Abstract Introduction Malignant astrocytomas are composed of heterogeneous cell populations. Compared to grade IV glioblastoma, low-grade astrocytomas have more differentiated cells and are associated with a better prognosis. Therefore, inducing cellular differentiation to alter the behaviour of high-grade astrocytomas may serve as a therapeutic strategy. The nuclear factor one (NFI) transcription factors are essential for normal astrocytic...
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Journal of Neurotrauma, Volume 36, Issue 23, Page 3316-3316, December 1, 2019.
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Numerous recent works highlight the limited utility of established tumor cell lines in recapitulating the heterogeneity of tumors in patients. More realistic preclinical cancer models are thought to be provided by transplantable, patient-derived tumor xenografts (PDX). Inter- and intra-tumor heterogeneity of PDX, however, present several challenges in developing optimal quantitative pipelines to assess response to therapy. The objective of this work was to develop and optimize image metrics of...
Fri Nov 22, 2019 20:43
Introduction: Aromatase inhibitors are the mainstay of hormonal therapy in estrogen receptor positive, postmenopausal breast cancer, although response rate is just over 50%. The goal of the present study was to validate and optimize positron emission tomography (PET) with 11C-vorozole for measuring aromatase expression in postmenopausal breast cancer. Methods: Ten newly diagnosed, postmenopausal women with biopsy confirmed breast cancer were administered 11C-vorozole intravenously and PET emission...
Fri Nov 22, 2019 20:43
Purpose: Molecular Radiotherapy (MRT) using 177Lu-DOTATATE is a most effective therapy for the treatment of somatostatin receptor expressing neuroendocrine tumors (NETs). Despite its frequent and successful use in the clinic, little or no radiobiological considerations are taken into account at the time of treatment planning or delivery, and upon positive uptake of octreotide-based PET/SPECT imaging, treatment is usually administered as a standard dose and number of cycles without adjustment for...
Fri Nov 22, 2019 20:43
The purpose of this study was to assess the predictive and prognostic value of interim FDG PET (iPET) in evaluating early response to immuno-chemotherapy after two cycles (PET-2) in diffuse large B-cell lymphoma (DLBCL) by applying two different methods of interpretation: the Deauville visual five-point scale (5-PS) and a change in standardised uptake value by semi-quantitative evaluation. Methods: 145 patients with newly diagnosed DLBCL underwent pre-treatment PET (PET-0) and PET-2 assessment....
Fri Nov 22, 2019 20:43
Purpose: To explore the value of 68Ga-PSMA-PET/CT for detection of phosphatase and tensin homolog (PTEN) - loss prostate cancer (PCa). Methods: We retrospectively enrolled 75 patients who underwent multiparametric MRI (mpMRI) and 68Ga-PSMA PET/CT before radical prostatectomy. Lesions were outlined on pathological images and regions of interest were drawn on matched mpMRI and PET/CT images. Imaging parameters including average apparent diffusion coefficient (ADCmean) and maximum standardized uptake...
Fri Nov 22, 2019 20:43
Abstract Objective Febrile seizures may follow vaccination. Common variants in the sodium channel gene, SCN1A, are associated with febrile seizures and rare pathogenic variants in SCN1A cause the severe developmental and epileptic encephalopathy Dravet Syndrome. Following vaccination, febrile seizures may raise the spectre of poor outcome and inappropriately implicate vaccination as the cause. We aimed to determine the prevalence of SCN1A variants in children having their first febrile seizure...
Fri Nov 22, 2019 22:03
Abstract Tecchio et al. (J Neurophysiology 104: 1134–1140, 2010) reported that the application of anodal tDCS at primary motor cortex (M1) immediately after practice of a procedural motor skill enhanced consolidation, which in turn improved offline gain. Tecchio et al. noted, however, that this study did not account for known after-effects associated with this form of non-invasive stimulation. The present study was designed to explicitly reevaluate Tecchio et al.’s claim. As in...
Fri Nov 22, 2019 02:00
Modern prosthetic hands are typically controlled using skin surface electromyographic signals (EMG) from remaining muscles in the residual limb. However, surface electrode performance is limited by changes in ...
Thu Nov 21, 2019 02:00
Motor impairment after stroke interferes with performance of everyday activities. Upper limb spasticity may further disrupt the movement patterns that enable optimal function; however, the specific features of...
Thu Nov 21, 2019 02:00
Powered exoskeletons provide a way to stand and walk for people with severe spinal cord injury. Here, we used the ReWalk exoskeleton to determine the training dosage required for walking proficiency, the senso...
Thu Nov 21, 2019 02:00
Publication date: February 2020Source: World Neurosurgery, Volume 134Author(s): Oscar Gutierrez-Avila, Junta Moroi, Tatsuya IshikawaBackgroundAdequate bypass harvesting of the superficial temporal artery (STA) is a standard procedure for every neurosurgeon, so mastery of techniques for its management and care is mandatory.MethodsHere, we report the effectiveness of using the bipolar forceps as a novel procedure.ResultsThis procedure improves safety, efficiency, and bleeding compared to the usual...
Fri Nov 22, 2019 13:03
Publication date: February 2020Source: World Neurosurgery, Volume 134Author(s): Isamu Miura, Motoo Kubota, Oji Momosaki, Miki Nyui, Kento Takebayashi, Takakazu Kawamata, Masahito YuzuriharaBackgroundMeningeal melanocytoma is a rare benign lesion found in the central nervous system. Preoperative diagnosis of meningeal melanocytoma is often a diagnostic challenge, as the clinical and neurologic features are often nonspecific. Various characteristics, including the natural course of this tumor, remain...
Fri Nov 22, 2019 13:03
Publication date: Available online 22 November 2019Source: World NeurosurgeryAuthor(s): Shigeomi Yokoya, Akihiko Hino, Hideki OkaAbstractAn unruptured anterior circulation, non-giant saccular cerebral aneurysm (located at the clinoid segment [C3] of the internal carotid artery [ICA], and growing into the carotid cave), was detected at a medical checkup, and diagnosed from subsequent examinations (Figure 1). The aneurysm was observed and followed up with radiological examinations. An examination performed...
Fri Nov 22, 2019 13:03
Publication date: Available online 22 November 2019Source: World NeurosurgeryAuthor(s): Tianhang XIE, Peng Xiu, Zhiqiang Yang, Duan Wang, Jiancheng Zeng, Yueming SongAbstractBackgroundThe optimal management of lumbar synovial cysts (LSC) has always been controversial. Open or minimally invasive partial hemilaminotomy as a direct decompression approach has been widely studied. Whereas, to our knowledge, there has been no report of an indirect decompression method for LSC.Case presentationA 60-year-old...
Fri Nov 22, 2019 13:03
Publication date: Available online 22 November 2019Source: World NeurosurgeryAuthor(s): Hui Zhang, Li Ma, Cheng Shu, Lian-qiang Dong, Ya-qun Ma, Yan ZhouAbstractObjectiveAs World Health Organization (WHO) grade II tumor in nervous system, clear cell meningioma (CCM) is an uncommon histological variant of meningioma. Spinal CCMs are even rarer, with only less than 100 spinal CCMs reported in the English literature. We present this study to characterize clinical manifestations of spinal CCMs and determine...
Fri Nov 22, 2019 13:03
Publication date: Available online 22 November 2019Source: World NeurosurgeryAuthor(s): Fernando Guedes, Rosana Siqueira Brown, Francisco José Lourenço Torrão-Júnior, Ana Caroline Siquara-de-Sousa, Rogério Martin Pires AmorimAbstractObjectiveLesions affecting the sciatic nerve (SN) can mimic lumbar radiculopathy. In patients presenting with sciatica, approximately 10% have a non-discogenic etiology. Through neurological examination and imaging, it may be possible to confirm non-discogenic sciatica...
Fri Nov 22, 2019 13:03
Publication date: Available online 22 November 2019Source: World NeurosurgeryAuthor(s): Jia-Nan Li, Qiang Li, Yi-Bin Fang, Qing-Hai Huang, Bo Hong, Rui Zhao, Yi Xu, Jian-Min LiuAbstractObjectEndovascular embolization with transvenous sinus preservation using balloon is at present the preferred modality for DAVFs involving venous sinuses (sagittal, transvers and sigmoid) with potential drainage function. The aim of the study was to evaluate the necessity and medium-term efficacy of this technique.MethodsPatients...
Fri Nov 22, 2019 13:03
Publication date: Available online 22 November 2019Source: World NeurosurgeryAuthor(s): Yi Wang
Fri Nov 22, 2019 13:03
Publication date: Available online 21 November 2019Source: World NeurosurgeryAuthor(s): Paul M. Foreman, Mohamed M. Salem, Christoph J. Griessenauer, Adam A. Dmytriw, Carmen Parra-Farinas, Patrick Nicholson, Nicola Limbucci, Anna Luisa Kühn, Ajit S. Puri, Leonardo Renieri, Sergio Nappini, Kimberly P. Kicielinski, Alejandro Bugarini, Vitor Mendes Pereira, Thomas R. Marotta, Clemens M. Schirmer, Christopher S. Ogilvy, Ajith J. ThomasAbstractObjectivePartially thrombosed intracranial aneurysms (PTIA)...
Fri Nov 22, 2019 13:03
Publication date: Available online 21 November 2019Source: World NeurosurgeryAuthor(s): Robert Y. North, Terence Verla, Erica Bartlett, Edward Reece, Howard L. Weiner, Alexander E. RopperAbstractBackgroundAn expanding cohort of spina bifida patients live well into adulthood and pose complex management challenges due to unique combinations of adult health issues overlying congenital problems.Case DescriptionWe present a case of a 45-year-old woman with an expanding, disfiguring, painful lumbar meningocele...
Fri Nov 22, 2019 13:03
Publication date: Available online 22 November 2019Source: Journal of Neuroscience MethodsAuthor(s): Wolfhardt Freinbichler, Bashkim Misini, Maria Alessandra Colivicchi, Wolfgang Linert, Keith F. Tipton, Laura Della CorteAbstractBackgroundFree, non-protein bound, Fe(II), which can catalyse the formation of the toxic highly-reactive oxygen species (hROS), has been implicated in several neurodegenerative conditions. The determination of free Fe(II) and Fe(III) in samples obtained from microdialysis...
Fri Nov 22, 2019 12:27
Publication date: Available online 21 November 2019Source: Journal of Neuroscience MethodsAuthor(s): Aditya Srinivasan, Arvind Srinivasan, Russell J. FerlandAbstractBackgroundSholl analysis has been used to analyze neuronal morphometry and dendritic branching and complexity for many years. While the process has become semi-automated in recent years, existing software packages are still dependent on user tracing and hence are subject to observer bias, variability, and increased user times for analyses....
Fri Nov 22, 2019 12:27
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