Integration of PET-imaging into radiotherapy treatment planning for low-grade meningiomas improves outcome

Abstract Purpose Meningiomas have an excellent survival prognosis, and radiotherapy (RT) is a central component of interdisciplinary treatment. During treatment planning, the definition of the target volume remains challenging using MR and CT imaging alone. This is the first study to analyze the impact of additional PET-imaging on local control (LC) and overall survival (OS) after high-precision RT. ...

European Journal of Nuclear Medicine and Molecular Imaging

Fri Nov 22, 2019 02:00

Prognostic significance of semi-quantitative FDG-PET parameters in stage I non-small cell lung cancer treated with carbon-ion radiotherapy

Abstract Purpose Prognostic significance of volumetric 18F-fluorodeoxyglucose (FDG) positron emission tomography/computer tomography (PET/CT) parameters in carbon-ion radiotherapy (C-ion RT) treated stage I non-small cell lung cancer, and need of histology-wise separate cut-off values for risk stratification were assessed. Methods Thirty-nine patients (29...

European Journal of Nuclear Medicine and Molecular Imaging

Fri Nov 22, 2019 02:00

225 Ac-PSMA-617/ 177 Lu-PSMA-617 tandem therapy of metastatic castration-resistant prostate cancer: pilot experience

Abstract Purpose Up to 30% of patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC) never respond or develop resistance to 177Lu-labeled PSMA-targeted radioligand monotherapy. Single-agent PSMA-targeted radioligand therapy (PRLT) with the alpha-emitter 225Ac showed promise against mCRPC but may cause severe and/or persistent xerostomia, which may substantially impair patients’...

European Journal of Nuclear Medicine and Molecular Imaging

Fri Nov 22, 2019 02:00

Prediction of the Depth of Tumor Invasion in Gastric Cancer: Potential Role of CT Radiomics

Publication date: Available online 22 November 2019Source: Academic RadiologyAuthor(s): Yue Wang, Wei Liu, Yang Yu, Jing-Juan Liu, Lin Jiang, Hua-Dan Xue, Jing Lei, ZhengYu Jin, Jian-Chun YuRationale and ObjectivesThe aim of this study was to investigate the value of computed tomography (CT) radiomics for the differentiation between T2 and T3/4 stage lesions in gastric cancer.Materials and methodsA total of 244 consecutive patients with pathologically proven gastric cancer were retrospectively included...

Academic Radiology

Fri Nov 22, 2019 17:46

Improvising at rest: Differentiating jazz and classical music training with resting state functional connectivity

Publication date: Available online 21 November 2019Source: NeuroImageAuthor(s): Alexander Belden, Tima Zeng, Emily Przysinda, Sheeba Arnold Anteraper, Susan Whitfield-Gabrieli, Psyche LouiAbstractJazz improvisation offers a model for creative cognition, as it involves the real-time creation of a novel, information-rich product. Previous research has shown that when musicians improvise, they recruit regions in the Default Mode Network (DMN) and Executive Control Network (ECN). Here, we ask whether...

NeuroImage

Fri Nov 22, 2019 16:37

QSMGAN: Improved Quantitative Susceptibility Mapping using 3D Generative Adversarial Networks with increased receptive field

Publication date: Available online 21 November 2019Source: NeuroImageAuthor(s): Yicheng Chen, Angela Jakary, Sivakami Avadiappan, Christopher P. Hess, Janine M. LupoAbstractQuantitative susceptibility mapping (QSM) is a powerful MRI technique that has shown great potential in quantifying tissue susceptibility in numerous neurological disorders. However, the intrinsic ill-posed dipole inversion problem greatly affects the accuracy of the susceptibility map. We propose QSMGAN: a 3D deep convolutional...

NeuroImage

Fri Nov 22, 2019 16:37