by Anaïs Darracq, Helen Pak, Vincent Bourgoin, Farah Zmiri, Graham Dellaire, El Bachir Affar, Eric Milot Nucleophosmin (NPM1) is frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation, which creates a nuclear export signal, is characterized by cytoplasmic localization and leukemogenic properties. Similarly, the NPM-MLF1 translocation product favors the partial cytoplasmic...
Fri Nov 01, 2019 21:13
by Alex Diaz-Papkovich, Luke Anderson-Trocmé, Chief Ben-Eghan, Simon Gravel Human populations feature both discrete and continuous patterns of variation. Current analysis approaches struggle to jointly identify these patterns because of modelling assumptions, mathematical constraints, or numerical challenges. Here we apply uniform manifold approximation and projection (UMAP), a non-linear dimension reduction tool, to three well-studied genotype datasets and discover overlooked subpopulations...
Fri Nov 01, 2019 21:13
Genes, Vol. 10, Pages 883: Identification of an Embryonic Cell-Specific Region within the Pineapple SERK1 Promoter Genes doi: 10.3390/genes10110883 Authors: Luan He Xie Chen Mao Wang Li Ding Lin Liu Xia He Plant tissue culture methods, such as somatic embryogenesis, are attractive alternatives to traditional breeding methods for plant propagation. However, they often suffer from limited efficiency. Somatic embryogenesis receptor kinase (SERK)1...
Fri Nov 01, 2019 02:00
Genes, Vol. 10, Pages 884: Roles of Topoisomerases in Heterochromatin, Aging, and Diseases Genes doi: 10.3390/genes10110884 Authors: Lee Wang Heterochromatin is a transcriptionally repressive chromatin architecture that has a low abundance of genes but an enrichment of transposons. Defects in heterochromatin can cause the de-repression of genes and transposons, leading to deleterious physiological changes such as aging, cancer, and neurological disorders. While the roles of topoisomerases...
Fri Nov 01, 2019 02:00
by Kathlyn Laval, Jolien Van Cleemput, Jonah B. Vernejoul, Lynn W. Enquist Pseudorabies virus (PRV), an alphaherpesvirus closely related to Varicella-Zoster virus (VZV) and Herpes simplex type 1 (HSV1) infects mucosa epithelia and the peripheral nervous system (PNS) of its host. We previously demonstrated that PRV infection induces a specific and lethal inflammatory response, contributing to severe neuropathy in mice. So far, the mechanisms that initiate this neuroinflammation remain unknown....
Fri Nov 01, 2019 19:37
Genes, Vol. 10, Pages 881: Sow Thistle Chloroplast Genomes: Insights into the Plastome Evolution and Relationship of Two Weedy Species, Sonchus asper and Sonchus oleraceus (Asteraceae) Genes doi: 10.3390/genes10110881 Authors: Cho Kim Kim Mejías Kim Prickly sow thistle, Sonchus asper (L.) Hill, and common sow thistle, Sonchus oleraceus L., are noxious weeds. Probably originating from the Mediterranean region, they have become widespread species. They share similar morphology...
Fri Nov 01, 2019 02:00
Genes, Vol. 10, Pages 882: The BRCA1 c.4096+3A>G Variant Displays Classical Characteristics of Pathogenic BRCA1 Mutations in Hereditary Breast and Ovarian Cancers, But Still Allows Homozygous Viability Genes doi: 10.3390/genes10110882 Authors: Arason Agnarsson Johannesdottir Johannsson Hilmarsdottir Reynisdottir Barkardottir Mutations in BRCA1 result in predisposal to breast and ovarian cancers, but many variants exist with unknown clinical significance (VUS)....
Fri Nov 01, 2019 02:00
Publication date: 15 January 2020Source: Gene, Volume 724Author(s):
Fri Nov 01, 2019 16:44
Genes, Vol. 10, Pages 878: Cloning, Characterization and Functional Analysis of the LtuPTOX Gene, a Homologue of Arabidopsis thaliana IMMUTANS Derived from Liriodendron tulipifera Genes doi: 10.3390/genes10110878 Authors: Ziyuan Hao Yaxian Zong Huanhuan Liu Zhonghua Tu Huogen Li Flower colour and colour patterns are crucial traits for ornamental species; thus, a comprehensive understanding of their genetic basis is extremely significant for plant breeders. The tulip tree...
Fri Nov 01, 2019 02:00
Genes, Vol. 10, Pages 879: The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene Genes doi: 10.3390/genes10110879 Authors: Jesse L. Berry Ashley Polski Webster K. Cavenee Thaddeus P. Dryja A. Linn Murphree Brenda L. Gallie The RB1 gene is the first described human tumor suppressor gene and plays an integral role in the development of retinoblastoma, a pediatric malignancy of the eye. Since its discovery, the stepwise characterization and cloning...
Fri Nov 01, 2019 02:00
Genes, Vol. 10, Pages 877: Whole-Genome Bisulfite Sequencing Reveals a Role for DNA Methylation in Variants from Callus Culture of Pineapple (Ananas comosus L.) Genes doi: 10.3390/genes10110877 Authors: Wenqiu Lin Xi’ou Xiao Hongna Zhang Yunhe Li Shenghui Liu Weisheng Sun Xiumei Zhang Qingsong Wu DNA methylation changes can occur in some loci during callus culture, resulting in somaclonal variations (SVs). In the present study, we applied whole genome bisulfite sequencing...
Fri Nov 01, 2019 02:00
Genes, Vol. 10, Pages 880: A Mechanogenetic Model of Exercise-Induced Pulmonary Haemorrhage in the Thoroughbred Horse Genes doi: 10.3390/genes10110880 Authors: Blott Cunningham Malkowski Brown Rauch Exercise-induced pulmonary haemorrhage (EIPH) occurs in horses performing high-intensity athletic activity. The application of physics principles to derive a ‘physical model’, which is coherent with existing physiology and cell biology data, shows that...
Fri Nov 01, 2019 02:00
Pathogens, Vol. 8, Pages 214: Rapid Discrimination of Methicillin-Resistant Staphylococcus aureus by MALDI-TOF MS Pathogens doi: 10.3390/pathogens8040214 Authors: Kim Kim Chung Chung Han Kim Methicillin-resistant Staphylococcus aureus (MRSA) is a serious pathogen in clinical settings and early detection is critical. Here, we investigated the MRSA discrimination potential of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)...
Fri Nov 01, 2019 02:00
Pathogens, Vol. 8, Pages 215: West Nile Virus Induced Cell Death in the Central Nervous System Pathogens doi: 10.3390/pathogens8040215 Authors: Peng Wang West Nile virus (WNV), a mosquito-borne, single-stranded flavivirus, has caused annual outbreaks of viral encephalitis in the United States since 1999. The virus induces acute infection with a clinical spectrum ranging from a mild flu-like febrile symptom to more severe neuroinvasive conditions, including meningitis, encephalitis,...
Fri Nov 01, 2019 02:00
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