IJMS, Vol. 20, Pages 5469: Problems Associated with Deprescribing of Proton Pump Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms20215469 Authors: Helgadottir Bjornsson Proton pump inhibitors (PPIs) are recommended as a first-line treatment for gastroesophageal reflux disease (GERD) and other acid related disorders. In recent years, concerns have been raised about the increasing prevalence of patients on long-term PPI therapy and inappropriate PPI use. It...
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IJMS, Vol. 20, Pages 5468: Biodistribution of Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Radiation Injury Bone Marrow Murine Model International Journal of Molecular Sciences doi: 10.3390/ijms20215468 Authors: Sicheng Wen Mark Dooner Elaine Papa Michael Del Tatto Mandy Pereira Theodor Borgovan Yan Cheng Laura Goldberg Olin Liang Giovanni Camussi Peter Quesenberry We have previously shown that injury induced by irradiation to murine marrow...
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IJMS, Vol. 20, Pages 5467: Immunomodulatory Effects of MSCs in Bone Healing International Journal of Molecular Sciences doi: 10.3390/ijms20215467 Authors: Dalia Medhat Clara I. Rodríguez Arantza Infante Mesenchymal stem cells (MSCs) are capable of differentiating into multilineage cells, thus making them a significant prospect as a cell source for regenerative therapy; however, the differentiation capacity of MSCs into osteoblasts seems to not be the main mechanism responsible...
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IJMS, Vol. 20, Pages 5466: Small RNA Sequencing Reveals Regulatory Roles of MicroRNAs in the Development of Meloidogyne incognita International Journal of Molecular Sciences doi: 10.3390/ijms20215466 Authors: Huawei Liu Robert L. Nichols Li Qiu Runrun Sun Baohong Zhang Xiaoping Pan MicroRNAs (miRNAs) are an extensive class of small regulatory RNAs. Knowing the specific expression and functions of miRNAs during root-knot nematode (RKN) (Meloidogyne incognita) development...
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IJMS, Vol. 20, Pages 5465: Cell Wall Modifications in Giant Cells Induced by the Plant Parasitic Nematode Meloidogyne incognita in Wild-Type (Col-0) and the fra2 Arabidopsis thaliana Katanin Mutant International Journal of Molecular Sciences doi: 10.3390/ijms20215465 Authors: Christianna Meidani Nikoletta G. Ntalli Eleni Giannoutsou Ioannis-Dimosthenis S. Adamakis Meloidogyne incognita is a root knot nematode (RKN) species which is among the most notoriously unmanageable crop...
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IJMS, Vol. 20, Pages 5464: Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms International Journal of Molecular Sciences doi: 10.3390/ijms20215464 Authors: Bergthor Traustason Matthew Cheeks Duygu Dikicioglu Chinese hamster ovary (CHO) cells are used for the production of the majority of biopharmaceutical drugs, and thus have remained the standard industry host for the past three decades....
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IJMS, Vol. 20, Pages 5463: Unravelling the Regions of Mutant F508del-CFTR More Susceptible to the Action of Four Cystic Fibrosis Correctors International Journal of Molecular Sciences doi: 10.3390/ijms20215463 Authors: Amico Brandas Moran Baroni Cystic fibrosis (CF) is a genetic disease associated with the defective function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that causes obstructive disease and chronic bacterial infections in airway...
Fri Nov 01, 2019 02:00
IJMS, Vol. 20, Pages 5461: Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis International Journal of Molecular Sciences doi: 10.3390/ijms20215461 Authors: Martina Mihalj Maro Bujak Josip Butković Željko Zubčić Maja Tolušić Levak Josip Čes Vlatko Kopić Mirela Baus Lončar Hrvoje Mihalj Trefoil family factor (TFF) proteins contribute to antimicrobial defense and the maintenance of sinonasal epithelial...
Fri Nov 01, 2019 02:00
IJMS, Vol. 20, Pages 5462: Involvement of Receptor for Advanced Glycation Endproducts in Hypertensive Disorders of Pregnancy International Journal of Molecular Sciences doi: 10.3390/ijms20215462 Authors: Akasaka Naruse Sado Uchiyama Makino Yamauchi Ota Sakuramoto-Tsuchida Itaya-Hironaka Takasawa Kobayashi Preeclampsia/hypertensive disorders of pregnancy (PE/HDP) is a serious and potentially life-threatening disease. Recently, PE/HDP has been considered...
Fri Nov 01, 2019 02:00
IJMS, Vol. 20, Pages 5459: Monocytic Myeloid Derived Suppressor Cells in Hematological Malignancies International Journal of Molecular Sciences doi: 10.3390/ijms20215459 Authors: Palumbo Parrinello Giallongo D’Amico Zanghì Puglisi Conticello Chiarenza Tibullo Raimondo Romano In the era of novel agents and immunotherapies in solid and liquid tumors, there is an emerging need to understand the cross-talk between the neoplastic cells, the host immune...
Fri Nov 01, 2019 02:00
IJMS, Vol. 20, Pages 5458: Targeted Delivery Prodigiosin to Choriocarcinoma by Peptide-Guided Dendrigraft Poly-l-lysines Nanoparticles International Journal of Molecular Sciences doi: 10.3390/ijms20215458 Authors: Kai Zhao Dan Li Guogang Cheng Baozhen Zhang Jinyu Han Jie Chen Baobei Wang Mengxia Li Tianxia Xiao Jian Zhang Dongpo Zhou Zheng Jin Xiujun Fan The available and effective therapeutic means to treat choriocarcinoma is seriously lacking, mainly...
Fri Nov 01, 2019 02:00
IJMS, Vol. 20, Pages 5460: Sequence and Structure Properties Uncover the Natural Classification of Protein Complexes Formed by Intrinsically Disordered Proteins via Mutual Synergistic Folding International Journal of Molecular Sciences doi: 10.3390/ijms20215460 Authors: Bálint Mészáros László Dobson Erzsébet Fichó István Simon Intrinsically disordered proteins mediate crucial biological functions through their interactions with other proteins. Mutual synergistic folding (MSF)...
Fri Nov 01, 2019 02:00
IJMS, Vol. 20, Pages 5457: Identifying Metabolic Perturbations and Toxic Effects of Rac-Metalaxyl and Metalaxyl-M in Mice Using Integrative NMR and UPLC-MS/MS Based Metabolomics International Journal of Molecular Sciences doi: 10.3390/ijms20215457 Authors: Ping Zhang Sheng Wang Yuhan He Yangyang Xu Dongmei Shi Furong Yang Weizhong Yu Wentao Zhu Lin He Although metabolic perturbations are sensitive indicators for low-dose toxic effects, the metabolic mechanisms...
Fri Nov 01, 2019 02:00
IJMS, Vol. 20, Pages 5456: NtMYB3, an R2R3-MYB from Narcissus, Regulates Flavonoid Biosynthesis International Journal of Molecular Sciences doi: 10.3390/ijms20215456 Authors: Muhammad Anwar Weijun Yu Hong Yao Ping Zhou Andrew C. Allan Lihui Zeng R2R3-MYB transcription factors play important roles in the regulation of plant flavonoid metabolites. In the current study, NtMYB3, a novel R2R3-MYB transcriptional factor isolated from Chinese narcissus (Narcissus tazetta L. var....
Fri Nov 01, 2019 02:00
IJMS, Vol. 20, Pages 5455: Targeting DNA Damage Response as a Strategy to Treat HPV Infections International Journal of Molecular Sciences doi: 10.3390/ijms20215455 Authors: N. Sanjib Banerjee Dianne Moore Cameron J. Parker Thomas R. Broker Louise T. Chow Mucosotropic human papillomaviruses (HPVs) cause prevalent anogenital infections, some of which can progress to cancers. It is imperative to identify efficacious drug candidates, as there are few therapeutic options. We...
Fri Nov 01, 2019 02:00
IJMS, Vol. 20, Pages 5454: The Roles of MicroRNAs (miRNAs) in Avian Response to Viral Infection and Pathogenesis of Avian Immunosuppressive Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20215454 Authors: Linyi Zhou Shijun J. Zheng MicroRNAs (miRNAs) are a class of non-coding small RNAs that play important roles in the regulation of various biological processes including cell development and differentiation, apoptosis, tumorigenesis, immunoregulation and viral...
Fri Nov 01, 2019 02:00
IJMS, Vol. 20, Pages 5453: Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases
IJMS, Vol. 20, Pages 5453: Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20215453 Authors: Magdalena Krajewska-Włodarczyk Agnieszka Owczarczyk-Saczonek Zbigniew Żuber Maja Wojtkiewicz Joanna Wojtkiewicz Rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) make up a group of chronic immune-mediated inflammatory diseases...
Fri Nov 01, 2019 02:00
JCDD, Vol. 6, Pages 39: Krox20 Regulates Endothelial Nitric Oxide Signaling in Aortic Valve Development and Disease Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd6040039 Authors: Gaëlle Odelin Emilie Faure Corinne Maurel-Zaffran Stéphane Zaffran Among the aortic valve diseases, the bicuspid aortic valve (BAV) occurs when the aortic valve has two leaflets (cusps), rather than three, and represents the most common form of congenital cardiac malformation, affecting...
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JCDD, Vol. 6, Pages 38: Inflammation and TGF-β Signaling Differ between Abdominal Aneurysms and Occlusive Disease Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd6040038 Authors: IJpma te Riet van de Luijtgaarden van Heijningen Burger Majoor-Krakauer Rouwet Essers Verhagen van der Pluijm Abdominal aortic aneurysms (AAA), are usually asymptomatic until rupture causes fatal bleeding, posing a major vascular health problem. AAAs are...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1845: Effectiveness of Chronic Wound Debridement with the Use of Larvae of Lucilia Sericata Journal of Clinical Medicine doi: 10.3390/jcm8111845 Authors: Dariusz Bazaliński Maria Kózka Magdalena Karnas Paweł Więch The process of successful wound healing depends on effective debridement and infection control. One method of wound debridement, known since antiquity, is based on the use of fly larvae. Solid scientific evidence proves that maggot debridement therapy...
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JCM, Vol. 8, Pages 1846: Targeting Endotypic Traits with Medications for the Pharmacological Treatment of Obstructive Sleep Apnea. A Review of the Current Literature Journal of Clinical Medicine doi: 10.3390/jcm8111846 Authors: Taranto-Montemurro Messineo Wellman Obstructive sleep apnea (OSA) is a highly prevalent condition with few therapeutic options. To date there is no approved pharmacotherapy for this disorder, but several attempts have been made in the past and are currently...
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JCM, Vol. 8, Pages 1844: Sarcopenia in Older Adults Journal of Clinical Medicine doi: 10.3390/jcm8111844 Authors: David Scott Sarcopenia was first described in 1988 as the age-related decline of skeletal muscle mass [...]
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JCM, Vol. 8, Pages 1841: Usefulness of Liquid Biopsy Biomarkers from Aqueous Humor in Predicting Anti-VEGF Response in Diabetic Macular Edema: Results of a Pilot Study Journal of Clinical Medicine doi: 10.3390/jcm8111841 Authors: Patricia Udaondo Cristina Hernández Laura Briansó-Llort Salvador García-Delpech Olga Simó-Servat Rafael Simó The objective was to investigate the usefulness of the “liquid biopsy” of aqueous humor (AH) to predict the clinical...
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JCM, Vol. 8, Pages 1843: Gastrointestinal Microbiota and Type 1 Diabetes Mellitus: The State of Art Journal of Clinical Medicine doi: 10.3390/jcm8111843 Authors: Marilena Durazzo Arianna Ferro Gabriella Gruden The incidence of autoimmune type 1 diabetes (T1DM) is increasing worldwide and disease onset tends to occur at a younger age. Unfortunately, clinical trials aiming to detect predictive factors of disease, in individuals with a high risk of T1DM, reported negative results....
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JCM, Vol. 8, Pages 1842: Investigation of the Correlation between Graves’ Ophthalmopathy and CTLA4 Gene Polymorphism Journal of Clinical Medicine doi: 10.3390/jcm8111842 Authors: Ding-Ping Chen Yen-Chang Chu Ying-Hao Wen Wei-Tzu Lin Ai-Ling Hour Wei-Ting Wang Graves’ disease (GD) is an autoimmune inflammatory disease, and Graves’ ophthalmopathy (GO) occurs in 25–50% of patients with GD. Several susceptible genes were identified to be associated...
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JCM, Vol. 8, Pages 1840: Symbolic Recurrence Analysis of RR Interval to Detect Atrial Fibrillation Journal of Clinical Medicine doi: 10.3390/jcm8111840 Authors: Jesús Pérez-Valero M. Victoria Caballero Pintado Francisco Melgarejo Antonio-Javier García-Sánchez Joan Garcia-Haro Francisco García Córdoba José A. García Córdoba Eduardo Pinar Arcadio García Alberola Mariano Matilla-García Paul Curtin Manish Arora Manuel Ruiz Marín Atrial fibrillation (AF)...
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JCM, Vol. 8, Pages 1838: Back to Basics: Recognition of Sepsis with New Definition Journal of Clinical Medicine doi: 10.3390/jcm8111838 Authors: Horak Martinkova Radej Matejovič Patients with serious infections at risk of deterioration represent highly challenging clinical situations, and in particular for junior doctors. A comprehensive clinical examination that integrates the assessment of vital signs, hemodynamics, and peripheral perfusion into clinical decision making...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1837: Prevotella Copri and Microbiota in Rheumatoid Arthritis: Fully Convincing Evidence? Journal of Clinical Medicine doi: 10.3390/jcm8111837 Authors: Drago : Gut microbiota regulates the host's immune system. Microorganisms and their compounds can co-exist peacefully with the immune system and coordinate its function and regulation. Some microbial clusters may be harmful and others helpful in the respective negative or positive balance of the immune network. These...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1836: Better Myocardial Function in Aortic Stenosis with Low Left Ventricular Mass: A Mechanism of Protection against Heart Failure Regardless of Stenosis Severity? Journal of Clinical Medicine doi: 10.3390/jcm8111836 Authors: Chyrchel Bolt Długosz Urbańska Nowak-Kępczyk Bałata Rożanowska Czestkowska Kruszelnicka Surdacki About one-tenth to one-third of patients with severe aortic stenosis (AS) do not develop left ventricular hypertrophy...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1835: β2-Adrenergic Receptor (ADRB2) Gene Polymorphisms and Risk of COPD Exacerbations: The Rotterdam Study Journal of Clinical Medicine doi: 10.3390/jcm8111835 Authors: Karimi Lahousse Ghanbari Terzikhan Uitterlinden van der Lei Brusselle Stricker Verhamme The role of the β2-adrenergic receptor (ADRB2) gene in patients with chronic obstructive pulmonary disease (COPD) is unclear. We investigated the association between ADRB2...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1834: Short-Term Therapies for Treatment of Acute and Advanced Heart Failure—Why so Few Drugs Available in Clinical Use, Why Even Fewer in the Pipeline? Journal of Clinical Medicine doi: 10.3390/jcm8111834 Authors: Pollesello Ben Gal Bettex Cerny Comin-Colet Eremenko Farmakis Fedele Fonseca Harjola Herpain Heringlake Heunks Husebye Ivancan Karason Kaul Kubica Mebazaa Mølgaard Parissis Parkhomenko...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1839: Identification of Clinical and Laboratory Parameters Associated with the Development of Acute Chest Syndrome during Vaso-Occlusive Episodes in Children with Sickle Cell Disease: A Preliminary Step before Assessing Specific and Early Treatment Strategies Journal of Clinical Medicine doi: 10.3390/jcm8111839 Authors: Madhi Kamdem Jung Carlier-Gonod Biscardi Busca Arnaud Hau Narbey Epaud Pondarre This prospective observational...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1832: 2017 ACC/AHA Blood Pressure Classification and Cardiovascular Disease in 15 Million Adults of Age 20–94 Years Journal of Clinical Medicine doi: 10.3390/jcm8111832 Authors: Lee Cho Park Park Kim The 2017 American College of Cardiology/American Heart Association (ACC/AHA) high blood pressure (BP) guideline lowered the cut-off for hypertension, but its age-specific association with cardiovascular disease (CVD) remains inconclusive in different populations....
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1831: A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations Journal of Clinical Medicine doi: 10.3390/jcm8111831 Authors: Mai Kim Hyun Park Lee Lee Chlorhexidine (CHX) has been incorporated into the composition of polymethyl methacrylate (PMMA) dental restorations to enhance their antimicrobial performance. However, the controlled delivery of CHX remains a challenge. Although previous findings...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1830: Emerging Technology in Promoting Physical Activity and Health: Challenges and Opportunities Journal of Clinical Medicine doi: 10.3390/jcm8111830 Authors: Gao Lee Sedentary behavior has been identified as one of the major causes of many chronic diseases such as cardiovascular disease, stroke, cancer, type 2 diabetes, and obesity [...]
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1829: Does Exercise Improve False Episodic Memory in Dementia? Journal of Clinical Medicine doi: 10.3390/jcm8111829 Authors: Ogoh Hashimoto Ando Ageing is a risk factor involved in decline in cognitive function, particularly in executive function, processing speed and episodic memory [...]
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1828: New Biomarkers of Ferric Management in Multiple Myeloma and Kidney Disease-Associated Anemia Journal of Clinical Medicine doi: 10.3390/jcm8111828 Authors: Banaszkiewicz Małyszko Vesole Woziwodzka Jurczyszyn Żórawski Krzanowski Małyszko Batko Kuźniewski Krzanowska Multiple myeloma (MM) is a malignancy of clonal plasma cells accounting for approximately 10% of haematological malignancies. MM mainly affects older patients,...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1827: Multi-Site Photoplethysmography Technology for Blood Pressure Assessment: Challenges and Recommendations Journal of Clinical Medicine doi: 10.3390/jcm8111827 Authors: Chan Cooper Hosanee Welykholowa Kyriacou Zheng Allen Abbott Lovell Fletcher Elgendi Hypertension is one of the most prevalent diseases and is often called the “silent killer” because there are usually no early symptoms. Hypertension is...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1833: PD-L1 Expression and Tumor-Infiltrating Lymphocytes in Thymic Epithelial Neoplasms Journal of Clinical Medicine doi: 10.3390/jcm8111833 Authors: Higuchi Goto Hirotsu Nakagomi Yokoyama Otake Amemiya Oyama Omata Thymic epithelial tumors (TETs) are rare malignant mediastinal tumors that are difficult to diagnose and treat. The programmed death 1 (PD-1) receptor and its ligand (PD-L1) are expressed in various malignant tumors and...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1826: Artificial Intelligence for Automatic Measurement of Sagittal Vertical Axis Using ResUNet Framework Journal of Clinical Medicine doi: 10.3390/jcm8111826 Authors: Chi-Hung Weng Chih-Li Wang Yu-Jui Huang Yu-Cheng Yeh Chen-Ju Fu Chao-Yuan Yeh Tsung-Ting Tsai We present an automated method for measuring the sagittal vertical axis (SVA) from lateral radiography of whole spine using a convolutional neural network for keypoint detection (ResUNet) with...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1824: Stress Exposure and the Course of ADHD from Childhood to Young Adulthood: Comorbid Severe Emotion Dysregulation or Mood and Anxiety Problems Journal of Clinical Medicine doi: 10.3390/jcm8111824 Authors: Catharina A. Hartman Nanda Rommelse Cees L. van der Klugt Rob B.K. Wanders Marieke E. Timmerman Background: Compared to typically developing individuals, individuals with attention-deficit-hyperactivity disorder (ADHD) are on average more often exposed...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1823: Cerebral White Matter Hyperintensity as a Healthcare Quotient Journal of Clinical Medicine doi: 10.3390/jcm8111823 Authors: Kaechang Park Kiyotaka Nemoto Yoshinori Yamakawa Fumio Yamashita Keitaro Yoshida Masashi Tamura Atsushi Kawaguchi Tetsuaki Arai Makoto Sasaki To better understand the risk factors and optimal therapeutic strategies of cerebral white matter hyperintensity (WMH), we examined a large population of adults with and without...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1825: Impaired Glucose Metabolism in People with Extremely Elevated High-Density Lipoprotein Cholesterol and Low Alcohol Consumption: Results of the Kanagawa Investigation of Total Checkup Data from the National Database-3 (KITCHEN-3) Journal of Clinical Medicine doi: 10.3390/jcm8111825 Authors: Kei Nakajima Ryoko Higuchi Background: Recently, we have shown that extremely high high-density lipoprotein cholesterol (HDL-C), which was observed mostly in heavy drinkers,...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1821: A Longitudinal, Population-Level, Big-Data Study of Helicobacter pylori-Related Disease across Western Australia Journal of Clinical Medicine doi: 10.3390/jcm8111821 Authors: Michael J. Wise Binit Lamichhane K. Mary Webberley Helicobacter pylori, responsible for chronic ulcers and most stomach cancers, infects half of the world’s population. The Urea Breath Test (UBT) is one of the most accurate and reliable non-invasive methods for diagnosing...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1822: Significance of Malignant Peritoneal Cytology on the Survival of Women with Early-Stage Cervical Cancer: A Japanese Gynecologic Oncology Group Study Journal of Clinical Medicine doi: 10.3390/jcm8111822 Authors: Koji Matsuo Muneaki Shimada Shinya Matsuzaki Hiroko Machida Yoshikazu Nagase Toshiaki Saito Shoji Kamiura Takashi Iwata Toru Sugiyama Mikio Mikami This study examined the association between peritoneal cytology and survival in...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1820: Validation and Adaptation of the Multidimensional Prognostic Index in an Older Australian Cohort Journal of Clinical Medicine doi: 10.3390/jcm8111820 Authors: Kimberley Bryant Michael J. Sorich Richard J. Woodman Arduino A. Mangoni Background and aims: The Multidimensional Prognostic Index (MPI), an objective and quantifiable tool based on the Comprehensive Geriatric Assessment, has been shown to predict adverse outcomes in European cohorts. We conducted...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1819: Medical Cannabis for Older Patients—Treatment Protocol and Initial Results Journal of Clinical Medicine doi: 10.3390/jcm8111819 Authors: Ran Abuhasira Addie Ron Inbal Sikorin Victor Novack Older adults may benefit from cannabis treatment for various symptoms such as chronic pain, sleep difficulties, and others, that are not adequately controlled with evidence-based therapies. However, currently, there is a dearth of evidence about the efficacy and safety...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1815: Oxidative Stress and Inflammation Interdependence in Multiple Sclerosis Journal of Clinical Medicine doi: 10.3390/jcm8111815 Authors: Rodica Padureanu Carmen Valeria Albu Radu Razvan Mititelu Manuela Violeta Bacanoiu Anca Oana Docea Daniela Calina Vlad Padureanu Gabriela Olaru Raluca Elena Sandu Ramona Denise Malin Ana-Maria Buga The study aims to explore the oxidative status related to inflammation in peripheral blood of stable...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1818: Heavy Water (D2O) Containing Preservation Solution Reduces Hepatic Cold Preservation and Reperfusion Injury in an Isolated Perfused Rat Liver (IPRL) Model Journal of Clinical Medicine doi: 10.3390/jcm8111818 Authors: Shingo Shimada Moto Fukai Kengo Shibata Sodai Sakamoto Kenji Wakayama Takahisa Ishikawa Norio Kawamura Masato Fujiyoshi Tsuyoshi Shimamura Akinobu Taketomi Background: Heavy water (D2O) has many biological effects due to...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1817: Androgen and Anti-Mullerian Hormone Concentrations at Term in Newborns and Their Mothers with and without Polycystic Ovary Syndrome Journal of Clinical Medicine doi: 10.3390/jcm8111817 Authors: Martina Kollmann Barbara Obermayer-Pietsch Elisabeth Lerchbaum Uwe Lang Sereina A. Herzog Christian Trummer Anna Scheuchenegger Daniela Ulrich Philipp Klaritsch Objectives: The aetiology of polycystic ovary syndrome (PCOS) is not particularly mapped;...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1816: Modular Strategies to Build Cell-Free and Cell-Laden Scaffolds towards Bioengineered Tissues and Organs Journal of Clinical Medicine doi: 10.3390/jcm8111816 Authors: Aurelio Salerno Giuseppe Cesarelli Parisa Pedram Paolo Antonio Netti Engineering three-dimensional (3D) scaffolds for functional tissue and organ regeneration is a major challenge of the tissue engineering (TE) community. Great progress has been made in developing scaffolds to support cells...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1811: Genes and Variants Underlying Human Congenital Lactic Acidosis—From Genetics to Personalized Treatment Journal of Clinical Medicine doi: 10.3390/jcm8111811 Authors: Irene Bravo-Alonso Rosa Navarrete Ana Isabel Vega Pedro Ruíz-Sala María Teresa García Silva Elena Martín-Hernández Pilar Quijada-Fraile Amaya Belanger-Quintana Sinziana Stanescu María Bueno Isidro Vitoria Laura Toledo María Luz Couce Inmaculada García-Jiménez Ricardo...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1813: High Betaine, a Trimethylamine N-Oxide Related Metabolite, Is Prospectively Associated with Low Future Risk of Type 2 Diabetes Mellitus in the PREVEND Study Journal of Clinical Medicine doi: 10.3390/jcm8111813 Authors: Erwin Garcia Maryse C. J. Osté Dennis W. Bennett Elias J. Jeyarajah Irina Shalaurova Eke G. Gruppen Stanley L. Hazen James D. Otvos Stephan J. L. Bakker Robin P.F. Dullaart Margery A. Connelly Background: Gut microbiota-related...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1812: Prognostic Implication of Metastatic Lymph Node Ratio in Colorectal Cancers: Comparison Depending on Tumor Location Journal of Clinical Medicine doi: 10.3390/jcm8111812 Authors: Jung-Soo Pyo Young-Min Shin Dong-Wook Kang Background: The proportion of the number of involved lymph nodes (LNs) to the number of examined LNs—defined as metastatic LN ratio (mLNR)—has been considered as a prognostic parameter. This study aims to elucidate the...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1814: The SGLT2 Inhibitor Empagliflozin Ameliorates the Inflammatory Profile in Type 2 Diabetic Patients and Promotes an Antioxidant Response in Leukocytes Journal of Clinical Medicine doi: 10.3390/jcm8111814 Authors: Francesca Iannantuoni Aranzazu M. de Marañon Noelia Diaz-Morales Rosa Falcon Celia Bañuls Zaida Abad-Jimenez Victor M. Victor Antonio Hernandez-Mijares Susana Rovira-Llopis Sodium–glucose co-transporter 2 inhibitors (iSGLT2)...
Fri Nov 01, 2019 02:00
JCM, Vol. 8, Pages 1809: Arginase Isoform Expression in Chronic Rhinosinusitis Journal of Clinical Medicine doi: 10.3390/jcm8111809 Authors: Diana Vlad Silviu Albu Nitric oxide (NO) has emerged as an important regulator of upper airway inflammation, mainly as part of the local naso-sinusal defense mechanisms. Increased arginase activity can reduce NO levels by decreasing the availability of its precursor, L-arginine. Chronic rhinosinusitis (CRS) has been associated with low levels...
Fri Nov 01, 2019 02:00
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