Related ArticlesWho Is a Pathologist According to Oncology Patients and Internet Users? A Survey Study. J Cancer Educ. 2019 Oct 30;: Authors: Kunc M, Miszewski K, Bieńkowski M, Kamieniecki A, Ekman M, Gorczyński A, Biernat W Abstract The pathologist is frequently called "the doctor's doctor." However, there are many uncertainties about the role of a pathologist among patients and policymakers and even among other medical specialties. The aim of the current...
Fri Nov 01, 2019 19:46
Related ArticlesTreatment for lymphoma and late cardiovascular disease risk: A systematic review and meta-analysis. Health Sci Rep. 2019 Oct;2(10):e135 Authors: Stone CR, Mickle AT, Boyne DJ, Mohamed A, Rabi DM, Brenner DR, Friedenreich CM Abstract Background and aims: Lymphoma patients are frequently treated with cancer therapies that may increase the risk of adverse health outcomes later in life, including cardiovascular disease (CVD) mortality. We...
Fri Nov 01, 2019 19:46
Related ArticlesRadiomics signature extracted from diffusion-weighted magnetic resonance imaging predicts outcomes in osteosarcoma. J Bone Oncol. 2019 Dec;19:100263 Authors: Zhao S, Su Y, Duan J, Qiu Q, Ge X, Wang A, Yin Y Abstract Objective: Osteosarcoma often requires multidisciplinary treatment including surgery, chemotherapy and radiotherapy. However, tumor behavior can vary widely among patients and selection of appropriate therapies in any individual...
Fri Nov 01, 2019 19:46
Related ArticlesPerspective on CETSA Literature: Toward More Quantitative Data Interpretation. SLAS Discov. 2019 Oct 30;:2472555219884524 Authors: Seashore-Ludlow B, Axelsson H, Lundbäck T Abstract The cellular thermal shift assay (CETSA) was introduced in 2013 to investigate drug-target engagement inside live cells and tissues. As with all thermal shift assays, the response measured by CETSA is not simply governed by ligand affinity to the investigated...
Fri Nov 01, 2019 19:46
Related ArticlesEpidemiology of injuries among amateur athletes who attended fitness activities: the role of the qualification of the trainer. J Sports Med Phys Fitness. 2019 Oct 25;: Authors: Bianchi FP, Labbate M, Castellana M, Stefanizzi P, De Nitto S, Notarnicola A, Tafuri S Abstract BACKGROUND: The fitness trainer could have an important role in the prevention of injuries among fitness attendants. In several Countries, including Italy, there is...
Fri Nov 01, 2019 19:46
Vaccines, Vol. 7, Pages 171: Post-Glycosylation Modification of Sialic Acid and Its Role in Virus Pathogenesis Vaccines doi: 10.3390/vaccines7040171 Authors: Park Sialic acids are a family of nine carbon keto-aldononulosonic acids presented at the terminal ends of glycans on cellular membranes. α-Linked sialoglycoconjugates often undergo post-glycosylation modifications, among which O-acetylation of N-acetyl neuraminic acid (Neu5Ac) is the most common in mammalian cells. Isoforms...
Fri Nov 01, 2019 02:00
Vaccines, Vol. 7, Pages 169: Development of Universal Influenza Vaccines Targeting Conserved Viral Proteins Vaccines doi: 10.3390/vaccines7040169 Authors: Jazayeri Poh Vaccination is still the most efficient way to prevent an infection with influenza viruses. Nevertheless, existing commercial vaccines face serious limitations such as availability during epidemic outbreaks and their efficacy. Existing seasonal influenza vaccines mostly induce antibody responses to the surface proteins...
Fri Nov 01, 2019 02:00
Vaccines, Vol. 7, Pages 168: Vaccination against Paediatric Respiratory Pathogens Vaccines doi: 10.3390/vaccines7040168 Authors: Bianchini Argentiero Camilloni Silvestri Alunno Esposito Acute respiratory infections (ARIs) are extremely common in children, especially those under 5 years old. They can lead to complications, super-infection, respiratory failure, and even compromised respiratory function in adulthood. For some of the responsible pathogens, vaccines are...
Fri Nov 01, 2019 02:00
Vaccines, Vol. 7, Pages 170: A Recombinant La Sota Vaccine Strain Expressing Multiple Epitopes of Infectious Bronchitis Virus (IBV) Protects Specific Pathogen-Free (SPF) Chickens against IBV and NDV Challenges Vaccines doi: 10.3390/vaccines7040170 Authors: Tan Wen Qiu Yuan Meng Sun Liao Song Liu Shi Shao Ding Infectious bronchitis (IB) and Newcastle disease (ND) are two major infectious diseases that are a threat to the domestic poultry industry....
Fri Nov 01, 2019 02:00
Vaccines, Vol. 7, Pages 166: First-In-Human Trials of GamTBvac, a Recombinant Subunit Tuberculosis Vaccine Candidate: Safety and Immunogenicity Assessment Vaccines doi: 10.3390/vaccines7040166 Authors: Vasina Kleymenov Manuylov Mazunina Koptev Tukhovskaya Murashev Gintsburg Gushchin Tkachuk Tuberculosis is known to be the biggest global health problem, causing the most deaths by a single infectious agent. Vaccine-development efforts are extremely...
Fri Nov 01, 2019 02:00
Viruses, Vol. 11, Pages 1018: Simultaneous Immunization with Multivalent Norovirus VLPs Induces Better Protective Immune Responses to Norovirus Than Sequential Immunization Viruses doi: 10.3390/v11111018 Authors: Maria Malm Timo Vesikari Vesna Blazevic Human noroviruses (NoVs) are a genetically diverse, constantly evolving group of viruses. Here, we studied the effect of NoV pre-existing immunity on the success of NoV vaccinations with genetically close and distant genotypes. A...
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Viruses, Vol. 11, Pages 1017: Measles Encephalitis: Towards New Therapeutics Viruses doi: 10.3390/v11111017 Authors: Ferren Horvat Mathieu Measles remains a major cause of morbidity and mortality worldwide among vaccine preventable diseases. Recent decline in vaccination coverage resulted in re-emergence of measles outbreaks. Measles virus (MeV) infection causes an acute systemic disease, associated in certain cases with central nervous system (CNS) infection leading to lethal...
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Viruses, Vol. 11, Pages 1016: A Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation Viruses doi: 10.3390/v11111016 Authors: Malik Ngo Bosma Rubin Mumps virus (MuV) is a neurotropic non-segmented, negative-stranded, enveloped RNA virus in the Paramyxovirus family. The 15.4 kb genome encodes seven genes, including the V/P, which encodes, among other proteins, the V protein. The MuV V protein has been shown...
Fri Nov 01, 2019 02:00
Viruses, Vol. 11, Pages 1015: Emergence of Rare Bovine–Human Reassortant DS-1-Like Rotavirus A Strains with G8P[8] Genotype in Human Patients in the Czech Republic Viruses doi: 10.3390/v11111015 Authors: Moutelíková Sauer Dvořáková Heroldová Holá Prodělalová Group A Rotaviruses (RVA) are the leading cause of acute gastroenteritis in children and a major cause of childhood mortality in low-income countries. RVAs are mostly host-specific, but interspecies transmission...
Fri Nov 01, 2019 02:00
Viruses, Vol. 11, Pages 1014: No Evidence of Mosquito Involvement in the Transmission of Equine Hepacivirus (Flaviviridae) in an Epidemiological Survey of Austrian Horses Viruses doi: 10.3390/v11111014 Authors: Marcha Badenhorst Phebe de Heus Angelika Auer Till Rümenapf Birthe Tegtmeyer Jolanta Kolodziejek Norbert Nowotny Eike Steinmann Jessika-M.V. Cavalleri Prevalence studies have demonstrated a global distribution of equine hepacivirus (EqHV), a member of the...
Fri Nov 01, 2019 02:00
Viruses, Vol. 11, Pages 1013: The Role of Temperature in Transmission of Zoonotic Arboviruses Viruses doi: 10.3390/v11111013 Authors: Ciota Keyel We reviewed the literature on the role of temperature in transmission of zoonotic arboviruses. Vector competence is affected by both direct and indirect effects of temperature, and generally increases with increasing temperature, but results may vary by vector species, population, and viral strain. Temperature additionally has a significant...
Fri Nov 01, 2019 02:00
Viruses, Vol. 11, Pages 1012: HIV-1 Envelope Glycoprotein Amino Acids Signatures Associated with Clade B Transmitted/Founder and Recent Viruses Viruses doi: 10.3390/v11111012 Authors: Alexis Kafando Christine Martineau Mohamed El-Far Eric Fournier Florence Doualla-Bell Bouchra Serhir Adama Kazienga Mohamed Ndongo Sangaré Mohamed Sylla Annie Chamberland Hugues Charest Cécile L. Tremblay Background: HIV-1 transmitted/founder viruses (TF) are selected during...
Fri Nov 01, 2019 02:00
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Fri Nov 01, 2019 17:17
Related ArticlesThe Pancreatic Endocrine Tumors - Experience of First Surgical Clinic Iasi. Chirurgia (Bucur). 2019 Sept-Oct;114(5):639-649 Authors: Târcoveanu E, Lupascu C, Vasilescu A, Moldovanu R, Andronic D, Ciobanu D, Bradea C Abstract Pancreatic neuroendocrine tumors (PNETs) are rare and characterized by widely variable clinical presentation and often challenging surgical management. Methods: Retrospective study conducted during the last 15 years...
Fri Nov 01, 2019 20:03
Related ArticlesPancreatic Neuroendocrine Tumour in Pregnancy - Diagnosis and Treatment Management. Chirurgia (Bucur). 2019 Sept-Oct;114(5):550-563 Authors: Predescu D Abstract Digestive cancers diagnosed during pregnancy are rare and are sporadically reported. The shift of pregnancy towards the age interval of 30-39 years old (and even 40-49 years old) could explain the more and more frequent superposition of pregnancy and cancer. Pancreatic Neuroendocrine...
Fri Nov 01, 2019 20:03
Risks, costs, and outcomes of cerebrospinal fluid leaks after pediatric skull fractures: a MarketScan analysis between 2007 and 2015. Neurosurg Focus. 2019 Nov 01;47(5):E10 Authors: Varshneya K, Rodrigues AJ, Medress ZA, Stienen MN, Grant GA, Ratliff JK, Veeravagu A Abstract OBJECTIVE: Skull fractures are common after blunt pediatric head trauma. CSF leaks are a rare but serious complication of skull fractures; however, little evidence exists on the...
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Related ArticlesSurgical management of clinically silent thyrotropin pituitary adenomas: A single center series of 20 patients. J Clin Neurosci. 2019 Oct 24;: Authors: Cyprich J, Donoho DA, Brunswick A, Hurth K, Carmichael JD, Weiss MH, Zada G Abstract Silent thyrotropin pituitary adenomas (TSHomas) are defined by absence of hyperthyroidism despite TSH immunopositivity. Data pertaining to clinical and surgical characteristics of silent TSHomas remains...
Fri Nov 01, 2019 20:17
Related ArticlesHigh-Resolution PET Cisternography With 64Cu-DOTA for CSF Leak Detection. Clin Nucl Med. 2019 Sep;44(9):735-737 Authors: Freesmeyer M, Schwab M, Besteher B, Gröber S, Waschke A, Drescher R Abstract Intracranial hypotension may lead to chronic, debilitating symptoms, and severe complications. The underlying CSF leak may be difficult to localize. To establish a new diagnostic option for the detection of CSF leaks, Cu-DOTA was developed...
Fri Nov 01, 2019 20:17
Related ArticlesUnexpected skin lesions secondary to metastasis of urothelial carcinoma. Int J Surg Case Rep. 2019 Oct 11;64:177-179 Authors: Taktak T, Boussaffa H, Ouanes Y, Zaghbib S, Sellami A, Ghorbel Z, Chelly I, Rhouma SB, Nouira Y Abstract INTRODUCTION: Metastatic spread of urothelial bladder carcinoma (UBC) rarely involves the skin which is associated with a poor prognosis. We present a rare case of UBC with cutaneous metastases which is exceptional...
Fri Nov 01, 2019 20:03
Related ArticlesEvolution and Impact of Subclonal Mutations in Papillary Thyroid Cancer. Am J Hum Genet. 2019 Oct 15;: Authors: Masoodi T, Siraj AK, Siraj S, Azam S, Qadri Z, Parvathareddy SK, Al-Sobhi SS, AlDawish M, Alkuraya FS, Al-Kuraya KS Abstract Unlike many cancers, the pattern of tumor evolution in papillary thyroid cancer (PTC) and its potential role in relapse have not been elucidated. In this study, multi-region whole-exome sequencing (WES)...
Fri Nov 01, 2019 20:03
Related ArticlesPrimary bulbo-medullary glioblastoma in a child: case report. Childs Nerv Syst. 2019 Oct 30;: Authors: Lakhdar F, Benzagmout M, Chakour K, Chaoui FM Abstract Glioblastoma (GBM) of the spinal cord represents a rare entity in children and account for less than 1% of all central nervous system (CNS) cancers. Their biology, localization, and controversial treatment options have been discussed in a few pediatric cases. Here, we report a case...
Fri Nov 01, 2019 20:03
Related ArticlesLow-grade appendiceal mucinous neoplasms with bowel obstruction. Pleura Peritoneum. 2019 Sep 01;4(3):20190020 Authors: Houlzé-Laroye C, Eveno C Abstract Background: Perforation of low-grade appendiceal mucinous neoplasms (LAMN) is characterized by its potential to spread mucin into peritoneal cavity, giving rise to pseudomyxoma peritonei, commonly treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.Symptoms...
Fri Nov 01, 2019 20:03
Related ArticlesSynchronous quadruple primary malignancies of the cervix, endometrium, ovary, and stomach in a single patient: A case report and review of literature. World J Clin Cases. 2019 Oct 26;7(20):3364-3371 Authors: Wang DD, Yang Q Abstract BACKGROUND: The diagnosis of multiple primary malignancies (MPMs) has increased due to the improvements and development of diagnostic techniques, in conjunction with extended life span. Notably however, reports...
Fri Nov 01, 2019 20:03
Related ArticlesFeasibility of laparoscopic isolated caudate lobe resection for rare hepatic mesenchymal neoplasms. World J Clin Cases. 2019 Oct 26;7(20):3194-3201 Authors: Li Y, Zeng KN, Ruan DY, Yao J, Yang Y, Chen GH, Wang GS Abstract BACKGROUND: Mesenchymal tumors such as perivascular epithelioid cell neoplasm (PEComa) and inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDC sarcoma) are relatively uncommon in the liver and...
Fri Nov 01, 2019 20:03
Related ArticlesAssessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma. Oncotarget. 2019 Oct 15;10(57):5958-5969 Authors: Chamseddin BH, Lee EE, Kim J, Zhan X, Yang R, Murphy KM, Lewis C, Hosler GA, Hammer ST, Wang RC Abstract Anal squamous cell carcinoma (ASCC) is a rare, potentially fatal malignancy primarily caused by high-risk human papillomaviruses (HPV). The prognostic implication of programmed death-ligand 1 (PD-L1)...
Fri Nov 01, 2019 20:03
Related ArticlesThe landscape of tyrosine kinase inhibitors in sarcomas: looking beyond pazopanib. Expert Rev Anticancer Ther. 2019 Oct 30;: Authors: Wilding CP, Elms ML, Judson I, Tan AC, Jones RL, Huang PH Abstract Introduction: Tyrosine kinases are key mediators of intracellular signalling cascades and aberrations in these proteins have been implicated in driving oncogenesis through the dysregulation of fundamental cellular processes including proliferation,...
Fri Nov 01, 2019 20:03
Related ArticlesBlue Rubber Bleb Nevus Syndrome: A Surgical Dilemma. Am Surg. 2019 Sep 01;85(9):e492-e493 Authors: Bazzell A, Williams S, Turner J, Chase A, Clark CE PMID: 31638551 [PubMed - indexed for MEDLINE]
Fri Nov 01, 2019 20:03
Related Articles[Renal clear cell carcinoma transferred to infratemporal fossa and pterygopalatine fossa: A case report]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Oct;33(10):998-999 Authors: Ye Y, Luo Q, Jiang HQ, Zhang J, Wang J, She J Abstract SummaryRenal clear cell carcinoma is prone to distant metastasis, especially in the head and neck, but it is rare to transfer to infratemporal fossa and pterygopalatine fossa. We reported a 62-year-old...
Fri Nov 01, 2019 20:03
Related ArticlesMale Breast Huge Malignant Phyllodes. Chirurgia (Bucur). 2019 Jul-Aug;114(4):512-517 Authors: Hamdy O, Saleh GA, Raafat S, Shebl AM, Denewer A Abstract Introduction: Phyllodes tumors are rare breast tumors. The best treatment is wide local excision with 1 cm safety margin unless metastatic. The three pathological types (benign, borderline and malignant were reported in men. Case presentation: A 73year-old male with huge left breast swelling...
Fri Nov 01, 2019 20:03
Related ArticlesThyroid nodules ≤ 1 cm and papillary thyroid microcarcinomas: Brazilian experts opinion. Arch Endocrinol Metab. 2019;63(5):456-461 Authors: Rosario PW, Ward LS, Graf H, Vaisman F, Mourão GF, Vaisman M Abstract The indolent evolution of low-risk papillary thyroid microcarcinoma (mPTC) in adult patients and the consequences of thyroidectomy require a revision of the management traditionally recommended. Aiming to spare patients unnecessary...
Fri Nov 01, 2019 20:03
Related ArticlesDiffuse Infiltration of Multiple Myeloma With Initial Manifestation of Cavernous Sinus Syndrome Unveiled by 18F-FDG PET/CT. Clin Nucl Med. 2019 Sep;44(9):746-747 Authors: Li C, Shao F, Yang Y, Lan X Abstract Intracranial infiltration is a rare complication of multiple myeloma (MM), which is usually seen in advanced stage. Here, we report a 47-year-old woman with only cavernous sinus syndrome as first manifestation. Brain MR revealed...
Fri Nov 01, 2019 20:03
Related Articles18F-FDG PET/CT in Oral Cuniculatum Carcinoma. Clin Nucl Med. 2019 Sep;44(9):741-742 Authors: Dejust S, El Farsaoui K, Bellefqih S, Lalire P, Morland D Abstract A 69-year-old woman was referred for initial staging of an oral cavity mass. F-FDG PET/CT displayed a homogeneous intense uptake of the 50-mm left hemipalatal mass with local extension to the dental arcade and maxillary sinus. Infracentimetric bilateral cervical nodes with faint...
Fri Nov 01, 2019 20:03
Related ArticlesRenal Pelvis Involvement of Immunoglobulin G4-Related Disease Mimicking Malignancy on 18F-FDG PET/CT. Clin Nucl Med. 2019 Sep;44(9):767-768 Authors: Jiang Y, Hou G, Cheng W Abstract A 70-year-old woman with bilateral submandibular gland enlargement was referred to our hospital. Submandibular gland biopsy indicated immunoglobulin G4 (IgG4)-related disease (IgG4-RD) involvement. Contrast-enhanced CT was undergone for evaluation of IgG4-RD...
Fri Nov 01, 2019 20:03
Related Articles[First Robotic Assisted Resection of a Retrorectal Tailgut Cyst - Video Case Report of a 27-Year-Old Female Patient]. Zentralbl Chir. 2019 Aug;144(4):337-339 Authors: Wilhelm P, Jansen K, Rolinger J, Kirschniak A, Axt S, Johannink J Abstract PURPOSE: Tailgut cysts are a rare form of retrorectal tumours. They are also referred to as cystic hamartomas and predominantly affect female patients. Malignant transformation is thought to occur...
Fri Nov 01, 2019 20:03
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