The perineal midsagittal view in male fetuses — pivotal for assessing genitourinary disorders Abstract A wide range of genitourinary pathologies can be diagnosed in utero, from a simple vesicoureteral reflux to a more complex disorder of sexual differentiation. The prognosis and neonatal management of these conditions differ significantly. Evaluation of the fetal perineal anatomy is paramount to making the right diagnosis. The aim of this pictorial essay is to show sonographers how to acquire a perineal midsagittal view in a male fetus, and to demonstrate how this specific view allows assessment of the urethra and penis, to differentiate various genitourinary pathologies.

Delayed diagnosis of posterior ankle impingement in pediatric and adolescent patients: does radiology play a role? Abstract Background Posterior ankle impingement syndrome (PAIS) results from the pinching of anatomical structures in the posterior part of the ankle. Objective To identify the possible role of imaging in the delayed diagnosis of PAIS and identify key findings on imaging to suggest PAIS in pediatric and adolescent patients. Materials and methods Data were collected prospectively in patients younger than 18 years of age who underwent arthroscopy after being diagnosed with PAIS. Imaging was reviewed retrospectively by two radiologists, compared with findings in literature and an age-matched control group, and correlated with arthroscopic findings. Pre- and postsurgical Visual Analogue Scale (VAS) pain and American Orthopedic Foot Ankle Society (AOFAS) ankle-hindfoot scores were noted. Results Thirty-eight patients (20 females, 18 males), 51 ankles, with an average age of 12.9 years had an average 18-month delay in diagnosis. Twenty-seven of the 38 (73%) patients had previously seen multiple medical providers and were given multiple misdiagnoses. Radiographs were reported normal in 34/47 (72%) ankles. Thirty patients had magnetic resonance imaging (MRI) and findings included the presence of an os trigonum/Stieda process (94%) with associated osseous edema (69%), flexor hallucis longus (FHL) tenosynovitis (16%), and edema in Kager’s fat pad (63%). Although individual findings were noted, the impression in the MRI reports in 16/32 (50%) did not mention PAIS as the likely diagnosis. There was a significant difference in the MRI findings of ankle impingement in the patient population when compared to the control group. Surgery was indicated after conservative treatment failed. All 51 ankles had a PAIS diagnosis confirmed during arthroscopy. At an average follow-up of 10.2 months, there was improvement of VAS pain (7.0 to 1.1) and AOFAS ankle-hindfoot scores (65.1 to 93.5). Conclusion PAIS as a diagnosis is commonly delayed clinically in young patients with radiologic misinterpretation being a contributing factor. Increased awareness about this condition is needed among radiologists and physicians treating young athletes.

Evaluation of low-contrast detectability for iterative reconstruction in pediatric abdominal computed tomography: a phantom study Abstract Background Iterative reconstruction is offered by all vendors to achieve similar or better CT image quality at lower doses than images reconstructed with filtered back-projection. Objective The purpose of this study was to investigate the dose-reduction potential for pediatric abdominal CT imaging when using either a commercially available hybrid or a commercially available model-based iterative reconstruction algorithm from a single manufacturer. Materials and methods A phantom containing four low-contrast inserts and a uniform background with total attenuation equivalent to the abdomen of an average 8-year-old child was imaged on a CT scanner (IQon; Philips Healthcare, Cleveland, OH). We reconstructed images using both hybrid iterative reconstruction (iDose4) and model-based iterative reconstruction (Iterative Model Reconstruction). The four low-contrast inserts had circular cross-section with diameters of 3 mm, 5 mm, 7 mm and 10 mm and contrasts of 14 Hounsfield units (HU), 7 HU, 5 HU and 3 HU, respectively. Helical scans with identical kilovoltage (kV), pitch, rotation time, and collimation were repeated on the phantom at volume CT dose index (CTDIvol) of 2.0 milligrays (mGy), 3.0 mGy, 4.5 mGy and 6.0 mGy. We measured the contrast-to-noise ratio (CNR) in each rod across scans. Additionally, we collected sub-images containing each rod and sub-images containing the background and used them in two-alternative forced choice observer experiments with four observers (two radiologists and two physicists). We calculated the dose-reduction potential of both iterative reconstruction algorithms relative to a scan performed at 6 mGy and reconstructed with filtered back-projection. Results We calculated dose-reduction potential by either matching average equal observer performance in the two-alternative forced choice experiments or matching CNR. When matching CNR, the dose-reduction potential was 34% to 45% for hybrid iterative reconstruction and 89% to 95% for model-based iterative reconstruction. When matching average observer performance, the dose-reduction potential was 9% to 30% for hybrid iterative reconstruction and 57% to 74% for model-based iterative reconstruction. The range in dose-reduction potential depended on the rod size and contrast level. Conclusion Observer performance in this phantom study indicates that the dose-reduction potential indicated by an observer study is less than that of CNR; extrapolating the results to clinical studies suggests that the dose-reduction potential would also be less.

T 1ρ -mapping for assessing knee joint cartilage in children with juvenile idiopathic arthritis — feasibility and repeatability Abstract Background Ongoing arthritis in children with juvenile idiopathic arthritis (JIA) can result in cartilage damage. Objective To study the feasibility and repeatability of T1ρ for assessing knee cartilage in JIA and also to describe T1ρ values and study correlation between T1ρ and conventional MRI scores for disease activity. Materials and methods Thirteen children with JIA or suspected JIA underwent 3-tesla (T) knee MRI that included conventional sequences and a T1ρ sequence. Segmentation of knee cartilage was carried out on T1ρ images. We used intraclass correlation coefficient to study the repeatability of segmentation in a subset of five children. We used the juvenile arthritis MRI scoring system to discriminate inflamed from non-inflamed knees. The Mann-Whitney U and Spearman correlation compared T1ρ between children with and without arthritis on MRI and correlated T1ρ with the juvenile arthritis MRI score. Results All children successfully completed the MRI examination. No images were excluded because of poor quality. Repeatability of T1ρ measurement had an intraclass correlation coefficient (ICC) of 0.99 (P<0.001). We observed no structural cartilage damage and found no differences in T1ρ between children with (n=7) and without (n=6) inflamed knees (37.8 ms vs. 31.7 ms, P=0.20). However, we observed a moderate correlation between T1ρ values and the juvenile arthritis MRI synovitis score (r=0.59, P=0.04). Conclusion This pilot study suggests that T1ρ is a feasible and repeatable quantitative imaging technique in children. T1ρ values were associated with the juvenile arthritis MRI synovitis score.

Two-dimensional ultrasound measurements vs. magnetic resonance imaging-derived ventricular volume of preterm infants with germinal matrix intraventricular haemorrhage Abstract Background Post-haemorrhagic ventricular dilatation can be measured accurately by MRI. However, two-dimensional (2-D) cranial US can be used at the bedside on a daily basis. Objective To assess whether the ventricular volume can be determined accurately using US. Materials and methods We included 31 preterm infants with germinal matrix intraventricular haemorrhage. Two-dimensional cranial US images were acquired and the ventricular index, anterior horn width and thalamo-occipital distance were measured. In addition, cranial MRI was performed. The ventricular volume on MRI was determined using a previously validated automatic segmentation algorithm. We obtained the correlation and created a linear model between MRI-derived ventricular volume and 2-D cranial US measurements. Results The ventricular index, anterior horn width and thalamo-occipital distance as measured on 2-D cranial US were significantly associated with the volume of the ventricles as determined with MRI. A general linear model fitted the data best: ∛ventricular volume (ml) = 1.096 + 0.094 × anterior horn width (mm) + 0.020 × thalamo-occipital distance (mm) with R2 = 0.831. Conclusion The volume of the lateral ventricles of infants with germinal matrix intraventricular haemorrhage can be estimated using 2-D cranial US images by application of a model.

Portraits in pediatric leadership: Maria Montessori

Introduction

Physeal bridges: causes, diagnosis, characterization and post-treatment imaging Abstract The cartilaginous primary physis, or growth plate, at the end of long bones in children allows for longitudinal bone growth. A variety of insults to the physis can lead to physeal bridge formation, which in turn can lead to limb-shortening and angular deformities. This paper begins with a description of the causes, risk factors and mechanisms by which bridges form. Then it reviews the use of imaging in the diagnosis and characterization of bridges and in the evaluation of treatment and post-treatment complications. It is important for radiologists taking care of children to be aware of the indirect and direct imaging findings of physeal bridges to aid in their diagnosis, to be able to characterize bridges as part of preoperative planning, and to know the imaging finding of post-resection complications.

Imaging of developmental dysplasia of the hip: ultrasound, radiography and magnetic resonance imaging Abstract Developmental dysplasia of the hip (DDH) describes a broad spectrum of developmental abnormalities of the hip joint that are traditionally diagnosed during infancy. Because the development of the hip joint is a dynamic process, optimal treatment depends not only on the severity of the dysplasia, but also on the age of the child. Various imaging modalities are routinely used to confirm suspected diagnosis, to assess severity, and to monitor treatment response. For infants younger than 4 months, screening hip ultrasound (US) is recommended only for those with risk factors, equivocal or positive exam findings, whereas for infants older than 4–6 months, pelvis radiography is preferred. Following surgical hip reduction, magnetic resonance (MR) imaging is preferred over computed tomography (CT) because MR can not only confirm concentric hip joint reduction, but also identify the presence of soft-tissue barriers to reduction and any unexpected postoperative complications. The routine use of contrast-enhanced MR remains controversial because of the relative paucity of well-powered and validated literature. The main objectives of this article are to review the normal and abnormal developmental anatomy of the hip joint, to discuss the rationale behind the current recommendations on the most appropriate selection of imaging modalities for screening and diagnosis, and to review routine and uncommon findings that can be identified on post-reduction MR, using an evidence-based approach. A basic understanding of the physiology and the pathophysiology can help ensure the selection of optimal imaging modality and reduce equivocal diagnoses that can lead to unnecessary treatment.

Imaging of osteochondrosis Abstract Osteochondrosis is an abnormality of the epiphyses or epiphyseal equivalents (round bones and apophyses) during later stages of endochondral ossification. This process of abnormal endochondral ossification can occur at various locations throughout the body. The pathogenesis of osteochondrosis is under active investigation. In humans, the process of abnormal endochondral ossification has been attributed to a combination of vascular insult and trauma. Although the proposed etiology of osteochondrosis varies based on body part affected, the overall process is defined by necrosis, revascularization and repair. As such, common radiologic findings include those of osseous destruction and associated inflammation. The purpose of this review is to discuss the current understanding of osteochondroses as a disease entity and explore imaging features of osteochondroses throughout the body.