpression as a surrogate for HPV infection in SNSCC is also unclear. We investigated the prognostic and diagnostic significances of HPV infection, EGFR alteration, and p16 expression in SNSCC. We analyzed high-risk HPV infection by HPV-RNA in situ hybridization and EGFR gene copy number...
Thu Nov 14, 2019 02:00
Sinonasal inverted papillomas (IPs) commonly recur, and transform to malignancy in 5% to 10% of patients. It has long been debated whether IPs are caused by high-risk or low-risk (lr) human papillomavirus (HPV) and whether the HPV is transcriptionally active. EGFR mutations have also been recently implicated in the pathogenesis of IP with an unclear relationship to HPV status. IP cases over a 10-year period were tested for p16 by immunohistochemistry and for transcriptionally active hrHPV and lrHPV...
Thu Nov 14, 2019 02:00
The accurate recognition of subtle melanomas and their distinction from benign mimics is an oft-recurring diagnostic problem, critical for patient management. Melanomas that bear resemblance to benign nevi (so-called nevoid melanomas, NMs) and benign mitotically active nevi in pregnancy (MANP) are 2 lesions particularly prone to error. Molecular data, including analysis of noncoding regions, in MANP and NM are very limited. This study sought to identify differences in clinical, pathologic, and molecular...
Thu Nov 14, 2019 02:00
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