Despite improved management, overall survival rates at hospital discharge among patients with out-of-hospital cardiac arrests do not exceed 20%, and neurologic outcomes remain poor. Even though controversies persist, targeted temperature management at 32 to 36°C remains recommended in patients with…
Thu Nov 07, 2019 02:00
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 51-year-old man…
Thu Nov 07, 2019 02:00
On January 23, 1922, insulin was successfully injected into a 14-year-old boy with severe type 1 diabetes mellitus. Type 1 diabetes had been considered a universally fatal disease, with mortality approaching 100% within months after diagnosis. For their discovery of insulin, Frederick Banting and…
Thu Nov 07, 2019 02:00
Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage. A 58-year-old…
Thu Nov 07, 2019 02:00
Related ArticlesConsumption of dietary supplements to support weight reduction in adults according to sociodemographic background, body mass index, waist-hip ratio, body fat and physical activity. J Health Popul Nutr. 2019 Nov 05;38(1):31 Authors: Lubowiecki-Vikuk A, Król-Zielińska M, Kantanista A Abstract BACKGROUND: The aim of this study was to analyse the use of dietary supplements to support weight reduction (DSSWR) in adults according to sociodemographic...
Thu Nov 07, 2019 21:26
Successful management of unilateral congenital patellar tendon aplasia: case report. Surg Radiol Anat. 2019 Nov 06;: Authors: Çevik HB, Bulut G Abstract Anatomical variation is discovered frequently in humans, and much such variation in the musculoskeletal system has been reported. We present a rare case of unilateral congenital patellar tendon aplasia with concomitant apparent shortness of the bilateral halluces as a result of shortened first metatarsals...
Thu Nov 07, 2019 21:25
Related ArticlesComments about the article "frequency, location, and morphology of accessory maxillary sinus ostia: a retrospective study using cone beam computed tomography (CBCT)". Surg Radiol Anat. 2019 Nov 04;: Authors: Liu J PMID: 31686132 [PubMed - as supplied by publisher]
Thu Nov 07, 2019 21:25
Related ArticlesDifference in coronal curvature of the medial and lateral femoral condyle morphology by gender in implant design for total knee arthroplasty. Surg Radiol Anat. 2019 Nov 04;: Authors: Koh YG, Nam JH, Chung HS, Kang KT Abstract PURPOSE: The purpose of this study was to investigate the morphometric data obtained from the three-dimensional magnetic resonance images of ethnic Korean knee osteoarthritis, and to evaluate the morphological differences...
Thu Nov 07, 2019 21:25
Related ArticlesHorseshoe adrenal gland associated with spinal and vascular anomalies. Surg Radiol Anat. 2019 Nov 04;: Authors: Romano N, Fischetti A, Pamparino S, Banderali S, Melani EF, Rollandi GA Abstract Horseshoe (or butterfly) adrenal gland (HAG) is an exceedingly rare congenital abnormality compared to horseshoe kidney. Here we present computed tomography findings of HAG in a 70-year-old man, associated with some spinal and vascular abnormalities;...
Thu Nov 07, 2019 21:25
Related ArticlesAlterations in Cortical Thickness in Young Male Patients With Childhood-Onset Adult Growth Hormone Deficiency: A Morphometric MRI Study. Front Neurosci. 2019;13:1134 Authors: Yang H, Li K, Liang X, Gu B, Wang L, Gong G, Feng F, You H, Hou B, Gong F, Zhu H, Pan H Abstract Background: The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis plays an important role in brain structure and maintenance of brain function. There is a...
Thu Nov 07, 2019 21:21
Related ArticlesMorphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype KATP Channel Activity in Mice. Front Neurosci. 2019;13:1122 Authors: Fisher C, Johnson K, Okerman T, Jurgenson T, Nickell A, Salo E, Moore M, Doucette A, Bjork J, Klein AH Abstract ATP-sensitive potassium (KATP) channels are found in the nervous system and are downstream targets of opioid receptors. KATP channel activity can effect morphine...
Thu Nov 07, 2019 21:21
Clustering the Brain With "CluB": A New Toolbox for Quantitative Meta-Analysis of Neuroimaging Data.
Related ArticlesClustering the Brain With "CluB": A New Toolbox for Quantitative Meta-Analysis of Neuroimaging Data. Front Neurosci. 2019;13:1037 Authors: Berlingeri M, Devoto F, Gasparini F, Saibene A, Corchs SE, Clemente L, Danelli L, Gallucci M, Borgoni R, Borghese NA, Paulesu E Abstract In this paper we describe and validate a new coordinate-based method for meta-analysis of neuroimaging data based on an optimized hierarchical clustering algorithm:...
Thu Nov 07, 2019 21:21
Related ArticlesLMNB1-Related Adult-Onset Autosomal Dominant Leukodystrophy Presenting as Movement Disorder: A Case Report and Review of the Literature. Front Neurosci. 2019;13:1030 Authors: Zhang Y, Li J, Bai R, Wang J, Peng T, Chen L, Wang J, Liu Y, Tian T, Lu H Abstract Adult-onset autosomal dominant leukodystrophy (ADLD) is a lately described rare form of leukodystrophy with only one family report from China. As the only disease associated with increased...
Thu Nov 07, 2019 21:21
Related ArticlesStructure and evaluation of a residency research program in a university hospital. BMC Med Educ. 2019 Nov 06;19(1):406 Authors: Tamim H, Zeineldine S, Tabbara F, Khoury S, Akiki Z, Khansa S, Taher A Abstract BACKGROUND: Most academic medical institutions lack a structured program that provides residents with an in-depth research training. The objectives of this paper are to describe a comprehensive residency research program at a university...
Thu Nov 07, 2019 21:20
Related ArticlesThe power of language-concordant care: a call to action for medical schools. BMC Med Educ. 2019 Nov 06;19(1):378 Authors: Molina RL, Kasper J Abstract We live in a world of incredible linguistic diversity; nearly 7000 languages are spoken globally and at least 350 are spoken in the United States. Language-concordant care enhances trust between patients and physicians, optimizes health outcomes, and advances health equity for diverse populations....
Thu Nov 07, 2019 21:20
Related ArticlesExploring the relationship between medical student basic psychological need satisfaction, resilience, and well-being: a quantitative study. BMC Med Educ. 2019 Nov 05;19(1):405 Authors: Neufeld A, Malin G Abstract BACKGROUND: There is increasing acknowledgment that medical training is stressful for students and can impact their well-being. An important aspect of this is self-determination and basic psychological need satisfaction. A better...
Thu Nov 07, 2019 21:20
Related ArticlesIncreased average number of medical publications per interviewee from 2009 to 2018: a study of 100 interviewees to an academic gastroenterology fellowship program. BMC Med Educ. 2019 Nov 04;19(1):402 Authors: Imam Z, Cappell MS Abstract BACKGROUND: Gastroenterology fellowship candidates may strive to improve their qualifications for this extremely competitive fellowship. OBJECTIVE: To analyze whether extreme competitiveness of...
Thu Nov 07, 2019 21:20
Related ArticlesPerceptions about trust: a phenomenographic study of clinical supervisors in occupational therapy. BMC Med Educ. 2019 Nov 04;19(1):404 Authors: Lundh P, Palmgren PJ, Stenfors T Abstract BACKGROUND: Finding the best way to facilitate student learning in clinical practice can be challenging for clinical supervisors. While high levels of trust might jeopardize patient safety, low trust might hinder student learning; however, carrying out...
Thu Nov 07, 2019 21:20
Related ArticlesComprehensive characterization of the alternative splicing landscape in head and neck squamous cell carcinoma reveals novel events associated with tumorigenesis and the immune microenvironment. Theranostics. 2019;9(25):7648-7665 Authors: Li ZX, Zheng ZQ, Wei ZH, Zhang LL, Li F, Lin L, Liu RQ, Huang XD, Lv JW, Chen FP, He XJ, Guan JL, Kou J, Ma J, Zhou GQ, Sun Y Abstract Alternative splicing (AS) has emerged as a key event in tumor development...
Thu Nov 07, 2019 21:20
Related ArticlesThe prognostic and therapeutic role of genomic subtyping by sequencing tumor or cell-free DNA in pulmonary large-cell neuroendocrine carcinoma. Clin Cancer Res. 2019 Nov 06;: Authors: Zhuo M, Guan Y, Yang X, Hong L, Wang Y, Li Z, Chen R, Abbas H, Chang L, Gong Y, Wu N, Zhong J, Chen W, Chen H, Dong Z, Zhu X, Li J, Wang Y, An T, Wu M, Wang Z, Wang J, Roarty EB, Rinsurongkawong W, Lewis J, Roth JA, Swisher SG, Lee JJ, Heymach JV, Wistuba II, Kalhor N, Yang...
Thu Nov 07, 2019 21:20
Related ArticlesCost-effectiveness analysis (CEA) of IMRT plus C12 boost vs IMRT only in adenoid cystic carcinoma (ACC) of the head and neck. Radiat Oncol. 2019 Nov 06;14(1):194 Authors: Jensen AD, Debus J Abstract BACKGROUND: Particle therapy provides steep dose gradients to facilitate dose escalation in challenging anatomical sites which has been shown not only to improve local control but also overall survival in patients with ACC. Cost-effectiveness...
Thu Nov 07, 2019 21:20
Related ArticlesCigarette smoke extract inhibits cell migration and contraction via the reactive oxygen species/adenosine monophosphate-activated protein kinase pathway in nasal fibroblasts. Int Forum Allergy Rhinol. 2019 Nov 06;: Authors: Shin JM, Park JH, Yang HW, Lee HM, Park IH Abstract BACKGROUND: Fibroblast migration plays a significant role in wound healing after endoscopic sinonasal surgery. Cigarette smoke extract (CSE) is a potent inhibitor...
Thu Nov 07, 2019 21:20
Related ArticlesDifferential gene expression analysis of HNSCC tumors deciphered tobacco dependent and independent molecular signatures. Oncotarget. 2019 Oct 22;10(58):6168-6183 Authors: Shaikh I, Ansari A, Ayachit G, Gandhi M, Sharma P, Bhairappanavar S, Joshi CG, Das J Abstract Head and neck cancer is the sixth most common cancer worldwide, with tobacco as the leading cause. However, it is increasing in non-tobacco users also, hence limiting our understanding...
Thu Nov 07, 2019 21:20
Related ArticlesSingle-cell sequencing and its applications in head and neck cancer. Oral Oncol. 2019 Nov 02;99:104441 Authors: Qi Z, Barrett T, Parikh AS, Tirosh I, Puram SV Abstract Head and neck squamous cell carcinoma (HNSCC), like many tumors, is characterized by significant intra-tumoral heterogeneity, namely transcriptional, genetic, and epigenetic differences that define distinct cellular subpopulations. While it has been established that intra-tumoral...
Thu Nov 07, 2019 21:20
Related ArticlesOral Dysfunction in Patients With Head and Neck Cancer: A Systematic Review. J Nurs Res. 2019 Dec;27(6):e58 Authors: Chen SC Abstract BACKGROUND: Head and neck cancers (HNCs) and their treatment may cause oral function impairment. PURPOSE: This study was designed to identify oral dysfunction in patients receiving treatment for HNCs using a systematic review. METHODS: The PubMed, Embase, and CINAHL databases were searched...
Thu Nov 07, 2019 21:20
Related ArticlesPaired-agent imaging for detection of head and neck cancers. Proc SPIE Int Soc Opt Eng. 2019 Feb;10853: Authors: Samkoe KS, Park Y, Marra K, Chen EY, Tichauer KM Abstract Head and neck cancers overwhelmingly overexpress epidermal growth factor receptor (EGFR). This overexpression has been utilized for head and neck cancers using molecular targeted agents for therapy and cancer cell detection. Significant progress has been made in using...
Thu Nov 07, 2019 21:20
Related ArticlesFeasibility of using a novel instrumented human head surrogate to measure helmet, head and brain kinematics and intracranial pressure during multidirectional impact tests. J Sci Med Sport. 2019 Aug;22 Suppl 1:S78-S84 Authors: Petrone N, Candiotto G, Marzella E, Uriati F, Carraro G, Bäckström M, Koptyug A Abstract OBJECTIVES: Aim of the work is to present the feasibility of using an Instrumented Human Head Surrogate (IHHS-1) during multidirectional...
Thu Nov 07, 2019 21:20
Related ArticlesDevelopment of augmented-reality applications in otolaryngology-head and neck surgery. Laryngoscope. 2019 10;129 Suppl 3:S1-S11 Authors: Rose AS, Kim H, Fuchs H, Frahm JM Abstract OBJECTIVES/HYPOTHESIS: Augmented reality (AR) allows for the addition of transparent virtual images and video to one's view of a physical environment. Our objective was to develop a head-worn, AR system for accurate, intraoperative localization of pathology...
Thu Nov 07, 2019 21:20
Related ArticlesDevelopment of a Mixed Reality Platform for Lateral Skull Base Anatomy. Otol Neurotol. 2018 12;39(10):e1137-e1142 Authors: McJunkin JL, Jiramongkolchai P, Chung W, Southworth M, Durakovic N, Buchman CA, Silva JR Abstract OBJECTIVES: A mixed reality (MR) headset that enables three-dimensional (3D) visualization of interactive holograms anchored to specific points in physical space was developed for use with lateral skull base anatomy....
Thu Nov 07, 2019 21:20
Related ArticlesMinimally Invasive Ponto Surgery Versus the Linear Incision Technique With Soft Tissue Preservation for Bone Conduction Hearing Implants: A Multicenter Randomized Controlled Trial. Otol Neurotol. 2018 08;39(7):882-893 Authors: Calon TGA, Johansson ML, de Bruijn AJG, van den Berge H, Wagenaar M, Eichhorn E, Janssen MML, Hof JR, Brunings JW, Joore MA, Jonhede S, van Tongeren J, Holmberg M, Stokroos RJ Abstract OBJECTIVE: To compare the...
Thu Nov 07, 2019 21:20
Related ArticlesAge- and Sex-Specific Analyses of Diet Quality and 4-Year Weight Change in Nonobese Adults Show Stronger Associations in Young Adulthood. J Nutr. 2019 Nov 05;: Authors: Vinke PC, Navis G, Kromhout D, Corpeleijn E Abstract BACKGROUND: Although the general importance of diet quality in the prevention of unintentional weight gain is known, it is unknown whether its influence is age or sex dependent. OBJECTIVE: The aim of this study...
Thu Nov 07, 2019 21:20
Related ArticlesWestern Dietary Pattern Derived by Multiple Statistical Methods Is Prospectively Associated with Subclinical Carotid Atherosclerosis in Midlife Women. J Nutr. 2019 Nov 05;: Authors: Wang D, Karvonen-Gutierrez CA, Jackson EA, Elliott MR, Appelhans BM, Barinas-Mitchell E, Bielak LF, Huang MH, Baylin A Abstract BACKGROUND: The menopause has adverse effects on cardiometabolic profiles that are linked to an increased risk of atherosclerosis...
Thu Nov 07, 2019 21:20
Related ArticlesInfant Formula Feeding Changes the Proliferative Status in Piglet Neonatal Mammary Glands Independently of Estrogen Signaling. J Nutr. 2019 Nov 05;: Authors: Mercer KE, Bhattacharyya S, Sharma N, Chaudhury M, Lin H, Yeruva L, Ronis MJ Abstract BACKGROUND: Soy infant formula contains isoflavones, which are able to bind to and activate estrogen receptor (ER) pathways. The mammary gland is sensitive to estrogens, raising concern that the...
Thu Nov 07, 2019 21:20
Related ArticlesThe Kidneys Are Quantitatively More Important than Pancreas and Gut as a Source of Guanidinoacetic Acid for Hepatic Creatine Synthesis in Sow-Reared Yucatan Miniature Piglets. J Nutr. 2019 Nov 05;: Authors: Dinesh OC, Brunton JA, Bertolo RF Abstract BACKGROUND: Arginine:glycine amidinotransferase, necessary for the conversion of arginine (Arg) to guanidinoacetic acid (GAA), is expressed mainly in kidney and pancreas. The methylation of...
Thu Nov 07, 2019 21:20
269 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/11/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Nov 07, 2019 21:18
Related ArticlesEffects of an Immersive Virtual Reality Environment on Muscle Strength, Proprioception, Balance, and Gait of a Middle-Aged Woman Who Had Total Knee Replacement: A Case Report. Am J Case Rep. 2019 Nov 07;20:1636-1642 Authors: Hong S, Lee G Abstract BACKGROUND The purpose of this case study was to apply a training program using virtual reality to a middle-aged woman who had total knee replacement surgery and to investigate its effects on...
Thu Nov 07, 2019 21:18
Related ArticlesComplete Response of Chemo-Refractory Metastatic Metaplastic Breast Cancer to Paclitaxel-Immunotherapy Combination. Am J Case Rep. 2019 Nov 06;20:1630-1635 Authors: Al Sayed AD, Elshenawy MA, Tulbah A, Al-Tweigeri T, Ghebeh H Abstract BACKGROUND Metaplastic breast cancer (MPBC) is a rare subtype of breast cancer that is difficult to manage and is resistant to therapy. Immunotherapy is becoming a promising option for care of several types...
Thu Nov 07, 2019 21:18
Related ArticlesA Case of Multiple Myeloma in a 17-Year-Old Girl Treated with Autologous Hematopoietic Stem Cell Transplantation (ASCT). Am J Case Rep. 2019 Nov 05;20:1623-1629 Authors: Man HV, Dung PC Abstract BACKGROUND Multiple myeloma is mainly a disease of the elderly. The diagnosis of multiple myeloma in patients under 30 years of age is rare. A rare case is presented of a 17-year-old girl diagnosed with multiple myeloma who was successfully treated...
Thu Nov 07, 2019 21:18
50 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2019/11/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Nov 07, 2019 21:17
Related ArticlesKnockout of the Placenta Specific 8 Gene Affects the Proliferation and Migration of Human Embryonic Kidney 293T Cell. Cell Biochem Biophys. 2019 Nov 06;: Authors: Qin XH, Wang HX, Ma L, Shen J, Liu QH, Xue L Abstract Candidate oncogene placenta specific 8 (PLAC8) has been identified to participate in different cellular process and human diseases. However, the effects of PLAC8 on cell proliferation and migration in human kidney cancer...
Thu Nov 07, 2019 21:15
Related Articles7-Chloroquinoline-1,2,3-triazoyl carboxamides induce cell cycle arrest and apoptosis in human bladder carcinoma cells. Invest New Drugs. 2019 Nov 06;: Authors: Sonego MS, Segatto NV, Damé L, Fronza M, Gomes CB, Oliveira TL, Seixas FK, Savegnago L, Schachtschneider KM, Alves D, Collares T Abstract In the present study, the antitumoral properties of a series of 7-chloroquinoline-1,2,3-triazoyl-carboxamides (QTCA) were investigated by analyzing...
Thu Nov 07, 2019 21:15
Related ArticlesThe multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo. Oncotarget. 2019 Oct 29;10(59):6323-6333 Authors: Flynn SM, Lesperance J, Macias A, Phanhthilath N, Paul MR, Kim JW, Tamayo P, Zage PE Abstract Neuroblastoma is the most common extracranial solid tumor of childhood and accounts for 15% of all pediatric cancer-related deaths. New therapies are needed to improve outcomes for children with high-risk...
Thu Nov 07, 2019 21:15
Related ArticlesATR, a DNA Damage Signaling Kinase, Is Involved in Aluminum Response in Barley. Front Plant Sci. 2019;10:1299 Authors: Szurman-Zubrzycka M, Nawrot M, Jelonek J, Dziekanowski M, Kwasniewska J, Szarejko I Abstract Ataxia Telangiectasia and Rad-3-related protein (ATR) is a DNA damage signaling kinase required for the monitoring of DNA integrity. Together with ATM and SOG1, it is a key player in the transcriptional regulation of DNA damage...
Thu Nov 07, 2019 21:15
Related ArticlesPterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma via Enhancing the Autophagic Flux. Front Pharmacol. 2019;10:1238 Authors: Wang D, Guo H, Yang H, Wang D, Gao P, Wei W Abstract Background: Human cholangiocarcinoma (CCA) is a highly lethal cancer that occurs in the biliary tract. It is characterized by early invasion, poor outcomes, and resistance to current chemotherapies....
Thu Nov 07, 2019 21:15
Related ArticlesPolyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation. Drug Des Devel Ther. 2019;13:3091-3103 Authors: Yuan YL, Jiang N, Li ZY, Song ZZ, Yang ZH, Xue WH, Zhang XJ, Du Y Abstract Purpose: Polyphyllin VI, a main active saponin isolated from traditional medicinal plant Paris polyphylla, has exhibited antitumor activities in several cancer cell lines. In the present study, we investigated...
Thu Nov 07, 2019 21:15
Related ArticlesNuclear receptor HNF4α performs a tumor suppressor function in prostate cancer via its induction of p21-driven cellular senescence. Oncogene. 2019 Nov 06;: Authors: Wang Z, Li Y, Wu D, Yu S, Wang Y, Leung Chan F Abstract Hepatocyte nuclear factor 4α (HNF4α, NR2A1) is a highly conserved member of the nuclear receptor superfamily. Recent advances reveal that it is a key transcriptional regulator of genes, broadly involved in xenobiotic...
Thu Nov 07, 2019 21:15
Related ArticlesCRISPR screening identifies WEE1 as a combination target for standard chemotherapy in malignant pleural mesothelioma. Mol Cancer Ther. 2019 Nov 06;: Authors: Xu D, Liang SQ, Yang H, Bruggmann R, Berezowska S, Yang Z, Marti TM, Hall SRR, Gao Y, Kocher GJ, Schmid RA, Peng RW Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer with dismal prognosis, largely due to poor response rates to and rapid relapse after first-line...
Thu Nov 07, 2019 21:15
Related ArticlesDevelopment and Mechanistic Insight into the Enhanced Cytotoxic Potential of Parvifloron D Albumin Nanoparticles in EGFR-Overexpressing Pancreatic Cancer Cells. Cancers (Basel). 2019 Nov 05;11(11): Authors: Santos-Rebelo A, Kumar P, Pillay V, Choonara YE, Eleutério C, Figueira M, Viana AS, Ascensão L, Molpeceres J, Rijo P, Correia I, Amaral J, Solá S, Rodrigues CMP, Gaspar MM, Reis CP Abstract Pancreatic cancer is one of the most lethal...
Thu Nov 07, 2019 21:15
Related ArticlesA novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth. Cancer Lett. 2019 Nov 03;: Authors: Celegato M, Messa L, Goracci L, Mercorelli B, Bertagnin C, Spyrakis F, Suarez I, Cousido-Siah A, Travé G, Banks L, Cruciani G, Palù G, Loregian A Abstract Despite prophylactic vaccination campaigns, human papillomavirus (HPV)-induced cancers still represent a...
Thu Nov 07, 2019 21:15
Related ArticlesDate Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance. Glob Chall. 2019 Nov;3(11):1900042 Authors: Nurkesh AA, Sun Q, Fan H, Dukenbayev K, Tsoy A, Altaikyzy A, Wang K, Xie Y Abstract Carbon nanodots (C-dots) are emerging as a new type of promising agent in anticancer, imaging, and new energy. Reports as well as the previous research indicate that certain C-dots can enhance targeted...
Thu Nov 07, 2019 21:15
Related ArticlesiNOS is associated with tumorigenicity as an independent prognosticator in human intrahepatic cholangiocarcinoma. Cancer Manag Res. 2019;11:8005-8022 Authors: Liu S, Jiang J, Huang L, Jiang Y, Yu N, Liu X, Lv Y, Li H, Zou L, Peng C, Yu X, Jiang B Abstract Background: Inducible nitric oxide synthase (iNOS) has supposed to implicate in inflammation, infection, liver cirrhosis, and neoplastic diseases. This study was designed to explore...
Thu Nov 07, 2019 21:15
Related ArticlesDownregulation of HDGF inhibits the tumorigenesis of bladder cancer cells by inactivating the PI3K-AKT signaling pathway. Cancer Manag Res. 2019;11:7909-7923 Authors: Zhang C, Chang X, Chen D, Yang F, Li Z, Li D, Yu N, Yan L, Liu H, Xu Z Abstract Background: Hepatoma-derived growth factor (HDGF) is a heparin-binding protein that has been observed to be abnormally expressed in numerous malignancies, but the definite role of HDGF in bladder...
Thu Nov 07, 2019 21:15
Related ArticlesInhibition of the hedgehog pathway for the treatment of cancer using Itraconazole. Onco Targets Ther. 2019;12:6875-6886 Authors: Li K, Fang D, Xiong Z, Luo R Abstract Itraconazole (ITZ) is an anti-fungal drug that has been used in clinical practice for nearly 35 years. Recently, numerous experiments have shown that ITZ possesses anti-cancer properties. The Hedgehog (Hh) pathway plays a pivotal role in fundamental processes, including...
Thu Nov 07, 2019 21:15
Related ArticlesTAE226, a dual inhibitor of focal adhesion kinase and insulin-like growth factor-I receptor, is effective for Ewing sarcoma. Cancer Med. 2019 Nov 06;: Authors: Moritake H, Saito Y, Sawa D, Sameshima N, Yamada A, Kinoshita M, Kamimura S, Konomoto T, Nunoi H Abstract The outcomes for relapsed and metastatic Ewing sarcoma (EWS) is extremely poor. Therefore, it is important to identify the tumor-specific targets in these intractable diseases....
Thu Nov 07, 2019 21:15
Related ArticlesCompromising the constitutive p16INK4a expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence. J Cell Biochem. 2019 Nov 06;: Authors: Kanugovi AV, Joseph C, Siripini S, Paithankar K, Amere SS Abstract The Hsp90 chaperone has become the attractive pharmacological target to inhibit tumor cell proliferation. However, tumor cells can evolve with mechanisms to overcome Hsp90 inhibition. Using...
Thu Nov 07, 2019 21:15
Related ArticlesThe regulatory role of HIF-1 in tubular epithelial cells in response to kidney injury. Histol Histopathol. 2019 Nov 06;:18182 Authors: Qiu Y, Huang X, He W Abstract The high sensitivity to changes in oxygen tension makes kidney vulnerable to hypoxia. Both acute kidney injury and chronic kidney disease are almost always accompanied by hypoxia. Tubular epithelial cells (TECs), the dominant intrinsic cells in kidney tissue, are believed...
Thu Nov 07, 2019 21:15
Related ArticlesFunctions of p53 in pluripotent stem cells. Protein Cell. 2019 Nov 06;: Authors: Fu X, Wu S, Li B, Xu Y, Liu J Abstract Pluripotent stem cells (PSCs) are capable of unlimited self-renewal in culture and differentiation into all functional cell types in the body, and thus hold great promise for regenerative medicine. To achieve their clinical potential, it is critical for PSCs to maintain genomic stability during the extended proliferation....
Thu Nov 07, 2019 21:15
Related ArticlesMYST1/KAT8 contributes to tumor progression by activating EGFR signaling in glioblastoma cells. Cancer Med. 2019 Nov 05;: Authors: Dong Z, Zou J, Li J, Pang Y, Liu Y, Deng C, Chen F, Cui H Abstract With short survival time, glioblastoma (GBM) is the most malignant tumor in the central nervous system. Recently, epigenetic enzymes play essential roles in the regulation of tumorigenesis and cancer development of GBM. However, little is known...
Thu Nov 07, 2019 21:15
Related ArticlesInhibition of sphingosine 1phosphate lyase activates human keratinocyte differentiation and attenuates psoriasis in mice. J Lipid Res. 2019 Nov 05;: Authors: Jeon S, Song J, Lee D, Kim GT, Park SH, Shin DY, Shin KO, Park K, Shim SM, Park TS Abstract Sphingosine 1-phosphate (S1P) lyase is an intracellular enzyme that catalyzes the irreversible degradation of S1P and has been suggested as a therapeutic target for the treatment of psoriasis...
Thu Nov 07, 2019 21:15
Related ArticlesPeriostin Promotes Cell Proliferation and Macrophage Polarization to Drive Repair after AKI. J Am Soc Nephrol. 2019 Nov 05;: Authors: Kormann R, Kavvadas P, Placier S, Vandermeersch S, Dorison A, Dussaule JC, Chadjichristos CE, Prakoura N, Chatziantoniou C Abstract BACKGROUND: The matricellular protein periostin has been associated with CKD progression in animal models and human biopsy specimens. Periostin functions by interacting with...
Thu Nov 07, 2019 21:15
Related ArticlesPolyphyllin I induces cell cycle arrest in prostate cancer cells via the upregulation of IL6 and P21 expression. Medicine (Baltimore). 2019 Nov;98(44):e17743 Authors: Zhang D, Liu S, Liu Z, Ma C, Jiang Y, Sun C, Li K, Cao G, Lin Z, Wang P, Zhang J, Xu D, Kong F, Zhao S Abstract BACKGROUND: Polyphyllin I has been reported to possess anticancer properties in various cancer types, including prostate cancer. However, little is known about...
Thu Nov 07, 2019 21:15
Related ArticlesA novel long non-coding RNA LINC00355 promotes proliferation of lung adenocarcinoma cells by down-regulating miR-195 and up-regulating the expression of CCNE1. Cell Signal. 2019 Nov 02;:109462 Authors: Liang Y, Rong X, Luo Y, Li P, Han Q, Wei L, Wang E Abstract Lung adenocarcinoma is the most common subtype of non-small-cell lung cancer affecting people all over the globe. Recent studies have indicated that long non-coding RNAs (lncRNAs)...
Thu Nov 07, 2019 21:15
Related ArticlesNicotine-upregulated miR-30a arrests cell cycle in G1 phase by directly targeting CCNE2 in human periodontal ligament cells. Biochem Cell Biol. 2019 Nov 05;: Authors: Wu L, Yang K, Gui Y, Wang X Abstract Both tobacco smoking and nicotine have been reported to regulate the occurrence and progression of periodontitis. Many studies have demonstrated that nicotine destroys regeneration of periodontal tissues primarily by inhibiting the proliferation...
Thu Nov 07, 2019 21:15
Related ArticlesMicroRNA-425-5p promotes breast cancer cell growth by inducing PI3K/AKT signaling. Kaohsiung J Med Sci. 2019 Nov 05;: Authors: Zhang LF, Zhang JG, Zhou H, Dai TT, Guo FB, Xu SY, Chen Y Abstract MicroRNA-425-5p (miR-425-5p) has been reported to be involved in the tumorigenesis of several tumors, but its function in breast cancer is still unknown. In this study, miR-425-5p was found significantly upregulated in breast cancer cells, and...
Thu Nov 07, 2019 21:15
Related ArticlesZebularine and trichostatin A sensitized human breast adenocarcinoma cells towards tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis. Heliyon. 2019 Sep;5(9):e02468 Authors: Kong WY, Yee ZY, Mai CW, Fang CM, Abdullah S, Ngai SC Abstract Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent due to its selective killing on cancer cells while sparing the normal...
Thu Nov 07, 2019 21:15
Related ArticlesCurcumin Inhibits Proliferation of Epstein-Barr Virus-Associated Human Nasopharyngeal Carcinoma Cells by Inhibiting EBV Nuclear Antigen 1 Expression. Biomed Res Int. 2019;2019:8592921 Authors: Liu L, Yang J, Ji W, Wang C Abstract This investigation aims to study the effect of curcumin on the proliferation, cycle arrest, and apoptosis of Epstein-Barr virus- (EBV-) positive nasopharyngeal carcinoma (NPC) cells. EBV+ NPC cells were subjected...
Thu Nov 07, 2019 21:15
Related ArticlesDual targeting of estrogen receptor α and estrogen-related receptor α: a novel endocrine therapy for endometrial cancer. Onco Targets Ther. 2019;12:6757-6767 Authors: Mao X, Dong B, Gao M, Ruan G, Huang M, Braicu EI, Sehouli J, Sun P Abstract Background: Endometrial cancer (EC) is a hormone dependent carcinoma that may involve complex molecular mechanisms. Endocrine therapy by blocking the estrogen and estrogen receptor α (ERα) has been...
Thu Nov 07, 2019 21:15
Related ArticlesUpregulated circZMIZ1 promotes the proliferation of prostate cancer cells and is a valuable marker in plasma. Neoplasma. 2019 Nov 04;: Authors: Jiang H, Lv DJ, Song XL, Wang C, Yu YZ, Zhao SC Abstract Increasing evidences have proved that circular RNAs (circRNAs), identified as a specific kind of non-coding RNAs, play a potential critical role in tumorigenesis including prostate cancer. However, the function of circRNAs in human prostate...
Thu Nov 07, 2019 21:15
Related ArticlesA Sialylated-Bortezomib Prodrug Strategy Based on a Highly Expressed Selectin Target for the Treatment of Leukemia or Solid Tumors. Pharm Res. 2019 Nov 04;36(12):176 Authors: Liu M, Tang X, Ding J, Liu M, Zhao B, Deng Y, Song Y Abstract PURPOSE: This study aimed to explore the potential of sialic acid - related selectin targeting strategy in the treatment of leukemia and some solid tumors. We expected it could "actively" bind tumor cells...
Thu Nov 07, 2019 21:15
Related ArticlesNew ruthenium polypyridyl complexes functionalized with fluorine atom or furan: Synthesis, DNA-binding, cytotoxicity and antitumor mechanism studies. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Oct 25;:117534 Authors: Jiang GB, Zhang WY, He M, Gu YY, Bai L, Wang YJ, Yi QY, Du F Abstract Two novel ruthenium(II) polypyridyl complexes, namely, [Ru(dmp)2(CAPIP)](ClO4)2 (Ru(II)-1) and [Ru(dmp)2(CFPIP)](ClO4)2 (Ru(II)-2), which respectively...
Thu Nov 07, 2019 21:15
Related ArticlesGene Expression Signature-Based Approach Identifies Antifungal Drug Ciclopirox As a Novel Inhibitor of HMGA2 in Colorectal Cancer. Biomolecules. 2019 Nov 02;9(11): Authors: Huang YM, Cheng CH, Pan SL, Yang PM, Lin DY, Lee KH Abstract Human high-mobility group A2 (HMGA2) encodes for a non-histone chromatin protein which influences a variety of biological processes, including the cell cycle process, apoptosis, the DNA damage repair process,...
Thu Nov 07, 2019 21:15
Related ArticlesSIRT1-Mediated Protective Effect of Aralia elata (Miq.) Seem against High-Glucose-Induced Senescence in Human Umbilical Vein Endothelial Cells. Nutrients. 2019 Nov 02;11(11): Authors: Kim GD Abstract Aralia elata (Miq.) Seem (AS) is widely been for treating many diseases, enhancing energy, and boosting immunity; however, its protective effects against high-glucose (HG)-triggered endothelial dysfunction and the potential underlying mechanisms...
Thu Nov 07, 2019 21:15
Related ArticlesScreening of Molecular Targets of Action of Atractylodin in Cholangiocarcinoma by Applying Proteomic and Metabolomic Approaches. Metabolites. 2019 Nov 01;9(11): Authors: Kotawong K, Chaijaroenkul W, Roytrakul S, Phaonakrop N, Na-Bangchang K Abstract Cholangiocarcinoma (CCA) is cancer of the bile duct and the highest incidence of CCA in the world is reported in Thailand. Our previous in vitro and in vivo studies identified Atractylodes...
Thu Nov 07, 2019 21:15
Related ArticlesAnnona coriacea Mart. Fractions Promote Cell Cycle Arrest and Inhibit Autophagic Flux in Human Cervical Cancer Cell Lines. Molecules. 2019 Nov 01;24(21): Authors: Gomes INF, Silva-Oliveira RJ, Oliveira Silva VA, Rosa MN, Vital PS, Barbosa MCS, Dos Santos FV, Junqueira JGM, Severino VGP, Oliveira BG, Romão W, Reis RM, Ribeiro RIMA Abstract Plant-based compounds are an option to explore and perhaps overcome the limitations of current antitumor...
Thu Nov 07, 2019 21:15
Related ArticlesIntegrative analysis of gene alterations and immunoexpression profiles of cell cycle checkpoints in oral squamous cell carcinoma. Cancer Biomark. 2019 Oct 25;: Authors: Pérez-Sayáns M, Chamorro-Petronacci CM, Lorenzo-Pouso AI, Peñaranda JMS, López-López J, Blanco-Carrión A, García-García A Abstract BACKGROUND: Oral squamous cell carcinoma (OSCC) represents 95% of all cancers of the head and neck region. The five-year survival rate of...
Thu Nov 07, 2019 21:15
Related ArticlesHistone acetylation plays an important role in MC-LR-induced apoptosis and cycle disorder in SD rat testicular cells. Chemosphere. 2019 Oct 12;241:125073 Authors: Wang Y, Liu H, Liu X, Zhang X, Wu J, Yuan L, Du X, Wang R, Ma Y, Chen X, Cheng X, Zhuang D, Zhang H Abstract Microcystin-leucine arginine (MC-LR) is a variant of microcystins (MCs), which poses a serious threat to the reproductive system. Histone acetylation modification can...
Thu Nov 07, 2019 21:15
Related ArticlesInhibition of cyclin E1 overcomes temozolomide resistance in glioblastoma by Mcl-1 degradation. Mol Carcinog. 2019 08;58(8):1502-1511 Authors: Liang H, Chen Z, Sun L Abstract Glioblastoma (GBM) is one of the major causes of brain cancer-related mortality worldwide. Temozolomide (TMZ) is an important agent against GBM. Acquired TMZ-resistance severely limits the chemotherapeutic effect and leads to poor GBM patient survival. To study...
Thu Nov 07, 2019 21:15
Related ArticlesDown-regulation of miR-9 promotes epithelial mesenchymal transition via regulating anoctamin-1 (ANO1) in CRC cells. Cancer Genet. 2019 02;231-232:22-31 Authors: Park YR, Lee ST, Kim SL, Zhu SM, Lee MR, Kim SH, Kim IH, Lee SO, Seo SY, Kim SW Abstract MicroRNA-9 (miR-9) has been reported to play a suppressive or promoting role according to cancer type. In this study, we investigated the effects of anoctamin-1 (ANO1) and miR-9 on colorectal...
Thu Nov 07, 2019 21:15
Related ArticlesRegulation of cyclin E1 expression in human pluripotent stem cells and derived neural progeny. Cell Cycle. 2018;17(14):1721-1744 Authors: Rodríguez Varela MS, Mucci S, Videla Richardson GA, Morris Hanon O, Furmento VA, Miriuka SG, Sevlever GE, Scassa ME, Romorini L Abstract Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells (hESCs and hiPSCs) show unique cell cycle characteristics, such as a...
Thu Nov 07, 2019 21:15
Related ArticlesThe novel KLF4/PLAC8 signaling pathway regulates lung cancer growth. Cell Death Dis. 2018 05 22;9(6):603 Authors: Jia Y, Ying X, Zhou J, Chen Y, Luo X, Xie S, Wang QC, Hu W, Wang L Abstract Accumulating evidence suggests that placenta-specific 8 (PLAC8) plays an important role in normal cellular process and human diseases, including multiple types of human tumors, and its role is highly relied upon in cellular and physiologic contexts....
Thu Nov 07, 2019 21:15
Related ArticlesDown-regulation of JARID1B expression inhibits cell proliferation, induces apoptosis and blocks cell cycle in human acute lymphoblastic leukemia cells. Eur Rev Med Pharmacol Sci. 2018 03;22(5):1366-1373 Authors: Huang YQ, Zou Y, Zheng RJ, Ma XD Abstract OBJECTIVE: Acute lymphocytic leukemia (ALL) is a multi-factorial blood disease with unknown pathogenesis. Histone H3K4 methylation was significantly reduced in ALL patients, whereas jumonji...
Thu Nov 07, 2019 21:15
Related ArticlesMicroRNA-574 enhances doxorubicin resistance through down-regulating SMAD4 in breast cancer cells. Eur Rev Med Pharmacol Sci. 2018 03;22(5):1342-1350 Authors: Sun FD, Wang PC, Luan RL, Zou SH, Du X Abstract OBJECTIVE: Drug resistance has become an important factor that threatens the survival and prognosis of patients with breast cancer, especially in patients with advanced breast cancer. Several microRNAs have been proved to participate...
Thu Nov 07, 2019 21:15
Related ArticlesWnt3 knockdown sensitizes human non-small cell type lung cancer (NSCLC) cells to cisplatin via regulating the cell proliferation and apoptosis. Eur Rev Med Pharmacol Sci. 2018 03;22(5):1323-1332 Authors: Xing Z, Wang HY, Su WY, Liu YF, Wang XX, Zhan P, Lv TF, Song Y Abstract OBJECTIVE: Aberrant activation of (Wingless and mouse homolog Int-1) Wnt/β-catenin signaling pathways closely involved in the occurrence and progression of several...
Thu Nov 07, 2019 21:15
Related Articlesmir-637 inhibits the proliferation of cholangiocarcinoma cell QBC939 through interfering CTSB expression. Eur Rev Med Pharmacol Sci. 2018 03;22(5):1265-1276 Authors: Li JX, Ding XM, Han S, Wang K, Jiao CY, Li XC Abstract OBJECTIVE: To investigate the role of mir-637 on the proliferation, migration and apoptosis in human cholangiocarcinoma (CCA) cell line QBC939, and the impact of mir-637 on Cathepsin B (CTSB) expression. MATERIALS...
Thu Nov 07, 2019 21:15
Related ArticlesInsulin suppresses transcriptional activity of YAP in insulin target cells. Mol Biol Cell. 2019 Nov 06;:mbcE19040205 Authors: Sayedyahossein S, Hedman AC, Sacks DB Abstract Yes-associated protein (YAP), the main transcriptional coactivator of the Hippo pathway, integrates multiple inputs from different signaling cascades. Evidence implicates YAP in the control of cellular nutrient and energy status, but the underlying mechanisms are not...
Thu Nov 07, 2019 21:15
Related ArticlesSteric regulation of tandem calponin homology domain actin-binding affinity. Mol Biol Cell. 2019 Nov 06;:mbcE19060317 Authors: Harris AR, Belardi B, Jreij P, Wei K, Shams H, Bausch A, Fletcher DA Abstract Tandem calponin homology (CH1-CH2) domains are common actin-binding domains in proteins that interact with and organize the actin cytoskeleton. Despite regions of high sequence similarity, CH1-CH2 domains can have remarkably different...
Thu Nov 07, 2019 21:15
Related ArticlesGenetic interactions between the DBL-1/BMP-like pathway and dpy body size-associated genes in Caenorhabditis elegans. Mol Biol Cell. 2019 Nov 06;:mbcE19090500 Authors: Lakdawala MF, Madhu B, Faure L, Vora M, Padgett RW, Gumienny TL Abstract Bone morphogenetic protein (BMP) signaling pathways control many developmental and homeostatic processes, including cell size and extracellular matrix remodeling. An understanding of how this pathway...
Thu Nov 07, 2019 21:15
Related ArticlesMigration regulates cellular mechanical states. Mol Biol Cell. 2019 Nov 06;:mbcE19020099 Authors: Chang SS, Rape AD, Wong SA, Guo WH, Wang YL Abstract Recent studies indicate that adherent cells are keenly sensitive to external physical environment, such as substrate rigidity and topography, and internal physical states, such as cell shape and spreading area. Many of these responses are believed to involve coupled output and input of...
Thu Nov 07, 2019 21:15
Related ArticlesArf-GEF localization and function at myosin-rich adherens junctions via coiled-coil hetero-dimerization with an adaptor protein. Mol Biol Cell. 2019 Nov 06;:mbcE19100566 Authors: Zheng S, West JJ, Yu CG, Harris TJC Abstract Tissue dynamics require regulated interactions between adherens junctions and cytoskeletal networks. For example, myosin-rich adherens junctions recruit the cytohesin Arf-GEF Steppke, which down-regulates junctional...
Thu Nov 07, 2019 21:15
Related ArticlesIntratympanic infliximab is a safe and effective rescue therapy for refractory immune-mediated hearing loss. Eur Arch Otorhinolaryngol. 2019 Nov 05;: Authors: Mata-Castro N, Sanz-López L, Varillas-Delgado D, García-Fernández A Abstract PURPOSE: To determine the efficacy and safety of the intratympanic infiltration of infliximab at the hearing threshold of patients in follow-up for refractory immune-mediated hearing loss. METHODS:...
Thu Nov 07, 2019 21:13
Related ArticlesAssessment of hearing loss induced by tympanic membrane perforations under blast environment. Eur Arch Otorhinolaryngol. 2019 Nov 05;: Authors: Xie P, Peng Y, Hu J, Peng A, Yi S Abstract PURPOSES: This study provides an approach to estimating tympanic membrane perforation-induced hearing loss (HL) using a human middle ear model. METHODS: Sixty-one cases of tympanic membrane perforation originating from fireworks were reported...
Thu Nov 07, 2019 21:13
Related ArticlesThe nasal valve: new insights on the static and dynamic NV with MR-imaging. Eur Arch Otorhinolaryngol. 2019 Nov 04;: Authors: San Nicoló M, Berghaus A, Jacobi C, Kisser U, Haack M, Flatz W Abstract PURPOSE: We assessed the static nasal valve angle with MR imaging in healthy subjects and evaluated the complex mechanism of nasal valve dynamics during physiologic and forced inspiration. METHODS: In 17 healthy subjects, measurements...
Thu Nov 07, 2019 21:13
Related ArticlesTumor-infiltrating and circulating granulocytic myeloid-derived suppressor cells correlate with disease activity and adverse clinical outcomes in mycosis fungoides. Clin Transl Oncol. 2019 Nov 06;: Authors: Argyropoulos KV, Pulitzer M, Perez S, Korkolopoulou P, Angelopoulou M, Baxevanis C, Palomba ML, Siakantaris M Abstract PURPOSE: Cutaneous T cell lymphomas (CTCL) are rare and histologically diverse lymphoproliferative neoplasms, with...
Thu Nov 07, 2019 21:11
Related ArticlesSmall-bowel carcinomas associated with celiac disease: transcriptomic profiling shows predominance of microsatellite instability-immune and mesenchymal subtypes. Virchows Arch. 2019 Nov 06;: Authors: Rizzo F, Vanoli A, Sahnane N, Cerutti R, Trapani D, Rinaldi A, Sellitto A, Ciacci C, Volta U, Villanacci V, Calabrò A, Arpa G, Luinetti O, Paulli M, Solcia E, Di Sabatino A, Sessa F, Weisz A, Furlan D Abstract Celiac disease (CD) is a risk...
Thu Nov 07, 2019 21:11
Related ArticlesStable transmission of complex chromosomal rearrangements involving chromosome 1q derived from constitutional chromoanagenesis. Mol Cytogenet. 2019;12:43 Authors: Gudipati MA, Waters E, Greene C, Goel N, Hoppman NL, Pitel BA, Webley MR, Zou Y Abstract Background: Chromoanagenesis events encompassing chromoanasynthesis, chromoplexy, and chromothripsis are described in cancers and can result in highly complex chromosomal rearrangements...
Thu Nov 07, 2019 21:11
Related ArticlesLong-Term Follow-Up of Significant Improvement After CAPTEM Treatment for Rare Adrenocorticotropin-Producing Cardiac Neuroendocrine Tumor. Front Endocrinol (Lausanne). 2019;10:713 Authors: Lu L, Meng Q, Xing X, Yuan T, Zhang H, Li N, Wang Y, Cheng Y, Bai C, Wang H, Cheng X, Xiao Y, Pan B, Li Y, Sun J, Liang Z, Zhu H, Wang R, Lu Z Abstract Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a rare cause of Cushing syndrome. If...
Thu Nov 07, 2019 21:11
Related ArticlesManagement of Gastrointestinal Neuroendocrine Tumors. Clin Med Insights Endocrinol Diabetes. 2019;12:1179551419884058 Authors: Wang R, Zheng-Pywell R, Chen HA, Bibb JA, Chen H, Rose JB Abstract Neuroendocrine neoplasms (NENs) are derived from neuroendocrine cell system and can have benign or malignant characteristics. They are rare tumors, but have been increasing in incidence over the past 40 years. Patients with NENs may develop symptoms...
Thu Nov 07, 2019 21:11
Related ArticlesBrain Metastases from Biliary Tract Cancers: A Case Series and Review of the Literature in the Genomic Era. Oncologist. 2019 Nov 06;: Authors: D'Andrea MR, Gill CM, Umphlett M, Tsankova NM, Fowkes M, Bederson JB, Brastianos PK, Shrivastava RK Abstract BACKGROUND: Biliary tract cancers (BTCs) are highly fatal malignancies that make up less than 1% of all cancers. BTC is often diagnosed at an unresectable stage; surgical resection remains...
Thu Nov 07, 2019 21:11
Related ArticlesManagement of pulmonary toxicity associated with immune checkpoint inhibitors. Eur Respir Rev. 2019 Dec 31;28(154): Authors: Delaunay M, Prévot G, Collot S, Guilleminault L, Didier A, Mazières J Abstract Immunotherapy has become a standard of care in oncology, following the recent approvals of cytotoxic T-lymphocyte-associated protein-4 and programmed cell death-1 inhibitors in lung cancer, melanoma, renal cell carcinoma, Hodgkin's lymphoma,...
Thu Nov 07, 2019 21:11
Related ArticlesIschemic stroke caused by giant cell arteritis associated with pulmonary adenocarcinoma. J Clin Neurosci. 2019 Nov 04;: Authors: Scopelliti G, Bertora P, Bortolami C, Rosa S, Pantoni L Abstract Giant cell arteritis (GCA) is the most common vasculitis in patients older than 50 years, and it is occasionally a cause of ischemic stroke. GCA as a paraneoplastic manifestation has been rarely described. We describe a 77-year-old man with a sudden...
Thu Nov 07, 2019 21:11
Related ArticlesThe Prognostic Role of CD8+ T Lymphocytes in Childhood Adrenocortical Carcinomas Compared to Ki-67, PD-1, PD-L1, and the Weiss Score. Cancers (Basel). 2019 Nov 05;11(11): Authors: Parise IZS, Parise GA, Noronha L, Surakhy M, Woiski TD, Silva DB, Costa TEB, Del-Valle MHCP, Komechen H, Rosati R, Ribeiro MG, Nascimento ML, Souza JA, Andrade DP, Paraizo MM, Galvão MMR, Barbosa JRS, Barbosa ML, Custódio GC, Figueiredo MMO, Fabro ALMR, Bond G, Volante M, Lalli...
Thu Nov 07, 2019 21:11
Related ArticlesOccurrence, behaviour, and human exposure pathways and health risks of toxic geogenic contaminants in serpentinitic ultramafic geological environments (SUGEs): A medical geology perspective. Sci Total Environ. 2019 Oct 18;700:134622 Authors: Gwenzi W Abstract Serpentinitic ultramafic geological environments (SUGEs) contain toxic geogenic contaminants (TGCs). Yet comprehensive reviews on the medical geology of SUGEs are still lacking....
Thu Nov 07, 2019 21:11
Related ArticlesMorphologic, Immunohistochemical, and Molecular Distinction Between Fibroepithelioma of Pinkus and "Fenestrated" Basal Cell Carcinoma. Am J Dermatopathol. 2019 Nov 05;: Authors: Russell-Goldman E, Lindeman NI, Laga AC, Hanna J Abstract Fibroepithelioma of Pinkus (FEP) is a rare cutaneous neoplasm with a characteristic fenestrated architecture and a prominent spindle cell stromal component and which invariably pursues an indolent course....
Thu Nov 07, 2019 21:11
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