Tue Nov 12, 2019 17:45
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Tue Nov 12, 2019 16:45
AbstractThe article by Blackburn (Am J Epidemiol. XXXX;XXX(XX):XXXX–XXXX)) describes the evolution from the Makarska Conference in 1968 to the planning of the JUMBO trial and the decision by the National Institutes of Health (NIH) to do the Multiple Risk Factor Intervention Trial. He attributes the failure of Multiple Risk Factor Intervention Trial to show a significant reduction in coronary heart disease or total mortality to the design of the trial, the multiple centers involved, and continued...
Tue Nov 12, 2019 02:00
AbstractCow’s milk is consumed by most North American children yet the relationships between the volume and fat content of cow’s milk consumed and childhood fracture risk are unclear. The primary objectives of this study were to evaluate whether the volume or fat content of cow’s milk consumed between 1-3 years of age was associated with the risk of fracture between 3-10 years of age. This was a prospective cohort study of 2466 children recruited between 2008 and 2016 in Toronto, Canada. The primary...
Tue Nov 12, 2019 02:00
AbstractWe examined the risk of any perinatal mental illness associated with pre-pregnancy diabetes and identified how diabetes duration, complexity, and intensity of care affect this risk. We performed a population-based study of 15 to 49-year-old women with (n=14,186) and without (n=843,818) pre-pregnancy diabetes who had a singleton livebirth (Ontario, Canada, 2005-2015) and no recent mental illness. Modified Poisson regression estimated perinatal mental illness risk between conception and 1 year...
Tue Nov 12, 2019 02:00
AbstractAsthma and obesity are two of the most prevalent chronic health conditions in children. Although there has been compelling evidence of co-occurrence of asthma and obesity, it is uncertain whether asthma contributes to the development of obesity or obesity contributes to the onset of asthma or both. In this study, we used a joint transition modeling approach with cross-lagged structure to understand how asthma and obesity influence each other dynamically over time. Subjects for this study...
Tue Nov 12, 2019 02:00
AbstractThere is broad agreement that religion is a social determinant of health. In the article by Chen and VanderWeele (Am J Epidemiol. 2018;187(11):2355–2364), the authors took an outcome-wide approach to demonstrate associations between religious practices early in the life-course (regular service attendance and prayer/mediation) and a wide range of health endpoints and behaviors later on. Is religion a panacea? The study adds to the evidence that religious practices are correlated with a broad...
Tue Nov 12, 2019 02:00
AbstractThe Folic Acid and Zinc Supplementation Trial (FAZST) was a multi-center, double-blind, block-randomized, placebo-controlled trial to determine whether folic acid and zinc supplementation in men improves semen quality and increases live birth rate among couples seeking infertility treatment (2013-2017). Eligible men were ages 18 years or older with their female partners ages 18-45 seeking infertility treatment. Men were randomized (1:1) to 5 mg folic acid and 30 mg elemental zinc daily or...
Tue Nov 12, 2019 02:00
AbstractThe concept of a multiple risk factor intervention trial (MRFIT) originated in mid-20th century efforts to determine whether modifying the “risk factors” established by cardiovascular disease (CVD) epidemiology would prevent heart attacks. The term “MRFIT” probably first appeared in the 1968 report to the National Heart Institute (NHI) from investigators of the National Diet-Heart Feasibility Study (1). Based on their pilot experience, they recommended a trial of diet alone. Aware, however,...
Tue Nov 12, 2019 02:00
AbstractHepatitis C virus (HCV) is common among people living with human immunodeficiency virus (PLWH). Extrahepatic manifestations of HCV, including myocardial infarction (MI), are a topic of active research. MI is classified into types, predominantly atheroembolic Type 1 MI (T1MI) and supply-demand mismatch Type 2 MI (T2MI). We examined the association between HCV and MI in the Centers for Acquired Immunodeficiency Syndrome Research Network of Integrated Clinical Systems, a multi-center clinical...
Tue Nov 12, 2019 02:00
Abstract Background Psychological distress is a strong and independent predictor of major depression. Assuming multiple roles (such as being both a mother and an employee) under stressful conditions may lead to psychological distress. This study evaluated, for the first time, the longitudinal effect of the simultaneous exposure to psychosocial work stressors and high family responsibilities on women's psychological distress. Methods Women were assessed at baseline (N = 1307) and at 3‐ and...
Tue Nov 12, 2019 20:19
The benefits of the regular exercise on quality of life of individuals living with a headache are well known. However, whether the benefits of the exercise training on headache parameters (i.e., intensity, frequency and pain duration) occur in an intensity-dependent fashion remains unknown. Objective To investigate the effects of different exercise intensities on headache parameters. Design A systematic review of clinical trials that analyzed the effect of physical exercise on headache,...
Mon Nov 11, 2019 02:00
Tendon injuries or tendinopathy are common painful and disabling conditions resulting from overuse and aging. Tendinopathy remains a challenging clinical problem since response to different treatment modalities is usually unsatisfactory and recovery is slow. We performed an extensive literature review focusing on non-surgical treatment options for tendinopathies, including nonsteroidal anti-inflammatory drugs, corticosteroid, eccentric exercise, extracorporeal shock wave therapy, therapeutic ultrasound,...
Mon Nov 11, 2019 02:00
Objective A reachable workspace evaluation using the Kinect sensor was previously introduced as a novel upper extremity outcome measure in neuromuscular and musculoskeletal conditions. This study investigated its usefulness in hemiplegic stroke patients. Design Forty-one patients with hemiplegic stroke were included. Kinect-based reachable workspace analysis was performed on both paretic and nonparetic sides. Upper extremity impairment was measured using the Fugl-Meyer Assessment and the...
Mon Nov 11, 2019 02:00
Agnes G Loeffler, Mark Smith, Elizabeth Way, Michelle Stoffel, Daniel F I KurtyczJournal of Pathology Informatics 2019 10(1):33-33 Since the advent of whole slide imaging, the utility of digitized slides for education in medical school and residency has been amply documented. Pathology departments at most major academic medical centers have made digitized slides available to pathology residents for study, even before the use of digitized slides for clinical purposes (i.e., primary diagnosis) has...
Tue Nov 12, 2019 00:00
Abstract We appreciate Kaur and colleagues for taking the time to express their concerns about recommending azithromycin in the management of chronic periodontitis. We agree that antibiotic resistance is an ever‐increasing issue, and that azithromycin is indeed an invaluable drug for many crucial medical indications.
Tue Nov 12, 2019 15:42
Blood Cancer Journal, Published online: 12 November 2019; doi:10.1038/s41408-019-0248-yPrognostic impact of peripheral blood WT1-mRNA expression in patients with MDS
Tue Nov 12, 2019 02:00
Blood Cancer Journal, Published online: 11 November 2019; doi:10.1038/s41408-019-0247-zEASIX for prediction of survival in lower-risk myelodysplastic syndromes
Mon Nov 11, 2019 02:00
This paper presents evidence from five studies (total White N = 7,209) that White American’s racial identity centrality is related to self‐reported levels of far‐right extremism. Furthermore, evidence from two of the studies shows that social dominance orientation (SDO) is another robust predictor of far‐right extremism. Results also show that SDO can moderate the relationship between White identity and extremism such that the association is stronger for Whites with a higher level of SDO. Therefore,...
Tue Nov 12, 2019 13:25
P. Martelli et al.
Tue Nov 12, 2019 07:00
E. Savani et al.
Tue Nov 12, 2019 07:00
BACKGROUND There is inadequate information on the association of pre-operative and postoperative peak level of lactate with mortality of surgical ICU patients. OBJECTIVE To investigate the association between peri-operative lactate level and 90-day mortality in patients admtted to the surgical ICU. DESIGN Retrospective cohort study. SETTING ICUs in single tertiary academic hospital. PATIENTS Adult patients postoperatively admitted to the ICU between January 2012 and December...
Wed Oct 16, 2019 03:00
Abstract Iron deficiency anemia (IDA) is the most prevalent and treatable form of anemia worldwide. The clinical management of patients with IDA requires a comprehensive understanding of the many etiologies that can lead to iron deficiency including pregnancy, blood loss, renal disease, heavy menstrual bleeding, inflammatory bowel disease, bariatric surgery, or extremely rare genetic disorders. The treatment landscape for many causes of IDA is currently shifting towards more abundant use of intravenous...
Tue Nov 12, 2019 21:25
We thank Dr Liapis et al. for their kind letter addressing our recently published work “Immediate impact of prosthetic graft replacement of the ascending aorta on circumferential strain in the descending aorta.” We congratulate Dr Liapis's group on their previous clinical studies and published work on changes in aortic pulse wave velocities, arterial stiffness, and biological markers such as N terminal prohormone brain natriuretic peptide (NT-proBNP) after endovascular aneurysm repair. While our...
Tue Nov 12, 2019 02:00
Diabetes mellitus has reached epidemic proportions. Foot ulceration is a multifactorial complication of diabetes associated with marked morbidity and mortality. Innate immune Toll-like receptor 4 (TLR4) mediated inflammation has been implicated in the systemic pathogenesis of diabetes and may contribute to impairment of wound healing. This study investigates the effect of high glucose and hypoxic conditions on TLR4 activation and signalling in vitro and in vivo.
Tue Nov 12, 2019 02:00
The aim of this study was to assess the post-operative volumetric evolution of common iliac arteries (CIA) ≥ 17 mm diameter with respect to the type of endovascular technique performed and to assess type 1b endoleak risk factors.
Tue Nov 12, 2019 02:00
ConclusionWhile educational intervention can promote a father ’s positive attitude towards HPV vaccination, it is ineffective at promoting a positive intention to follow through to inoculate their daughters or improving their willingness to assist in the decision-making process. (Source: International Journal of Clinical Oncology)
Tue Nov 12, 2019 00:00
Tue Nov 12, 2019 14:06
CONCLUSIONS & IMPLICATIONS: Although PCC-obs developed significantly from ages 3 to 5, children with UCLP as a group did not catch up to typically developing Danish children at age 5. Furthermore, the LHPC group at age 5 did not reach the 3-year level of the EHPC group, which means that delaying hard palate closure until age 3 is detrimental to obstruent development. Both CSCs and DSCs at age 3 were important predictors of PCC-obs at age 5 and should be considered when determining need for intervention....
Mon Nov 11, 2019 00:00
IJMS, Vol. 20, Pages 5679: Epigenetic Mechanisms and Posttranslational Modifications in Systemic Lupus Erythematosus International Journal of Molecular Sciences doi: 10.3390/ijms20225679 Authors: Elkin Navarro Quiroz Valeria Chavez-Estrada Karime Macias-Ochoa María Fernanda Ayala-Navarro Aniyensy Sarai Flores-Aguilar Francisco Morales-Navarrete Fernando de la Cruz Lopez Lorena Gomez Escorcia Carlos G. Musso Gustavo Aroca Martinez Henry Gonzales Torres Anderson...
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IJMS, Vol. 20, Pages 5678: Goals and Challenges in Bacterial Phosphoproteomics International Journal of Molecular Sciences doi: 10.3390/ijms20225678 Authors: Paula Yagüe Nathaly Gonzalez-Quiñonez Gemma Fernánez-García Sergio Alonso-Fernández Angel Manteca Reversible protein phosphorylation at serine, threonine and tyrosine is a well-known dynamic post-translational modification with stunning regulatory and signalling functions in eukaryotes. Shotgun phosphoproteomic analyses...
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IJMS, Vol. 20, Pages 5677: Development and Characterization of a Genetic Mouse Model of KRAS Mutated Colorectal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20225677 Authors: Radhashree Maitra Thongthai Thavornwatanayong Madhu Kumar Venkatesh Carol Chandy Dov Vachss Titto Augustine Hillary Guzik Wade Koba Qiang Liu Sanjay Goel Patients with KRAS mutated colorectal cancer (CRC) represent a cohort with unmet medical needs, with limited...
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IJMS, Vol. 20, Pages 5676: Genome-Wide Characterization, Expression Profile Analysis of WRKY Family Genes in Santalum album and Functional Identification of Their Role in Abiotic Stress International Journal of Molecular Sciences doi: 10.3390/ijms20225676 Authors: Haifeng Yan Mingzhi Li Yuping Xiong Jianming Wu Jaime A. Teixeira da Silva Guohua Ma WRKY proteins are a large superfamily of transcription factors that are involved in diverse biological processes including...
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IJMS, Vol. 20, Pages 5675: Genome-Wide Correlation of 36 Agronomic Traits in the 287 Pepper (Capsicum) Accessions Obtained from the SLAF-seq-Based GWAS International Journal of Molecular Sciences doi: 10.3390/ijms20225675 Authors: Lang Wu Peng Wang Yihao Wang Qing Cheng Qiaohua Lu Jinqiu Liu Ting Li Yixin Ai Wencai Yang Liang Sun Huolin Shen There are many agronomic traits of pepper (Capsicum L.) with abundant phenotypes that can benefit pepper growth. Using...
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IJMS, Vol. 20, Pages 5674: Excitatory Amino Acid Transporters (EAATs): Glutamate Transport and Beyond International Journal of Molecular Sciences doi: 10.3390/ijms20225674 Authors: Simona Magi Silvia Piccirillo Salvatore Amoroso Vincenzo Lariccia Na+-dependent excitatory amino acid transporters (EAATs) are the major transport mechanisms for extracellular glutamate removal in the central nervous system (CNS). The primary function assigned to EAATs is the maintenance of low extracellular...
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IJMS, Vol. 20, Pages 5673: DGKα in Neutrophil Biology and Its Implications for Respiratory Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20225673 Authors: Gianluca Baldanzi Mario Malerba Diacylglycerol kinases (DGKs) play a key role in phosphoinositide signaling by removing diacylglycerol and generating phosphatidic acid. Besides the well-documented role of DGKα and DGKζ as negative regulators of lymphocyte responses, a robust body of literature...
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IJMS, Vol. 20, Pages 5672: The Anti-Tumorigenic Activity of Sema3C in the Chick Embryo Chorioallantoic Membrane Model International Journal of Molecular Sciences doi: 10.3390/ijms20225672 Authors: Valiulytė Curkūnavičiūtė Ribokaitė Kazlauskas Vaitkevičiūtė Skauminas Valančiūtė Sema3C protein, a member of the class 3 family of secreted semaphorins, play an important role in tumor development by regulating cell proliferation, migration, invasion, and angiogenesis...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5670: Candidate Domestication-Related Genes Revealed by Expression Quantitative Trait Loci Mapping of Narrow-Leafed Lupin (Lupinus angustifolius L.) International Journal of Molecular Sciences doi: 10.3390/ijms20225670 Authors: Plewiński Książkiewicz Rychel-Bielska Rudy Wolko The last century has witnessed rapid domestication of the narrow-leafed lupin (Lupinus angustifolius L.) as a grain legume crop, exploiting discovered alleles conferring low-alkaloid...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5671: Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System International Journal of Molecular Sciences doi: 10.3390/ijms20225671 Authors: Malik Willnow Excitatory amino acid transporters (EAATs) encompass a class of five transporters with distinct expression in neurons and glia of the central nervous system (CNS). EAATs are mainly recognized for their role in uptake of the amino acid glutamate, the major excitatory neurotransmitter....
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5669: Quantification of Surface GalNAc Ligands Decorating Nanostructured Lipid Carriers by UPLC-ELSD International Journal of Molecular Sciences doi: 10.3390/ijms20225669 Authors: Gauthier Varache Couffin Lebrun Delangle Gateau Texier Nanoparticles have been extensively studied for drug delivery and targeting to specific organs. The functionalization of the nanoparticle surface by site-specific ligands (antibodies, peptides, saccharides)...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5667: Genome-Wide Analysis of the DYW Subgroup PPR Gene Family and Identification of GmPPR4 Responses to Drought Stress International Journal of Molecular Sciences doi: 10.3390/ijms20225667 Authors: Hong-Gang Su Bo Li Xin-Yuan Song Jian Ma Jun Chen Yong-Bin Zhou Ming Chen Dong-Hong Min Zhao-Shi Xu You-Zhi Ma Pentatricopeptide-repeat (PPR) proteins were identified as a type of nucleus coding protein that is composed of multiple tandem repeats....
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5668: Lessons from the Trials for the Desirable Effects of Sodium Glucose Co-Transporter 2 Inhibitors on Diabetic Cardiovascular Events and Renal Dysfunction International Journal of Molecular Sciences doi: 10.3390/ijms20225668 Authors: Wakisaka Kamouchi Kitazono Recent large placebo-controlled trials of sodium glucose co-transporter 2 (SGLT2) inhibitors revealed desirable effects on heart failure (HF) and renal dysfunction; however, the mechanisms underlying...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5664: Key Factors for A One-Pot Enzyme Cascade Synthesis of High Molecular Weight Hyaluronic Acid International Journal of Molecular Sciences doi: 10.3390/ijms20225664 Authors: Gottschalk Zaun Eisele Kuballa Elling In the last decades, interest in medical or cosmetic applications of hyaluronic acid (HA) has increased. Size and dispersity are key characteristics of biological function. In contrast to extraction from animal tissue or bacterial fermentation,...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5665: Rhododenol Activates Melanocytes and Induces Morphological Alteration at Sub-Cytotoxic Levels International Journal of Molecular Sciences doi: 10.3390/ijms20225665 Authors: Minjeong Kim Chang-Seok Lee Kyung-Min Lim Rhododenol (RD), a whitening cosmetic ingredient, was withdrawn from the market due to RD-induced leukoderma (RIL). While many attempts have been made to clarify the mechanism underlying RIL, RIL has not been fully understood yet. Indeed, affected...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5652: Correction: Li, Q., et al. Differential and Interactive Effects of Substrate Topography and Chemistry on Human Mesenchymal Stem Cell Gene Expression. Int. J. Mol. Sci. 2018, 19, 2344 International Journal of Molecular Sciences doi: 10.3390/ijms20225652 Authors: Qiongfang Li Bo Zhang Naresh Kasoju Jinmin Ma Aidong Yang Zhanfeng Cui Hui Wang Hua Ye The authors wish to make the following correction to this paper [...]
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5666: Bovine Lactoferrin Pre-Treatment Induces Intracellular Killing of AIEC LF82 and Reduces Bacteria-Induced DNA Damage in Differentiated Human Enterocytes International Journal of Molecular Sciences doi: 10.3390/ijms20225666 Authors: Maria Stefania Lepanto Luigi Rosa Antimo Cutone Mellani Jinnett Scotti Antonietta Lucia Conte Massimiliano Marazzato Carlo Zagaglia Catia Longhi Francesca Berlutti Giovanni Musci Piera Valenti Maria Pia...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5663: Correction: Abdulle, A.E., et al. Hydrogen Sulfide: A Therapeutic Option in Systemic Sclerosis. Int. J. Mol. Sci. 2018, 19, 4121 International Journal of Molecular Sciences doi: 10.3390/ijms20225663 Authors: Amaal Eman Abdulle Harry van Goor Douwe J. Mulder The authors wish to make the following correction to this paper [...]
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5661: Development of a Gut-On-A-Chip Model for High Throughput Disease Modeling and Drug Discovery International Journal of Molecular Sciences doi: 10.3390/ijms20225661 Authors: Claudia Beaurivage Elena Naumovska Yee Xiang Chang Edo D. Elstak Arnaud Nicolas Heidi Wouters Guido van Moolenbroek Henriëtte L. Lanz Sebastiaan J. Trietsch Jos Joore Paul Vulto Richard A.J. Janssen Kai S. Erdmann Jan Stallen Dorota Kurek A common...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5660: Investigations of the Kinetics and Mechanism of Reduction of a Carboplatin Pt(IV) Prodrug by the Major Small-Molecule Reductants in Human Plasma International Journal of Molecular Sciences doi: 10.3390/ijms20225660 Authors: Yang Liu Hongwu Tian Liyao Xu Li Zhou Jinhu Wang Benyan Xu Chunli Liu Lars I. Elding Tiesheng Shi The development of Pt(IV) anticancer prodrugs to overcome the detrimental side effects of Pt(II)-based anticancer drugs...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5659: Trends in Atopic Dermatitis—From Standard Pharmacotherapy to Novel Drug Delivery Systems International Journal of Molecular Sciences doi: 10.3390/ijms20225659 Authors: Eliana B. Souto João Dias-Ferreira Jéssica Oliveira Elena Sanchez-Lopez Ana Lopez-Machado Marta Espina Maria L. Garcia Selma B. Souto Carlos Martins-Gomes Amélia M. Silva Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5662: A Meta-Analysis of Comparative Transcriptomic Data Reveals a Set of Key Genes Involved in the Tolerance to Abiotic Stresses in Rice International Journal of Molecular Sciences doi: 10.3390/ijms20225662 Authors: Matteo Buti Elena Baldoni Elide Formentin Justyna Milc Giovanna Frugis Fiorella Lo Schiavo Annamaria Genga Enrico Francia Several environmental factors, such as drought, salinity, and extreme temperatures, negatively affect plant...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5658: A Newly Established Murine Cell Line as a Model for Hepatocellular Cancer in Non-Alcoholic Steatohepatitis International Journal of Molecular Sciences doi: 10.3390/ijms20225658 Authors: Andreas Kroh Jeanette Walter Herdit Schüler Jochen Nolting Roman Eickhoff Daniel Heise Ulf Peter Neumann Thorsten Cramer Tom Florian Ulmer Athanassios Fragoulis Non-alcoholic steatohepatitis (NASH) has become a major risk factor for hepatocellular...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5654: Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20225654 Authors: Vincenzo Carafa Angelita Poziello Laura Della Torre Pia Giovannelli Marzia Di Donato Elham Safadeh Zhijun Yu Alfonso Baldi Gabriella Castoria Daniela Tomaselli Antonello Mai Dante Rotili Angela Nebbioso Lucia Altucci Sirtuins, a family of nicotinamide adenine...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5657: Defect of Interferon γ Leads to Impaired Wound Healing through Prolonged Neutrophilic Inflammatory Response and Enhanced MMP-2 Activation International Journal of Molecular Sciences doi: 10.3390/ijms20225657 Authors: Emi Kanno Hiromasa Tanno Airi Masaki Ayako Sasaki Noriko Sato Maiko Goto Mayu Shisai Kenji Yamaguchi Naoyuki Takagi Miki Shoji Yuki Kitai Ko Sato Jun Kasamatsu Keiko Ishii Tomomitsu Miyasaka Kaori Kawakami...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5656: Recent Advances in ROS-Responsive Cell Sheet Techniques for Tissue Engineering International Journal of Molecular Sciences doi: 10.3390/ijms20225656 Authors: Min-Ah Koo Mi Hee Lee Jong-Chul Park Cell sheet engineering has evolved rapidly in recent years as a new approach for cell-based therapy. Cell sheet harvest technology is important for producing viable, transplantable cell sheets and applying them to tissue engineering. To date, most cell sheet studies...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5655: Claudin-2: Roles beyond Permeability Functions International Journal of Molecular Sciences doi: 10.3390/ijms20225655 Authors: Shruthi Venugopal Shaista Anwer Katalin Szászi Claudin-2 is expressed in the tight junctions of leaky epithelia, where it forms cation-selective and water permeable paracellular channels. Its abundance is under fine control by a complex signaling network that affects both its synthesis and turnover in response to various environmental...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5650: A Preclinical Evaluation towards the Clinical Application of Oxygen Consumption Measurement by CERMs by a Mouse Chimera Model International Journal of Molecular Sciences doi: 10.3390/ijms20225650 Authors: Takashi Kuno Masahito Tachibana Ayako Fujimine-Sato Misaki Fue Keiko Higashi Aiko Takahashi Hiroki Kurosawa Keisuke Nishio Naomi Shiga Zen Watanabe Nobuo Yaegashi We have developed an automated device for the measurement of oxygen...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5653: Salvianolic Acid B Slows the Progression of Breast Cancer Cell Growth via Enhancement of Apoptosis and Reduction of Oxidative Stress, Inflammation, and Angiogenesis International Journal of Molecular Sciences doi: 10.3390/ijms20225653 Authors: Mohamed A. Katary Rafik Abdelsayed Abdulmohsin Alhashim Mohamed Abdelhasib Ahmed A. Elmarakby Breast cancer is the current leading cause of cancer death in females worldwide. Although current chemotherapeutic...
Tue Nov 12, 2019 02:00
IJMS, Vol. 20, Pages 5651: Expression Analysis of mRNA Decay of Maternal Genes during Bombyx mori Maternal-to-Zygotic Transition International Journal of Molecular Sciences doi: 10.3390/ijms20225651 Authors: Meirong Zhang Pingzhen Xu Huilin Pang Tao Chen Guozheng Zhang Maternal genes play an important role in the early embryonic development of the silkworm. Early embryonic development without new transcription depends on maternal components stored in the egg during oocyte...
Tue Nov 12, 2019 02:00
Galacto-oligosaccharides (GOS) have been increasingly used globally to supplement commercially available milk formulations and dairy products for their health benefits.1 Intriguingly, when GOS were introduced into Southeast Asian countries as an ingredient in milk formula, a few acute allergic reactions and anaphylactic responses to GOS were promptly observed.2-4 Anaphylaxis to GOS occurred on first consumption in all our patients with allergic reactions, which was an indication of the presence of...
Tue Oct 15, 2019 00:00
Morbidity and mortality associated with childhood asthma are driven disproportionately by children with severe asthma. However, it is not known from longitudinal studies whether children outgrow severe asthma. (Source: Journal of Allergy and Clinical Immunology)
Mon Oct 14, 2019 00:00
(Source: Journal of Cancer Education)
Tue Nov 12, 2019 00:00
(Source: Journal of Cancer Research and Clinical Oncology)
Tue Nov 12, 2019 00:00
Publication date: Available online 11 November 2019Source: Journal of Clinical EpidemiologyAuthor(s): Samuel Jellison, Johnny Nolan, Nam Vo, Mark Thai, Livia Puljak, Matt Vassar
Tue Nov 12, 2019 17:02
Researchers are increasingly using routine clinical data for care evaluations and feedback to patients and clinicians. The quality of these evaluations depends on the quality and completeness of the input data.
Tue Nov 12, 2019 02:00
(Source: Journal of Clinical Immunology)
Mon Nov 11, 2019 00:00
ConclusionPNP is a variable immunodeficiency and should be considered in various clinical contexts, with or without neurological manifestations. HSCT offers a good treatment option, with excellent clinical outcomes, when preformed in a timely manner. (Source: Journal of Clinical Immunology)
Sat Nov 09, 2019 00:00
JCM, Vol. 8, Pages 1952: Cranial Irradiation in Childhood Acute Lymphoblastic Leukemia Is Related to Subclinical Left Ventricular Dysfunction and Reduced Large Artery Compliance in Cancer Survivors Journal of Clinical Medicine doi: 10.3390/jcm8111952 Authors: Joanna Sulicka-Grodzicka Bernadeta Chyrchel Justyna Totoń-Żurańska Ewelina Nowak Paweł P. Wołkow Andrzej Surdacki Tomasz Grodzicki Long-term survivors of acute lymphoblastic leukemia (ALL), the most common childhood...
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JCM, Vol. 8, Pages 1951: Cushing’s Disease Journal of Clinical Medicine doi: 10.3390/jcm8111951 Authors: Nishioka Yamada In patients with Cushing’s disease (CD), prompt diagnosis and treatment are essential for favorable long-term outcomes, although this remains a challenging task. The differential diagnosis of CD is still difficult in some patients, even with an organized stepwise diagnostic approach. Moreover, despite the use of high-resolution magnetic resonance imaging...
Tue Nov 12, 2019 02:00
JCM, Vol. 8, Pages 1948: Urinary Excretion of N1-Methylnicotinamide, as a Biomarker of Niacin Status, and Mortality in Renal Transplant Recipients Journal of Clinical Medicine doi: 10.3390/jcm8111948 Authors: Carolien P.J. Deen Anna van der Veen Martijn van Faassen Isidor Minović António W. Gomes-Neto Johanna M. Geleijnse Karin J. Borgonjen-van den Berg Ido P. Kema Stephan J.L. Bakker Renal transplant recipients (RTR) commonly suffer from vitamin B6 deficiency...
Tue Nov 12, 2019 02:00
JCM, Vol. 8, Pages 1949: Increased Paracetamol Bioavailability after Sleeve Gastrectomy: A Crossover Pre- vs. Post-Operative Clinical Trial Journal of Clinical Medicine doi: 10.3390/jcm8111949 Authors: Daniel Porat Milica Markovic Moran Zur Noa Fine-Shamir Carmil Azran Gad Shaked David Czeiger Julie Vaynshtein Ilya Replyanski Gilbert Sebbag Arik Dahan Oral drug bioavailability may be significantly altered after laparoscopic sleeve gastrectomy (LSG), the...
Tue Nov 12, 2019 02:00
JCM, Vol. 8, Pages 1950: Clinical Factors Associated with a Shorter or Longer Course of Antibiotic Treatment in Patients with Exacerbations of Bronchiectasis: A Prospective Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm8111950 Authors: Giulia Scioscia Rosanel Amaro Victoria Alcaraz-Serrano Albert Gabarrús Patricia Oscanoa Laia Fernandez Rosario Menendez Raul Mendez Maria Pia Foschino Barbaro Antoni Torres Background: Bronchiectasis exacerbations...
Tue Nov 12, 2019 02:00
JCM, Vol. 8, Pages 1946: A Systematic Review and Meta-Analysis of Within-Person Changes in Cardiac Vagal Activity across the Menstrual Cycle: Implications for Female Health and Future Studies Journal of Clinical Medicine doi: 10.3390/jcm8111946 Authors: Katja M. Schmalenberger Tory A. Eisenlohr-Moul Lena Würth Ekaterina Schneider Julian F. Thayer Beate Ditzen Marc N. Jarczok Interest in cardiac vagal activity (CVA; e.g., parasympathetically-mediated heart rate variability)...
Tue Nov 12, 2019 02:00
JCM, Vol. 8, Pages 1947: Acute Effects of Immersive Virtual Reality Exercise on Young Adults’ Situational Motivation Journal of Clinical Medicine doi: 10.3390/jcm8111947 Authors: Wenxi Liu Nan Zeng Zachary C. Pope Daniel J. McDonough Zan Gao The development of innovative technology, such as virtual reality (VR), has provided opportunities for promoting physical activity (PA) in a fun and engaging manner. The purpose of this study was to examine differences in young adults’...
Tue Nov 12, 2019 02:00
JCM, Vol. 8, Pages 1945: Conversion Surgery for Advanced Pancreatic Cancer Journal of Clinical Medicine doi: 10.3390/jcm8111945 Authors: Thomas Hank Oliver Strobel While primarily unresectable locally advanced pancreatic cancer (LAPC) used to be an indication for palliative therapy, a strategy of neoadjuvant therapy (NAT) and conversion surgery is being increasingly used after more effective chemotherapy regimens have become available for pancreatic ductal adenocarcinoma. While high-level...
Tue Nov 12, 2019 02:00
JCM, Vol. 8, Pages 1944: Exciting Opportunities in Nuclear Medicine Imaging and Therapy Journal of Clinical Medicine doi: 10.3390/jcm8111944 Authors: Constantin Lapa Nuclear medicine has experienced a number of unprecedented developments in recent years. Above all, the concept of “theranostics”, the combination of a predictive biomarker with a therapeutic agent, has been a central part of this success. For example, a phase III randomized, controlled trial provided...
Tue Nov 12, 2019 02:00
JCM, Vol. 8, Pages 1943: Exacerbation of Hangover Symptomology Significantly Corresponds with Heavy and Chronic Alcohol Drinking: A Pilot Study Journal of Clinical Medicine doi: 10.3390/jcm8111943 Authors: Vatsalya Vatsalya Hamza Z. Hassan Maiying Kong Bethany L. Stangl Melanie L. Schwandt Veronica Y. Schmidt-Teron Joris C. Verster Vijay A. Ramchandani Craig J. McClain Alcohol hangover is a combination of mental, sympathetic, and physical symptoms experienced...
Tue Nov 12, 2019 02:00
This clinical trial demonstrated no significant effect for adjunctive treatment with resveratrol on irritability of patients with ASD. However, it provided preliminary evidence indicating that resveratrol could improve hyperactivity/non‐compliance of ASD patients. Abstract What is known and objective The underlying pathophysiology of autism spectrum disorder (ASD) has been linked to immune dysregulation, oxidative stress and excitation‐inhibition imbalance. Among associated symptoms of ASD,...
Tue Nov 12, 2019 15:48
Abstract Objective We examined Veterans’ perspectives on discussing moral injury in veterans affairs (VA) evidence‐based psychotherapies (EBPs) for posttraumatic stress disorder (PTSD) and other VA treatment. Methods Fourteen male warzone veterans (ages 25–74) who completed an EBP for PTSD within the past year participated in semistructured interviews related to discussing moral injury in VA treatment (e.g., EBPs for PTSD, chaplaincy). Qualitative interviews were evaluated using a thematic...
Tue Nov 12, 2019 16:08
Abstract Retention of volunteers is a main issue for no‐profit organizations. In the present study, using a cross‐sectional design, determinants of volunteers’ intentions to continue their service were investigated in a sample of 116 volunteers at different Italian organizations (Mage = 42.32, SDage = 15.91). Guided by the conceptual model of the volunteer process, we hypothesized that organizational socialization should mediate the link between prosocial personality and intention to continue volunteering....
Tue Nov 12, 2019 12:34
ABSTRACT: Objectives: To explore the relationship between congenital cytomegalovirus (CMV) and inattention and hyperactivity among school-aged children. Methods: The Behavior Assessment System for Children, Second Edition, parent- and self-report, was completed among children with symptomatic congenital CMV (ScCMV) (n = 36), asymptomatic congenital CMV (AcCMV) (n = 76), and controls (n = 29) enrolled in a longitudinal cohort. The proportions of children with ScCMV, AcCMV, and controls...
Thu Nov 07, 2019 02:00
Author: Hove, Michael J.; Martinez, Steven A.; Stupacher, Jan DOI: 10.1037/xge0000708 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:29
Author: Noyes, Alexander; Keil, Frank C. DOI: 10.1037/xge0000711 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:29
Author: Zarzeczna, Natalia; von Hecker, Ulrich; Proulx, Travis; Haddock, Geoffrey DOI: 10.1037/xhp0000699 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:16
Author: Ruess, Miriam; Thomaschke, Roland; Kiesel, Andrea DOI: 10.1037/xhp0000700 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:16
Author: Flavell, Jonathan C.; Over, Harriet; Tipper, Steven P. DOI: 10.1037/xhp0000702 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:16
Author: Suh, Jihyun; Abrams, Richard A. DOI: 10.1037/xhp0000706 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:16
Author: Robbins, Arryn; Hout, Michael C. DOI: 10.1037/xhp0000707 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:16
Author: Hayes, William M.; Wedell, Douglas H.; Rashotte, Matthew A. DOI: 10.1037/xhp0000710 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:16
Author: Cochrane, Brett A.; Milliken, Bruce DOI: 10.1037/xhp0000713 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:16
Author: Bauml, Karl-Heinz T.; Wallner, Lisa DOI: 10.1037/xlm0000782 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:26
Author: Collins, Peter J.; Hahn, Ulrike DOI: 10.1037/xlm0000786 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:26
Author: Mulligan, Neil W.; Buchin, Zachary L.; West, John T. DOI: 10.1037/xlm0000787 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:26
Author: Entel, Olga; Tzelgov, Joseph DOI: 10.1037/xlm0000790 Publication Date: November 7, 2019
Tue Nov 12, 2019 20:26
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